| No. | Result | Record | Opponent | Type | Round, time | Date | Location | Notes |
| 68 | Win | 60–6–1 (1) | Emilio Zarate | KO | 1 (10), 2:20 | May 21, 2016 | The O2 Arena, London, England | |
| 67 | Win | 59–6–1 (1) | Michael Marrone | KO | 2 (10), 2:52 | Sep 5, 2015 | Hard Rock Live, Hollywood, Florida, U.S. | |
| 66 | Win | 58–6–1 (1) | Zoltan Petranyi | KO | 1 (10), 1:52 | Mar 27, 2015 | Sortis Hotel Spa & Casino, Panama City, Panama | |
| 65 | Win | 57–6–1 (1) | Richard Carmack | KO | 1 (10), 2:59 | Nov 1, 2014 | Isle of Capri Casino, Lula, Mississippi, U.S. | |
| 64 | Win | 56–6–1 (1) | Cory Phelps | TKO | 1 (10), 1:18 | Aug 23, 2014 | Ring of Dreams Boxing Gym, Winston-Salem, North Carolina, U.S. | Retained NABA heavyweight title;Won WBC Latino interim heavyweight title |
| 63 | Win | 55–6–1 (1) | Raphael Zumbano Love | UD | 12 | Jun 28, 2014 | Remington Park, Oklahoma City, Oklahoma, U.S. | Won vacant NABA heavyweight title |
| 62 | Win | 54–6–1 (1) | Matthew Greer | TKO | 1 (10), 0:27 | May 17, 2014 | Mountaineer Casino Racetrack and Resort, New Cumberland, West Virginia, U.S. | |
| 61 | Win | 53–6–1 (1) | Francisco Mireles | KO | 1 (10), 0:27 | Apr 19, 2014 | Black Bear Casino Resort, Carlton, Minnesota, U.S. | |
| 60 | Win | 52–6–1 (1) | Maurenzo Smith | KO | 1 (10), 2:59 | Apr 11, 2014 | DoubleTree, Tampa, Florida, U.S. | |
| 59 | Loss | 51–6–1 (1) | Vitali Klitschko | UD | 12 | Oct 16, 2010 | O2 World, Hamburg, Germany | For WBC heavyweight title |
| 58 | Win | 51–5–1 (1) | Rob Calloway | TKO | 1 (10), 1:38 | May 28, 2010 | Scope, Norfolk, Virginia, U.S. | |
| 57 | Win | 50–5–1 (1) | Dominique Alexander | TKO | 1 (10), 0:20 | May 21, 2010 | Capitale, New York City, New York, U.S. | |
| 56 | Win | 49–5–1 (1) | Rafael Pedro | KO | 1 (10), 0:28 | Apr 13, 2010 | Hard Rock Live, Hollywood, Florida, U.S. | Won vacant WBC Latino heavyweight title |
| 55 | NC | 48–5–1 (1) | Marcus McGee | KO | 1 (8), 2:01 | Dec 3, 2009 | Manhattan Center Grand Ballroom, New York City, New York, U.S. | Originally a KO win for Briggs, later ruled NC after he failed a drug test |
| 54 | Loss | 48–5–1 | Sultan Ibragimov | UD | 12 | Jun 2, 2007 | Boardwalk Hall, Atlantic City, New Jersey, U.S. | Lost WBO heavyweight title |
| 53 | Win | 48–4–1 | Siarhei Liakhovich | TKO | 12 (12), 2:59 | Nov 4, 2006 | Chase Field, Phoenix, Arizona, U.S. | Won WBO heavyweight title |
| 52 | Win | 47–4–1 | Chris Koval | RTD | 3 (12), 3:00 | May 24, 2006 | Hammerstein Ballroom, New York City, New York, U.S. | Retained NABA and NABO heavyweight titles;Won vacant USBA heavyweight title |
| 51 | Win | 46–4–1 | Dicky Ryan | KO | 4 (12), 2:37 | Mar 18, 2006 | Convention Center, Fort Smith, Arkansas, U.S. | Won vacant NABA and NABO heavyweight titles |
| 50 | Win | 45–4–1 | Luciano Zolyone | KO | 1 (12), 0:11 | Dec 10, 2005 | Roberto Clemente Coliseum, San Juan, Puerto Rico | Won vacant WBC FECARBOX heavyweight title |
| 49 | Win | 44–4–1 | Brian Scott | KO | 1 (10), 1:10 | Nov 26, 2005 | Convention Center, Fort Smith, Arkansas, U.S. | |
| 48 | Win | 43–4–1 | Ray Mercer | KO | 7 (10), 0:41 | Aug 26, 2005 | Hard Rock Live, Hollywood, Florida, U.S. | |
| 47 | Win | 42–4–1 | Abraham Okine | TKO | 3 (10), 0:54 | Jun 10, 2005 | Turning Stone Resort & Casino, Verona, New York, U.S. | |
