| No. | Result | Record | Opponent | Type | Round, time | Date | Age | Location | Notes |
| 61 | Loss | 56–5 | Trevor Berbick | UD | 10 | Dec 11, 1981 | 39 years, 328 days | Queen Elizabeth Sports Centre, Nassau, Bahamas | |
| 60 | Loss | 56–4 | Larry Holmes | RTD | 10 (15), 3:00 | Oct 2, 1980 | 38 years, 259 days | Caesars Palace, Paradise, Nevada, U.S. | For WBC and vacant The Ring heavyweight titles |
| 59 | Win | 56–3 | Leon Spinks | UD | 15 | Sep 15, 1978 | 36 years, 241 days | Superdome, New Orleans, Louisiana, U.S. | Won WBA and The Ring heavyweight titles |
| 58 | Loss | 55–3 | Leon Spinks | SD | 15 | Feb 15, 1978 | 36 years, 29 days | Las Vegas Hilton, Winchester, Nevada, U.S. | Lost WBA, WBC, and The Ring heavyweight titles |
| 57 | Win | 55–2 | Earnie Shavers | UD | 15 | Sep 29, 1977 | 35 years, 255 days | Madison Square Garden, New York City, New York, U.S. | Retained WBA, WBC, and The Ring heavyweight titles |
| 56 | Win | 54–2 | Alfredo Evangelista | UD | 15 | May 16, 1977 | 35 years, 119 days | Capital Centre, Landover, Maryland, U.S. | Retained WBA, WBC, and The Ring heavyweight titles |
| 55 | Win | 53–2 | Ken Norton | UD | 15 | Sep 28, 1976 | 34 years, 255 days | Yankee Stadium, New York City, New York, U.S. | Retained WBA, WBC, and The Ring heavyweight titles |
| 54 | Win | 52–2 | Richard Dunn | TKO | 5 (15), 2:05 | May 24, 1976 | 34 years, 128 days | Olympiahalle, Munich, West Germany | Retained WBA, WBC, and The Ring heavyweight titles |
| 53 | Win | 51–2 | Jimmy Young | UD | 15 | Apr 30, 1976 | 34 years, 104 days | Capital Centre, Landover, Maryland, U.S. | Retained WBA, WBC, and The Ring heavyweight titles |
| 52 | Win | 50–2 | Jean-Pierre Coopman | KO | 5 (15), 2:46 | Feb 20, 1976 | 34 years, 34 days | Roberto Clemente Coliseum, San Juan, Puerto Rico | Retained WBA, WBC, and The Ring heavyweight titles |
| 51 | Win | 49–2 | Joe Frazier | RTD | 14 (15), 3:00 | Oct 1, 1975 | 33 years, 257 days | Philippine Coliseum, Quezon City, Philippines | Retained WBA, WBC, and The Ring heavyweight titles |
| 50 | Win | 48–2 | Joe Bugner | UD | 15 | July 1, 1975 | 33 years, 164 days | Stadium Merdeka, Kuala Lumpur, Malaysia | Retained WBA, WBC, and The Ring heavyweight titles |
| 49 | Win | 47–2 | Ron Lyle | TKO | 11 (15), 1:08 | May 16, 1975 | 33 years, 119 days | Las Vegas Convention Center, Winchester, Nevada, U.S. | Retained WBA, WBC, and The Ring heavyweight titles |
| 48 | Win | 46–2 | Chuck Wepner | TKO | 15 (15), 2:41 | Mar 24, 1975 | 33 years, 66 days | Coliseum, Richfield, Ohio, U.S. | Retained WBA, WBC, and The Ring heavyweight titles |
| 47 | Win | 45–2 | George Foreman | KO | 8 (15), 2:58 | Oct 30, 1974 | 32 years, 286 days | Stade du 20 Mai, Kinshasa, Zaire | Won WBA, WBC, and The Ring heavyweight titles |
