| Date | Aircraft | People missing | Type of incident | Location (assumed) | Remarks |
| April 24, 1924 | Fokker F.III (H-NABS) | 3 | Unknown | Atlantic Ocean(North Sea) | KLM passenger flight from Lympne to Rotterdam. |
| May 5, 1927 | Farman F.61 Goliath (F-ADFN) | 4 | Unknown | Atlantic Ocean | SGTA cargo flight from St. Louis to Petrolina. A Brazilian fisherman claimed to have found a wheel from the missing plane June 18 that year. |
| May 8, 1927 | L'Oiseau Blanc(Levasseur PL.8) | 2(François Coli & Charles Nungesser) | Unknown | North Atlantic Ocean or Maine | This was an attempted transatlantic flight competing for the Orteig Prize. |
| May 26, 1927 | Airco DH.9(G-IAAB) | 2(John James Crofts Cocks & LAC Rowston) | Unknown | Turkey(Konya & Eskişehir or Kütahya & Bandırma) | Cocks and Rowston left on a private flight on May 11 from Lahore, British India to Lympne, England. |
| August 16, 1927 | Golden Eagle(NX913) | 2(Jack Frost & Gordon Scott) | Unknown | North Pacific Ocean | Competitor in Dole Air Race. |
| August 16, 1927 | Miss Doran(NX2915) | 3(John "Auggie" Pedlar, Vilas R. Knope & Mildred Doran) | Unknown | North Pacific Ocean | Competitor in Dole Air Race. |
| August 19, 1927 | Dallas Spirit(NX941) | 2(William Portwood Erwin & Alvin Eichwaldt) | Unknown | North Pacific Ocean | Competitor in Dole Air Race, searching for Miss Doran & Golden Eagle. |
| August 31, 1927 | Saint Raphael(Fokker F.VIIA) | 3(Frederick F. Minchin, Leslie Hamilton & Princess Anne of Löwenstein-Wertheim-Freudenberg) | Unknown | North Atlantic Ocean(near Newfoundland) | Attempted transatlantic flight (east to west). |
| November 16, 1927 | Junkers F13 (with floats) K-SALD | 4 | Weather(presumed) | Gulf of Finland | Aero OY passenger flight from Tallinn to Helsinki carrying two Finnish Army officers, a pilot, and a flight mechanic. Extreme fog present at time of disappearance. Finnish Air Force and Navy and Estonian Navy searches found no trace of the aircraft. |
| December 23, 1927 | The Dawn(Sikorsky S-36) | 4 (Oskar Omdal, Brice Goldsborough, Frank Koehler & Frances Wilson Grayson) | Unknown | North Atlantic Ocean(near Nova Scotia) | Intended to attempt Newfoundland to London flight. |
| January 10, 1928 | Aotearoa(Ryan B-1 Brougham, G-AUNZ) | 2(John Robert Moncrieff & George Hood) | Unknown | South Pacific Ocean(Tasman Sea) | Departed from Sydney, Australia for Trentham, New Zealand. Radio signals ceased when the aircraft should have been about two hours out from New Zealand; see Moncrieff and Hood disappearance |
| March 13, 1928 | Endeavour(Stinson SM-1 Detroiter) | 2(Walter G. R. Hinchliffe & Elsie Mackay) | Unknown | North Atlantic Ocean | Attempted transatlantic flight (east to west). |
| May 25, 1928 | Italia(airship) | 6(Aldo Pontremoli, Renato Alessandrini, Ugo Lago, Ettore Arduino, Calisto Ciocca & Attilio Caratti) | Crash landing | North Atlantic Ocean(Barents Sea) | One person died in the crash, subsequent searches were unsuccessful. Notable people who disappeared included Aldo Pontremoli. |
| June 18, 1928 | Latham 47.02 | 6 | Unknown | North Atlantic Ocean(Barents Sea) | This group was searching for survivors of the missing airship Italia. Roald Amundsen and René Guilbaud were among the missing attempted rescuers. |
| September 6, 1928 | Blackburn(N9834) | 3 | Unknown | North Atlantic Ocean(North Sea) | Pilot Officer Samuel Hatton, Lt. Charles Sheldon Booth RN and Telegraphist Edmund George Bourke Grigson missing; No. 422 (Fleet Spotter) Flight, HMS Argus. |
| August 19, 1929 | Jung Schweizerland(Farman F.190, CH-245) | 2 | Unknown | North Atlantic Ocean | Disappeared with 2 Swiss pilots during attempted transatlantic flight from Lisbon to New York. |
| December 24, 1929 | CMASA/Dornier Do J Wal Asso 500 Cabina(I-AZDB) | 5 | Ditching | North Atlantic Ocean(Aegean Sea) | Aero Espresso Italiana flight from Istanbul to Athens. Signaled passing Isola d'Strati at 12:30 but made an emergency landing at 13:00 near Agios Eustratios at 39.336489, 24.755684. Nothing found. |
