| Year | Batter | Event | Date and Site | Pitcher | Situation | Final score | Notes |
| 1955 | Rich Cominski, Morrisville, Pennsylvania | Little League World Series | August 26, Williamsport, Pennsylvania | Tommy Trotman, Merchantville, New Jersey | 3–3, 7thLeadoff | 4–3 | Cominski leads off the seventh inning of the title game with a home run after the teams are tied following six regulation innings. Both batter and pitcher are regular catchers playing out of position—Cominski in right field due to an injured thumb, and Trotman due to the starter reaching the series limit for pitchers' innings. Cy Young threw out the first pitch of the tournament, two months before his death at age 88. |
| 1996 | Warren Morris, LSU | College World Series | June 8, Rosenblatt Stadium | Robbie Morrison, Miami | 7–8, 9th1 on, 2 out | 9–8 | Morris hits a two-out, two-run game-winning home run on the last pitch in the championship game, giving the LSU Tigers their 3rd CWS title—it was also Morris' first and only home run of the season—and the only walk-off championship-winning home run in College World Series history. In addition, it is the only two-out, ninth inning, walk-off home run in a championship of any collegiate or professional level. The home run also won Morris the 1997 Showstopper of the Year ESPY Award. |
| 2001 | Hirotoshi Kitagawa, Osaka Kintetsu Buffaloes | NPB regular season | September 26, Osaka, Japan | Masanobu Okubo, Orix BlueWave | 2–5, 9th3 on, 0 out | 6–5 | Kitagawa hits a pinch-hit grand slam that erased a 3-run deficit and won the Pacific League pennant for the Osaka Kintetsu Buffaloes, their final pennant in franchise history before being merged into the Orix Blue Wave to form the Orix Buffaloes in the 2004-05 NPB off-season. |
| 2005 | Michael Memea, Ewa Beach, Hawaii | Little League World Series | August 28, Lamade Stadium | Christopher Garia, Willemstad, Curaçao | 6–6, 7thLeadoff | 7–6 | Memea hits a game winning solo home run in the bottom of the seventh inning of the championship game, giving Hawaii the title over the defending champions from Curaçao. Hawaii had only been put into position for the dramatic extra-inning win with a furious three-run rally in the bottom of the sixth. |
| 2007 | Deion Rosalia, Willemstad, Curaçao | Little League World Series | August 23, Volunteer Stadium | Reinaldo Amaro, Maracaibo, Venezuela | 1–2, 7th2 on, 2 out | 4–2 | In a semifinal of the International bracket, the Curaçao and Venezuela teams were tied 1–1 at the end of the regulation six innings. Venezuela's Bryan Charry led off the top of the seventh with a solo homer, staking them to a 2–1 lead. Curaçao had no one on with two out in their half of the seventh, but a single and walk set the table for Rosalia, who was down to his last strike before hitting his game-ending shot. |
| 2007 | Ryo Kanekubo, Tokyo, Japan | Little League World Series | August 25, Lamade Stadium | Rudson Pietersz, Willemstad, Curaçao | 3–4, 6th3 on, 1 out | 7–4 | Two days later, in the championship game of the international bracket, Curaçao becomes the victim of a game-winning shot. They take a 4–3 lead into the bottom of the sixth, but the Japan team responds by loading the bases for Kanekubo's shot, sending them to the title game the next day. |
| 2007 | Dalton Carriker, Warner Robins, Georgia | Little League World Series | August 26, Lamade Stadium | Junsho Kiuchi, Tokyo, Japan | 2–2, 8thLeadoff | 3–2 | This time, the Japan team becomes a game-winning victim as Carriker hits a solo home run in the bottom of the eighth inning, giving the state of Georgia its second straight title and the U.S. a third straight title. |
| 2016 | Haruki Nishikawa, Hokkaido Nippon-Ham Fighters | Japan Series | October 27, Sapporo Dome | Shota Nakazaki, Hiroshima Toyo Carp | 1–1, 9th3 on, 1 out | 5–1 | In Game 5 of the 2016 Japan Series, Nishikawa hits the first walk-off grand slam since 1992 when, on a 1–0 count in the bottom of the ninth, he connects on a Nakazaki pitch to right field. The win was the third consecutive win by the Fighters, which would go on to win Game 6 and the series after losing the first two games. |
| 2019 | Bryce Blaum, Texas A&M Aggies | Morgantown Regional, NCAA Division I tournament | June 2, Monongalia County Ballpark | Sam Kessler, West Virginia Mountaineers | 7–10, 9th3 on, 2 out | 11–10 | In an elimination game, the top regional seed West Virginia (which was designated the away team for this game despite playing at home) took leads of 6–0 in the middle of the fifth inning and 9–1 in the middle of the seventh, only to see A&M put up 6 runs in the bottom of the seventh. West Virginia took a 3-run lead into the bottom of the ninth, but loaded the bases for Blaum, who eliminated the Mountaineers with a grand slam on a 3–2 count with two outs. |
| 2022 | Cal Raleigh, Seattle Mariners | 2022 MLB Regular season | September 30, T-Mobile Park | Domingo Acevedo, Oakland Athletics | 1–1, 9th0 on, 2 out | 2–1 | Cal Raleigh hits a pinch hit, solo walk-off home run to help the Mariners clinch their first postseason berth since 2001, ending their 21 year drought. |
| 2023 | Louis Lappe, El Segundo, California | Little League World Series | August 27, Lamade Stadium | Jay-Dlynn Wiel, Willemstad, Curaçao | 5–5, 6thLeadoff | 6–5 | After Nasir El-Ossais of Curaçao tied the game 5-5 in the top of the 5th inning with a grand slam, Louis Lappe of El Segundo California sent a 1-0 pitch over the left field wall to clinch the Little League World Series title for the team from California. |
| 2024 | Shohei Ohtani, Los Angeles Dodgers | 2024 MLB Regular season | August 23, Dodger Stadium | Colin Poche, Tampa Bay Rays | 3–3, 9th3 on, 2 out | 7–3 | Ohtani stole his 40th base of the season in the 4th inning of the game, then proceeded to hit a walk-off grand slam to become the fastest player in MLB history to reach 40 home runs and 40 stolen bases in a single season. |