| 46 | Win | 44–2 | Joe Frazier | UD | 12 | Jan 28, 1974 | 32 years, 11 days | Madison Square Garden, New York City, New York, U.S. | Retained NABF heavyweight title |
| 45 | Win | 43–2 | Rudie Lubbers | UD | 12 | Oct 20, 1973 | 31 years, 276 days | Gelora Bung Karno Stadium, Jakarta, Indonesia | |
| 44 | Win | 42–2 | Ken Norton | SD | 12 | Sep 10, 1973 | 31 years, 236 days | The Forum, Inglewood, California, U.S. | Won NABF heavyweight title |
| 43 | Loss | 41–2 | Ken Norton | SD | 12 | Mar 31, 1973 | 31 years, 73 days | San Diego Sports Arena, San Diego, California, U.S. | Lost NABF heavyweight title |
| 42 | Win | 41–1 | Joe Bugner | UD | 12 | Feb 14, 1973 | 31 years, 28 days | Las Vegas Convention Center, Winchester, Nevada, U.S. | |
| 41 | Win | 40–1 | Bob Foster | KO | 8 (12), 0:40 | Nov 21, 1972 | 30 years, 309 days | Sahara Tahoe, Stateline, Nevada, U.S. | Retained NABF heavyweight title |
| 40 | Win | 39–1 | Floyd Patterson | RTD | 7 (12), 3:00 | Sep 20, 1972 | 30 years, 247 days | Madison Square Garden, New York City, New York, U.S. | Retained NABF heavyweight title |
| 39 | Win | 38–1 | Alvin Lewis | TKO | 11 (12), 1:15 | Jul 19, 1972 | 30 years, 184 days | Croke Park, Dublin, Ireland | |
| 38 | Win | 37–1 | Jerry Quarry | TKO | 7 (12), 0:19 | Jun 27, 1972 | 30 years, 162 days | Las Vegas Convention Center, Winchester, Nevada, U.S. | Retained NABF heavyweight title |
| 37 | Win | 36–1 | George Chuvalo | UD | 12 | May 1, 1972 | 30 years, 105 days | Pacific Coliseum, Vancouver, British Columbia, Canada | Retained NABF heavyweight title |
| 36 | Win | 35–1 | Mac Foster | UD | 15 | Apr 1, 1972 | 30 years, 75 days | Nippon Budokan, Tokyo, Japan | |
| 35 | Win | 34–1 | Jürgen Blin | KO | 7 (12), 2:12 | Dec 26, 1971 | 29 years, 343 days | Hallenstadion, Zürich, Switzerland | |
| 34 | Win | 33–1 | Buster Mathis | UD | 12 | Nov 17, 1971 | 29 years, 304 days | Astrodome, Houston, Texas, U.S. | Retained NABF heavyweight title |
| 33 | Win | 32–1 | Jimmy Ellis | TKO | 12 (12), 2:10 | Jul 26, 1971 | 29 years, 190 days | Astrodome, Houston, Texas, U.S. | Won vacant NABF heavyweight title |
| 32 | Loss | 31–1 | Joe Frazier | UD | 15 | Mar 8, 1971 | 29 years, 50 days | Madison Square Garden, New York City, New York, U.S. | For WBA, WBC, and The Ring heavyweight titles |
| 31 | Win | 31–0 | Oscar Bonavena | TKO | 15 (15), 2:03 | Dec 7, 1970 | 28 years, 324 days | Madison Square Garden, New York City, New York, U.S. | Won vacant NABF heavyweight title |
| 30 | Win | 30–0 | Jerry Quarry | RTD | 3 (15), 3:00 | Oct 26, 1970 | 28 years, 282 days | Municipal Auditorium, Atlanta, Georgia, U.S. | |
| 29 | Win | 29–0 | Zora Folley | KO | 7 (15), 1:48 | Mar 22, 1967 | 25 years, 64 days | Madison Square Garden, New York City, New York, U.S. | Retained WBA, WBC, NYSAC, and The Ring heavyweight titles |