| December 26, 1929 | de Havilland DH.60M Moth (N-42) | 2 | Unknown | Antarctica(South Pole area) | Hvalfangstselskapet Kosmos A/S aircraft flying out of the whaling vessel Kosmos. Pilot Leif Lier and observer Dr. Ingvald Schreiner lost. |
| November 21, 1930 | Dornier Do R4 Superwal (I-RONY) | 6 | Unknown | North Atlantic Ocean(Mediterranean Sea) | SANA passenger flight from Barcelona to Marseille. Last known radio contact was at 09:40 off of Cap de Creus. Part of the wreckage was found on December 5, 30 miles off between Leucate and Port-Vendres. |
| February 1, 1932 | Fairchild (model and registration unknown) | 5 | Unknown | North Atlantic Ocean(Straits of Florida) | Disappeared during a 45-minute Bimini Airlines flight from Miami to Bimini. Piloted by Cal Chik, the passengers were suspected bootlegger Phillip Mannes and three unnamed employees (two white and one black). Search called off February 3rd. |
| May 30, 1932 | de Havilland DH.60 Moth(CF-AGL) | 2 | Unknown | North Atlantic Ocean(near St. Anthony, Newfoundland and Labrador) | Arthur Sullivan (pilot), Dr Kurt K. (Karl) Kuenhert vanished on pleasure flight. |
| August 12, 1932 | Avro 616 Avian IVM(G-AAKA) | 2 | Unknown | Indian Ocean(Gulf of Martaban) | English planters, G.W. Salt and F.B. Taylor left for England on a pleasure flight. |
| September 14, 1932 | The American Nurse(Bellanca CH-400 Skyrocket, NR796W) | 3 | Unknown | North Atlantic Ocean(near Cape Finisterre, Spain) | Attempted New York City to Rome flight |
| June 20, 1933 | Cuatro Vientos(Br.19 TF Super Bidon) | 2 | Unknown | Mexico(near Villahermosa) | The duo were on their final leg of the flight that went from Seville to Mexico City. |
| July 18, 1933 | CMASA Wal(I-AZEE) | 6 | Ditching | North Atlantic Ocean(Aegean Sea) | Aero Espresso Italiana flight from Athens to Rhodes forced to ditch due to gale-force winds. SAR operations by Greece and Italy were unsuccessful. |
| December 3, 1934 | Stella Australis(Airspeed Envoy) | 3 | Fuel starvation | North Pacific Ocean(near Hawaii) | Charles Ulm disappeared along with copilot G.M. Littlejohn and navigator/radio operator J.S. Skilling. It is most probable that the aircraft overflew Hawaii. |
| December 21, 1934 | Trimotor Hydroplane(Bach 3-CT-6 Air Yacht, NC850E) | 7 | Unknown | Pacific Ocean(Gulf of California) | Líneas Aéreas Occidentales (LAO) passenger flight from Mazatlán to La Paz. 2 Americans (pilot and mechanic) and 5 Mexicans (2 male, 2 female, and a female infant) on board; no trace found. |
| November 8, 1935 | Lady Southern Cross(Lockheed Altair) | 2(Charles Kingsford Smith & John T. Pethybridge) | Unknown | Indian Ocean(Andaman Sea) | Attempt to break the England to Australia speed record. Only the undercarriage leg and wheel has ever been found. |
| January 21, 1936 | Dauphine (CAMS 53-1, F-AJIR) | 6 | Engine failure | North Atlantic Ocean(Mediterranean Sea) | Air France passenger flight from Marseille to Ajaccio and Tunis. Vanished off of Corsica after sending a distress call. |
| February 10, 1936 | Ville de Buenos Aires(Latécoère 301, F-AOIK) | 6 | Weather(storm loss) | South Atlantic Ocean(near Saint Peter and Saint Paul Archipelago) | Notable people lost include Émile Barrière. The nonstop flight from Natal, Brazil was operated by Air France. |
| February 15, 1936 | Tornado(Dornier Do J-2F Bos Wal, D-ADYS) | 4 | Unknown | South Atlantic Ocean | Lost during a Deutsche Lufthansa cargo flight from Natal to Bodensee via Bathurst. |
| December 7, 1936 | Croix-du-Sud(Latécoère 300) | 5 | Engine failure(presumed) | South Atlantic Ocean | A final incomplete radio message reported engine failure minutes after the last position report. Notable lost passengers included Jean Mermoz. |
| February 15, 1937 | Blackburn Shark(K5619) | 3 | Unknown | North Atlantic Ocean(Mediterranean Sea) | The crew of this military patrol included Sub-Lt George Eric Lake, Lt Roderick W. MacDonald, & Telegraphist William H. Currie. They were all from the 821st Naval Air Squadron Fleet Air Arm of HMS Courageous. |
