| Dates | Production | Director | Notes |
| 22 June 1964 | Actors Studio | Lee Strasberg | New English version by Randall Jarrell; cast included Geraldine Page, Kim Stanley, Shirley Knight, Robert Loggia, Kevin McCarthy among others |
| 24 May 1965 | BBC Home Service | John Tydeman | English translation by Elisaveta Fen; adapted for radio by Peter Watts; cast included Paul Scofield, Lynn Redgrave, Ian McKellen, Jill Bennett, among others |
| 29 September 1979 | The Other Place, Stratford-upon-Avon | Trevor Nunn | Version by Richard Cottrell with Suzanne Bertish as Masha, Emily Richard as Irina and Janet Dale as Olga. |
| 28 March 1990 | Gate Theatre, Dublin and Royal Court Theatre, London | Adrian Noble | Version by Frank McGuinness with real-life sisters in the title roles: Sinéad Cusack as Masha, Sorcha Cusack as Olga and Niamh Cusack as Irina. Their father, Cyril Cusack played Chebutykin. |
| 30 August – 13 October 2007 | Soulpepper Theatre, Toronto | László Marton | Version by Nicolas Billon |
| November 2008 | Regent's Canal, Camden, London. | Tanya Roberts | An adaptation by the Metra Theatre |
| 29 July – 3 August 2008 | Playhouse, QPAC, Brisbane | Declan Donnellan | Chekhov International Theatre Festival (Moscow), part of Brisbane Festival 2008 |
| 5 May 2009 – 14 June 2009 | Artists Repertory Theatre, Portland | Jon Kretzu | Adapted by Tracy Letts |
| 12 January – 6 March 2011 | Classic Stage Company, NYC | Austin Pendleton | Real-life husband and wife actors Maggie Gyllenhaal and Peter Sarsgaard starred, alongside Jessica Hecht and Juliet Rylance. |
| 14 February – 8 March 2020 | The Bindery, San Francisco | Angie Higgins | Starring Marcia Aguilar |