| Res. | Record | Opponent | Method | Event | Date | Round | Time | Location | Notes |
| Win | 30–16 (1) | Niko Price | KO (punches) | UFC 290 | July 8, 2023 | 1 | 0:38 | Las Vegas, Nevada, United States | |
| Loss | 29–16 (1) | Bryan Barberena | TKO (punches) | UFC 276 | July 2, 2022 | 2 | 4:47 | Las Vegas, Nevada, United States | Fight of the Night. |
| Win | 29–15 (1) | Nick Diaz | TKO (retirement) | UFC 266 | September 25, 2021 | 3 | 0:44 | Las Vegas, Nevada, United States | Middleweight bout. |
| Loss | 28–15 (1) | Neil Magny | Decision (unanimous) | UFC Fight Night: Smith vs. Rakić | August 29, 2020 | 3 | 5:00 | Las Vegas, Nevada, United States | |
| Loss | 28–14 (1) | Colby Covington | Decision (unanimous) | UFC on ESPN: Covington vs. Lawler | August 3, 2019 | 5 | 5:00 | Newark, New Jersey, United States | |
| Loss | 28–13 (1) | Ben Askren | Technical Submission (bulldog choke) | UFC 235 | March 2, 2019 | 1 | 3:20 | Las Vegas, Nevada, United States | |
| Loss | 28–12 (1) | Rafael dos Anjos | Decision (unanimous) | UFC on Fox: Lawler vs. dos Anjos | December 16, 2017 | 5 | 5:00 | Winnipeg, Manitoba, Canada | |
| Win | 28–11 (1) | Donald Cerrone | Decision (unanimous) | UFC 214 | July 29, 2017 | 3 | 5:00 | Anaheim, California, United States | |
| Loss | 27–11 (1) | Tyron Woodley | KO (punches) | UFC 201 | July 30, 2016 | 1 | 2:12 | Atlanta, Georgia, United States | Lost the UFC Welterweight Championship. |
| Win | 27–10 (1) | Carlos Condit | Decision (split) | UFC 195 | January 2, 2016 | 5 | 5:00 | Las Vegas, Nevada, United States | Defended the UFC Welterweight Championship. Fight of the Night. |
| Win | 26–10 (1) | Rory MacDonald | TKO (punches) | UFC 189 | July 11, 2015 | 5 | 1:00 | Las Vegas, Nevada, United States | Defended the UFC Welterweight Championship. Fight of the Night. |
| Win | 25–10 (1) | Johny Hendricks | Decision (split) | UFC 181 | December 6, 2014 | 5 | 5:00 | Las Vegas, Nevada, United States | Won the UFC Welterweight Championship. |
| Win | 24–10 (1) | Matt Brown | Decision (unanimous) | UFC on Fox: Lawler vs. Brown | July 26, 2014 | 5 | 5:00 | San Jose, California, United States | UFC Welterweight title eliminator; Brown missed weight (172.5 lb). Fight of the Night. |
| Win | 23–10 (1) | Jake Ellenberger | TKO (knee and punches) | UFC 173 | May 24, 2014 | 3 | 3:06 | Las Vegas, Nevada, United States | |
| Loss | 22–10 (1) | Johny Hendricks | Decision (unanimous) | UFC 171 | March 15, 2014 | 5 | 5:00 | Dallas, Texas, United States | For the vacant UFC Welterweight Championship. Fight of the Night. |
| Win | 22–9 (1) | Rory MacDonald | Decision (split) | UFC 167 | November 16, 2013 | 3 | 5:00 | Las Vegas, Nevada, United States | |
| Win | 21–9 (1) | Bobby Voelker | KO (head kick and punch) | UFC on Fox: Johnson vs. Moraga | July 27, 2013 | 2 | 0:24 | Seattle, Washington, United States | |
| Win | 20–9 (1) | Josh Koscheck | TKO (punches) | UFC 157 | February 23, 2013 | 1 | 3:57 | Anaheim, California, United States | Return to Welterweight. Knockout of the Night. |
| Loss | 19–9 (1) | Lorenz Larkin | Decision (unanimous) | Strikeforce: Rockhold vs. Kennedy | July 14, 2012 | 3 | 5:00 | Portland, Oregon, United States | |
| Win | 19–8 (1) | Adlan Amagov | TKO (flying knee and punches) | Strikeforce: Rockhold vs. Jardine | January 7, 2012 | 1 | 1:48 | Las Vegas, Nevada, United States | |
| Loss | 18–8 (1) | Tim Kennedy | Decision (unanimous) | Strikeforce: Fedor vs. Henderson | July 30, 2011 | 3 | 5:00 | Hoffman Estates, Illinois, United States | |
| Loss | 18–7 (1) | Ronaldo Souza | Submission (rear-naked choke) | Strikeforce: Diaz vs. Cyborg | January 29, 2011 | 3 | 2:00 | San Jose, California, United States | For the Strikeforce Middleweight Championship. |
