| Year | Work | Award | Result | Ref. |
| 2003 | Ally McBeal | NAACP Image Award for Outstanding Supporting Actress in a Comedy Series | Nominated | |
| 2005 | Danika | Best Actress – San Diego Film Festival | Won | |
| 2018 | Girls Trip | NAACP Image Award for Outstanding Supporting Actress in a Motion Picture | Nominated | |
| Support the Girls | African-American Film Critics Association Award for Best Actress | Won | |
| Austin Film Critics Association Award for Best Actress | Nominated | |
| Black Reel Award for Outstanding Actress | Nominated | |
| Boston Online Film Critics Association Award for Best Ensemble | Won | |
| Chicago Film Critics Association Award for Best Actress | Nominated | |
| Florida Film Critics Circle Award for Best Cast | Runner-up | |
| Gotham Independent Film Award for Best Actress | Nominated | |
| Independent Spirit Award for Best Female Lead | Nominated | |
| Online Film Critics Society Award for Best Actress | Nominated | |
| National Society of Film Critics Award for Best Actress | Runner-up | |
| New York Film Critics Circle Award for Best Actress | Won | |
| San Francisco Film Critics Circle Award for Best Actress | Nominated | |
| Seattle Film Critics Society Award for Best Actress | Nominated | |
| Vancouver Film Critics Circle Award for Best Actress | Won | |
| Talk Film Society Award for Best Actress | Nominated | |
| Toronto Film Critics Association Award for Best Actress | Nominated | |
| 2019 | The Hate U Give | Women's Image Network Awards for Best Supporting Actress, Feature Film | Won | |
| NAACP Image Award for Outstanding Supporting Actress in a Motion Picture | Nominated | |
| 2020 | Black Monday | Black Reel Award for Outstanding Supporting Actress, Comedy Series | Nominated | |
| NAACP Image Award for Outstanding Actress in a Comedy Series | Nominated | |
| 2019 BET Awards Ceremony | NAACP Image Award for Outstanding Host in a Reality, Game Show or Variety (Series or Special) | Nominated |
| 2021 | Nine Perfect Strangers | Newport Beach Film Festival - Spotlight Award (Artist of Distinction) | Won | |
| Black Monday | NAACP Image Award for Outstanding Actress in a Comedy Series | Nominated | |
| 2022 | NAACP Image Award for Outstanding Actress in a Comedy Series | Nominated | |
| Nine Perfect Strangers | NAACP Image Award for Outstanding Supporting Actress in a TV Movie, Limited-Series orDramatic Special | Won |
| Life's Work | San Diego International Film Festival - Cinema Vanguard Award | Honored | |
| Honk for Jesus. Save Your Soul. | Napa Valley Film Festival - Maverick Award | Honored | |
| 2023 | Independent Spirit Award for Best Lead Performance | Nominated | |
| San Diego Film Critics Society Award for Best Actress | Nominated | |
| Black Reel Award for Outstanding Actress | Nominated | |
| NAACP Image Award for Outstanding Actress in a Motion Picture | Nominated | |
| The Best Man: The Final Chapters | NAACP Image Award for Outstanding Actress in a TV Movie, Limited-Series or Dramatic Special | Nominated | |
| 2025 | One Battle After Another | SCAD Savannah Film Festival - Gold Derby Spotlight Award | Honored | |
| Critics Choice Awards Celebration of Cinema & Television - Best Ensemble | Honored | |
| New York Film Critics Online | Nominated | |
| Georgia Film Critics - Best Supporting Actress | Runner-up | |
| Women Film Critics Circle - Best Supporting Actress | Won | |
| 2026 | Astra Film Awards - Best Supporting Actress | Pending | |
| AARP Movies for Grownups Awards | Pending | |
| Black Reel Awards - Outstanding Supporting Performance | Pending | |