| Inmate Name | Register Number | Photo | Status | Details |
| Whitey Bulger | 02182-748 | | Murdered in custody on October 30, 2018. | Notorious long-time fugitive, crime figure and leader of Boston's Winter Hill Gang; Murdered by other prisoners within hours of his arrival. |
| Vernon Lance Thomas | 09890-424 | | Sentenced to life imprisonment without the possibility of parole in 1993. Currently incarcerated. | Accomplice of a series of murders in Richmond, Virginia in 1992. One of Thomas's accomplices, Corey Johnson, was executed in 2021 while another two sentenced to death for the murders had their sentences commuted to life without parole. |
| Frank "Cadillac Frank" Salemme | 24914-013 | | Died on December 13, 2022, while serving a life sentence. | Boston mobster who became a hitman and eventually the boss of the Patriarca crime family from 1991 - 1996. |
| Fotios "Freddy" Geas | 05244-748 | | Serving a life sentence. Now at USP Florence ADMAX. | Massachusetts mobster and hitman. Suspect in Bulger death. |
| Paul DeCologero | 23952-038 | | Serving a 25-year sentence; scheduled release December 14, 2026. Now at USP McCreary. | Patriarca crime family associate, allegedly involved in the beating and murder of James “Whitey” Bulger. |
| James Alex Fields Jr. | 22239-084 | | Serving a life sentence. Now at USP Allenwood. | White supremacist, pleaded guilty in 2019 of 29 federal hate crime charges using his car to harm counter-protestors during the Unite the Right rally in Charlottesville, Virginia, killing 32 year-old Heather Heyer and injuring up to 19 more. |
| Juan García Ábrego | 09935-000 | | Serving 11 life sentences. | Mexican former drug lord who is reported to be the former head of a criminal dynasty along the Mexico–United States border now called the Gulf Cartel. |
| Aljermiah Mack | 86943-054 | | Serving a 17-year sentence, scheduled for release in 2033. Now at USP Coleman I. | Leader of the Nine Trey Gangsters and affiliate of rapper 6ix9ine, convicted of racketeering due to involvement in the gang's activities during the Trial of the Nine Trey Gangsters. |
| Nidal Ayyad | 16917-050 | | Serving a 240-year sentence, which has since been reduced several times; scheduled for release in 2067. Now at USP Coleman. | Convicted and sentenced to life imprisonment for his role in the 1993 World Trade center bombing. |
| James Timothy "Tim" Norman | 22122-043 | | Serving a life sentence. | Star of reality TV show Welcome to Sweetie Pies. He arranged the murder of his nephew Andre Montgomery in contract killing plot in order to obtain $450,000 from life insurance policy. |
| Eljvir Duka | 61282-066 | | Serving a life sentence. | One of the men who conspired to attack and kill military personnel at a base located in Fort Dix, New Jersey. He was sentenced to life imprisonment alongside his brothers, Shain and Dritan and two other individuals in 2008. |
| James Rosemond | 17903-054 | | Serving a life sentence plus 30 years. Transferred to USP Pollock. | Former music representative, charged in 2012 with Drug trafficking, obstruction of justice and possessing and using firearms, conspiracy to commit murder. He was at first sentenced to life plus 20 years in 2015 but had his conviction overturned the following year. In 2017 he stood trial for a third time and was sentenced to life plus 30 years. |
| Zachary Adam Chesser | 76715-083 | | Serving a 25-year sentence; scheduled for release on January 1, 2032. Now at FCI McDowell. | Convicted in 2010 for attempting to provide material support to a designated foreign terrorist organization by aiding Al-Shabaab, a militant group with ties to Al-Qaeda. He was also convicted for sending threats (via Revolution Muslim website) to Trey Parker and Matt Stone, creators of South Park, after they aired an episode of the show with depictions of Muhammad. |
| Alfredo Beltrán Leyva | 58525-007 | | Serving a life sentence plus 50 years. Now at ADX Florence. | Former leader of the Beltran-Leyva Cartel that operated out of Sinaloa, Mexico. Between the 1990s and 2000s, Beltran Leyva was responsible for the wholesale shipment of cocaine and methamphetamine between the United States, Mexico, and South America. On November 15, 2014, Beltran Leyva was extradited to the United States to face trial for shipping at least 27.9 tons of narcotics into the US. On February 23, 2016, Beltran Leyva pled guilty to charges of international narcotics trafficking and in 2017 was sentenced to life imprisonment plus 50 years. |
| Patrick Andrews | 12550-007 | | Serving a life sentence at USP Beaumont. | Criminal who murdered two people (in 1997 and 2000) and later killed a fellow inmate at Hazelton in 2007. Received another sentence of life imprisonment in 2015 and was transferred to USP Florence High. |
| James T. Murphy | 99478-555 | | Serving a life sentence. He is now at USP Terre Haute. | A former Army Sergeant, was stationed in Germany. On August 20, 1987 before leaving Germany, appellant went to his wife's (Petra Murphy, a German national) apartment. There, according to his confession, he killed her by smashing in her head with a hammer. He also admitted that he killed Tim and James, Jr., the two children. He was convicted and sentenced to death for three specifications of premeditated murder, and single specifications of larceny, bigamy, and false swearing. Transferred to USP Florence High after sentence commuted from death row. |
| Juan Orlando Hernandez | 91441-054 | | Serving a 45-year sentence. | Juan Orlando Hernández, former president of Honduras, was involved in a large-scale drug trafficking and money laundering scheme. U.S. prosecutors linked him to a conspiracy leveraging drug trafficking to maintain political power, with allegations that $1.5 million in drug proceeds helped fund his 2013 election. His brother, Tony Hernández, was sentenced to life in prison for drug-related crimes. Hernández accepted bribes from traffickers, including the Sinaloa Cartel, and provided them with protection using law enforcement and military intelligence. He was extradited to the U.S. in 2022, found guilty of drug trafficking and weapons conspiracy in 2024, and sentenced to 45 years in prison. |
