| Year | Title | Role | Notes |
| 2004 | Movies at Our House | Herself | 3 episodes |
| Comedy Central Presents | Episode: "Tig" |
| 2006 | Dog Bites Man | Leigh Roy | Episode: "Assignment: Undercover Homosexual" |
| 2007–2010 | The Sarah Silverman Program | Tig | 9 episodes |
| 2008 | Held Up | Homeless Translator | Television film |
| Biography | Herself | Episode: "Sarah Silverman" |
| 2009 | In the Motherhood | Rhoda | 4 episodes |
| Back on Topps | Mom | Episode: "Rejuvenated" |
| 2010 | MTV Movie Awards | | Writer |
| Community | Bartender | Episode: "Mixology Certification" |
| 2011 | The Life & Times of Tim | Receptionist | Voice, episode: "The Model from Newark/Tim's Hair Looks Amazing" |
| 2012 | The Office | Single Mom | Episode: "Test the Store" |
| This American Life Live!: Invisible Made Visible | Herself | Television film |
| Stand Down: True Tales from Stand-Up Comedy | Herself | Episode: "Tig Notaro Creates an Emergency" |
| Susan 313 | Beth Ann | NBC pilot |
| 2013, 2021 | Bob's Burgers | Jody / Officer Large (voice) | 2 episodes |
| 2013 | Inside Amy Schumer | Tig | 2 episodes; also writer |
| Why We Laugh: Funny Women | Herself | TV documentary |
| 2013–2014 | Comedy Bang! Bang! | Police Officer | 2 episodes |
| 2014 | 56th Grammy Awards Pre-Telecast Ceremony | Herself (host) | TV special |
| Suburgatory | Rebecca Dunn | Episode: "Dalia Nicole Smith" |
| Maron | Sydney | Episode: "Mouth Cancer Gig" |
| Garfunkel and Oates | Pumpernickel Place Producer | Episode: "Rule 34" |
| 2014–2019 | Transparent | Barb | 6 episodes |
| 2014–2017 | Clarence | Sue / Annie | Voice, 5 episodes |
| 2015 | Sundance Film Festival Closing Night Awards Ceremony | Herself (host) | TV special |
| Tig Notaro: Boyish Girl Interrupted | Herself | Stand-up special; also director, writer, executive producer |
| No, You Shut Up! | Herself | Episode: "Jiggle the Handle" |
| Adventure Time | Purple Comet | Voice, episode: "The Comet" |
| 2015–2017 | One Mississippi | Tig Bavaro | 12 episodes; also creator, writer, director, and executive producer |
| 2016 | Lady Dynamite | Herself | Episode: "Loaf Coach" |
| The Jim Gaffigan Show | Gomez | Episode: "Ugly" |
| 2017 | Hollywood Horror Stories | Herself | Episode: "Tig Notaro" |
| The Gorburger Show | Herself | Episode: "Gorbabies" |
| 2018 | Tig Notaro: Happy to Be Here | Herself | Stand-up special; also director, writer, executive producer |
| 2 Dope Queens | | Series director |
| Fresh Off the Boat | Ms. Doris | 2 episodes |
| New Girl | Bar Lady | Episode: "Where the Road Goes" |
| 2019–2024 | Star Trek: Discovery | Denise "Jett" Reno | 19 episodes |
| 2019 | Tuca & Bertie | Yeast Week MC & Dr. Sherman | Voice, episode: "Yeast Week" |
| 2019 | Under a Rock with Tig Notaro | Herself (host) | 12 episodes |
| 2020–2021 | The Fungies! | Commander Lazer | Voice, 2 episodes |
| 2021 | Tig Notaro: Drawn | Herself | Animated stand-up special; also writer, executive producer |
| 2022 | StoryBots: Answer Time | | Voice, episode: "Lasers" |
| 2023–2025 | Star Wars: Young Jedi Adventures | Ace Kallisto | Voice, 4 episodes |
| The Morning Show | Amanda Robinson | 8 episodes Nominated – Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Drama Series |
| 2024 | After Midnight | Herself | Contestant; Episode 22 |
| Tig Notaro: Hello Again | Herself | Stand-up special; also writer, executive producer |
| 2024–2025 | The Sex Lives of College Girls | Professor Friedman | 5 episodes |
