| Year | Title | Role | Notes |
| 1915 | Father and the Boys | Tuck Bartholomew | Lost film |
| 1916 | The Grip of Jealousy | Silas Lacey | Working title was Love Thine Enemy Lost film |
| 1916 | Tangled Hearts | John Hammond | Roughly two minutes of footage exist in a private collection |
| 1916 | The Gilded Spider | Giovanni | Working title was The Full Cup A print was rediscovered in 2008. |
| 1916 | Bobbie of the Ballet | Hook Hoover | Lost film |
| 1916 | The Grasp of Greed | Jimmie | About half the film still exists (incomplete print) at the George Eastman House Film Archive |
| 1916 | The Mark of Cain | Dick Temple | Chaney received first billing in this film for the first time in his career. Working title was By Fate's Decree. Lost film (only a few fragments exist in the Danish Film Archive) |
| 1916 | If My Country Should Call | Dr. George Ardrath | Incomplete print (reels 2, 3 and 5 of 5) exists at the National Archives of Canada and the Library of Congress. |
| 1916 | The Place Beyond the Winds | Jerry Jo | Working title was Mansion of Despair Four of the five reels (reels 2, 3, 4 and 5) still survive in the film archive in the Library of Congress and in the National Archives of Canada. |
| 1916 | The Price of Silence | Dr. Edmond Stafford | A print exists in the CNC French Film Archives |
| 1917 | The Piper's Price | Billy Kilmartin | Lost film |
| 1917 | Hell Morgan's Girl | Sleter Noble | Working title was The Wrong Side of Paradise Lost film |
| 1917 | The Girl in the Checkered Coat | Hector Maitland | Lost film |
| 1917 | The Flashlight | Dual Role as both Henry Norton and as Porter Brixton (two step-brothers) | Lost film |
| 1917 | A Doll's House | Nils Krogstad | Lost film |
| 1917 | Fires of Rebellion | Russell Hanlon | Lost film |
| 1917 | The Rescue | Thomas Holland | Lost film |
| 1917 | Pay Me! | Joe Lawson | Alternate title: Vengeance of the West |
| 1917 | Triumph | Paul Neihoff | An incomplete print consisting only of the first three reels were discovered in England and have been preserved at AMPAS |
| 1917 | The Empty Gun | Frank | Lost film |
| 1917 | Bondage | The Seducer | Uncredited (his appearance in this film is unconfirmed, but Blake's book says Chaney was in the film) Lost film |
| 1917 | Anything Once | Waught Moore | Working title was A Fool for Luck; a . The Maverick Lost film |
| 1917 | The Scarlet Car | Paul Revere Forbes | Prints exist at the Library of Congress and elsewhere Clips included in the 1995 documentary Lon Chaney: Behind the Mask |
| 1918 | Broadway Love | Elmer Watkins | A print of the film survives in the George Eastman Museum Motion Picture Collection. |
| 1918 | The Grand Passion | Paul Argos | Working title was The Boss of Powderville Lost film |
| 1918 | The Kaiser, the Beast of Berlin | Bethmann-Hollweg | Lost film |
| 1918 | Fast Company | Dan McCarty | Lost film |
| 1918 | A Broadway Scandal | "Kink" Colby | Lost film |
| 1918 | Riddle Gawne | Hame Bozzam | Two of the five reels exist in the Library of Congress (incomplete print) |
| 1918 | That Devil, Bateese | Louis Courteau | Lost film |
| 1918 | The Talk of the Town | Jack Lanchome (Langhorne in some sources) | Based on a novelette called Discipline of Genevra Lost film |
| 1918 | Danger, Go Slow | Bud | Lost film |
| 1919 | The False Faces | Karl Eckstrom, a German spy | Based on the novel by Louis Joseph Vance The film's working title was The Lone Wolf Complete print exists at the George Eastman House Available on DVD |
| 1919 | The Wicked Darling | Stoop Connors | Chaney's first collaboration with Tod Browning Working titles were The Gutter Rose and Rose of the Night A complete print (with some decomposition) exists at the Netherlands Filmmuseum in Amsterdam Available on DVD |
| 1919 | A Man's Country | "Three Card" Duncan | A small portion of this film was discovered at the Danish Film Institute film archive in Denmark. The fragment does not contain any of Chaney's scenes |
| 1919 | The Miracle Man | The Frog | Lost film A 3-minute fragment exists showing Chaney in the faith healing sequence |
| 1919 | Paid in Advance | Bateese Le Blanc | A nitrate stock print (with Czech subtitles) is housed at the Narodni Filmovy Archive in Czechoslovakia |
| 1919 | When Bearcat Went Dry | Kindard Powers | A complete print exists at the American Film Institute, donated by a collector |
| 1919 | Victory | Ricardo | With Wallace Beery; complete film available on DVD |
| 1920 | Daredevil Jack | Royce Rivers, bandit leader | 15-chapter serial Segments of this film (mainly Chapters 1, 2 and 4) are stored at the University of California, Los Angeles Chaney does not appear in the existing footage |
| 1920 | Treasure Island | Dual role as two pirates, Blind Pew and Merry | Lost film |
| 1920 | The Gift Supreme | Merney Stagg | An incomplete print (reel one of six) survives and is preserved in a private collection. |
| 1920 | Nomads of the North | Raoul Challoner | Available on DVD |
| 1920 | The Penalty | Blizzard | Available on DVD |
| 1920 | Outside the Law | Dual role as Black Mike Sylva and Ah Wing | Print exists in the Film Preservation Associates film collection Available on DVD. |
| 1921 | For Those We Love | Trix Ulner | Lost film |
| 1921 | Bits of Life | Chin Chow | Lost film |
| 1921 | The Ace of Hearts | Farallone | Available on DVD |
| 1921 | Voices of the City | Red O'Rourke, gangster | Released originally as The Night Rose, the film was then re-edited and retitled Voices of the City; Chaney's character's name was changed from Red O'Rourke to Duke McGee; Lost film |