| Win | 18–6 (1) | Matt Lindland | KO (punch) | Strikeforce: Henderson vs. Babalu II | December 4, 2010 | 1 | 0:50 | St. Louis, Missouri, United States | |
| Loss | 17–6 (1) | Renato Sobral | Decision (unanimous) | Strikeforce: Los Angeles | June 16, 2010 | 3 | 5:00 | Los Angeles, California, United States | Catchweight (195 lb) bout. |
| Win | 17–5 (1) | Melvin Manhoef | KO (punch) | Strikeforce: Miami | January 30, 2010 | 1 | 3:33 | Sunrise, Florida, United States | |
| Loss | 16–5 (1) | Jake Shields | Submission (guillotine choke) | Strikeforce: Lawler vs. Shields | June 6, 2009 | 1 | 2:02 | St. Louis, Missouri, United States | Catchweight (180 lb) bout. |
| Win | 16–4 (1) | Scott Smith | TKO (kicks and punches) | EliteXC: Unfinished Business | July 26, 2008 | 2 | 2:35 | Stockton, California, United States | Defended the EliteXC Middleweight Championship. |
| NC | 15–4 (1) | Scott Smith | NC (thumb in the eye) | EliteXC: Primetime | May 31, 2008 | 3 | 3:26 | Newark, New Jersey, United States | Retained the EliteXC Middleweight Championship. Accidental eye poke rendered Smith unable to continue. |
| Win | 15–4 | Murilo Rua | KO (punches) | EliteXC: Uprising | September 15, 2007 | 3 | 2:04 | Honolulu, Hawaii, United States | Won the EliteXC Middleweight Championship. |
| Win | 14–4 | Frank Trigg | KO (punches) | ICON Sport: Epic | March 31, 2007 | 4 | 1:40 | Honolulu, Hawaii, United States | Won the ICON Sport Middleweight Championship. |
| Win | 13–4 | Eduardo Pamplona | TKO (punches) | IFL: Atlanta | February 23, 2007 | 3 | 1:36 | Atlanta, Georgia, United States | |
| Win | 12–4 | Joey Villaseñor | KO (flying knee and punches) | PRIDE 32 | October 21, 2006 | 1 | 0:22 | Las Vegas, Nevada, United States | |
| Loss | 11–4 | Jason Miller | Submission (arm-triangle choke) | ICON Sport: Mayhem vs. Lawler | September 2, 2006 | 3 | 2:50 | Honolulu, Hawaii, United States | Lost the ICON Sport Middleweight Championship. |
| Win | 11–3 | Falaniko Vitale | KO (punches) | ICON Sport: Lawler vs. Niko II | February 25, 2006 | 1 | 3:38 | Honolulu, Hawaii, United States | Won the ICON Sport Middleweight Championship. |
| Win | 10–3 | Jeremy Brown | Submission (armbar) | KOTC: Xtreme Edge | September 17, 2005 | 1 | 2:48 | Indianapolis, Indiana, United States | |
| Win | 9–3 | Falaniko Vitale | KO (punches) | SuperBrawl: Icon | July 23, 2005 | 2 | 4:36 | Honolulu, Hawaii, United States | Won the SuperBrawl Middleweight Championship. |
| Loss | 8–3 | Evan Tanner | Submission (triangle choke) | UFC 50 | October 22, 2004 | 1 | 2:22 | Atlantic City, New Jersey, United States | Middleweight debut. |
| Loss | 8–2 | Nick Diaz | KO (punch) | UFC 47 | April 2, 2004 | 2 | 1:31 | Las Vegas, Nevada, United States | |
| Win | 8–1 | Chris Lytle | Decision (unanimous) | UFC 45 | November 21, 2003 | 3 | 5:00 | Uncasville, Connecticut, United States | |
| Loss | 7–1 | Pete Spratt | TKO (knee injury) | UFC 42 | April 25, 2003 | 2 | 2:28 | Miami, Florida, United States | |
| Win | 7–0 | Tiki Ghosn | KO (punches) | UFC 40 | November 22, 2002 | 1 | 1:29 | Las Vegas, Nevada, United States | |
| Win | 6–0 | Steve Berger | TKO (punches) | UFC 37.5 | June 22, 2002 | 2 | 0:27 | Las Vegas, Nevada, United States | |
| Win | 5–0 | Aaron Riley | Decision (unanimous) | UFC 37 | May 10, 2002 | 3 | 5:00 | Bossier City, Louisiana, United States | |
| Win | 4–0 | Saburo Kawakatsu | TKO (punches) | Shogun 1 | December 15, 2001 | 1 | 4:49 | Honolulu, Hawaii, United States | |
| Win | 3–0 | Marco Macera | TKO (punches) | Extreme Challenge 41 | July 13, 2001 | 1 | 1:19 | Davenport, Iowa, United States | |
| Win | 2–0 | Landon Showalter | KO (punches) | IFC: Warriors Challenge 13 | June 15, 2001 | 1 | 0:14 | Fresno, California, United States | |
| Win | 1–0 | John Reed | TKO (punches) | Extreme Challenge 39 | April 7, 2001 | 1 | 2:14 | Springfield, Illinois, United States | |