| Name | Location | Country | Year | Deaths | Injuries | Origin | Accelerant | Notes |
| Study Club fire | Detroit, Michigan | United States | 1929 | 22 | 50 | undetermined; possibly a lit cigarette | draperies, decorations | Prohibition-era speakeasy nightclub |
| Rhythm Club fire | Natchez, Mississippi | United States | 1940 | 209 | 200 | discarded match or cigarette | Spanish moss sprayed with Flit | At the time of incident, second-worst club fire in American history |
| Cocoanut Grove fire | Boston, Massachusetts | United States | 1942 | 492 | 130 | undetermined (disputed) | draperies, decorations, possibly a refrigerant leak (methyl chloride) | Deadliest club fire in history, and the third-worst single-building fire in American history (third only to the Iroquois Theatre fire and the September 11 attacks) |
| Karlslust dance hall fire | Berlin, Germany | Germany | 1947 | 81 | 150 | stove pipe | | Worst fire disaster in Berlin since World War II; death toll reported between 80-88, but considered to be 81 |
| Top Storey Club | Bolton, Lancashire, England | United Kingdom | 1961 | 19 | | | solvents, paints | 14 died in the fire and 5 died of injuries received from jumping out of windows |
| Dale's Penthouse | Montgomery, Alabama | United States | 1967 | 26 | 8 | non-extinguished tobacco pipe left in jacket pocket in the cloakroom | | Restaurant/lounge on the top floor of an 11-story building with no fire escape |
| Club Cinq-Sept fire | Saint-Laurent-du-Pont | France | 1970 | 146 | | undetermined (disputed) | polyurethane, papier-mâché | |
| Blue Bird Café fire | Montreal, Quebec | Canada | 1972 | 37 | 56 | arson | gasoline | |
| Playtown Cabaret fire | Osaka | Japan | 1972 | 118 | 81 | discarded match or cigarette butt | clothing | Club on the top floor of a seven-story building with no fire escape |
| Whiskey Au Go Go fire | Fortitude Valley, Brisbane, Queensland | Australia | 1973 | 15 | | arson | gasoline | |
| UpStairs Lounge arson attack | New Orleans, Louisiana | United States | 1973 | 32 | 15 | arson | Ronsonol lighter fluid | Deadliest arson attack in New Orleans at that time, and one of the deadliest attacks on LGBT people in United States history |
| Gulliver's nightclub fire | Port Chester, New York | United States | 1974 | 24 | 32 | arson | | Future Kiss drummer Eric Carr survived the fire, he played there with the band Creation. |
| Time Club fire | Seoul | South Korea | 1974 | 64 | | short circuit | | The total death toll for the entire Daewang Corner building fire was 88; 8 died from jumping out of windows |
| Dance bar 6-9 fire | La Louvière | Belgium | 1976 | 15 | 40 | cigarette lighters during a power failure | paper and plastic party decorations | |
| Puerto Rican Social Club fire | New York City | United States | 1976 | 25 | 24 | arson | gasoline | |
| Beverly Hills Supper Club fire | Southgate, Kentucky | United States | 1977 | 165 | 200 | possibly electrical | carpeting, wooden paneling | Third-worst club fire in American history |
| Fire at Stadt | Borås | Sweden | 1978 | 20 | 59 | most likely a discarded cigarette | High-school graduation party at city hotel |
| Infinity Disco fire | Manhattan, New York | United States | 1979 | 0 | 0 | possibly arson | | Former location of Pfaff's Beer Cellar |
| Denmark Place fire | Central London | United Kingdom | 1980 | 37 | 23 | arson | gasoline | |
| Limelight Disco fire | Hallandale, Florida | United States | 1980 | 0 | 1 | possibly arson | | Formerly the Old Heidelberg restaurant and Rumbottoms disco |
| Stardust fire | Artane, Dublin | Ireland | 1981 | 48 | 214 | possibly electrical | flammable internal materials | |
| Alcalá 20 nightclub fire | Madrid | Spain | 1983 | 82 | 27 | electrical | | |
| Chowon (Greenfield) disco fire | Daegu | South Korea | 1983 | 25 | 67 | short circuit | | mostly underage victims; exit reportedly chained shut to prevent them from leaving without paying |
