| Year | Seed | Round | Opponent | Result |
| 1982 | | First roundSweet Sixteen | East Carolina#2 Kentucky | W 79–54L 69–73 |
| 1986 | | First round | Middle Tenn | L 77–78 |
| 1988 | | First roundSecond round | Alabama#1 Texas | W 77–63L 58–77 |
| 1989 | | First round | Tennessee Tech | L 73–77 |
| 1990 | | First roundSecond roundSweet Sixteen | Bowling Green#4 Northwestern#1 Washington | W 93–50W 76–67L 61–73 |
| 1991 | | First round | Vanderbilt | L 64–73 |
| 2002 | | First roundSecond roundSweet SixteenElite Eight | Liberty#6 Cincinnati#7 Drake#1 Duke | W 69–61W 75–56W 79–65L 68–77 |
| 2003 | | First roundSecond round | UT Chattanooga#4 Penn State | W 68–54L 67–77 |
| 2012 | | First roundSecond roundSweet Sixteen | Eastern Michigan#4 Purdue#1 Stanford | W 80–48W 72–61L 60–76 |
| 2013 | | First roundSecond round | South Dakota State#12 Kansas | W 74–53L 69–75 |
| 2014 | | First roundSecond roundSweet Sixteen | Cal St Northridge#9 Oregon State#4 North Carolina | W 73–58W 78–69L 58–65 |
| 2015 | | First roundSecond roundSweet SixteenElite EightFinal Four | Savannah State#8 Syracuse#4 North Carolina#2 Florida State#1 Notre Dame | W 81–48W 97–68W 67–65W 80–74L 65–66 |
| 2016 | | First roundSecond roundSweet Sixteen | Jacksonville#9 Kansas State#4 Syracuse | W 77–41W 73–47L 72–80 |
| 2017 | | First roundSecond roundSweet SixteenElite EightFinal FourNational Championship | UNC Asheville#8 Arizona State#12 Quinnipiac#3 Florida State#2 Stanford#2 Mississippi State | W 90–40W 71–68W 100–58W 71–64W 62–53W 67–55 |
| 2018 | | First roundSecond roundSweet SixteenElite Eight | North Carolina A&T#10 Virginia#11 Buffalo#1 Connecticut | W 63–52W 66–56W 79–63L 65–94 |
| 2019 | | First roundSecond roundSweet Sixteen | Belmont#5 Florida State#1 Baylor | W 74–52W 72–64L 68–93 |
| 2021 | | First roundSecond roundSweet SixteenElite EightFinal Four | Mercer#8 Oregon State#5 Georgia Tech#6 Texas#1 Stanford | W 79–53W 59–42W 76–65W 62–34L 65–66 |
| 2022 | | First roundSecond roundSweet SixteenElite EightFinal FourNational Championship | Howard#8 Miami#5 North Carolina#10 Creighton#1 Louisville#2 Connecticut | W 79–21W 49–33W 69–61W 80–50W 72–59W 64–49 |
| 2023 | | First roundSecond RoundSweet SixteenElite EightFinal Four | Norfolk State#8 South Florida#4 UCLA#2 Maryland#2 Iowa | W 72–40W 76–45W 59–43W 86–75L 73–77 |
| 2024 | | First roundSecond RoundSweet SixteenElite EightFinal FourNational Championship | Presbyterian#8 North Carolina#4 Indiana#3 Oregon State#3 NC State#1 Iowa | W 91–39 W 88–41 W 79–75 W 70–58W 78–59W 87–75 |
| 2025 | | First RoundSecond RoundSweet SixteenEite EightFinal FourNational Championship | Tennessee Tech#9 Indiana#4 Maryland#2 Duke#1 Texas#2 UConn | W 108–48W 64–53W 71–67W 54–50W74–57L 59–82 |