| No. | Result | Record | Opponent | Type | Round, time | Date | Location | Notes |
| 37 | Loss | 34–2–1 | Oleksandr Usyk | UD | 12 | 21 Dec 2024 | Kingdom Arena, Riyadh, Saudi Arabia | For WBA (Super), WBC, WBO, IBO and The Ring heavyweight titles |
| 36 | Loss | 34–1–1 | Oleksandr Usyk | SD | 12 | 18 May 2024 | Kingdom Arena, Riyadh, Saudi Arabia | Lost WBC heavyweight title;For WBA (Super), IBF, WBO, IBO, and The Ring heavyweight titles |
| 35 | Win | 34–0–1 | Francis Ngannou | SD | 10 | 28 Oct 2023 | Kingdom Arena, Riyadh, Saudi Arabia | |
| 34 | Win | 33–0–1 | Derek Chisora | TKO | 10 (12), 2:51 | 3 Dec 2022 | Tottenham Hotspur Stadium, London, England | Retained WBC heavyweight title |
| 33 | Win | 32–0–1 | Dillian Whyte | TKO | 6 (12), 2:59 | 23 Apr 2022 | Wembley Stadium, London, England | Retained WBC and The Ring heavyweight titles |
| 32 | Win | 31–0–1 | Deontay Wilder | KO | 11 (12), 1:10 | 9 Oct 2021 | T-Mobile Arena, Paradise, Nevada, US | Retained WBC and The Ring heavyweight titles |
| 31 | Win | 30–0–1 | Deontay Wilder | TKO | 7 (12), 1:39 | 22 Feb 2020 | MGM Grand Garden Arena, Paradise, Nevada, US | Won WBC and vacant The Ring heavyweight titles |
| 30 | Win | 29–0–1 | Otto Wallin | UD | 12 | 14 Sep 2019 | T-Mobile Arena, Paradise, Nevada, US | |
| 29 | Win | 28–0–1 | Tom Schwarz | TKO | 2 (12), 2:54 | 15 Jun 2019 | MGM Grand Garden Arena, Paradise, Nevada, US | Won WBO Inter-Continental heavyweight title |
| 28 | Draw | 27–0–1 | Deontay Wilder | SD | 12 | 1 Dec 2018 | Staples Center, Los Angeles, California, US | For WBC heavyweight title |
| 27 | Win | 27–0 | Francesco Pianeta | PTS | 10 | 18 Aug 2018 | Windsor Park, Belfast, Northern Ireland | |
| 26 | Win | 26–0 | Sefer Seferi | RTD | 4 (10), 3:00 | 9 Jun 2018 | Manchester Arena, Manchester, England | |
| 25 | Win | 25–0 | Wladimir Klitschko | UD | 12 | 28 Nov 2015 | Esprit Arena, Düsseldorf, Germany | Won WBA (Super), IBF, WBO, IBO, and The Ring heavyweight titles |
| 24 | Win | 24–0 | Christian Hammer | RTD | 8 (12), 3:00 | 28 Feb 2015 | The O2 Arena, London, England | Retained WBO International heavyweight title |
| 23 | Win | 23–0 | Derek Chisora | RTD | 10 (12), 3:00 | 29 Nov 2014 | ExCeL, London, England | Won European, WBO International, and vacant British heavyweight titles |
| 22 | Win | 22–0 | Joey Abell | TKO | 4 (10), 1:48 | 15 Feb 2014 | Copper Box Arena, London, England | |
| 21 | Win | 21–0 | Steve Cunningham | KO | 7 (12), 2:55 | 20 Apr 2013 | The Theater at Madison Square Garden, New York City, New York, US | |
| 20 | Win | 20–0 | Kevin Johnson | UD | 12 | 1 Dec 2012 | Odyssey Arena, Belfast, Northern Ireland | |
| 19 | Win | 19–0 | Vinny Maddalone | TKO | 5 (12), 1:35 | 7 Jul 2012 | Hand Arena, Clevedon, England | Won vacant WBO Inter-Continental heavyweight title |
| 18 | Win | 18–0 | Martin Rogan | TKO | 5 (12), 3:00 | 14 Apr 2012 | Odyssey Arena, Belfast, Northern Ireland | Won vacant Irish heavyweight title |
| 17 | Win | 17–0 | Neven Pajkić | TKO | 3 (12), 2:44 | 12 Nov 2011 | EventCity, Manchester, England | Retained Commonwealth heavyweight title |
| 16 | Win | 16–0 | Nicolai Firtha | TKO | 5 (12), 2:19 | 18 Sep 2011 | King's Hall, Belfast, Northern Ireland | |
| 15 | Win | 15–0 | Derek Chisora | UD | 12 | 23 Jul 2011 | Wembley Arena, London, England | Won British and Commonwealth heavyweight titles |
| 14 | Win | 14–0 | Marcelo Nascimento | KO | 5 (10), 2:48 | 19 Feb 2011 | Wembley Arena, London, England | |
| 13 | Win | 13–0 | Zack Page | UD | 8 | 19 Dec 2010 | Colisée Pepsi, Quebec City, Quebec, Canada | |
| 12 | Win | 12–0 | Rich Power | PTS | 8 | 10 Sep 2010 | York Hall, London, England | |
| 11 | Win | 11–0 | John McDermott | TKO | 9 (12), 1:08 | 25 Jun 2010 | Brentwood Centre Arena, Brentwood, England | Won vacant English heavyweight title |
| 10 | Win | 10–0 | Hans-Jörg Blasko | TKO | 1 (8), 2:14 | 5 Mar 2010 | Leisure Centre, Huddersfield, England | |
| 9 | Win | 9–0 | Tomas Mrazek | PTS | 6 | 26 Sep 2009 | The O2, Dublin, Ireland | |
| 8 | Win | 8–0 | John McDermott | PTS | 10 | 11 Sep 2009 | Brentwood Centre Arena, Brentwood, England | Won English heavyweight title |
| 7 | Win | 7–0 | Aleksandrs Selezens | TKO | 3 (6), 0:48 | 18 Jul 2009 | York Hall, London, England | |
| 6 | Win | 6–0 | Scott Belshaw | TKO | 2 (8), 0:52 | 23 May 2009 | Colosseum, Watford, England | |
| 5 | Win | 5–0 | Matthew Ellis | KO | 1 (6), 0:48 | 11 Apr 2009 | York Hall, London, England | |
| 4 | Win | 4–0 | Lee Swaby | RTD | 4 (6), 3:00 | 14 Mar 2009 | Aston Events Centre, Birmingham, England | |
| 3 | Win | 3–0 | Daniil Peretyatko | RTD | 2 (6), 3:00 | 28 Feb 2009 | Showground, Norwich, England | |
| 2 | Win | 2–0 | Marcel Zeller | TKO | 3 (6), 2:50 | 17 Jan 2009 | DW Stadium, Wigan, England | |
| 1 | Win | 1–0 | Béla Gyöngyösi | TKO | 1 (6), 2:14 | 6 Dec 2008 | National Ice Centre, Nottingham, England | |