| Year | Award | Category | Nominated work | Result |
| 2002 | NAACP Image Award | Outstanding Actress in a Comedy Series | Girlfriends | Nominated |
| 2003 | Prism Award | Best Performance in a Comedy Series | Nominated |
| 2003 | NAACP Image Award | Outstanding Actress in a Comedy Series | Nominated |
| 2004 | BET Comedy Awards | Outstanding Lead Actress in a Comedy Series | Nominated |
| NAACP Image Award | Outstanding Actress in a Comedy Series | Nominated |
| 2005 | BET Comedy Awards | Outstanding Lead Actress in a Comedy Series | Won |
| NAACP Image Award | Outstanding Actress in a Comedy Series | Nominated |
| 2006 | NAACP Image Award | Outstanding Actress in a Comedy Series | Nominated |
| 2007 | NAACP Image Award | Outstanding Actress in a Comedy Series | Won |
| 2008 | NAACP Image Award | Outstanding Actress in a Comedy Series | Nominated |
| 2009 | NAACP Image Award | Outstanding Directing in a Comedy Series | Nominated |
| Outstanding Actress in a Comedy Series | Won |
| 2012 | NAACP Image Award | Outstanding Actress in a Television Movie, Mini-Series or Dramatic Special | Five | Nominated |
| Outstanding Actress in a Comedy Series | Reed Between the Lines | Won |
| Black Reel Awards | Outstanding Actress in a Television Movie or Mini-Series | Five | Nominated |
| NAMIC Vision Award | Outstanding Actress in a Comedy Series | Reed Between the Lines | Nominated |
| 2015 | NAACP Image Award | Outstanding Actress in a Comedy Series | Black-ish | Won |
| BET Awards | Best Actress | Nominated |
| EWwy Awards | Best Actress, Comedy | Nominated |
| 2016 | Critics' Choice Television Award | Best Actress in a Comedy Series | Nominated |
| NAACP Image Award | Outstanding Actress in a Comedy Series | Won |
| Online Film & Television Association Award | Best Actress in a Comedy Series | Nominated |
| Primetime Emmy Award | Outstanding Lead Actress in a Comedy Series | Nominated |
| Satellite Award | Best Actress – Television Series Musical or Comedy | Nominated |
| BET Awards | Best Actress | Nominated |
| 2017 | Critics' Choice Television Award | Best Actress in a Comedy Series | Nominated |
| Golden Globe Award | Best Actress – Television Series Musical or Comedy | Won |
| Screen Actors Guild Award | Outstanding Performance by an Ensemble in a Comedy Series | Nominated |
| NAACP Image Award | Outstanding Actress in a Comedy Series | Won |
| Primetime Emmy Award | Outstanding Lead Actress in a Comedy Series | Nominated |
| 2018 | Screen Actors Guild Award | Outstanding Performance by an Ensemble in a Comedy Series | Nominated |
| NAACP Image Award | Outstanding Actress in a Comedy Series | Won |
| Primetime Emmy Award | Outstanding Lead Actress in a Comedy Series | Nominated |
| 2019 | People's Choice Awards | Favorite Comedy TV Star | Nominated |
| Satellite Awards | Best Actress in a Series, Comedy or Musical | Nominated |
| NAACP Image Award | Outstanding Actress in a Comedy Series | Won |
| Black Reel Awards | Outstanding Directing, Comedy Series | Nominated |
| Black Reel Awards | Outstanding Actress, Comedy Series | Nominated |
| 2020 | NAACP Image Award | Outstanding Actress in a Comedy Series | Won |
| Primetime Emmy Award | Outstanding Lead Actress in a Comedy Series | Nominated |
| Black Reel Awards | Outstanding Comedy Series | Nominated |
| Black Reel Awards | Outstanding Actress, Comedy Series | Nominated |
| People's Choice Awards | Fashion icon | | Won |
| People's Choice Awards | Favorite Drama Movie Star | The High Note | Nominated |
| Hollywood Critics Association | Best Supporting Actress | Nominated |
| Guild of Music Supervisors Awards | Best Song Written and/or Recording Created for a Film | Nominated |
| 2021 | NAACP Image Award | Outstanding Actress in a Motion Picture | Nominated |
| NAACP Image Award | Outstanding Actress in a Comedy Series | Black-ish | Nominated |
| Primetime Emmy Award | Outstanding Lead Actress in a Comedy Series | Nominated |