| Common People fire | Seoul | South Korea | 1984 | 10 | 2 | oil stove knocked over during quarrel | oil fire spread to the couch | fire broke out at 4:20 am; victims mostly underage |
| Happy Land fire | The Bronx, New York | United States | 1990 | 87 | 6 | arson | gasoline | Fifth-worst club fire in American history |
| Flying nightclub fire | Zaragoza, Aragon | Spain | 1990 | 43 | | electrical | | |
| Daegu Gosonggwan fire | Daegu | South Korea | 1991 | 16 | 13 | arson | 6 liters of gasoline | Fire started by spiteful rejected customer |
| Kheyvis fire | Olivos, Buenos Aires | Argentina | 1993 | 17 | 24 | burning furniture (prank) | | Second-worst club fire in Argentine history |
| Yiyuan Disco fire | Fuxin, Liaoning | China | 1994 | 233 | 16 | sofa (caused by burning newspaper) | decorations | |
| Ozone Disco fire | Quezon City, Metro Manila | Philippines | 1996 | 162 | 95 | possibly electrical | | Worst fire in Philippine history |
| Rolling Stones fire | Seoul | South Korea | 1996 | 11 | 3 | discarded cigarette butt | wet paint | fire trucks delayed by cars parked in narrow alley |
| Gothenburg discothèque fire | Gothenburg | Sweden | 1998 | 63 | 214 | arson | | Most victims were underage - event for secondary school students |
| Incheon club fire | Incheon | South Korea | 1999 | 56 | 78 | basement construction work | | mostly underage victims; exit reportedly chained shut to prevent them from leaving without paying |
| LA2 fire | London | United Kingdom | 1999 | 0 | | pyrotechnics | | Pyro from the band Toilet Böys set fire to netting suspended from the ceiling. |
| Luoyang Christmas fire | Luoyang, Henan | China | 2000 | 309 | 7 | welding | | Second deadliest nightclub fire in history. Construction and retail staff in the same building evacuated after internal broadcast, nightclub patrons on level 4 were forgotten about |
| Lobohombo explosion | Mexico City | Mexico | 2000 | 22 | 24 | | gas canisters | |
| Volendam New Year's fire | Volendam | Netherlands | 2001 | 14 | 241 | pyrotechnics (sparkler) | decorations (Christmas) | |
| Canecão Mineiro nightclub fire | Belo Horizonte | Brazil | 2001 | 7 | 197 | pyrotechnics | | |
| Myojo 56 building fire | Kabukicho, Shinjuku | Japan | 2001 | 44 | 3 | suspected arson | | Fifth-deadliest fire in post-war Japanese history |
| Club La Guajira fire | Caracas | Venezuela | 2002 | 47 | 28 | | Christmas decoration | Bouncer delayed exit asking patrons not to leave without paying |
| Utopía nightclub fire | Santiago de Surco, Lima | Peru | 2002 | 29 | 57 | torch | acoustic foam | |
| The Station nightclub fire | West Warwick, Rhode Island | United States | 2003 | 100 | 230 | pyrotechnics | acoustic foam | Deadliest firework accident and fourth-deadliest club fire in American history |
| República Cromañón nightclub fire | Buenos Aires | Argentina | 2004 | 194 | 1432 | pyrotechnics | plastic net (media sombra), styrofoam and wood decorations, acoustic panels | Worst club fire in Argentine history |
| El Festival Ballroom fire | Houston, Texas | United States | 2004 | 1 | 3 | arson | | Firefighter killed in fire; initially thought to have been started by a truck, quickly ruled as arson |
| 911 nightclub fire | Moscow | Russia | 2007 | 10 | 4 | pyrotechnics | | |
| Lounge cafe fire | Novi Sad | Serbia | 2008 | 8 | 2 | arson | shag carpet on the walls | Fire was intentionally set by a patron named Miloš Malešev. He was sentenced to nine years and his companion to two years. Two owners of the bar were sentenced to seven years each. |
| Quito Ultratumba nightclub fire | Quito | Ecuador | 2008 | 15 | 35 | pyrotechnics | | This incident prompted years of investigation, including a human rights investigation and summary report. |
| Wuwang Club fire | Shenzhen, Guangdong | China | 2008 | 43 | 88 | pyrotechnics | | |
| Santika Club fire | Watthana, Bangkok | Thailand | 2009 | 67 | 222 | fireworks or electrical explosion | tar paper, plastic waterproofing | |