| No. | Result | Record | Opponent | Type | Round, time | Date | Location | Notes |
| 54 | Win | 50–4 | Chuck Wepner | TKO | 9 (10), 3:00 | Jun 29, 1970 | National Guard Armory, Jersey City, New Jersey, U.S. | |
| 53 | Loss | 49–4 | Leotis Martin | KO | 9 (12), 1:08 | Dec 6, 1969 | Las Vegas Hilton, Winchester, Nevada, U.S. | For vacant NABF heavyweight title |
| 52 | Win | 49–3 | Sonny Moore | KO | 3 (10) | Sep 23, 1969 | Coliseum, Houston, Texas, U.S. | |
| 51 | Win | 48–3 | George Johnson | TKO | 7 (10), 2:55 | May 19, 1969 | Convention Center, Winchester, Nevada, U.S. | |
| 50 | Win | 47–3 | Billy Joiner | UD | 10 | Mar 28, 1969 | Kiel Auditorium, St. Louis, Missouri, U.S. | |
| 49 | Win | 46–3 | Amos Lincoln | KO | 2 (10), 2:46 | Dec 10, 1968 | Civic Center, Baltimore, Maryland, U.S. | |
| 48 | Win | 45–3 | Roger Rischer | KO | 3 (10), 2:23 | Nov 12, 1968 | Civic Arena, Pittsburgh, Pennsylvania, U.S. | |
| 47 | Win | 44–3 | Willis Earls | KO | 2 (10), 1:52 | Nov 3, 1968 | Plaza de Toros, Ciudad Juárez, Mexico | |
| 46 | Win | 43–3 | Sonny Moore | TKO | 3 (10) | Oct 14, 1968 | Veterans Memorial Coliseum, Phoenix, Arizona, U.S. | |
| 45 | Win | 42–3 | Henry Clark | TKO | 7 (10), 2:47 | Jul 6, 1968 | Cow Palace, Daly City, California, U.S. | |
| 44 | Win | 41–3 | Billy Joiner | RTD | 7 (10), 3:00 | May 23, 1968 | Grand Olympic Auditorium, Los Angeles, California, U.S. | |
| 43 | Win | 40–3 | Bill McMurray | TKO | 4 (10), 0:47 | Mar 16, 1968 | Centennial Coliseum, Reno, Nevada, U.S. | |
| 42 | Win | 39–3 | Elmer Rush | TKO | 6 (10) | Apr 28, 1967 | Stockholm, Sweden | |
| 41 | Win | 38–3 | Dave Bailey | KO | 1 (10), 2:22 | Mar 30, 1967 | Mässhallen, Gothenburg, Sweden | |
| 40 | Win | 37–3 | Amos Johnson | KO | 3 (10), 1:48 | Aug 19, 1966 | Nya Ullevi, Gothenburg, Sweden | |
| 39 | Win | 36–3 | Gerhard Zech | KO | 7 (10), 1:11 | Jul 1, 1966 | Stockholm, Sweden | |
| 38 | Loss | 35–3 | Muhammad Ali | KO | 1 (15), 2:12 | May 25, 1965 | St. Dominic's Hall, Lewiston, Maine, U.S. | For WBC, NYSAC, and The Ring heavyweight titles |
| 37 | Loss | 35–2 | Cassius Clay | RTD | 6 (15), 3:00 | Feb 25, 1964 | Convention Center, Miami Beach, Florida, U.S. | Lost WBA, WBC, NYSAC, and The Ring heavyweight titles |
| 36 | Win | 35–1 | Floyd Patterson | KO | 1 (15), 2:10 | July 22, 1963 | Las Vegas Convention Center, Winchester, Nevada, U.S. | Retained WBA, NYSAC, and The Ring heavyweight titles;Won inaugural WBC heavyweight title |
| 35 | Win | 34–1 | Floyd Patterson | KO | 1 (15), 2:06 | Sep 25, 1962 | Comiskey Park, Chicago, Illinois, U.S. | Won WBA, NYSAC, and The Ring heavyweight titles |
| 34 | Win | 33–1 | Albert Westphal | KO | 1 (10), 1:58 | Dec 4, 1961 | Convention Hall, Philadelphia, Pennsylvania, U.S. | |
| 33 | Win | 32–1 | Howard King | TKO | 3 (10), 0:53 | Mar 8, 1961 | Municipal Auditorium, Miami Beach, Florida, U.S. | |
| 32 | Win | 31–1 | Eddie Machen | UD | 12 | Sep 7, 1960 | Sick's Stadium, Seattle, Washington, U.S. | |
