| Year | Title | Role | Notes |
| 1982 | Voyagers! | Union Prisoner | Episode: "The Day the Rebs Took Lincoln" |
| 1988 | Loving | Ned Bates | Unknown episode |
| 1988–1989 | Another World | Kenny | 10 episodes |
| 1990–1995;1998–2000 | Beverly Hills, 90210 | Dylan McKay | 199 episodes |
| 1993 | Saturday Night Live | Himself (host) | Episode: "Luke Perry/Mick Jagger" |
| The Simpsons | Himself | Voice, episode: "Krusty Gets Kancelled" |
| 1994–1995 & 2007 | Biker Mice from Mars | Napoleon Brie | Voice, 7 episodes |
| 1996 | Mortal Kombat: Defenders of the Realm | Sub-Zero | Voice, 13 episodes |
| 1996–1997 | The Incredible Hulk | Rick Jones | Voice, 4 episodes |
| 1997 | Spin City | Spence | Episode: "Kiss Me, Stupid" |
| Riot | Boomer | Television film |
| Invasion | Beau Stark |
| 1998–1999 | Pepper Ann | Stuart Walldinger | Voice, 4 episodes: "Presenting Stewart Walldinger", "P.A.'s Life in a Nutshell", "Like Riding a Bike" & "Pepper Ann's Day Off-Kilter" |
| 1999 | The Night of the Headless Horseman | Brom Bones | Television film |
| 2000 | Johnny Bravo | Himself | Voice, episode: "Luke Perry's Guide to Love" |
| Family Guy | Himself | Voice, episode: "The Story on Page One" |
| 2001 | Night Visions | Dr. Michael Sears | Episode: "Now He's Coming Up the Stairs" |
| The Triangle | Stu Sheridan | Television film |
| 2001–2002 | Oz | Rev. Jeremiah Cloutier | 10 episodes |
| 2002 | Jackson County War | Harry Hammett | Television film |
| 2002–2004 | Jeremiah | Jeremiah | 35 episodes |
| 2003 | Clone High | Ponce de León | Voice, episode: "Litter Kills - Literally" |
| 2005 | Will & Grace | Aaron | Episode: "The Birds and the Bees" |
| What I Like About You | Todd | 3 episodes |
| Descent | Dr. Jake Rollins | Television |
| Supernova | Dr. Chris Richardson |
| 2006 | Windfall | Peter Schaefer | 13 episodes |
| 2007 | John from Cincinnati | Linc Stark | 10 episodes |
| 2008 | Law & Order: Special Victims Unit | Noah Sibert | Episode: "Trials" |
| A Gunfighter's Pledge | Matt Austin | Television film |
| A Very Merry Daughter of the Bride | Charlie |
| 2008;2018 | Criminal Minds | Benjamin Cyrus | 2 episodes |
| 2009 | The Storm | Stillman |
| Angel and the Badman | Laredo Stevens | Television film |
| 2010 | Leverage | Dalton Rand | Episode: "The Future Job" |
| Generator Rex | Jacob | Voice, episode: "The Architect" |
| FCU: Fact Checkers Unit | Luke | 8 episodes |
| 2011 | Pound Puppies | Fang | Voice, episode: "Rebel Without a Collar" |
| Goodnight for Justice | John Goodnight | Television film |
| 2012 | Goodnight for Justice: The Measure of a Man | John Goodnight |
| Goodnight for Justice: Queen of Hearts | John Goodnight |
| Raising Hope | Ghost of Arbor Day | Episode: "Arbor Daze" |
| 2012–2013 | Body of Proof | CDC Officer Dr. Charlie Stafford | 5 episodes |
| 2013 | Community | American Inspector Spacetime | Episode: "Conventions of Space and Time" |
| 2014 | Major Crimes | Jon Worth | Episode: "Cutting Loose" |
| Hot in Cleveland | Trevor | Episode: "The Bachelors" |
| 2015 | Welcome Home | Stewart Paylor | Television film |
| Jesse Stone: Lost in Paradise | Richard Steele |
| Ties That Bind | Tim Olson |