| 46 | Win | 41–4–1 | Demetrice King | TKO | 2 (6), 1:49 | Mar 3, 2005 | Madison Square Garden, New York City, New York, U.S. | |
| 45 | Win | 40–4–1 | Jeff Pegues | TKO | 1 (10), 0:35 | Mar 6, 2004 | Turning Stone Resort Casino, Verona, New York, U.S. | |
| 44 | Win | 39–4–1 | Wade Lewis | TKO | 3 (8) | Aug 28, 2003 | The Plex, North Charleston, South Carolina, U.S. | |
| 43 | Win | 38–4–1 | John Sargent | TKO | 1 (12), 0:17 | Jul 19, 2003 | War Memorial Auditorium, Fort Lauderdale, Florida, U.S. | Won vacant IBU heavyweight title |
| 42 | Win | 37–4–1 | Marvin Hill | TKO | 1 (10), 0:33 | Mar 27, 2003 | War Memorial Auditorium, Fort Lauderdale, Florida, U.S. | |
| 41 | Loss | 36–4–1 | Jameel McCline | UD | 10 | Apr 27, 2002 | Madison Square Garden, New York City, New York, U.S. | |
| 40 | Win | 36–3–1 | Reynaldo Minus | KO | 1 (8), 2:21 | Dec 1, 2001 | Jacob K. Javits Convention Center, New York City, New York, U.S. | |
| 39 | Win | 35–3–1 | Jason Waller | TKO | 1 (10), 0:37 | Oct 19, 2001 | The Orleans, Paradise, Nevada, U.S. | |
| 38 | Win | 34–3–1 | Russell Chasteen | KO | 1 (10), 2:55 | Apr 7, 2001 | Coeur d'Alene Casino Resort Hotel, Worley, Idaho, U.S. | |
| 37 | Win | 33–3–1 | Eric Curry | KO | 1 (10), 2:34 | Nov 2, 2000 | Coeur d'Alene Casino Resort Hotel, Worley, Idaho, U.S. | |
| 36 | Loss | 32–3–1 | Sedreck Fields | MD | 8 | Apr 27, 2000 | Hammerstein Ballroom, New York City, New York, U.S. | |
| 35 | Win | 32–2–1 | Warren Williams | TKO | 3 (10), 2:22 | Feb 24, 2000 | Hammerstein Ballroom, New York City, New York, U.S. | |
| 34 | Draw | 31–2–1 | Francois Botha | MD | 10 | Aug 7, 1999 | Etess Arena, Atlantic City, New Jersey, U.S. | |
| 33 | Win | 31–2 | Marcus Rhode | TKO | 1 (10), 2:55 | Dec 8, 1998 | Roseland Ballroom, New York City, New York, U.S. | |
| 32 | Loss | 30–2 | Lennox Lewis | TKO | 5 (12), 1:45 | Mar 28, 1998 | Convention Center, Atlantic City, New Jersey, U.S. | For WBC heavyweight title |
| 31 | Win | 30–1 | George Foreman | MD | 12 | Nov 22, 1997 | Etess Arena, Atlantic City, New Jersey, U.S. | |
| 30 | Win | 29–1 | Jorge Valdes | RTD | 9 (10), 3:00 | Jun 24, 1997 | Argosy Festival Atrium, Baton Rouge, Louisiana, U.S. | |
| 29 | Win | 28–1 | Melton Bowen | TKO | 1 (10), 0:26 | Apr 15, 1997 | South Mountain Arena, West Orange, New Jersey, U.S. | |
| 28 | Win | 27–1 | Eric French | TKO | 2 (8), 2:23 | Feb 21, 1997 | Mahi Temple Shrine Auditorium, Miami, Florida, U.S. | |
| 27 | Win | 26–1 | Tim Ray | KO | 1 (10) | Sep 25, 1996 | Robert Treat Hotel, Newark, New Jersey, U.S. | |
| 26 | Loss | 25–1 | Darroll Wilson | TKO | 3 (10), 2:17 | Mar 15, 1996 | Convention Hall, Atlantic City, New Jersey, U.S. | |
| 25 | Win | 25–0 | Calvin Jones | TKO | 1 (10), 0:54 | Dec 15, 1995 | Madison Square Garden, New York City, New York, U.S. | |
| 24 | Win | 24–0 | Sherman Griffin | TKO | 1 (10), 1:17 | Sep 22, 1995 | Civic Center, Lewiston, Maine, U.S. | |
| 23 | Win | 23–0 | Will Hinton | TKO | 1 (8), 1:50 | Aug 25, 1995 | Bally's, Atlantic City, New Jersey, U.S. | |
| 22 | Win | 22–0 | Marion Wilson | PTS | 8 | Mar 24, 1995 | South Mountain Arena, West Orange, New Jersey, U.S. | |
| 21 | Win | 21–0 | Craig Payne | UD | 8 | Jan 13, 1995 | Bally's, Atlantic City, New Jersey, U.S. | |
| 20 | Win | 20–0 | Mike Faulkner | KO | 2 | Oct 21, 1994 | Palm Springs, California, U.S. | |