| Title | Year | Peak chart positions | Certifications | Album |
| US | USAlt. | USRock | AUS | CAN | IRE | NOR | SWE | UK | WW |
| "When I'm Down"(with Whethan) | 2016 | — | — | — | — | — | — | — | — | — | — | RIAA: Gold | Non-album singles |
| "All You Ever Talk About"(with Whethan) | 2017 | — | — | — | — | — | — | — | — | — | — | |
| "All I Got" / "Welcome to LA" | — | — | — | — | — | — | — | — | — | — | | Alien Boy |
| "Cheapskate" | — | — | — | — | — | — | — | — | — | — | | Non-album single |
| "Enemy"(with Whethan) | — | — | — | — | — | — | — | — | — | — | | Alien Boy |
| "Upside Down" | 2018 | — | — | — | — | — | — | — | — | — | — | |
| "Alien Boy" | — | — | — | — | — | — | — | — | — | — | RIAA: Platinum BPI: Silver MC: Platinum | Alien Boy, Do You Feel Me?, & Ugly Is Beautiful |
| "Movement" | — | — | — | — | — | — | — | — | — | — | | Non-album single |
| "Hurt" | — | 4 | 11 | — | — | — | — | — | — | — | RIAA: Platinum MC: Gold | Do You Feel Me? & Ugly Is Beautiful |
| "Fuck" | 2019 | — | — | — | — | — | — | — | — | — | — | | Non-album single |
| "Miracle Man" | — | — | 22 | — | — | — | — | — | — | — | RIAA: Gold | Do You Feel Me? & Ugly Is Beautiful |
| "Cash Machine" | — | — | 13 | — | — | — | — | — | — | — | | Ugly Is Beautiful |
| "Let Me Down" | 2020 | — | 26 | 9 | — | — | — | — | — | — | — | RIAA: Gold |
| "Bury Me Alive" | — | — | 34 | — | — | — | — | — | — | — | |
| "Let Me Down"(featuring Blink-182) | — | — | — | — | — | — | — | — | — | — | | Non-album single |
| "Out of Ordinary" | 2021 | — | — | — | — | — | — | — | — | — | — | | Ugly Is Beautiful: Shorter, Thicker & Uglier |
| "Life Goes On" | 71 | 27 | 7 | 34 | 46 | 33 | 14 | 63 | 33 | 26 | RIAA: Platinum BPI: Silver MC: Platinum |
| "Turn It Up" (with Little Big featuring Tommy Cash) | — | — | — | — | — | — | — | — | — | — | | Welcome to the Internet |
| "Cowboys Don't Cry" | 2022 | — | 28 | 18 | — | — | — | — | — | — | — | | Cowboy Tears |
| "Freaks & Geeks" | — | — | — | — | — | — | — | — | — | — | |
| "I Hate You" | — | — | — | — | — | — | — | — | — | — | | Cowboy Tears Drown the World in a Swimming Pool of Sorrow |
| "Placeholder" | — | — | — | — | — | — | — | — | — | — | |
| "Miss You"(with Robin Schulz) | 84 | — | — | 4 | 28 | 2 | 3 | 21 | 3 | 11 | ARIA: 2× Platinum BPI: Platinum MC: 2× Platinum RIAA: Platinum | Alone in a Crowd |
| "Here We Go Again"(with David Guetta) | 2023 | — | — | — | — | — | — | — | — | — | — | | Non-album single |
| "Bounce" | — | — | — | — | — | — | — | — | — | — | | Alone in a Crowd |
| "One & Only" | — | — | — | — | — | — | — | — | — | — | |
| "Essence" featuring Super Computer) | — | — | — | — | — | — | — | — | — | — | |
| "Fairweather Friends" | — | — | — | — | — | — | — | — | — | — | |
| "Ultraman"(with Diplo) | 2024 | — | — | — | — | — | — | — | — | — | — | | Non-album single |
| "Superhero" | 2025 | — | — | — | — | — | — | — | — | — | — | | Non-album single |
| "Joyride" | — | — | — | — | — | — | — | — | — | — | | Non-album single |
| "—" denotes a recording that did not chart or was not released. |
