| Portrait | Name (Birth–death) | Term of office | Party | Government | Composition | Legislature (Election) | President (Tenure) | Ref. |
| Took office | Left office | Time in office |
| | Alcide De Gasperi (1881–1954) | 13 July 1946 | 2 February 1947 | 7 years, 35 days | | Christian Democracy | De Gasperi II | CLN DC • PSIUP • PCI • PRI | Constituent Assembly (1946) | Enrico De Nicola (1946–1948) | |
| 2 February 1947 | 1 June 1947 | De Gasperi III | CLN DC • PSI • PCI • PDL |
| 1 June 1947 | 24 May 1948 | De Gasperi IV | Centrism DC • PSLI • PLI • PRI |
| 24 May 1948 | 27 January 1950 | De Gasperi V | I (1948) | Luigi Einaudi (1948–1955) |
| 27 January 1950 | 26 July 1951 | De Gasperi VI | Centrism DC • PSLI • PRI |
| 26 July 1951 | 16 July 1953 | De Gasperi VII | Centrism DC • PRI |
| 16 July 1953 | 17 August 1953 | De Gasperi VIII | DC | II (1953) |
| | Giuseppe Pella (1902–1981) | 17 August 1953 | 19 January 1954 | 155 days | | Christian Democracy | Pella | DC | |
| | Amintore Fanfani (1908–1999) | 19 January 1954 | 10 February 1954 | 22 days | | Christian Democracy | Fanfani I | DC | |
| | Mario Scelba (1901–1991) | 10 February 1954 | 6 July 1955 | 1 year, 146 days | | Christian Democracy | Scelba | Centrism DC • PSDI • PLI | |
| | Antonio Segni (1891–1972) | 6 July 1955 | 20 May 1957 | 1 year, 318 days | | Christian Democracy | Segni I | Centrism DC • PSDI • PLI | Giovanni Gronchi (1955–1962) | |
| | Adone Zoli (1887–1960) | 20 May 1957 | 2 July 1958 | 1 year, 43 days | | Christian Democracy | Zoli | DC | |
| | Amintore Fanfani (1908–1999) | 2 July 1958 | 16 February 1959 | 229 days | | Christian Democracy | Fanfani II | Centrism DC • PSDI | III (1958) | |
| | Antonio Segni (1891–1972) | 16 February 1959 | 26 March 1960 | 1 year, 39 days | | Christian Democracy | Segni II | DC | |
| | Fernando Tambroni (1901–1963) | 26 March 1960 | 27 July 1960 | 123 days | | Christian Democracy | Tambroni | DC | |
| | Amintore Fanfani (1908–1999) | 27 July 1960 | 22 February 1962 | 2 years, 330 days | | Christian Democracy | Fanfani III | DC | |
| 22 February 1962 | 22 June 1963 | Fanfani IV | DC • PSDI • PRI | Antonio Segni (1962–1964) |
| | Giovanni Leone (1908–2001) | 22 June 1963 | 5 December 1963 | 166 days | | Christian Democracy | Leone I | DC | IV (1963) | |
| | Aldo Moro (1916–1978) | 5 December 1963 | 23 July 1964 | 4 years, 203 days | | Christian Democracy | Moro I | Organic centre-left DC • PSI • PSDI • PRI | |
| 23 July 1964 | 24 February 1966 | Moro II | Giuseppe Saragat (1964–1971) |
| 24 February 1966 | 25 June 1968 | Moro III |
| | Giovanni Leone (1908–2001) | 25 June 1968 | 13 December 1968 | 171 days | | Christian Democracy | Leone II | DC | V (1968) | |
| | Mariano Rumor (1915–1990) | 13 December 1968 | 6 August 1969 | 1 year, 236 days | | Christian Democracy | Rumor I | Organic centre-left DC • PSU • PRI | |
| 6 August 1969 | 28 March 1970 | Rumor II | DC |
