| Year | Title | Role | Notes |
| 1978 | Up in Smoke | Anthony "Man" Stoner | Also writer, director |
| 1980 | Cheech & Chong's Next Movie | Chong |
| 1981 | Nice Dreams |
| 1982 | It Came from Hollywood | Himself | |
| Things Are Tough All Over | Chong / Prince Habib | Also writer |
| 1983 | Still Smokin' | Chong | Also writer, director |
| Yellowbeard | El Nebuloso | |
| 1984 | Cheech & Chong's The Corsican Brothers | Lucian Corsican | Also writer, director |
| 1985 | Get Out of My Room | The Man | |
| After Hours | Pepe | |
| 1989 | Tripwire | Merle Shine | |
| 1990 | Far Out Man | Far Out Man | Also writer director |
| 1992 | Life After Sex | Awkward Naked Guy | |
| FernGully: The Last Rainforest | Root | Voice role |
| 1995 | National Lampoon's Senior Trip | Red | |
| 1997 | McHale's Navy | Armando / Ernesto | |
| 1998 | Half Baked | Squirrel Master | |
| 2001 | The Wash | Dee's Connection | |
| 2002 | High Times' Potluck | Himself | |
| 2003 | Best Buds | Tommy Chong / Carlos | |
| Pauly Shore Is Dead | Himself | |
| 2005 | Secret Agent 420 | QP | |
| 2006 | Evil Bong | Jimbo Leary | |
| 2007 | American Drug War: The Last White Hope | Himself | |
| The Union: The Business Behind Getting High | |
| 2008 | I Am Somebody: No Chance in Hell [cy; es; it; uk] | Deputy Tom | Original title: Chinaman's Chance |
| a/k/a Tommy Chong | Himself | DVD release |
| 2010 | Cheech & Chong's Hey Watch This | Documentary film |
| 2011 | Hoodwinked Too! Hood vs. Evil | Stone | Voice role |
| 2013 | Cheech & Chong's Animated Movie | Chong | Voice role; also writer |
| 2014 | The Fluffy Movie | Video store clerk | |
| 2016 | Zootopia | Yax | Voice role |
| 2017 | It's Gawd! | Gawd | |
| 2018 | Railroad to Hell: A Chinaman's Chance | Deputy Tom | |
| 2019 | Color Out of Space | Ezra | |
| Jay and Silent Bob Reboot | Alfred | |
| 2024 | Cheech & Chong's Last Movie | Himself | Documentary |
| 2025 | Zootopia 2 | Yax | Voice role |