| Year | Title | Role | Notes |
| 1992 | The Odyssey | Realtor | Episode: "A Place Called Nowhere" |
| 1992 | Neon Rider | Annie | Episode: "Labour Day" |
| 1992 | City Boy | Angelica | Television film |
| 1993–1997, 2018 | Roseanne | Becky Conner-Healy / Andrea | Main role (seasons 6–7, 9); Recurring role (seasons 8, 10) |
| 1996 | Robin of Locksley | Marion Fitzwater | Television film |
| 1996 | Stand Against Fear | Krista Wilson | Television film |
| 1997 | A Child's Wish | Melinda | Television film |
| 1997 | Dying to Belong | Drea Davenport | Television film |
| 1997 | Daughters | Annie Morrell | Television film |
| 1997 | Dead Man's Gun | Muriel Jakes | Episode: "The Bounty Hunter" |
| 1998 | I've Been Waiting for You | Sarah Zoltanne | Television film |
| 1998–2000 | Nothing Too Good for a Cowboy | Gloria Hobson | Main role |
| 1999 | First Wave | Chloe Wells | Episode: "The Channel" |
| 2001–2010 | Scrubs | Elliot Reid | Main role (seasons 1–8); Recurring role (season 9) |
| 2002 | It's a Very Merry Muppet Christmas Movie | Elliot Reid | Television film |
| 2002–2003 | Clone High | X-Stream Erin / Marie Antoinette (voice) | 3 episodes |
| 2003–2004 | The 'Bu | Melissa | Main role, The Lonely Island web series |
| 2006 | Why I Wore Lipstick to My Mastectomy | Geralyn Lucas | Television film |
| 2008 | Little Britain USA | Lisa Warren | Deleted scene |
| 2008–2009, 2014 | How I Met Your Mother | Stella Zinman | 10 episodes |
| 2009 | Scrubs: Interns | Dr. Elliot Reid | Episode: "Our Bedside Manner" |
| 2009 | Maneater | Clarissa Alpert | Main role |
| 2009 | The Fresh Beat Band | The Good Witch | Episodes: "The Wizard of Song: Parts 1 & 2" |
| 2009 | Prep & Landing | Magee (voice) | Television film |
| 2011 | Mad Love | Kate Swanson | Main role |
| 2011–2019 | American Dad! | Cam / Meredith / Photographer (voice) | 3 episodes |
| 2011 | Prep & Landing: Naughty vs. Nice | Magee (voice) | Television film |
| 2012 | Cougar Town | Angie | 4 episodes |
| 2013 | Grey's Anatomy | Casey Hedges | Episode: "Can't Fight This Feeling" |
| 2013 | How to Live with Your Parents (For the Rest of Your Life) | Polly Green-Tatham | Main role |
| 2013–present | Rick and Morty | Beth Smith and Space Beth (voice) | Main role |
| 2015 | Backstrom | Amy Gazanian | 6 episodes |
| 2015 | Undateable | Sarah Chalke | Episode: "A Rock and a Hard Place Walk Into a Bar" |
| 2016 | Angie Tribeca | Mrs. Parsons | Episode: "The Famous Ventriloquist Did It" |
| 2016 | Inside Amy Schumer | Amy | Episode: "Psychopath Test" |
| 2016–2019 | Milo Murphy's Law | Mrs. Murawski (voice) | 6 episodes |
| 2017–2019 | Speechless | Melanie | 8 episodes |
| 2018 | Nobodies | Sarah Chalke | Episode: "Alone Star State" |
| 2018 | The Conners | Andrea | Episode: "One Flew Over the Conners' Nest" |
| 2018 | Friends from College | Merrill Morgan | 4 episodes |
| 2018–2021 | Paradise PD | Gina Jabowski (voice) | Main role, Seasons 1–3 |
| 2020 | Psych 2: Lassie Come Home | Dolores O'Riordan | Television film |
| 2021–2023 | Firefly Lane | Kate Mularkey | Main role |
| 2021–2022 | Dogs in Space | Stella (voice) | Main role |
| 2023 | Hailey's On It! | The Professor (voice) | Recurring role |
| 2024 | Animal Control | Yasmine | Episode: "Raccoons and Mutts" |
| 2025 | Prep & Landing: The Snowball Protocol | Magee (voice) | Television film |
