| Year | Title | Role | Director | Notes |
| 1999 | Rosetta | Rosetta | Dardenne brothers | Cannes Film Festival Award for Best ActressChicago Film Critics Association Award for Most Promising ActressJoseph Plateau Award for Best Belgian ActressNominated - César Award for Most Promising ActressNominated - European Film Award for Best Actress |
| 2001 | Brotherhood of the Wolf | Marianne de Morangias | Christophe Gans | Cabourg Romantic Film Festival - Best New Actress |
| Yes, But... | Eglantine Laville | Yves Lavandier | Avanca Film Festival - Best Acting |
| 2002 | Une femme de ménage | Laura | Claude Berri | Nominated - César Award for Most Promising Actress |
| Jean Moulin | Lili | Yves Boisset | TV movie |
| 2003 | The Very Merry Widows | Laurence Milcaux | Catherine Corsini | Nominated - Joseph Plateau Award for Best Belgian Actress |
| 2004 | The Light | Brigitte | Philippe Lioret | Nominated - César Award for Best Supporting Actress |
| The Bridge of San Luis Rey | Doña Clara | Mary McGuckian | |
| L'américain | Nelly | Patrick Timsit | |
| Kaamelott | Edern | Alexandre Astier | TV series (1 Episode) |
| 2005 | The United States of Albert (Les États-Unis d'Albert) | Grace Carson | André Forcier | |
| Avant qu'il ne soit trop tard | Aurélia | Laurent Dussaux | |
| La ravisseuse | Charlotte | Antoine Santana | |
| 2006 | Le Grand Meaulnes | Valentine | Jean-Daniel Verhaeghe | |
| Écoute le temps | Charlotte | Alantė Kavaitė | |
| Du rouge sur la croix | Cécile Thuillier | Dominique Othenin-Girard | TV movie |
| 2007 | To Each His Own Cinema | The crying woman | Dardenne brothers (2) | |
| La Vie d'artiste | Cora | Marc Fitoussi | |
| Confidences | | Laurent Dussaux (2) | TV Mini-Series |
| 2008 | Rien dans les poches | Judith Miro | Marion Vernoux | TV movie |
| Charlotte Corday | Charlotte Corday | Henri Helman | TV movie |
| Miroir, mon beau miroir | Marion | Serge Meynard | TV movie |
| 2009 | The Girl on the Train | Jeanne Fabre | André Téchiné | Taormina International Film Festival - Best Acting Performance |
| J'ai oublié de te dire | Marie | Laurent Vinas-Raymond | |
| Obsession(s) | Sarah Lisbourne | Frédéric Tellier | TV movie |
| 2010 | The Pack | Charlotte Massot | Franck Richard | New York City Horror Film Festival - Best Actress |
| 2011 | Mystère au Moulin Rouge | Diane Barraud | Stéphane Kappes | TV movie |
| 2012 | Our Children | Murielle | Joachim Lafosse | Cannes Film Festival - Un Certain Regard - Best ActressMagritte Award for Best ActressPalm Springs International Film Festival - Best ActressNominated - European Film Award for Best ActressNominated - Dublin Film Critics' Circle - Best ActressNominated - Globes de Cristal Award for Best ActressNominated - Satellite Award for Best Actress – Motion Picture |
| La traversée | Sarah Arendt | Jérôme Cornuau | |
| 2013 | Möbius | Sandra | Éric Rochant | |
| 2014 | Not My Type | Jennifer | Lucas Belvaux | Magritte Award for Best ActressCabourg Romantic Film Festival - Best ActressNominated - César Award for Best ActressNominated - Globes de Cristal Award for Best ActressNominated - Lumière Award for Best ActressNominated - Trophees Francophones du Cinema - Best Actress |
| Divin Enfant | Sarah | Olivier Doran | |
| The Missing | Laurence Relaud | Tom Shankland | TV series (8 Episodes) |
| 2015 | Par accident | Angélique | Camille Fontaine | |
| Souviens-toi | Emilie Auclair | Philippe Venault | TV movie |
| 2016 | Trainee Day | Cyrielle | Marc Fitoussi (2) | |
| Accusé | | | TV series (1 Episode) |
| 2017 | See You Up There | Madeleine Péricourt | Albert Dupontel | |
| Les Hommes du feu | Bénédicte | Pierre Jolivet | |
| This Is Our Land | Pauline Duhez | Lucas Belvaux (2) | Magritte Award for Best Actress |
| 2020 | Love Affair(s) | Louise | Emmanuel Mouret | César Award for Best Supporting ActressNominated - Magritte Award for Best Supporting Actress |
| 2022 | Close | Sophie | Lukas Dhont | |
| 2023 | Année Zéro | Juliette Kharoub | Olivier Barma [fr] | TV series (4 episodes) |
| Mr. Blake at Your Service! | Odile | Gilles Legardinier | |
