| Date | Member | Constituency | Party | Reason for resignation |
| 23 October 2000 | Betty Boothroyd | West Bromwich West | | Speaker | Retiring as Speaker of the House of Commons. |
| 22 June 2004 | Terry Davis | Birmingham Hodge Hill | | Lab | Appointed Secretary-General of the Council of Europe. |
| 27 June 2007 | Tony Blair | Sedgefield | | Lab | Appointed Envoy of the Quartet on the Middle East. |
| 18 June 2008 | David Davis | Haltemprice and Howden | | Con | Seeking re-election in protest to the Counter-Terrorism Act 2008. |
| 8 June 2009 | Ian Gibson | Norwich North | | Lab | Alleged misuse of allowances led to his being ruled ineligible for selection as a Labour candidate by an NEC panel. |
| 13 January 2010 | Iris Robinson | Strangford | | DUP | Ill health; followed allegations about her personal life. |
| 8 February 2011 | Eric Illsley | Barnsley Central | | Lab | Pleaded guilty to false accounting in relation to claims for parliamentary expenses. |
| 2 March 2012 | Marsha Singh | Bradford West | | Lab | Ill health. |
| 22 October 2012 | Alun Michael | Cardiff South and Penarth | | Lab | To contest the Police and Crime Commissioner election for South Wales Police Force Area. |
| 5 November 2012 | Denis MacShane | Rotherham | | Lab | Standards and Privileges Committee of the House of Commons recommended that he be suspended from the service of the House for six months, for knowingly submitting false invoices. |
| 5 February 2013 | Chris Huhne | Eastleigh | | Lib Dem | Pleaded guilty to perverting the course of justice. |
| 30 April 2014 | Patrick Mercer | Newark | | Ind | Elected as Conservative, but had quit the whip at the commencement of investigations on 31 May 2013. The Standards Committee of the House of Commons agreed a report recommending he be suspended from the service of the House for six months for breaking the rule against paid advocacy. |
| 30 September 2014 | Mark Reckless | Rochester and Strood | | Con | To seek re-election as a UKIP candidate. |
| 9 May 2016 | Sadiq Khan | Tooting | | Lab | Elected as Mayor of London. |
| 26 October 2016 | Zac Goldsmith | Richmond Park | | Con | Seeking re-election having pledged to do so should the Government endorse a third runway at Heathrow Airport. |
| 23 January 2017 | Hon. Tristram Hunt | Stoke-on-Trent Central | | Lab | To direct the Victoria and Albert Museum. |
| 16 January 2018 | Barry McElduff | West Tyrone | | SF | Became embroiled in a controversy over the Kingsmill massacre on social media. |
| 28 October 2019 | John Mann | Bassetlaw | | Lab | Nomination to House of Lords announced in 2019 Prime Minister's Resignation Honours. No by-election held due to the 2019 general election being called. |
| 16 March 2021 | Mike Hill | Hartlepool | | Lab | Pending sexual harassment tribunal. |
| 10 May 2021 | Tracy Brabin | Batley and Spen | | Lab Co-op | Election as Mayor of West Yorkshire. |
| 3 May 2022 | Imran Ahmad Khan | Wakefield | | Con | Criminal conviction for sexual assault. Elected as Conservative in 2019, suspended from the party in June 2021 pending a trial. Expelled after he was convicted in April 2022. |
| 21 October 2022 | Christian Matheson | City of Chester | | Lab | Independent Expert Panel parliamentary watchdog recommended he be suspended for "serious sexual misconduct". |
| 30 November 2022 | Rosie Cooper | West Lancashire | | Lab | To take up the role of chair of Mersey Care NHS Foundation Trust. |
| 12 June 2023 | Boris Johnson | Uxbridge and South Ruislip | | Con | Resignation after being handed draft results of investigation into allegations he misled Parliament over Partygate. |
| 29 August 2023 | Nadine Dorries | Mid Bedfordshire | | Con | Resigned regarding a dispute relating to not receiving a peerage in Johnson's resignation honours. The appointment came 81 days after she announced her resignation "with immediate effect". |
| 8 January 2024 | Chris Skidmore | Kingswood | | Con | Resigned over disagreements with the Government's policy on net zero. |
| 17 March 2025 | Mike Amesbury | Runcorn and Helsby | | Lab | Resigned after receiving a suspended prison sentence for assaulting a constituent. |
| 14 May 2026 | Stephen Gethins | Arbroath and Broughty Ferry | | SNP | Resigned after being elected to the Scottish Parliament for Dundee City East, and as per the Scottish Elections (Representation and Reform) Act 2025, individuals are banned from holding both a seat in the Scottish Parliament and the House of Commons. |
| 18 May 2026 | Josh Simons | Makerfield | | Lab | Resigned to trigger a by-election in order for Andy Burnham to stand for election to the House of Commons. |