| Res. | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
| Loss | 18–6 | Kelvin Gastelum | TKO (punches) | UFC 206 | December 10, 2016 | 3 | 2:45 | Toronto, Ontario, Canada | |
| Loss | 18–5 | Yoel Romero | TKO (punches) | UFC 178 | September 27, 2014 | 3 | 0:58 | Las Vegas, Nevada, United States | Fight of the Night |
| Win | 18–4 | Michael Bisping | Decision (unanimous) | The Ultimate Fighter Nations Finale: Bisping vs. Kennedy | April 16, 2014 | 5 | 5:00 | Quebec City, Quebec, Canada | |
| Win | 17–4 | Rafael Natal | KO (punches) | UFC: Fight for the Troops 3 | November 6, 2013 | 1 | 4:40 | Fort Campbell, Kentucky, United States | Knockout of the Night |
| Win | 16–4 | Roger Gracie | Decision (unanimous) | UFC 162 | July 6, 2013 | 3 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 15–4 | Trevor Smith | Submission (guillotine choke) | Strikeforce: Marquardt vs. Saffiedine | January 12, 2013 | 3 | 1:36 | Oklahoma City, Oklahoma, United States | |
| Loss | 14–4 | Luke Rockhold | Decision (unanimous) | Strikeforce: Rockhold vs. Kennedy | July 14, 2012 | 5 | 5:00 | Portland, Oregon, United States | For the Strikeforce Middleweight Championship |
| Win | 14–3 | Robbie Lawler | Decision (unanimous) | Strikeforce: Fedor vs. Henderson | July 30, 2011 | 3 | 5:00 | Hoffman Estates, Illinois, United States | |
| Win | 13–3 | Melvin Manhoef | Submission (rear-naked choke) | Strikeforce: Feijao vs. Henderson | March 5, 2011 | 1 | 3:41 | Columbus, Ohio, United States | |
| Loss | 12–3 | Ronaldo Souza | Decision (unanimous) | Strikeforce: Houston | August 21, 2010 | 5 | 5:00 | Houston, Texas, United States | For the vacant Strikeforce Middleweight Championship |
| Win | 12–2 | Trevor Prangley | Submission (rear-naked choke) | Strikeforce: Los Angeles | June 16, 2010 | 1 | 3:35 | Los Angeles, California, United States | |
| Win | 11–2 | Zak Cummings | Submission (North-South choke) | Strikeforce Challengers: Kennedy vs. Cummings | September 25, 2009 | 2 | 2:43 | Bixby, Oklahoma, United States | |
| Win | 10–2 | Nick Thompson | TKO (submission to punches) | Strikeforce Challengers: Villasenor vs. Cyborg | June 19, 2009 | 2 | 2:37 | Kent, Washington, United States | |
| Win | 9–2 | Elias Rivera | KO (punches) | IFL: World Grand Prix Finals | December 29, 2007 | 1 | 2:00 | Uncasville, Connecticut, United States | |
| Loss | 8–2 | Jason Miller | Decision (unanimous) | HDNetFIGHTS: Reckless Abandon | December 15, 2007 | 3 | 5:00 | Dallas, Texas, United States | |
| Win | 8–1 | Ryan McGivern | Submission (guillotine choke) | IFL: Chicago | June 19, 2007 | 2 | 1:25 | Chicago, Illinois, United States | |
| Win | 7–1 | Dante Rivera | TKO (submission to punches) | IFL: Atlanta | February 23, 2007 | 2 | 2:29 | Atlanta, Georgia, United States | Light Heavyweight bout |
| Win | 6–1 | Héctor Urbina | KO (punches) | Fight Fest 7 | September 23, 2006 | 1 | 1:28 | Cleveland, Ohio, United States | |
| Win | 5–1 | Cruz Chacon | TKO (punches) | Extreme Challenge 50 | February 23, 2003 | 2 | 1:21 | Salt Lake City, Utah, United States | Won the Extreme Challenge Middleweight Tournament |
| Win | 4–1 | Jason Miller | Decision (unanimous) | Extreme Challenge 50 | February 23, 2003 | 3 | 5:00 | Salt Lake City, Utah, United States | |
| Win | 3–1 | Ryan Narte | TKO (punches) | Extreme Challenge 50 | February 23, 2003 | 1 | 1:22 | Salt Lake City, Utah, United States | Return to Middleweight |
| Win | 2–1 | Mack Brewer | TKO (punches) | WEC 5: Halloween Havoc | October 18, 2002 | 1 | 1:03 | Lemoore, California, United States | Light Heavyweight debut |
| Win | 1–1 | Jody Burke | Submission (forearm choke) | IFC: Warriors Challenge 16 | November 9, 2001 | 1 | 0:44 | Oroville, California, United States | Welterweight debut |
| Loss | 0–1 | Scott Smith | TKO (doctor stoppage) | IFC: Warriors Challenge 15 | August 31, 2001 | 1 | 2:53 | Oroville, California, United States | |