| July 2, 1937 | Lockheed Electra 10E(NR 16020) | 2(Amelia Earhart & Fred Noonan) | Fuel starvation(most likely) | Central Pacific Ocean(Numerous theories exist on location) | This is perhaps one of the most famous aerial disappearances of all time. Amelia Earhart and Fred Noonan were on their third-from-last leg of an attempted round-the-world flight when they went missing. At the time, the search for Earhart was the largest of its kind in history. |
| August 13, 1937 | Bolkhovitinov DB-A(prototype) | 6 | Unknown | Arctic Ocean | Sigizmund Levanevsky was among the passengers that went missing. This was an attempted long-distance flight from Moscow to Fairbanks, Alaska, via the North Pole. Possible wreckage of the plane was sighted on the sea floor in 1999. |
| October 27, 1937 | Antares(Dewoitine D.333, F-ANQA) | 6 | Unknown | North Atlantic Ocean(near El Jadida) | Air France passenger flight from Dakar to Toulouse lost before a stopover in Casablanca. Crew reported passing Agadir at 03:05 but sent an SOS call received at 04:23. 2 mail bags washed up on the beach, but no wreckage was recovered. |
| February 13, 1938 | CANT Z-506(I-ORIA) | 14 | Weather(presumed) | North Atlantic Ocean(Mediterranean Sea) | Ala Littoria flight from Cádiz to Rome with stopovers in Pollença and Alghero, lost in a storm shortly after second stop at 14:30. |
| April 4, 1938 | Vickers Vildebeest Mark II(K2944) | 3 | Unknown | North Pacific Ocean(Singapore Strait) | The flight crew consisted of Sgt. W.D.M. Roberts (pilot), AC1 E.J. Beisly & AC1 M.R. Hunter of No. 100 Sqn RAF, RAF Seletar, Singapore. |
| April 17, 1938 | Taylor Cub | 1(Andrew Carnegie Whitfield) | Unknown | North Atlantic Ocean(near Long Island, United States) | This was a private flight. |
| July 28, 1938 | Hawaii Clipper(Martin M-130, NC14714) | 15 | Unknown | North Pacific Ocean(East of the Philippine coast) | |
| August 6, 1938 | Hawker Hector(K9759) | 1 | Unknown | North Atlantic Ocean(North Sea off Blackhall Rocks) | Lost: P/O Douglas St Quentin Robinson, No. 13 Sqn RAF, RAF Odiham. |
| August 8, 1938 | Avro Anson(K8831) | 4 | Unknown | North Atlantic Ocean(North Sea off Bridlington) | Lost: Sgt. Cecil Joseph Le Patrick Gordon (pilot), AC2 Thomas Charles Andrews, AC1 Melville George Brand, AC1 Leslie Freeman, No. 233 Sqn RAF, RAF Thornaby. |
| October 1, 1938 | Pampero(Dornier DO.18, D-AROZ) | 5 | Unknown | North Atlantic Ocean(off Bathurst) | Deutsche Lufthansa flight from Natal that was just a few minutes from landing. |
| October 6, 1938 | Handley Page H.P.54 Harrow(K6971) | 3 | Weather(storm loss) | North Atlantic Ocean(English Channel off Dungeness) | Lost: F/O D.A. Hamilton, P/O R.N. Haynes, P/O T.I.S. Munro, LAC C.S. Lodge & AC1 T. Prowse, No. 215 Sqn, RAF Honington, Suffolk. |
| May 9, 1939 | Westland Wallace(K3570) | 2 | Fouling of tail by towing cable | North Atlantic Ocean(North Sea) | Lost: P/O M.T. Lloyd & AC J. Flannery of No. 1 Air Armament School. |
| May 16, 1939 | Monocoupe 90A(SE-AGM/NX19421) | 1 | Unknown | North Atlantic Ocean | Swedish-American pilot Carl Backman took the registration SE-AGM from a Areonca C-3 in his hometown of Leksand and used on this plane on an attempted flight from the US to Sweden. Planned route was from St. Louis to Rommehed with stops in Bangor and Gander; disappeared on last leg of flight. |
| August 9, 1939 | Vickers Wellington I(L4258) | 5 | Unknown | North Atlantic Ocean(North Sea) | Lost: F/O T.A. Darling, P/O F.E. Board, A/Sgt A. Linkley, AC1 R.C.B, Collins & AC1 J.W. Sadler of No. 149 Sqn RAF. |
| August 11, 1939 | Shalom(Ryan C-2 Foursome) | 2 | Unknown | North Atlantic Ocean | NYC to Palestine flight by Betar activists Alex Loeb and Richard Decker. |
| August 19, 1939 | Supermarine Stranraer | 6 | Unknown | North Atlantic Ocean(North Sea) | Lost: Act. Flt. Lt. F.E.R. King, F/O A.F. Barber, LAC D. Fulcher, AC1 D.G.P. Ash, AC1 L.S. Freshwater & AC1 W.J. Jeckells, No. 209 Sqn RAF, RAF Invergordon, Ross & Cromarty. |