| 28 | Win | 28–0 | Ernie Terrell | UD | 15 | Feb 6, 1967 | 25 years, 20 days | Astrodome, Houston, Texas, U.S. | Retained WBC, NYSAC, and The Ring heavyweight titles;Won WBA heavyweight title |
| 27 | Win | 27–0 | Cleveland Williams | TKO | 3 (15), 1:08 | Nov 14, 1966 | 24 years, 301 days | Astrodome, Houston, Texas, U.S. | Retained WBC, NYSAC, and The Ring heavyweight titles |
| 26 | Win | 26–0 | Karl Mildenberger | TKO | 12 (15), 1:30 | Sep 10, 1966 | 24 years, 236 days | Waldstadion, Frankfurt, West Germany | Retained WBC, NYSAC, and The Ring heavyweight titles |
| 25 | Win | 25–0 | Brian London | KO | 3 (15), 1:40 | Aug 6, 1966 | 24 years, 201 days | Earls Court Exhibition Centre, London, England | Retained WBC, NYSAC, and The Ring heavyweight titles |
| 24 | Win | 24–0 | Henry Cooper | TKO | 6 (15), 1:38 | May 21, 1966 | 24 years, 124 days | Arsenal Stadium, London, England | Retained WBC, NYSAC, and The Ring heavyweight titles |
| 23 | Win | 23–0 | George Chuvalo | UD | 15 | Mar 29, 1966 | 24 years, 71 days | Maple Leaf Gardens, Toronto, Canada | Retained WBC, NYSAC, and The Ring heavyweight titles |
| 22 | Win | 22–0 | Floyd Patterson | TKO | 12 (15), 2:18 | Nov 22, 1965 | 23 years, 309 days | Las Vegas Convention Center, Winchester, Nevada, U.S. | Retained WBC, NYSAC, and The Ring heavyweight titles |
| 21 | Win | 21–0 | Sonny Liston | KO | 1 (15), 2:12 | May 25, 1965 | 23 years, 128 days | Civic Center, Lewiston, Maine, U.S. | Retained WBC, NYSAC, and The Ring heavyweight titles |
| 20 | Win | 20–0 | Sonny Liston | RTD | 6 (15), 3:00 | Feb 25, 1964 | 22 years, 39 days | Convention Center, Miami Beach, Florida, U.S. | Won WBA, WBC, NYSAC, and The Ring heavyweight titles |
| 19 | Win | 19–0 | Henry Cooper | TKO | 5 (10), 2:15 | Jun 18, 1963 | 21 years, 152 days | Wembley Stadium, London, England | |
| 18 | Win | 18–0 | Doug Jones | UD | 10 | Mar 13, 1963 | 21 years, 55 days | Madison Square Garden, New York City, New York, U.S. | |
| 17 | Win | 17–0 | Charlie Powell | KO | 3 (10), 2:04 | Jan 24, 1963 | 21 years, 7 days | Civic Arena, Pittsburgh, Pennsylvania, U.S. | |
| 16 | Win | 16–0 | Archie Moore | TKO | 4 (10), 1:35 | Nov 15, 1962 | 20 years, 302 days | Memorial Sports Arena, Los Angeles, California, U.S. | |
| 15 | Win | 15–0 | Alejandro Lavorante | KO | 5 (10), 1:48 | Jul 20, 1962 | 20 years, 184 days | Memorial Sports Arena, Los Angeles, California, U.S. | |
| 14 | Win | 14–0 | Billy Daniels | TKO | 7 (10), 2:21 | May 19, 1962 | 20 years, 122 days | St. Nicholas Arena, New York City, New York, U.S. | |
| 13 | Win | 13–0 | George Logan | TKO | 4 (10), 1:34 | Apr 23, 1962 | 20 years, 96 days | Memorial Sports Arena, Los Angeles, California, U.S. | |