| Portrait | Prime ministerOffice(lifespan) | Term of office | Mandate | Ministerial offices held as prime minister | Party | Government | MonarchReign |
| Start | End | Duration |
| | | Robert WalpoleMP for King's Lynn (to 1742) 1st Earl of Orford (from 1742) (1676–1745) | 3 April 1721 | 11 February 1742 | 20 years, 315 days | 1722 | Chancellor of the Exchequer First Lord of the Treasury Leader of the House of Commons | Whig | Walpole–Townshend | George Ir. 1714–1727 |
| 1727 | George IIr. 1727–1760 |
| 1734 | Walpole |
| 1741 |
| | Spencer Compton1st Earl of Wilmington (1673–1743) | 16 February 1742 | 2 July 1743 | 1 year, 137 days | — | First Lord of the Treasury | Carteret |
| | Henry PelhamMP for Sussex (1694–1754) | 27 August 1743 | 6 March 1754 | 10 years, 192 days | — | Chancellor of the Exchequer First Lord of the Treasury Leader of the House of Commons | Broad Bottom I |
| 1747 | Broad Bottom II |
| | Thomas Pelham-Holles1st Duke of Newcastle (1693–1768) | 16 March 1754 | 11 November 1756 | 2 years, 241 days | 1754 | First Lord of the Treasury Leader of the House of Lords | Newcastle I |
| | William Cavendish4th Duke of Devonshire (1720–1764) | 16 November 1756 | 29 June 1757 | 226 days | — | First Lord of the Treasury Leader of the House of Lords Lord Treasurer of Ireland | Pitt–Devonshire |
| 1757 Caretaker |
| | Thomas Pelham-Holles1st Duke of Newcastle (1693–1768) | 29 June 1757 | 26 May 1762 | 4 years, 332 days | 1761 | First Lord of the Treasury Leader of the House of Lords | Pitt–Newcastle |
| Bute–Newcastle(Tory–Whig) | George IIIr. 1760–1820 |
| | | John Stuart3rd Earl of Bute (1713–1792) | 26 May 1762 | 8 April 1763 | 318 days | — | First Lord of the Treasury Leader of the House of Lords | Tory | Bute |
| | | George GrenvilleMP for Buckingham (1712–1770) | 16 April 1763 | 10 July 1765 | 2 years, 86 days | — | Chancellor of the Exchequer First Lord of the Treasury Leader of the House of Commons | Whig(Grenvillite) | Grenville(mainly Whig) |
| | Charles Watson-Wentworth2nd Marquess of Rockingham (1730–1782) | 13 July 1765 | 30 July 1766 | 1 year, 18 days | — | First Lord of the Treasury Leader of the House of Lords | Whig(Rockinghamite) | Rockingham I |
| | William Pitt the ElderMP for Bath (to 1766) 1st Earl of Chatham (from 1766) (1708–1778) | 30 July 1766 | 14 October 1768 | 2 years, 77 days | 1768 | Lord Privy Seal | Whig(Chathamite) | Chatham |
| | Augustus FitzRoy3rd Duke of Grafton (1735–1811) | 14 October 1768 | 28 January 1770 | 1 year, 107 days | — | First Lord of the Treasury Leader of the House of Lords | Grafton |
| | | Frederick NorthLord North MP for Banbury (1732–1792) | 28 January 1770 | 27 March 1782 | 12 years, 59 days | 1774 | Chancellor of the Exchequer First Lord of the Treasury Leader of the House of Commons | Tory(Northite) | North |
| 1780 |
| | | Charles Watson-Wentworth2nd Marquess of Rockingham (1730–1782) | 27 March 1782 | 1 July 1782 | 97 days | — | First Lord of the Treasury | Whig(Rockinghamite) | Rockingham II |
| | William Petty2nd Earl of Shelburne (1737–1805) | 4 July 1782 | 26 March 1783 | 266 days | — | First Lord of the Treasury Leader of the House of Lords | Whig(Chathamite) | Shelburne |
| | William Cavendish-Bentinck3rd Duke of Portland (1738–1809) | 2 April 1783 | 18 December 1783 | 261 days | — | First Lord of the Treasury Leader of the House of Lords | Whig | Fox–North |
| | | William Pitt the YoungerMP for Appleby, later Cambridge University (1759–1806) | 19 December 1783 | 14 March 1801 | 17 years, 86 days | 1784 | Chancellor of the Exchequer First Lord of the Treasury Leader of the House of Commons | Tory(Pittite) | Pitt I |
