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Norovirus

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Norovirus

Norovirus, also known as Norwalk virus and sometimes referred to as the winter vomiting disease, is the most common cause of gastroenteritis. Infection is characterized by non-bloody diarrhea, vomiting, and stomach pain. Fever or headaches may also occur. Symptoms usually develop 24 hours after being exposed, and recovery typically occurs within one to three days. Complications are uncommon, but may include dehydration, especially in the young, the old, and those with other health problems. The virus is usually spread by the fecal–oral route. This may be through contaminated food or water or person-to-person contact. It may also spread via contaminated surfaces or through air from the vomit of an infected person. Risk factors include unsanitary food preparation and sharing close quarters. Diagnosis is generally based on symptoms. Confirmatory testing is not usually available but may be performed by public health agencies during outbreaks. Prevention involves proper hand washing and disinfection of contaminated surfaces. There is no vaccine or specific treatment for norovirus. Management involves supportive care such as drinking sufficient fluids or intravenous fluids. Oral rehydration solutions are the preferred fluids to drink, although other drinks without caffeine or alcohol can help. Hand sanitizers based on alcohols tend to be ineffective against noroviruses due to their being non-enveloped, although some virus genotypes are more susceptible. Norovirus results in about 685 million cases of disease and 200,000 deaths globally a year. It is common both in the developed and developing world. Those under the age of five are most often affected, and in this group it results in about 50,000 deaths in the developing world. Norovirus infections occur more commonly during winter months. It often occurs in outbreaks, especially among those living in close quarters. In the United States, it is the cause of about half of all foodborne disease outbreaks. The virus is named after the city of Norwalk, Ohio, where an outbreak occurred in 1968.

Infobox

Other names
Winter vomiting bug, stomach bug
Specialty
Infectious diseases
Symptoms
Diarrhea, vomiting, stomach pain, headache
Complications
Dehydration
Usual onset
12 to 48 hours after exposure
Duration
1 to 3 days
Causes
Norovirus
Diagnostic method
Based on symptoms
Prevention
Hand washing, disinfection of contaminated surfaces
Treatment
Supportive care (drinking sufficient fluids or intravenous fluids)
Frequency
688 million cases per year
Deaths
200,000 per year

Tables

· Virology › Structure
Norovirus
Norovirus
Genus
Norovirus
Structure
Icosahedral
Symmetry
T=1, T=3
Capsid
Non-enveloped
Genomic arrangement
Linear
Genomic segmentation
Monopartite
Genus
Structure
Symmetry
Capsid
Genomic arrangement
Genomic segmentation
Norovirus
Icosahedral
T=1, T=3
Non-enveloped
Linear
Monopartite
· Virology › Replication cycle
Norovirus
Norovirus
Genus
Norovirus
Host details
Humans; mammals
Tissue tropism
Intestinal epithelium
Entry details
Cell receptor endocytosis
Release details
Lysis
Replication site
Cytoplasm
Assembly site
Cytoplasm
Transmission
Oral-fecal
Genus
Host details
Tissue tropism
Entry details
Release details
Replication site
Assembly site
Transmission
Norovirus
Humans; mammals
Intestinal epithelium
Cell receptor endocytosis
Lysis
Cytoplasm
Cytoplasm
Oral-fecal

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