| Year | Award | Category | Work | Result |
| 2006 | Broadway.com Audience Award | Favorite Female Replacement | Wicked | Nominated |
| 2009 | Drama Desk Award | Outstanding Actress in a Musical | 9 to 5: The Musical |
| Drama League Award | Distinguished Performance |
| Outer Critics Circle Award | Outstanding Actress in a Musical |
| Grammy Award | Best Musical Theater Album |
| Broadway.com Audience Award | Favorite Actress in a Musical |
| 2013 | Dorian Awards | TV Musical Performance of the Year | "Let Me Be Your Star" from Smash |
| Behind the Voice Actors Award | Best Vocal Ensemble in a New Television Series | Robot and Monster |
| Best Vocal Ensemble in a TV Special/Direct-to-DVD Title or Theatrical Short | Secret of the Wings |
| 2015 | The Pirate Fairy |
| Best Female Vocal Performance in a Feature Film in a Supporting Role | Legends of Oz: Dorothy's Return |
| 2016 | Broadway.com Audience Award | Favorite Featured Actress in a Play | Noises Off | Won |
| Tony Award | Best Featured Actress in a Play | Nominated |
| Drama Desk Award | Outstanding Featured Actress in a Play |
| Drama League Award | Distinguished Performance |
| 2025 | Tony Award | Best Performance by an Actress in a Leading Role in a Musical | Death Becomes Her | Nominated |
| Grammy Award | Best Musical Theater Album |
| Drama League Award | Distinguished Performance |
| Broadway.com Audience Award | Favorite Leading Actress in a Musical | Nominated |
| Favorite Diva Performance |
| Favorite Funny Performance |
| Favorite Onstage Pair (with Jennifer Simard) | Won |
| Performance of the Year (Musical) |