| Flight | Date | Aircraft | Location | Description | Casualties |
| 1455 | March 5, 2000 | Boeing 737-300 N668SW | Burbank, California | The aircraft overran the runway upon landing at Burbank-Glendale-Pasadena Airport, injuring 44. The accident resulted in the dismissal of the captain. The aircraft was damaged beyond repair. | Two serious injuries, forty-two minor injuries |
| 1763 | August 11, 2000 | Boeing 737-700 N798SW | In flight | The aircraft was flying from Las Vegas, Nevada, to Salt Lake City, Utah when 19-year-old Jonathan Burton attempted to storm the cockpit in an apparent case of air rage. He was restrained by six to eight other passengers. In the scuffle, Burton died of asphyxiation. | One death, one minor injury |
| 1248 | December 8, 2005 | Boeing 737-700 N471WN | Chicago, Illinois | The aircraft overran the runway during landing at Chicago Midway International Airport in heavy snow and slid into a nearby street, striking several cars and killing a six-year-old boy inside one of them. Injuries to several passengers and other people on the ground. | One death, nine seriously injured (on ground); three minor injuries (on board) |
| 2294 | July 13, 2009 | Boeing 737-300 N387SW | In flight | The flight from Nashville International Airport to Baltimore-Washington International Airport was forced to divert to Yeager Airport in Charleston, West Virginia after a hole formed on the top of the aircraft's fuselage near the tail, resulting in depressurization of the cabin and deployment of the oxygen masks. The aircraft landed safely and was repaired. | None |
| 812 | April 1, 2011 | Boeing 737-300 N632SW | In flight | The crew of the flight from Phoenix Sky Harbor Airport to Sacramento International Airport diverted to Yuma International Airport after a hole appeared in the top of the aircraft fuselage. The aircraft landed safely. | Two minor injuries |
| 345 | July 22, 2013 | Boeing 737-700 N753SW | Queens, New York | The flight from Nashville International Airport was severely damaged in a hard landing at New York's LaGuardia Airport. The nose landing gear collapsed with sufficient force to penetrate a nearby electronics bay; the aircraft then slid off the runway. The captain was fired and the aircraft was ultimately scrapped. | Ten minor injuries |
| 149 | August 4, 2016 | Boeing 737-300 N368SW | Anne Arundel County, Maryland | During pushback at Baltimore/Washington International Thurgood Marshall Airport, the aircraft suffered a failure of the nose landing gear because of the tug operators speed during pushback. The nose landing gear collapsed in a forward direction, causing severe damage to the gear structure, nose gear wheel and crushing the forward bulkhead. The plane was substantially damaged and written off. | None |
| 3472 | August 27, 2016 | Boeing 737-700 N766SW | In flight | The flight from Louis Armstrong New Orleans International Airport to Orlando International Airport suffered an uncontained engine failure, damaging the engine nacelle and causing a gash in the fuselage. The aircraft diverted and landed without further incident at Pensacola International Airport. | None |
| 1380 | April 17, 2018 | Boeing 737-700 N772SW | In flight | The flight from New York-LaGuardia to Dallas made an emergency landing at Philadelphia International Airport after debris from an uncontained engine failure smashed a passenger window. The resulting depressurization pushed a passenger partially out a window, causing critical injuries that led to her death. The pilot's efforts to land the crippled aircraft were rewarded with numerous awards and accolades. | One death, eight minor injuries |
| 728 | December 6, 2018 | Boeing 737-700 N752SW | Burbank, California | The flight from Oakland International Airport overran the runway upon landing at Burbank, but the aircraft was stopped by an engineered materials arrestor system (EMAS) that had been implemented as a result of the Flight 1455 accident. | None |
| 1392 | May 7, 2020 | Boeing 737-700 N401WN | Austin, Texas | Shortly after landing at Austin–Bergstrom International Airport, a pilot reported having seen someone on Runway 17R; subsequent investigation by airport operations found the body of a man on the runway, having seemingly been struck by the aircraft during or shortly after it touched down.[citation needed] | One death (on ground) |
| 307 | August 13, 2023 | Boeing 737-700 N7737E | Houston, Texas | Shortly after takeoff at William P. Hobby Airport, reports say that the 737-700's right engine was found engulfed in flames because of a mechanical issue. The plane landed back at the airport. | None |
| 2494 | November 15, 2024 | Boeing 737-800 N8744B | Dallas, Texas | Struck near the cockpit by a bullet while preparing to take off from Love Field. No injuries were reported, the aircraft safely returned to the gate, and the passengers transferred to another aircraft. The incident aircraft was taken out of service. Dallas police, Dallas Fire-Rescue, and the FAA initiated investigations. | None |
