| Sketch | Notes |
| Opening Monologue | Steve Martin hosts with featured cameos from John Mulaney and Martin Short, with David Letterman appearing in the audience. Mikey Day and Devon Walker appear as ICE agents escorting Short off the stage. |
| The Lawrence Welk Show & The Maharelle Sisters | Fred Armisen as Lawrence Welk, Will Ferrell as Robert Goulet, Kristen Wiig as Dooneese, Ana Gasteyer as Margaret, Kim Kardashian as Holly, and Scarlett Johansson as Janice. Kenan Thompson briefly appears as Florian Trent, a body contortionist. |
| Black Jeopardy! | Kenan Thompson reprises his role as Black Jeopardy! host Darnell Hayes with Leslie Jones as Shanice, Tracy Morgan as Darius, Eddie Murphy as Tracy Morgan, Chris Rock as a Special Guest Clue, and Tom Hanks reprising his role as Doug. |
| Physical Comedy clip montage | Emma Stone and Molly Shannon as Sally O'Malley present a montage dedicated to physical comedy on SNL. |
| Domingo: Vow Renewal | Martin Short and Molly Shannon as parents of the bride, Chloe Fineman and Andrew Dismukes as the couple, Sabrina Carpenter, Heidi Gardner, Sarah Sherman, and Ego Nwodim as bridesmaids, Andy Samberg, Bowen Yang, Beck Bennett, Kyle Mooney as the Groomsmen, Marcello Hernández as Domingo, Pedro Pascal as Renaldo, and Bad Bunny as Santiago. |
| Deep Thoughts by Jack Handey | Handey's voice reminisces about 50 years of SNL, but values his salary above anything. |
| Q&A Segment | Tina Fey and Amy Poehler answer questions from audience members Quinta Brunson, Tim Meadows, Ryan Reynolds, Nate Bargatze, Donna Richards (host dresser), Jon Lovitz, Julia Louis-Dreyfus, Adam Driver, Cher, Keith Richards, Zach Galifianakis, Jon Hamm, Bad Bunny, Seth Meyers, Al Sharpton, Ray Romano, Jason Momoa, Fred Armisen, and Peyton Manning. |
| SNL Digital Short | Bowen Yang, Andy Samberg, Sarah Sherman, Chris Parnell, Ana Gasteyer, Molly Shannon, Will Forte, Taran Killam, James Austin Johnson, Kenan Thompson, Beck Bennett and Kyle Mooney appear in a musical pre-taped digital short about anxiety at SNL. |
| Weekend Update | Colin Jost and Michael Che host Weekend Update. Che pays tribute to both Norm Macdonald and O. J. Simpson. Cecily Strong plays The Girl You Wish You Hadn't Started a Conversation with at a Party alongside Bobby Moynihan as Drunk Uncle. Seth Meyers introduces "Lorne's Best Friends from Growing Up" (Vanessa Bayer, Fred Armisen). Bill Murray ranks his favorite Weekend Update anchors. He makes a callback to earlier material in the sketch by ranking Norm Macdonald a favorite anchor and referring to his jokes about O.J. Simpson. |
| "Close Encounters" sketch | Aidy Bryant and Jon Hamm play officials investigating an alien abduction. Kate McKinnon reprises her role as Colleen Rafferty with Pedro Pascal and Woody Harrelson playing other abductees and Meryl Streep playing Colleen Sr., Rafferty's mother. |
| "The Stagehand" pre-taped sketch | Laraine Newman reminiscences being around Studio 8H and meets Chad (Pete Davidson). Cameo from Mikey Day. |
| "Moving to New York" musical sketch | Musical sketch featuring John Mulaney as Big Nick, Pete Davidson, David Spade, Adam Driver, Maya Rudolph, Emil Wakim, Alex Moffat, Paul Shaffer, G. E. Smith, Nathan Lane, Chloe Fineman, Jason Sudeikis, Will Forte, Kristen Wiig, Beck Bennett, Kyle Mooney, Scarlett Johansson, Paul Rudd, James Austin Johnson, Kenan Thompson, Cecily Strong, Nick Jonas, Taran Killam, and Ana Gasteyer with Kate McKinnon reprising her role as Rudy Giuliani, Lin-Manuel Miranda reprising his role as Alexander Hamilton, Sarah Sherman as Michael Bloomberg, and Devon Walker as Eric Adams. Audience members Jenna Ortega and Kevin Costner also take part, perhaps unintentionally, sitting between two of the singers. Natasha Lyonne played the role of a Guardian Angel in the final scene, but was obscured by Driver’s hot dog costume and not visible on camera. |
| Commercial parody clip montage | Alec Baldwin introduces a montage of commercial parodies (with Sarah Sherman). |
| "Bronx Beat with Betty & Jodi" Sketch | Amy Poehler and Maya Rudolph as Betty and Jodi with Miles Teller and Mike Myers who reprises his role as Linda Richman. |
| In Memoriam to cancelled sketches | Tom Hanks presents an In Memoriam to cancelled characters, stereotypes, jokes in poor taste, or "sketches that have aged horribly." |
| "Debbie Downer" sketch | Jimmy Fallon, Ayo Edebiri, Drew Barrymore, and Robert De Niro appear with Rachel Dratch reprising her role as Debbie Downer working as a bartender. |
| "Scared Straight" sketch | Sketch featuring Eddie Murphy, Kenan Thompson reprising his role as Lorenzo McIntosh, Will Ferrell, Jason Sudeikis reprising his role as Officer Sikorski, Mikey Day, Michael Longfellow, and Marcello Hernández. |
| "Don't Look Back in Anger" short | Garrett Morris introduces the Schiller's Reel short "Don't Look Back in Anger" starring John Belushi. |
| SNL goodnights | Martin Short salutes the original cast and thanks Lorne Michaels on-stage as they began the famous SNL goodnights. |
