| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| I-70 | 2171 | 3,495 | I-15 in Cove Fort, Utah | I-695 at Woodlawn, Baltimore County, Maryland | 01956-01-011956 | current | Serves one Northeastern state: Pennsylvania Associated routes: I-270, I-370 |
| I-76 | 435 | 701 | I-71 in Westfield Center, Ohio | I-295 at Bellmawr, New Jersey | 01964-01-011964 | current | Serves two Northeastern states: Pennsylvania, New Jersey Associated routes: I-176, I-276, I-376, I-476, I-676 |
| I-78 | 146 | 235 | I-81 at Jonestown, Pennsylvania | Canal Street in New York City | 01957-01-011957 | current | Serves three Northeastern states: Pennsylvania, New Jersey, New York Associated routes: I-278, I-478, I-678, I-878 |
| I-79 | 343 | 552 | I-77 in Charleston, West Virginia | PA 5 in Erie, Pennsylvania | 01967-01-011967 | current | Serves one Northeastern state: Pennsylvania Associated routes: I-279, I-579 |
| I-80 | 2899 | 4,666 | US 101 in San Francisco, California | I-95 in Teaneck, New Jersey | 01956-01-011956 | current | Serves two Northeastern states: Pennsylvania and New Jersey Associated routes: I-180, I-380, I-280 |
| I-81 | 855 | 1,376 | I-40 in Dandridge, Tennessee | Canadian border at Wellesley Island, New York | 01961-01-011961 | current | Serves two Northeastern states: Pennsylvania, New York Associated routes:I-481 and I-781 |
| I-83 | 85 | 136 | President Street and Fayette Street in Baltimore, Maryland | I-81 in Harrisburg, Pennsylvania | 01959-01-011959 | current | Serves one Northeastern state: Pennsylvania Associated route: I-283 |
| I-84 | 232 | 374 | I-81 in Scranton, Pennsylvania | I-90 in Sturbridge, Massachusetts | 01963-01-011963 | current | Serves four Northeastern states: Pennsylvania, New York, Connecticut, Massachusetts Associated routes: I-384, I-684 |
| I-86 | 223 | 359 | I-90 near North East, Pennsylvania | NY 17/NY 79 in Windsor, New York | 01999-01-011999 | current | Unfinished in New York Serves two Northeastern states: Pennsylvania, New York Associated routes: none |
| I-87 | 333 | 536 | I-278 in New York City | A-15 at Canadian border in Champlain, New York | 01957-01-011957 | current | New York only Associated routes: I-287, I-587, I-787 |
| I-88 | 117 | 189 | I-81 in Binghamton, New York | I-90 in Schenectady, New York | 01968-01-011968 | current | New York only Associated routes: none |
| I-89 | 191 | 307 | I-93/SR 3A in Bow, New Hampshire | Route 133/Future A-35 at Canadian border in Highgate, Vermont | 01960-01-011960 | current | Serves two Northeastern states: New Hampshire, Vermont Associated route: I-189 |
| I-90 | 3020 | 4,860 | SR 519/4th Avenue/Edgar Martinez Drive in Seattle, Washington | MA 1A in Boston, Massachusetts | 01956-01-011956 | current | Serves three Northeastern states: Pennsylvania, New York, Massachusetts Associated routes: I-190 (New York), I-290 (New York), I-390, I-490, I-590, I-690, I-790, I-890, I-990, I-190 (Massachusetts), I-290 (Massachusetts) Longest Interstate highway in the US |
| I-91 | 290 | 467 | I-95 in New Haven, Connecticut | A-55 at Canadian border in Derby Line, Vermont | 01958-01-011958 | current | Serves three Northeastern states: Connecticut, Massachusetts, Vermont Associated routes: I-291 (Connecticut), I-291 (Massachusetts) I-391, I-691 |
| I-93 | 189 | 305 | I-95/US 1 in Canton, Massachusetts | I-91 in St. Johnsbury, Vermont | 01957-01-011957 | current | Serves three Northeastern states: Massachusetts, New Hampshire, Vermont Associated routes: I-293, I-393 |
| I-95 | 1919 | 3,088 | US 1 in Miami, Florida | NB 95 at Canadian border in Houlton, Maine | 01957-01-011957 | current | Serves eight Northeastern states: Pennsylvania, New Jersey, New York, Connecticut, Rhode Island, Massachusetts, New Hampshire, Maine Associated routes: I-195, I-295, I-395, I-495, I-695, I-895 Longest primary north-south Interstate highway |
| I-99 | 98 | 158 | I-70/I-76 in Bedford, Pennsylvania | I-86/NY 17 in Painted Post, New York | 01998-01-011998 | current | Unfinished in Pennsylvania Serves two Northeastern states: Pennsylvania, New York Associated routes: none |