| 1790 |
| 1796 |
| | Henry AddingtonMP for Devizes (1757–1844) | 17 March 1801 | 10 May 1804 | 3 years, 55 days | 1801 | Chancellor of the Exchequer First Lord of the Treasury Leader of the House of Commons | Tory(Addingtonian) | Addington |
| 1802 |
| | William Pitt the YoungerMP for Cambridge University (1759–1806) | 10 May 1804 | 23 January 1806 | 1 year, 259 days | — | Chancellor of the Exchequer First Lord of the Treasury Leader of the House of Commons | Tory(Pittite) | Pitt II |
| | | William Grenville1st Baron Grenville (1759–1834) | 11 February 1806 | 25 March 1807 | 1 year, 43 days | 1806 | First Lord of the Treasury Leader of the House of Lords | Whig | All the Talents(Whig–Tory) |
| | | William Cavendish-Bentinck3rd Duke of Portland (1738–1809) | 31 March 1807 | 4 October 1809 | 2 years, 188 days | 1807 | First Lord of the Treasury | Tory(Pittite) | Portland II |
| | Spencer PercevalMP for Northampton (1762–1812) | 4 October 1809 | 11 May 1812 | 2 years, 221 days | — | Chancellor of the Duchy of Lancaster Chancellor of the Exchequer Commissioner of the Treasury for Ireland (1810–1812) First Lord of the Treasury Leader of the House of Commons | Perceval |
| | Robert Jenkinson2nd Earl of Liverpool (1770–1828) | 8 June 1812 | 9 April 1827 | 14 years, 306 days | 1812 | First Lord of the Treasury Leader of the House of Lords | Liverpool |
| 1818 | George IVr. 1820–1830 |
| 1820 |
| 1826 |
| | George CanningMP for Seaford (1770–1827) | 12 April 1827 | 8 August 1827 | 119 days | — | Chancellor of the Exchequer First Lord of the Treasury Leader of the House of Commons | Tory(Canningite) | Canning(Canningite–Whig) |
| | Frederick John Robinson1st Viscount Goderich (1782–1859) | 31 August 1827 | 8 January 1828 | 131 days | — | First Lord of the Treasury Leader of the House of Lords | Tory(Canningite) | Goderich |
| | Arthur Wellesley1st Duke of Wellington (1769–1852) | 22 January 1828 | 16 November 1830 | 2 years, 299 days | — | First Lord of the Treasury Leader of the House of Lords | Tory | Wellington–Peel |
| (1830) | William IVr. 1830–1837 |
| | | Charles Grey2nd Earl Grey (1764–1845) | 22 November 1830 | 9 July 1834 | 3 years, 230 days | 1831 | First Lord of the Treasury Leader of the House of Lords | Whig | Grey |
| 1832 |
| | William Lamb2nd Viscount Melbourne (1779–1848) | 16 July 1834 | 14 November 1834 | 122 days | — | First Lord of the Treasury Leader of the House of Lords | Melbourne I |
| | | Arthur Wellesley1st Duke of Wellington (1769–1852) | 17 November 1834 | 9 December 1834 | 23 days | (—) | First Lord of the Treasury Leader of the House of Lords Sec. of State for Foreign Affairs Sec. of State for the Home Dept Sec. of State for War & Colonies | Tory | Wellington Caretaker |
| | | Robert PeelBaronet MP for Tamworth (1788–1850) | 10 December 1834 | 8 April 1835 | 120 days | (—) | Chancellor of the Exchequer First Lord of the Treasury Leader of the House of Commons | Conservative | Peel I |
| | | William Lamb2nd Viscount Melbourne (1779–1848) | 18 April 1835 | 30 August 1841 | 6 years, 135 days | 1835 | First Lord of the Treasury Leader of the House of Lords | Whig | Melbourne II |
| 1837 | Victoriar. 1837–1901 |
| | | Robert PeelBaronet MP for Tamworth (1788–1850) | 30 August 1841 | 29 June 1846 | 4 years, 304 days | 1841 | First Lord of the Treasury Leader of the House of Commons | Conservative | Peel II |
| | | Lord John RussellMP for City of London (1792–1878) | 30 June 1846 | 21 February 1852 | 5 years, 237 days | (1847) | First Lord of the Treasury Leader of the House of Commons | Whig | Russell I |