| Award | Year | Category | Nominee(s) | Result | Ref. |
| American Cinema Editors Awards | 2018 | Best Edited Drama Series for Non-Commercial Television | Julian Clarke and Wendy Hallam Martin (for "Offred") | Won | |
| American Film Institute Awards | 2017 | Top 10 TV Programs of the Year | The Handmaid's Tale | Won | |
| American Society of Cinematographers Awards | 2019 | Outstanding Achievement in Cinematography in Regular Series for Non-Commercial Television | Colin Watkinson (for "The Word") | Nominated | |
| Zoe White (for "Holly") | Nominated |
| 2020 | Outstanding Achievement in Cinematography in Regular Series for Non-Commercial Television | Colin Watkinson (for "Night") | Won | |
| 2022 | Outstanding Achievement in Cinematography in Regular Series for Non-Commercial Television | Stuart Biddlecombe (for "The Wilderness") | Nominated | |
| Art Directors Guild Awards | 2018 | One-Hour Contemporary Single-Camera Series | Julie Berghoff (for "Offred", "Birth Day", "Nolite Te Bastardes Carborundorum") | Won | |
| Andrew Stearn (for "The Bridge") | Nominated |
| 2019 | One-Hour Contemporary Single-Camera Series | Mark White and Elisabeth Williams (for "June" and "Unwomen") | Won | |
| 2020 | One-Hour Contemporary Single-Camera Series | Elisabeth Williams (for "Mayday") | Nominated | |
| 2022 | One-Hour Contemporary Single-Camera Series | Elisabeth Williams (for "Chicago") | Nominated | |
| British Academy Television Awards | 2018 | Best International Programme | The Handmaid's Tale | Won | |
| 2019 | Best International Programme | The Handmaid's Tale | Nominated | |
| Casting Society of America | 2018 | Television Pilot and First Season – Drama | Sharon Bialy, Sherry Thomas, Russell Scott, Robin D. Cook, and Jonathan Oliveira | Won | |
| 2019 | Television Series – Drama | Sharon Bialy, Sherry Thomas, Russell Scott, Robin D. Cook, and Jonathan Oliveira | Nominated | |
| 2020 | Television Series – Drama | Sharon Bialy, Sherry Thomas, Russell Scott, Robin D. Cook, Stacia Kimler, and Jonathan Oliveira | Nominated | |
| 2021 | Television Series – Drama | Sharon Bialy, Sherry Thomas, Russell Scott, Robin D. Cook, Stacia Kimler, and Jonathan Oliveira | Nominated | |
| 2022 | Television Series – Drama | Sharon Bialy, Sherry Thomas, Russell Scott, Robin D. Cook, Stacia Kimler, and Jonathan Oliveira | Nominated | |
| Cinema Audio Society Awards | 2018 | Outstanding Achievement in Sound Mixing for Television Series – One Hour | John J. Thomson, Lou Solakofski, Joe Morrow, and Don White (for "Offred") | Nominated | |
| 2019 | Outstanding Achievement in Sound Mixing for Television Series – One Hour | Sylvain Arseneault, Lou Solakofski, Joe Morrow, Scott Michael Smith, Adam Taylor, Mark DeSimone, and Jack Heeren (for "Holly") | Nominated | |
| 2020 | Outstanding Achievement in Sound Mixing for Television Series – One Hour | Sylvain Arseneault, Lou Solakofski, Joe Morrow, Scott Michael Smith, Adam Taylor, Andrea Rusch, and Kevin Schultz (for "Heroic") | Nominated | |
| Costume Designers Guild Awards | 2018 | Excellence in Contemporary Television Series | Ane Crabtree | Won | |
| 2019 | Excellence in Sci-Fi/Fantasy Television | Ane Crabtree | Nominated | |
| 2020 | Excellence in Sci-Fi/Fantasy Television | Natalie Bronfman (for "Household") | Nominated | |
| 2022 | Excellence in Sci-Fi/Fantasy Television | Debra Hanson (for "Nightshade") | Nominated | |
| Critics' Choice Television Awards | 2018 | Best Drama Series | The Handmaid's Tale | Won | |
| Best Actress in a Drama Series | Elisabeth Moss | Won |
| Best Supporting Actress in a Drama Series | Ann Dowd | Won |
| 2019 | Best Actress in a Drama Series | Elisabeth Moss | Nominated | |
| Directors Guild of America Awards | 2018 | Outstanding Directorial Achievement for a Drama Series | Reed Morano (for "Offred") | Won | |
| 2019 | Outstanding Directorial Achievement for a Drama Series | Daina Reid (for "Holly") | Nominated | |
| GLAAD Media Awards | 2019 | Outstanding Drama Series | The Handmaid's Tale | Nominated | |
| Golden Globe Awards | 2018 | Best Television Series – Drama | The Handmaid's Tale | Won | |
| Best Actress – Television Series Drama | Elisabeth Moss | Won |
| Best Supporting Actress – Series, Miniseries or Television Film | Ann Dowd | Nominated |
| 2019 | Best Actress – Television Series Drama | Elisabeth Moss | Nominated | |
| Best Supporting Actress – Series, Miniseries or Television Film | Yvonne Strahovski | Nominated |
| 2022 | Best Actress – Television Series Drama | Elisabeth Moss | Nominated | |
| Hollywood Critics Association TV Awards | 2021 | Best Streaming Series, Drama | The Handmaid's Tale | Nominated | |
| Best Actress in a Streaming Series, Drama | Elisabeth Moss | Nominated |
| Best Supporting Actor in a Streaming Series, Drama | Bradley Whitford | Nominated |
| Best Supporting Actress in a Streaming Series, Drama | Alexis Bledel | Nominated |
| Ann Dowd | Nominated |
| Yvonne Strahovski | Nominated |
| Samira Wiley | Nominated |
| Location Managers Guild Awards | 2018 | Outstanding Locations in Contemporary Television | John Musikka and Geoffrey Smither | Nominated | |
| Make-Up Artists and Hair Stylists Guild Awards | 2018 | Best Television Series, Mini-Series or New Media Series – Best Contemporary Make-Up | Burton LeBlanc, Talia Reinhold, Erika Caceres | Nominated | |
| 2019 | Best Television Series, Mini-Series or New Media Series – Best Contemporary Make-Up | Burton LeBlanc, Talia Reingold, Erika Caceres | Nominated | |
| Best Television Series, Mini-Series or New Media Series – Contemporary Hair Styling | Karola Dirnberger and Ewa Cynk | Nominated |
