| Party | Abbr. | Founded | Position | Ideology | Leader | Representation |
| Senators | Deputies |
| | | National Action Party Partido Acción Nacional | PAN | 1939 | Centre-right to right-wing | National conservatism Christian democracy | Jorge Romero Herrera | 21 / 128 | 70 / 500 |
| | | Institutional Revolutionary Party Partido Revolucionario Institucional | PRI | 1929 (PNR) 1938 (PRM) 1946 (PRI) | Centre to centre-right | Catch-all politics | Alito Moreno | 13 / 128 | 37 / 500 |
| | | Ecologist Green Party of Mexico Partido Verde Ecologista de México | PVEM | 1986 (PVM) 1991 (PEM) 1993 (PVEM) | Centre-left | Green politics | Karen Castrejón Trujillo | 14 / 128 | 62 / 500 |
| | | Labor Party Partido del Trabajo | PT | 1990 | Left-wing to far-left | Socialism Maoism Socialism of the 21st century | Alberto Anaya | 6 / 128 | 49 / 500 |
| | | Citizens' Movement Movimiento Ciudadano | MC | 1999 (CpD) 2002 (CON) 2011 (MC) | Centre to centre-left | Social democracy Participatory democracy Progressivism | Jorge Máynez | 6 / 128 | 28 / 500 |
| | | National Regeneration Movement Movimiento Regeneración Nacional | Morena | 2014 | Centre-left to left-wing | Anti-neoliberalism Alter-globalization Left-wing populism Left-wing nationalism | Ariadna Montiel Reyes | 67 / 128 | 253 / 500 |