| 28 March 1970 | 6 August 1970 | Rumor III | Organic centre-left DC • PSI • PSDI • PRI |
| | Emilio Colombo (1920–2013) | 6 August 1970 | 18 February 1972 | 1 year, 196 days | | Christian Democracy | Colombo | Organic centre-left DC • PSI • PSDI • PRI | |
| | Giulio Andreotti (1919–2013) | 18 February 1972 | 26 June 1972 | 1 year, 140 days | | Christian Democracy | Andreotti I | DC | Giovanni Leone (1971–1978) | |
| 26 June 1972 | 8 July 1973 | Andreotti II | DC • PSDI • PLI | VI (1972) |
| | Mariano Rumor (1915–1990) | 8 July 1973 | 15 March 1974 | 1 year, 138 days | | Christian Democracy | Rumor IV | Organic centre-left DC • PSI • PSDI • PRI | |
| 15 March 1974 | 23 November 1974 | Rumor V | Organic centre-left DC • PSI • PSDI |
| | Aldo Moro (1916–1978) | 23 November 1974 | 12 February 1976 | 1 year, 250 days | | Christian Democracy | Moro IV | DC • PRI | |
| 12 February 1976 | 30 July 1976 | Moro V | DC |
| | Giulio Andreotti (1919–2013) | 30 July 1976 | 13 March 1978 | 3 years, 6 days | | Christian Democracy | Andreotti III | Historic Compromise DC | VII (1976) | |
| 13 March 1978 | 21 March 1979 | Andreotti IV | Sandro Pertini (1978–1985) |
| 21 March 1979 | 5 August 1979 | Andreotti V | DC • PSDI • PRI |
| | Francesco Cossiga (1928–2010) | 5 August 1979 | 4 April 1980 | 1 year, 74 days | | Christian Democracy | Cossiga I | DC • PSDI • PLI | VIII (1979) | |
| 4 April 1980 | 18 October 1980 | Cossiga II | Organic centre-left DC • PSI • PRI |
| | Arnaldo Forlani (1925–2023) | 18 October 1980 | 28 June 1981 | 253 days | | Christian Democracy | Forlani | Organic centre-left DC • PSI • PSDI • PRI | |
| | Giovanni Spadolini (1925–1994) | 28 June 1981 | 23 August 1982 | 1 year, 156 days | | Italian Republican Party | Spadolini I | Pentapartito DC • PSI • PSDI • PRI • PLI | |
| 23 August 1982 | 1 December 1982 | Spadolini II |
| | Amintore Fanfani (1908–1999) | 1 December 1982 | 4 August 1983 | 246 days | | Christian Democracy | Fanfani V | DC • PSI • PSDI • PLI | |
| | Bettino Craxi (1934–2000) | 4 August 1983 | 1 August 1986 | 3 years, 257 days | | Italian Socialist Party | Craxi I | Pentapartito DC • PSI • PRI • PSDI • PLI | IX (1983) | |
| 1 August 1986 | 18 April 1987 | Craxi II | Francesco Cossiga (1985–1992) |
| | Amintore Fanfani (1908–1999) | 18 April 1987 | 29 July 1987 | 102 days | | Christian Democracy | Fanfani VI | DC | |
| | Giovanni Goria (1943–1994) | 29 July 1987 | 13 April 1988 | 259 days | | Christian Democracy | Goria | Pentapartito DC • PSI • PRI • PSDI • PLI | X (1987) | |
| | Ciriaco De Mita (1928–2022) | 13 April 1988 | 23 July 1989 | 1 year, 101 days | | Christian Democracy | De Mita | Pentapartito DC • PSI • PRI • PSDI • PLI | |
| | Giulio Andreotti (1919–2013) | 23 July 1989 | 13 April 1991 | 2 years, 341 days | | Christian Democracy | Andreotti VI | Pentapartito DC • PSI • PRI • PSDI • PLI | |
| 13 April 1991 | 28 June 1992 | Andreotti VII | Quadripartito DC • PSI • PSDI • PLI |