| Person | Year | Decision | Notes |
| Bella Moore | 1910 | Convicted | In People v. Moore, an all-white jury convicted Bella Moore, a mixed race woman from New York, for the "compulsory prostitution" of two white women, Alice Milton and Belle Woods, using the Mann Act. |
| Jack Johnson | 1913 | Convicted (pardoned in 2018) | In October and November 1912, boxer Jack Johnson was arrested twice under the Mann Act. It was generally acknowledged that the arrests were racially motivated. A posthumous presidential pardon was granted in 2018 by President Donald Trump. |
| Farley Drew Caminetti | 1913 | Convicted | Caminetti and Maury Diggs took their mistresses from Sacramento, California to Reno, Nevada. Their wives informed the police, and both men were arrested in Reno. Caminetti v. United States expanded Mann Act prosecutions from prostitution to non-commercial extramarital sex. |
| William I. Thomas | 1918 | Acquitted | Pioneering sociologist William I. Thomas's academic career at the University of Chicago was irreversibly damaged after he was arrested under the Mann Act when caught in the company of Mrs. Granger, whose husband was an army officer with the American forces in France. Thomas was acquitted at trial. |
| Fred Toney | 1918 | Convicted | Toney, a professional baseball player, pleaded guilty to traveling with a woman, whom he falsely claimed was his wife, from Louisville, Kentucky to Cincinnati, Ohio where they lived together while he played for the Cincinnati Reds. He was sentenced to four months in jail. |
| Frank Lloyd Wright | 1926 | Charges dropped | In October 1926, Wright and his future wife, Olga Lazovich Hinzenburg were accused of violating the Mann Act and he was arrested in Minnetonka, Minnesota. |
| Finis Dake | 1937 | Convicted | In 1937, he was convicted of violating the Mann Act by willfully transporting Emma Barelli, age 16, across the Wisconsin state line "for the purpose of debauchery and other immoral practices". The May 27, 1936, issue of the Chicago Daily Tribune reported that Dake registered at hotels in Waukegan, Bloomington, and East St. Louis with the girl under the name "Christian Anderson and wife". In order to avoid a jury trial and the possibility of being sentenced to a maximum of 10 years in prison and a fine of $10,000, Dake pleaded guilty. Subsequently, he served six months in the House of Corrections in Milwaukee, Wisconsin. |
| George Barker | 1940 | Charges dropped | The British poet was arrested crossing a state border with his lover Canadian author Elizabeth Smart in 1940. She described the arrest in her book By Grand Central Station I Sat Down and Wept. |
| Charlie Chaplin | 1944 | Acquitted | Chaplin met Joan Barry, age 24, in 1941. He signed her to a $75-a-week contract for a film he was putting together, and she became his mistress. By mid-1942, Chaplin let her contract expire. To send her home, Chaplin paid her train fare to New York which led to his arrest. Chaplin was acquitted of the charges. |
| Rex Ingram | 1949 | Convicted | Pleading guilty to the charge of transporting a teenage girl to New York for immoral purposes, the actor was sentenced to eighteen months in jail. He served just ten months of his sentence, but the incident had a serious impact on his career for the next six years. |
| Frank La Salle | 1950 | Convicted | La Salle was tried, convicted, and sentenced to 30 to 35 years in prison under the Mann Act for abducting and raping Florence Sally Horner during a 21-month period while traveling from New Jersey to California.[citation needed] |
| Kid Cann | 1959 | Convicted/ Acquitted on appeal | Cann, who was an organized crime figure from Minneapolis, Minnesota, was prosecuted and convicted for transporting a prostitute from Chicago to Minnesota. His conviction was later overturned on appeal. Cann was later prosecuted and convicted of offering a $25,000 bribe to a juror at his Mann Act trial.[citation needed] |
| Charles Manson | 1960 | Charges dropped | Manson took two prostitutes from California to New Mexico to work. |
| Chuck Berry | 1962 | Convicted | In January 1962, Berry was sentenced to three years in prison for offenses under the Mann Act when he had transported a girl, age 14, across state lines. |
| Tony Alamo | 2008 | Convicted | The former American religious leader was arrested under the Mann Act in September 2008. He was subsequently convicted on 10 counts of interstate transportation of minors for illegal sexual purposes, rape, sexual assault, and contributing to the delinquency of minors. |
| Brian David Mitchell | 2010 | Convicted | Former street preacher and pedophile; convicted in 2010 of interstate kidnapping and unlawful transportation of a minor across state lines in connection with the 2002 abduction of Elizabeth Smart; currently serving a life sentence in federal prison. |
| Jack Schaap | 2012 | Convicted | Pastor at mega-church First Baptist Church and Chancellor of Hyles–Anderson College, pleaded guilty to transportation of a minor, age 16, across state lines to have sex with her. He was sentenced to 12 years in prison. |
| R. Kelly | 2021 | Convicted | Singer/actor who has faced multiple sexual abuse trials. At his first federal trial, he was charged with: one count of racketeering comprising 14 predicate acts against six females. Six of the acts were Mann Act offenses against four of the victims. He was found guilty of racketeering on the basis that 12 of the 14 acts were proved, including five Mann Act offenses against three of the victims. eight Mann Act offenses against two of the victims, corresponding to four of the racketeering predicate acts; he was found guilty on all counts. |
| Ghislaine Maxwell | 2021 | Convicted | Socialite/publishing heiress charged with sex trafficking of minors for Jeffrey Epstein. In December 2021, a jury found her guilty on five of six counts involving sex trafficking of minors, and in June 2022, she was sentenced to 20 years. Her conviction and sentence were upheld on appeal. |
| Sean Combs ("Diddy") | 2025 | Convicted | In 2025, a jury in federal court in New York found Combs guilty of two counts of violating the Mann Act; he was acquitted of sex trafficking and racketeering. |