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Sara Gilbert (born Sara Rebecca Abeles; January 29, 1975) is an American actress best known for portraying Darlene Conner on Roseanne (1988–97; 2018) and its sequel, The Conners (2018–25), a role for which she received two Primetime Emmy Award nominations. She is also the creator and was a co-host of the CBS daytime talk show The Talk, and had the recurring role of Leslie Winkle on CBS's The Big Bang Theory.
| Year | Title | Role | Notes |
| 1992 | Poison Ivy | Sylvie Cooper | Nominated — Independent Spirit Award for Best Supporting Actress |
| 1994 | Dead Beat | Martha | Film is based on the killings of Charles Schmid. |
| 1997 | Walkin' on Sunshine: The Movie | Neural Nurse 256 | |
| 1998 | $30 | Emily / Michelle | Short film |
| 1999 | Desert Blue | Sandy | |
| Light It Up | Lynn Sabatini | ||
| The Big Tease | Gretle Dickens | ||
| 2000 | High Fidelity | Anaugh Moss | |
| Boys Life 3 | Emily/Michelle | Short film; Segment: "$30" | |
| 2001 | Riding in Cars with Boys | Tina Barr | |
| 2004 | Laws of Attraction | Gary Gadget's Assistant | Cameo |
| 2023 | 80 for Brady | Sara |
| Year | Title | Role | Notes |
| 1984 | Calamity Jane | Jean | TV movie |
| 1988 | ABC Weekend Special | Stephie | Episode: "Runaway Ralph" |
| 1988–1997;2018 | Roseanne | Darlene Conner-Healy | 190 episodes Executive producer 2x Young Artist Award for Outstanding Young Comedienne in a Television SeriesTV Land Award for Innovator AwardNominated — Primetime Emmy Award for Outstanding Supporting Actress in a Comedy Series (1993–1994)Nominated — TV Land Award for Character Most Desperately in Need of a TimeoutNominated — Young Artist Award for Best Young Actress Supporting Role in a Television Series |
| 1989 | A&E's An Evening at the Improv | Herself | Season 4, Episode 6 |
| 1990 | Sudie and Simpson | Sudie Harrigan | TV movie Young Artist Award for Best Young Actress in a Cable Special |
| 1992; 1994 | The Simpsons | Laura Powers (voice) | Episodes: "New Kid on the Block" and "Another Simpsons Clip Show" (archival recordings) |
| 1994 | Saturday Night Live | Herself – Host | Episode: "Sara Gilbert/Counting Crows" |
| 1996 | ABC Afterschool Special | Jessie | Episode: "Me and My Hormones" |
| 1997 | Broken Record | TV movie | |
| 2000–2001 | Welcome to New York | Amy Manning | 13 episodes |
| 2002 | Rugrats | Cindy (voice) | Episode: "Cynthia Comes Alive/Trading Phil" |
| 24 | Paula Schaeffer | 5 episodes, Season 2 | |
| 2003 | Will & Grace | Cheryl | Episode: "Fanilow" |
| 2004 | Strong Medicine | Charlayne | Episode: "Cinderella in Scrubs" |
| 2004–2007 | ER | Dr. Jane Figler | 15 episodes |
| 2005 | In the Game | Unsold TV pilot | |
| The Clinic | Mrs. Jennings | Episode: 3.1 | |
| 2005–2006 | Twins | Mitchee Arnold | Lead role |
| 2006 | Girls on the Bus | Helen | Episode: "Pilot" |
| 2006–2007 | The Class | Fern Velch | 6 episodes |
| 2007 | Private Practice | Kelly | Episode: "In Which Sam Gets Taken For a Ride" |
| mw- 2007–2010;2016 | The Big Bang Theory | Leslie Winkle | Recurring role (season 1) Main role (season 2) Guest role (seasons 3, 9) |
| 2008 | Law & Order: Special Victims Unit | Caitlyn Ryan | Episode: "Trials" |
| 2010 | HawthoRNe | Malia Price | 3 episodes |
| Grey's Anatomy | Kim | Episode: "Suicide is Painless" | |
| 2010–2019 | The Talk | Herself | Also creator and executive producer |
| 2014 | Bad Teacher | Irene Dudek | Main role |
| 2016 | Supergirl | Herself | Episode: "Falling" |
| 2018 | Jane the Virgin | Herself | Episode: "Chapter Seventy-Four" |
| Living Biblically | Cheryl | Main role | |
| 2018–2025 | The Conners | Darlene Conner-Healy | Main role; 112 episodes |
| 2019 | Weird City | Jathryn | Episode: "Smart House" |
| Atypical | Professor Judd | Recurring role (season 3) | |
| 2020 | Equal | From Cleveland | Docuseries |
| Media offices | ||
| First | The Talk co-host 2010–2019 | Succeeded byMarie Osmond |