| Congress | Dates | Democratic whip | Democratic leader | Majority | Republican leader | Republican whip |
| 63rd | May 28, 1913 –March 4, 1915 | J. Hamilton Lewis(Illinois) | None | Democratic← majority | None | None |
| 64th | March 4, 1915 –December 6, 1915 |
| December 6, 1915 –December 13, 1915 | James Wadsworth(New York) |
| December 13, 1915 –March 4, 1917 | Charles Curtis(Kansas) |
| 65th | March 4, 1917 –March 4, 1919 |
| 66th | March 4, 1919 –April 27, 1920 | Peter Gerry(Rhode Island) | Republicanmajority → | Henry Cabot Lodge(Massachusetts, Unofficial) |
| April 27, 1920 –March 4, 1921 | Oscar Underwood(Alabama) |
| 67th | March 4, 1921 –March 4, 1923 |
| 68th | March 4, 1923 –December 3, 1923 |
| December 3, 1923 –November 9, 1924 | Joseph T. Robinson(Arkansas) |
| November 9, 1924 –March 4, 1925 | Charles Curtis(Kansas, Acting) | Wesley Jones(Washington, Acting) |
| 69th | March 4, 1925 –March 4, 1927 | Charles Curtis(Kansas) | Wesley Jones(Washington) |
| 70th | March 4, 1927 –March 4, 1929 |
| 71st | March 4, 1929 –March 4, 1931 | Morris Sheppard(Texas) | James E. Watson(Indiana) | Simeon Fess(Ohio) |
| 72nd | March 4, 1931 –March 4, 1933 |
| 73rd | March 4, 1933 –January 3, 1935 | J. Hamilton Lewis(Illinois) | Democratic← majority | Charles L. McNary(Oregon) | Felix Hebert(Rhode Island) |
| 74th | January 3, 1935 –January 3, 1937 | None |
| 75th | January 3, 1937 –July 14, 1937 |
| July 14, 1937 –January 3, 1939 | Alben W. Barkley(Kentucky) |
| 76th | January 3, 1939 –April 9, 1939 |
| April 9, 1939 –January 3, 1940 | Sherman Minton(Indiana) |
| January 3, 1940 –January 3, 1941 | Warren Austin(Vermont, Acting) |
| 77th | January 3, 1941 –January 3, 1943 | J. Lister Hill(Alabama) | Charles L. McNary(Oregon) |
| 78th | January 3, 1943 –February 25, 1944 | Kenneth Wherry(Nebraska) |
| February 25, 1944 –January 3, 1945 | Wallace H. White(Maine, Acting) |
| 79th | January 3, 1945 –January 3, 1947 | Wallace H. White(Maine) |
| 80th | January 3, 1947 –January 3, 1949 | Scott W. Lucas(Illinois) | Republicanmajority → |
| 81st | January 3, 1949 –January 3, 1951 | Francis Myers(Pennsylvania) | Scott W. Lucas(Illinois) | Democratic← majority | Kenneth S. Wherry(Nebraska) | Leverett Saltonstall(Massachusetts) |
| 82nd | January 3, 1951 –January 3, 1952 | Lyndon B. Johnson(Texas) | Ernest McFarland(Arizona) |
| January 3, 1952 –January 3, 1953 | Styles Bridges(New Hampshire) |
| 83rd | January 3, 1953 –July 31, 1953 | Earle Clements(Kentucky) | Lyndon B. Johnson(Texas) | Republicanmajority → | Robert A. Taft(Ohio) |
| August 3, 1953 –January 3, 1955 | William Knowland(California) |
| 84th | January 3, 1955 –January 3, 1957 | Democratic← majority |
| 85th | January 3, 1957 –January 3, 1959 | Mike Mansfield(Montana) | Everett Dirksen(Illinois) |
| 86th | January 3, 1959 –January 3, 1961 | Everett Dirksen(Illinois) | Thomas Kuchel(California) |
| 87th | January 3, 1961 –January 3, 1963 | Hubert Humphrey(Minnesota) | Mike Mansfield(Montana) |
| 88th | January 3, 1963 –January 3, 1965 |
| 89th | January 3, 1965 –January 3, 1967 | Russell Long(Louisiana) |
| 90th | January 3, 1967 –January 3, 1969 |
| 91st | January 3, 1969 –September 7, 1969 | Ted Kennedy(Massachusetts) | Hugh Scott(Pennsylvania) |
| September 24, 1969 –January 3, 1971 | Hugh Scott(Pennsylvania) | Robert Griffin(Michigan) |
| 92nd | January 3, 1971 –January 3, 1973 | Robert Byrd(West Virginia) |
| 93rd | January 3, 1973 –January 3, 1975 |
| 94th | January 3, 1975 –January 3, 1977 |
| 95th | January 3, 1977 –January 3, 1979 | Alan Cranston(California) | Robert Byrd(West Virginia) | Howard Baker(Tennessee) | Ted Stevens(Alaska) |
| 96th | January 3, 1979 –November 1, 1979 |
| November 1, 1979 –March 5, 1980 | Ted Stevens(Alaska, Acting) |
| March 5, 1980 –January 3, 1981 | Howard Baker(Tennessee) |
| 97th | January 3, 1981 –January 3, 1983 | Republicanmajority → |
