| Date | Member | Constituency | Party | Reason for resignation |
| 25 October 1950 | Hon. Sir Stafford Cripps | Bristol South East | | Lab | Medical advice |
| 22 March 1951 | Sir Ronald Ross, Bt | Londonderry | | Con | Appointed Agent of the Government of Northern Ireland in London |
| 11 May 1951 | Rhys Davies | Westhoughton | | Lab | Ill health |
| 8 October 1952 | Hon. Sir Hugh O'Neill | North Antrim | | Con | Retirement |
| 21 January 1953 | Sidney Schofield | Barnsley | | Lab | Personal and domestic reasons |
| 14 February 1953 | Hon. Edward Carson | Isle of Thanet | | Con | Ill health |
| 3 June 1953 | Peter Bennett | Birmingham Edgbaston | | Con | Raised to the peerage as Baron Bennett of Edgbaston |
| 27 October 1953 | William J. Field | Paddington North | | Lab | Convicted of importuning for immoral purposes |
| 15 January 1954 | Richard Law | Haltemprice | | Con | Raised to the peerage as Baron Coleraine |
| 12 February 1954 | William Cuthbert | Arundel and Shoreham | | Con | Ill health |
| 3 October 1954 | Sidney Marshall | Sutton and Cheam | | Con | Ill health |
| 28 November 1954 | Lord Malcolm Douglas-Hamilton | Inverness | | Con | Ill health; to help economic development of the Highlands through private enterprise |
| 7 May 1956 | Gerald Wellington Williams | Tonbridge | | Con | Ill health |
| 26 November 1956 | Stanley Evans | Wednesbury | | Lab | Requested to resign by his Constituency Labour Party after supporting the Government over the Suez Crisis |
| 2 May 1957 | William Darling | Edinburgh South | | Con | Ill health |
| 8 November 1957 | Victor Raikes | Liverpool Garston | | Con | To take up a business appointment in Southern Rhodesia |
| 18 April 1958 | Angus Maude | Ealing South | | Con | To become editor of The Sydney Morning Herald. |
| 1 June 1961 | Hon. David Ormsby-Gore | Oswestry | | Con | Appointed British Ambassador to the United States |
| 29 November 1961 | Hilary Marquand | Middlesbrough East | | Lab | Appointed Director of the Institute of Labour Studies at the International Labour Office |
| 22 January 1962 | George Chetwynd | Stockton-on-Tees | | Lab | Appointed Director of the North East Development Council |
| 6 June 1963 | John Profumo | Stratford-on-Avon | | Con | Confessed to misleading the House (the Profumo affair) |
| 9 March 1964 | Peter Smithers | Winchester | | Con | Appointed Secretary General of the Council of Europe |
| 24 June 1965 | Anthony Marlowe | Hove | | Con | Medical advice |
| 29 September 1967 | William Roots | Kensington South | | Con | Ill health |
| 15 January 1968 | Leslie Hale | Oldham West | | Lab | Ill health |
| 6 February 1969 | William Teeling | Brighton Pavilion | | Con | Ill health |
| 7 March 1969 | Francis Noel-Baker | Swindon | | Lab | Ill health |
| 11 January 1971 | Horace King | Southampton Itchen | | Speaker | Retiring Speaker of the House of Commons |
| 30 March 1972 | Ray Gunter | Southwark | | Ind | Had left the Labour Party; decided it would be improper to remain as an independent having been elected as Labour |
| 29 December 1972 | George Thomson | Dundee East | | Lab | Appointed a European Commissioner |
| 1 June 1973 | Antony Lambton | Berwick-upon-Tweed | | Con | Prostitution scandal |
| 27 August 1976 | John Stonehouse | Walsall North | | Eng Nat | Convicted on 18 counts of theft and fraud, sentenced to seven years' imprisonment |
| 12 November 1976 | David Lane | Cambridge | | Con | Appointed Chairman of the Commission for Racial Equality |
| 5 January 1977 | Roy Jenkins | Birmingham Stechford | | Lab | Appointed President of the European Commission |
| 16 June 1977 | Brian Walden | Birmingham Ladywood | | Lab | In order to become a broadcast journalist on Weekend World |
| 6 April 1978 | Peter Rawlinson | Epsom and Ewell | | Con | Retiring from the Commons; was made a life peer |
| 24 October 1979 | Geoffrey Dodsworth | South West Hertfordshire | | Con | Medical advice[citation needed] |
| 1 November 1982 | Robert Mellish | Bermondsey | | Ind | Left the Labour Party in opposition to the selection of his successor; to become vice-chairman of the London Docklands Development Corporation |
| 17 December 1985 | James Molyneaux | Lagan Valley | | UUP | Seeking re-election in protest at the Anglo-Irish Agreement |
| 17 December 1985 | Roy Beggs | East Antrim | | UUP | Seeking re-election in protest at the Anglo-Irish Agreement |
| 17 December 1985 | Harold McCusker | Armagh | | UUP | Seeking re-election in protest at the Anglo-Irish Agreement |
| 17 December 1985 | William Ross | Londonderry | | UUP | Seeking re-election in protest at the Anglo-Irish Agreement |
| 17 December 1985 | John Taylor | Strangford | | UUP | Seeking re-election in protest at the Anglo-Irish Agreement |
| 17 December 1985 | James Kilfedder | North Down | | UPUP | Seeking re-election in protest at the Anglo-Irish Agreement |
| 17 December 1985 | Jim Nicholson | Newry and Armagh | | UUP | Seeking re-election in protest at the Anglo-Irish Agreement |
| 17 December 1985 | William McCrea | Mid Ulster | | DUP | Seeking re-election in protest at the Anglo-Irish Agreement |
| 24 June 1986 | John Golding | Newcastle-under-Lyme | | Lab | Elected General Secretary of the National Communications Union |
| 18 October 1988 | Bruce Millan | Glasgow Govan | | Lab | Appointed a European Commissioner |
| 18 May 1989 | Stuart Holland | Vauxhall | | Lab | In order to take up a lectureship at the European University Institute |