| Duration as youngest | Name | State | | Party | Start age | End age |
| March 4, 1789 – July 25, 1789 | James Gunn | GA | | Anti-Administration | 35 years, 356 days | 36 years, 134 days |
| July 25, 1789 – December 6, 1790 | Rufus King | NY | | Pro-Administration | 34 years, 123 days | 35 years, 257 days |
| December 6, 1790 – March 4, 1791 | James Monroe | VA | | Anti-Administration | 32 years, 222 days | 32 years, 310 days |
| March 4, 1791 – December 2, 1793 | John Rutherfurd | NJ | | Pro-Administration | 30 years, 165 days | 33 years, 73 days |
| December 2, 1793 – February 28, 1794 | Albert Gallatin | PA | | Anti-Administration | 32 years, 307 days | 33 years, 30 days |
| February 28, 1794 – April 24, 1794 | John Rutherfurd | NJ | | Pro-Administration | 33 years, 161 days | 33 years, 216 days |
| April 24, 1794 – December 6, 1796 | James Ross | PA | | Federalist | 31 years, 286 days | 34 years, 147 days |
| April 12, 1796 – December 6, 1796 | Josiah Tattnall | GA | | Democratic-Republican | 33–34 | 33–34 |
| December 6, 1796 – November 22, 1797 | Richard Stockton | NJ | | Federalist | 32 years, 233 days | 33 years, 219 days |
| November 22, 1797 – April 1, 1798 | Andrew Jackson | TN | | Democratic-Republican | 30 years, 252 days | 31 years, 17 days |
| April 1, 1798 – February 4, 1799 | Ray Greene | RI | | Federalist | 33 years, 58 days | 34 years, 2 days |
| February 4, 1799 – March 3, 1801 | William Wells | DE | | Federalist | 30 years, 28 days | 32 years, 56 days |
| March 4, 1801 – October 17, 1803 | Samuel White | DE | | Federalist | 30 years, 93 days | 32 years, 320 days |
| October 17, 1803 – December 29, 1806 | Thomas Worthington | OH | | Democratic-Republican | 30 years, 93 days | 33 years, 166 days |
| December 29, 1806 – March 4, 1807 | Henry Clay | KY | | Democratic-Republican | 29 years, 261 days | 29 years, 326 days |
| March 4, 1807 – September 1807 | James Fenner | RI | | Democratic-Republican | 36 years, 41 days | 36 years, 222 days |
| September 1807 – December 9, 1807 | Samuel White | DE | | Federalist | 36 years, 274 days | 37 years, 8 days |
| December 9, 1807 – January 12, 1810 | William Crawford | GA | | Democratic-Republican | 35 years, 288 days | 37 years, 322 days |
| May 26, 1809 – January 12, 1810 | Jenkin Whiteside | TN | | Democratic-Republican | 36–37 | 37–38 |
| January 12, 1810 – March 3, 1813 | Alexander Campbell | OH | | Democratic-Republican | 30–31 | 33–34 |
| March 4, 1813 – May 27, 1813 | Outerbridge Horsey | DE | | Federalist | 35 years, 364 days | 36 years, 80 days |
| May 24, 1813 – May 27, 1813 | William Bulloch | GA | | Democratic-Republican | 35–36 | 35–36 |
| May 27, 1813 – December 6, 1813 | Robert Goldsborough | MD | | Federalist | 34 years, 143 days | 34 years, 336 days |
| December 6, 1813 – April 9, 1814 | William Bibb | GA | | Democratic-Republican | 32 years, 65 days | 32 years, 189 days |
| April 9, 1814 – February 2, 1815 | Jesse Wharton | TN | | Democratic-Republican | 31 years, 254 days | 32 years, 188 days |
| February 2, 1815 – January 22, 1816 | William Barry | KY | | Democratic-Republican | 30 years, 362 days | 31 years, 351 days |
| January 22, 1816 – March 3, 1817 | Armistead Mason | VA | | Democratic-Republican | 28 years, 171 days | 29 years, 212 days |
| March 4, 1817 – November 16, 1818 | John Crittenden | KY | | Democratic-Republican | 29 years, 175 days | 31 years, 67 days |
| November 16, 1818 – March 3, 1821 | John Eaton | TN | | Democratic-Republican | 28 years, 151 days | 30 years, 259 days |
| March 4, 1821 – December 3, 1821 | Samuel Southard | NJ | | Democratic-Republican | 33 years, 268 days | 34 years, 177 days |
| December 3, 1821 – March 3, 1823 | John Eaton | TN | | Democratic-Republican | 31 years, 168 days | 32 years, 259 days |
| March 4, 1823 – March 3, 1825 | Robert Hayne | SC | | Democratic-Republican | 31 years, 114 days | 33 years, 114 days |
| March 4, 1825 – March 3, 1829 | Elias Kane | IL | | Jacksonian | 30 years, 270 days | 34 years, 270 days |
| March 4, 1829 – December 16, 1833 | John Clayton | DE | | Anti-Jacksonian | 32 years, 223 days | 37 years, 145 days |
| December 16, 1833 – December 31, 1833 | Lewis Linn | MO | | Jacksonian | 37 years, 41 days | 37 years, 56 days |
| December 31, 1833 – March 3, 1835 | John King | GA | | Jacksonian | 34 years, 272 days | 35 years, 335 days |
| March 4, 1835 – December 5, 1836 | Robert Walker | MS | | Jacksonian | 33 years, 228 days | 35 years, 139 days |
| December 5, 1836 – February 2, 1837 | Ambrose Sevier | AR | | Jacksonian | 35 years, 31 days | 35 years, 90 days |
| February 2, 1837 – March 3, 1837 | Alexandre Mouton | LA | | Jacksonian | 32 years, 75 days | 32 years, 105 days |
| March 4, 1837 – January 11, 1841 | Franklin Pierce | NH | | Democratic | 32 years, 101 days | 36 years, 49 days |
| January 11, 1841 – February 7, 1842 | Alfred Nicholson | TN | | Democratic | 32 years, 133 days | 33 years, 160 days |
| February 7, 1842 – February 28, 1842 | Franklin Pierce | NH | | Democratic | 37 years, 76 days | 37 years, 97 days |
| February 28, 1842 – March 1, 1842 | Alexandre Mouton | LA | | Democratic | 37 years, 101 days | 37 years, 102 days |
| March 1, 1842 – April 14, 1842 | William Graham | NC | | Whig | 37 years, 177 days | 37 years, 221 days |
| April 14, 1842 – July 6, 1842 | Charles Conrad | LA | | Whig | 37 years, 111 days | 37 years, 194 days |
| July 6, 1842 – March 3, 1843 | William Dayton | NJ | | Whig | 35 years, 139 days | 36 years, 15 days |
| March 4, 1843 – December 4, 1843 | Ned Hannegan | IN | | Democratic | 35 years, 252 days | 36 years, 162 days |
| December 4, 1843 – March 3, 1845 | David Atchison | MO | | Democratic | 36 years, 115 days | 37 years, 205 days |
| March 4, 1845 – March 3, 1847 | Jesse Bright | IN | | Democratic | 32 years, 76 days | 34 years, 76 days |