| Award | Year | Category | Nominated work | Result | Ref. |
| Critics' Choice Television Awards | 2019 | Best Actor in a Comedy Series | Ramy | Nominated | |
| 2021 | Nominated | |
| Golden Globe Awards | 2020 | Best Actor in a Television Series – Musical or Comedy | Won | |
| 2021 | Nominated | |
| Gotham Awards | 2019 | Breakthrough Series – Short Form | Nominated | |
| NAACP Image Awards | 2021 | Outstanding Breakthrough Creative – Television | Nominated | |
| Primetime Emmy Awards | 2020 | Outstanding Lead Actor in a Comedy Series | Ramy (episode: "You Are Naked in Front of Your Shaikh") | Nominated | |
| Outstanding Directing for a Comedy Series | Ramy (episode: "Miakhalifa.mov") | Nominated |
| 2024 | Outstanding Directing for a Comedy Series | The Bear (Episode: "Honeydew") | Nominated | |
| Satellite Awards | 2021 | Best Actor in a Musical or Comedy Series | Ramy | Nominated | |
| Screen Actors Guild Awards | 2021 | Outstanding Performance by a Male Actor in a Comedy Series | Nominated | |
| TCA Awards | 2020 | Individual Achievement in Comedy | Nominated | |
| Writers Guild of America Awards | 2020 | Comedy/Variety – Specials | Ramy Youssef: Feelings | Nominated | |
| Peabody Awards | 2023 | Entertainment | Mo | Won | |
| Directors Guild of America Awards | 2024 | Outstanding Directing – Comedy Series | The Bear (Episode: "Honeydew") | Nominated | |