| Year | Title | Role | Notes |
| 1999–2007 | Saturday Night Live | Herself/Various | Main cast (150 episodes) |
| 1999 | Saturday Night Live 25th Anniversary Special | Herself | Television special |
| 2000 | Third Watch | Darla | Episode: "History" |
| 2002 | Kim Possible | Adrena Lynn | Voice, episode: "All the News" |
| 2002–2004 | The King of Queens | Denise Ruth Battaglia | 6 episodes |
| 2004 | Soundtracks Live | Dorothy Baker | TV film |
| Monk | Julie Parlo | Episodes: "Mr. Monk and the Missing Granny" |
| Game Over | Alice Smashburn | Voice, main role (6 episodes) |
| Frasier | Horny Date | Episode: "Match Game" |
| 2005–2006 | O'Grady | Brooke | Voice, 2 episodes |
| 2006–2012 | 30 Rock | Greta Johansen/Various | 15 episodes |
| 2008 | Aqua Teen Hunger Force | Robot Wife | Voice, episode: "Robots Are Everywhere" |
| Squidbillies | Hippie Woman | Voice, episode: "Earth Worst" |
| Assy McGee | Various Roles | Voice, 6 episodes |
| Avatar: The Last Airbender | Actress Aang | Voice, 2 episodes |
| Superjail! | Various | Voice, episode: "Ladies Night" |
| 2009 | Yo Gabba Gabba! | Herself | Episode: "Clean" |
| Wizards of Waverly Place | Darling | Episode: "Future Harper" |
| Ugly Betty | Penny Meadows/Mindy Meadows | Episode: "The Fall Issue" |
| Sherri | Teacher | Episode: "Indecision '09" |
| 2010 | Delocated | Cellist | Episode: "Mixer" |
| 2010–2013 | Fish Hooks | Esmargot/Koi | Voice, 28 episodes |
| 2011 | Funny or Die Presents | Dirkson | 4 episodes |
| Submissions Only | Fiona Evans | Episode: "Somethin' Else" |
| 2012 | The Secret Policeman's Ball 2012 | Herself | Television special |
| Up All Night | Linda | Episode: "Swingers" |
| iCarly | Herself | Episode: "iShock America" |
| Suburgatory | Paula Weingelb | Episode: "The Witch of East Chatswin" |
| RuPaul's Drag Race All Stars | Herself/Guest Judge | Episode: "Queens Behaving Badly" |
| The Cleveland Show | Maggie | Episode: Tis the Cleveland to Be Sorry" |
| 2013–2014 | The Middle | Principal Barker | 2 episodes |
| 2013–2015 | The Awesomes | Joyce Mandrake/Tom Boy | Voice, 15 episodes |
| 2014 | The Neighbors | Pearl | Episode: "A Night in (Lou Ferrigno's Hibachi) Heaven" |
| Inside Amy Schumer | Lisa | Episode: "Boner Doctor" |
| 2014–2019 | Broad City | Linda Lodi | 3 episodes |
| 2014–2025 | Bob's Burgers | Jodi/Various | Voice, 8 episodes |
| 2015 | Salem Rogers: Model of the Year 1998 | Agatha Todd | Television pilot |
| Parks and Recreation | Roz Pinwheel | Episode: "Donna & Joe" |
| Saturday Night Live 40th Anniversary Special | Debbie Downer | Television special |
| Sesame Street | Museum Guard | Episode: "The Cookie Thief" |
| Unforgettable | Rosie Webb | Episode: "Gut Check" |
| 2015–2016 | Difficult People | Chemo Woman/Casting Director | 2 episodes |
| 2015–2025 | Last Week Tonight with John Oliver | Wanda Jo Oliver | 8 episodes |
| 2016 | The Simpsons | Bostonian Doctor | Voice, episode: "The Town" |
| 2016–2017 | Nature Cat | Lulu Ladybug/Flo | Voice, 2 episodes |
| 2016–2018 | Rachel Dratch's Late Night Snack | Herself/Host | Main cast (57 episodes) |
| 2017 | Man Seeking Woman | Methelda | Episode: "Horse" |
| Imaginary Mary | Mary | Voice, main cast (9 episodes) |
| Angie Tribeca | Masha Chekhov | Episode: "Hey, I'm Solvin' Here!" |