| 31 | Win | 30–1 | Zora Folley | KO | 3 (12), 0:28 | Jul 18, 1960 | Coliseum, Denver, Colorado, U.S. | |
| 30 | Win | 29–1 | Roy Harris | TKO | 1 (10), 2:35 | Apr 25, 1960 | Coliseum, Houston, Texas, U.S. | |
| 29 | Win | 28–1 | Cleveland Williams | TKO | 2 (10), 2:13 | Mar 21, 1960 | Coliseum, Houston, Texas, U.S. | |
| 28 | Win | 27–1 | Howard King | RTD | 7 (10), 3:00 | Feb 23, 1960 | Municipal Auditorium, Miami Beach, Florida, U.S. | |
| 27 | Win | 26–1 | Willi Besmanoff | RTD | 6 (10), 3:00 | Dec 9, 1959 | Cleveland Arena, Cleveland, Ohio, U.S. | |
| 26 | Win | 25–1 | Niño Valdés | KO | 3 (10), 0:47 | Aug 5, 1959 | Chicago Stadium, Chicago, Illinois, U.S. | |
| 25 | Win | 24–1 | Cleveland Williams | TKO | 3 (10), 2:13 | Apr 15, 1959 | Municipal Auditorium, Miami Beach, Florida, U.S. | |
| 24 | Win | 23–1 | Mike DeJohn | TKO | 6 (10), 2:43 | Feb 18, 1959 | Exhibition Hall, Miami Beach, Florida, U.S. | |
| 23 | Win | 22–1 | Ernie Cab | RTD | 7 (10), 3:00 | Nov 18, 1958 | Municipal Auditorium, Miami Beach, Florida, U.S. | |
| 22 | Win | 21–1 | Bert Whitehurst | UD | 10 | Oct 24, 1958 | St. Louis Arena, St. Louis, Missouri, U.S. | |
| 21 | Win | 20–1 | Frankie Daniels | KO | 1 (10), 2:22 | Oct 7, 1958 | Municipal Auditorium, Miami Beach, Florida, U.S. | |
| 20 | Win | 19–1 | Wayne Bethea | TKO | 1 (10), 1:09 | Aug 6, 1958 | Chicago Stadium, Chicago, Illinois, U.S. | |
| 19 | Win | 18–1 | Julio Mederos | RTD | 2 (10) | May 14, 1958 | Chicago Stadium, Chicago, Illinois, U.S. | |
| 18 | Win | 17–1 | Bert Whitehurst | PTS | 10 | Apr 3, 1958 | Kiel Auditorium, St. Louis, Missouri, U.S. | |
| 17 | Win | 16–1 | Ben Wise | TKO | 4 (8) | Mar 11, 1958 | Midwest Gymnasium, Chicago, Illinois, U.S. | |
| 16 | Win | 15–1 | Billy Hunter | TKO | 2 (6) | Jan 29, 1958 | Chicago Stadium, Chicago, Illinois, U.S. | |
| 15 | Win | 14–1 | Marty Marshall | UD | 10 | Mar 6, 1956 | Pittsburgh Gardens, Pittsburgh, Pennsylvania, U.S. | |
| 14 | Win | 13–1 | Larry Watson | TKO | 4 (10) | Dec 13, 1955 | Alnad Shriner Temple, East St. Louis, Illinois, U.S. | |
| 13 | Win | 12–1 | Johnny Gray | TKO | 6 (10) | Sep 13, 1955 | Victory Field, Indianapolis, Indiana, U.S. | |
| 12 | Win | 11–1 | Calvin Butler | TKO | 2 (8), 2:18 | May 25, 1955 | St. Louis Arena, St. Louis, Missouri, U.S. | |
| 11 | Win | 10–1 | Emil Brtko | TKO | 5 (10), 2:55 | May 5, 1955 | Duquesne Gardens, Pittsburgh, Pennsylvania, U.S. | |
| 10 | Win | 9–1 | Marty Marshall | TKO | 6 (8) | Apr 21, 1955 | Kiel Auditorium, St. Louis, Missouri, U.S. | |
| 9 | Win | 8–1 | Neal Welch | PTS | 8 | Mar 1, 1955 | New Masonic Temple, St. Louis, Missouri, U.S. | |
| 8 | Loss | 7–1 | Marty Marshall | SD | 8 | Sep 7, 1954 | Motor City Arena, Detroit, Michigan, U.S. | |
| 7 | Win | 7–0 | Johnny Summerlin | SD | 8 | Aug 10, 1954 | Motor City Arena, Detroit, Michigan, U.S. | |
| 6 | Win | 6–0 | Johnny Summerlin | UD | 8 | Jun 29, 1954 | Motor City Arena, Detroit, Michigan, U.S. | |