| Number | Portrait | Name | State of residence | Took office | Left office | President(s) |
| 1 | | Thomas Ewing | Ohio | March 8, 1849 | July 22, 1850 | | Zachary Taylor(1849–1850) |
| | Millard Fillmore(1850–1853) |
| 2 | | Thomas McKennan | Pennsylvania | August 15, 1850 | August 26, 1850 |
| 3 | | Alexander Stuart | Virginia | September 14, 1850 | March 7, 1853 |
| 4 | | Robert McClelland | Michigan | March 8, 1853 | March 9, 1857 | | Franklin Pierce(1853–1857) |
| 5 | | Jacob Thompson | Mississippi | March 10, 1857 | January 8, 1861 | | James Buchanan(1857–1861) |
| 6 | | Caleb Smith | Indiana | March 5, 1861 | December 31, 1862 | | Abraham Lincoln(1861–1865) |
| 7 | | John Usher | Indiana | January 1, 1863 | May 15, 1865 | |
| Andrew Johnson(1865–1869) |
| 8 | | James Harlan | Iowa | May 16, 1865 | August 31, 1866 | |
| 9 | | Orville Browning | Illinois | September 1, 1866 | March 4, 1869 | |
| 10 | | Jacob Cox | Ohio | March 5, 1869 | October 31, 1870 | | Ulysses S. Grant(1869–1877) |
| 11 | | Columbus Delano | Ohio | November 1, 1870 | September 30, 1875 |
| 12 | | Zachariah Chandler | Michigan | October 19, 1875 | March 11, 1877 |
| 13 | | Carl Schurz | Missouri | March 12, 1877 | March 7, 1881 | | Rutherford B. Hayes(1887–1881) |
| 14 | | Samuel J. Kirkwood | Iowa | March 8, 1881 | April 17, 1882 | | James A. Garfield(1881) |
| | Chester A. Arthur(1881–1885) |
| 15 | | Henry M. Teller | Colorado | April 18, 1882 | March 3, 1885 |
| 16 | | Lucius Lamar | Mississippi | March 6, 1885 | January 10, 1888 | | Grover Cleveland(1885–1889) |
| 17 | | William Vilas | Wisconsin | January 16, 1888 | March 6, 1889 |
| 18 | | John Noble | Missouri | March 7, 1889 | March 6, 1893 | | Benjamin Harrison(1889–1893) |
| 19 | | Hoke Smith | Georgia | March 6, 1893 | September 1, 1896 | | Grover Cleveland(1893–1897) |
| 20 | | David R. Francis | Missouri | September 3, 1896 | March 5, 1897 |
| 21 | | Cornelius Bliss | New York | March 6, 1897 | February 19, 1899 | | William McKinley(1897–1901) |
| 22 | | Ethan Hitchcock | Missouri | February 20, 1899 | March 4, 1907 |
| | Theodore Roosevelt(1901–1909) |
| 23 | | James Garfield | Ohio | March 5, 1907 | March 4, 1909 |
| 24 | | Richard A. Ballinger | Washington | March 6, 1909 | March 12, 1911 | | William Howard Taft(1909–1913) |
| 25 | | Walter L. Fisher | Illinois | March 13, 1911 | March 5, 1913 |
| 26 | | Franklin Lane | California | March 6, 1913 | February 29, 1920 | | Woodrow Wilson(1913–1921) |
| – | | Alexander T. VogelsangActing | California | February 29, 1920 | March 13, 1920 |
| 27 | | John Payne | Illinois | March 15, 1920 | March 4, 1921 |
| 28 | | Albert B. Fall | New Mexico | March 5, 1921 | March 4, 1923 | | Warren G. Harding(1921–1923) |
| 29 | | Hubert Work | Colorado | March 5, 1923 | July 24, 1928 |
| | Calvin Coolidge(1923–1929) |
| 30 | | Roy West | Illinois | July 25, 1928 | March 4, 1929 |
| 31 | | Ray Lyman Wilbur | California | March 5, 1929 | March 4, 1933 | | Herbert Hoover(1929–1933) |
| 32 | | Harold L. Ickes | Illinois | March 4, 1933 | February 15, 1946 | | Franklin D. Roosevelt(1933–1945) |
| | Harry S. Truman(1945–1953) |
| – | | Oscar L. ChapmanActing | Colorado | February 15, 1946 | March 18, 1946 |
| 33 | | Julius Krug | Wisconsin | March 18, 1946 | December 1, 1949 |
| 34 | | Oscar L. Chapman | Colorado | December 1, 1949 | January 20, 1953 |
| 35 | | Douglas McKay | Oregon | January 21, 1953 | April 15, 1956 | | Dwight D. Eisenhower(1953–1961) |
| – | | Clarence DavisActing | Nebraska | April 15, 1956 | June 8, 1956 |
| 36 | | Fred Seaton | Nebraska | June 8, 1956 | January 20, 1961 |
| 37 | | Stewart Udall | Arizona | January 21, 1961 | January 20, 1969 | | John F. Kennedy(1961–1963) |
| | Lyndon B. Johnson(1963–1969) |
| 38 | | Wally Hickel | Alaska | January 24, 1969 | November 25, 1970 | | Richard Nixon(1969–1974) |
| – | | Fred J. RussellActing | California | November 25, 1970 | January 29, 1971 |