| Year | Title | Role | Notes |
| 1997–2000 | The Chris Rock Show | Various Characters | 7 episodes |
| 1999 | Best of the Chris Rock Show | TV special |
| Dr. Katz, Professional Therapist | Wanda | Voice, 2 episodes |
| 2001 | The Downer Channel | Various | 2 episodes |
| The Drew Carey Show | Christine Watson | 3 episodes |
| 2001–11 | Curb Your Enthusiasm | Herself | 9 episodes |
| 2002–05; 2019–22 | Crank Yankers | Wanda / Gladys Murphy | Voice, 19 episodes |
| 2003 | Wanda at Large | Wanda Mildred Hawkins | 19 episodes |
| Chappelle's Show | Herself | Episode: "The Best of Chappelle's Show: Volume 2 Mixtape" |
| Mad TV | Season 9 episode 903 |
| 2004 | Wanda Does It | 6 episodes |
| 2006 | Will & Grace | Cricket Walker | Episode: "Buy, Buy Baby" |
| 2006 | Sick and Tired | Herself | HBO comedy special |
| 2006–10 | The New Adventures of Old Christine | Barbara "Barb" Baran | 54 episodes; (Recurring Seasons 1–2, Starring Seasons 3–5) |
| 2007–11 | Back at the Barnyard | Bessy | Voice, 50 episodes |
| 2009 | Wanda Sykes: I'ma Be Me | Herself | HBO comedy special |
| White House Correspondents' Dinner | Herself (host) | TV special |
| 2009–10 | The Wanda Sykes Show | Herself | 21 episodes; also creator, writer, executive producer |
| 2011 | Drop Dead Diva | Judge | Episode: "Prom" |
| 2012 | Bubble Guppies | The Witch | Voice, episode: "Bubble Puppy's Fin-tastic Fairy Tale!" |
| Futurama | Bev the vending machine | Voice, episode: "The Bots and the Bees" |
| 2013 | The Simpsons | School Therapist / Counselor | Voice, episode: "What Animated Women Want" |
| Real Husbands of Hollywood | Wanda Sykes | 2 episodes |
| 2013–2014 | Alpha House | Senator Rosalyn DuPeche | Recurring role |
| 2014, 2019 | Last Week Tonight with John Oliver | Herself | 2 episodes |
| 2015 | Repeat After Me | 1 episode |
| 2015, 2017 | Penn Zero: Part-Time Hero | Shirley B. Awesome | Voice, 2 episodes |
| 2015–20 | Black-ish | Daphne Lido | 16 episodes |
| 2016 | Bob's Burgers | Sofa Queen | Voice, episode: "Sacred Couch" |
| Animals | Chance | Voice, 2 episodes |
| What Happened... Ms. Sykes? | Herself | Epix comedy special |
| 2017 | Lip Sync Battle | Episode: "Don Cheadle vs. Wanda Sykes" |
| Doc McStuffins | Thea | Voice, episode: "The Emergency Plan" |
| 2017–21 | Vampirina | Gregoria the Gargoyle | Voice, main role |
| 2017–19 | Broad City | Dara | Recurring role |
| 2018 | Ask the StoryBots | Doctor | Episode: "How Do People Catch a Cold?" |
| BoJack Horseman | Mary-Beth | Voice, episode: "INT. SUB" |
| 2019 | The Bravest Knight | Mona the Mayor | Voice, episode: "Cedric & the Pixies" |
| Scooby-Doo and Guess Who? | Herself | Voice, episode: "Peebles' Pet Shop of Terrible Terrors!" |
| Live in Front of a Studio Audience | Louise Jefferson | Episode: "Norman Lear's All in the Family and The Jeffersons" |
| Wanda Sykes: Not Normal | Herself | Netflix comedy special |
| Summer Camp Island | Ethel | Episode: "The Great Elf Invention Convention" |
| Big Mouth | Ghost of Harriet Tubman | Voice, episode: "Duke" |
| The Marvelous Mrs. Maisel | Moms Mabley | Episode: "A Jewish Girl Walks Into the Apollo..." |
| RuPaul's Drag Race | Herself | Episode: "Bring Back My Queens!" |
| 2019–23 | The Other Two | Shuli Kucerac | Recurring role |
| 2019–20 | Harley Quinn | Tsaritsa / Queen of Fables | Voice, 3 episodes |
| 2020 | Mapleworth Murders | Leigh Drain | Episode: "Killer Voices – Part 2" |
| 2020–21 | Tig n' Seek | Nuritza | Voice, 15 episodes |
