| Rank | Largest deficit | Season | Week | Winning team | Losing team | Venue | Scores | Notes | Ref |
| 1 | 33 points | 2022 | 15 | Minnesota Vikings | Indianapolis Colts | Bank Stadium, Minneapolis, Minnesota | Colts led33–0Vikings won39–36 (OT) | The current NFL record. Minnesota gave up return touchdowns from a blocked punt and an interception and trailed 33–0 at halftime. Between 8:22 to play in the 3rd quarter and 2:15 to play in the fourth quarter, the Vikings outscored Indianapolis 36–3; they scored five touchdowns in seven possessions. In overtime, Minnesota drove 60 yards and Greg Joseph won the game on a 40-yard field goal with three seconds left in the extra period. | |
| 2 | 32 points | 1992 | Wild Card | Buffalo Bills | Houston Oilers | Rich Stadium, Orchard Park, New York | Oilers led35–3Bills won41–38 (OT) | Playoff record. Backup quarterback Frank Reich led the Bills to four touchdowns between 8:52 and 2:00 of the third quarter to begin the comeback. Buffalo took the lead on Andre Reed's third touchdown catch with 3:08 to in the fourth quarter, before the Oilers forced overtime with a field goal. Nate Odomes intercepted a Warren Moon pass early in overtime, and Steve Christie won the game with a 32-yard field goal. Popularly known as "The Comeback." | |
| 3 | 28 points | 2013 | Wild Card | Indianapolis Colts | Kansas City Chiefs | Lucas Oil Stadium, Indianapolis, Indiana | Chiefs led38–10Colts won45–44 | The largest comeback not requiring overtime. Starting with 11:47 remaining in the 3rd quarter, Indianapolis scored five touchdowns while conceding only two field goals. After the Colts took the lead with 4:21 remaining, Kansas City drove into Colts territory before turning the ball over on downs. Indianapolis quarterback Andrew Luck threw for four touchdowns on the day and scored another on a fumble recovery. | |
| 1980 | 14 | San Francisco 49ers | New Orleans Saints | Candlestick Park, San Francisco, California | Saints led35–749ers won38–35 (OT) | After trailing by 28 points at halftime, San Francisco scored four unanswered touchdowns in the second half and tied the score with 1:50 to play. After forcing a New Orleans punt on the first possession of overtime, the 49ers drove for Ray Wersching's game-winning field goal. | |
| 5 | 27 points | 2022 | Wild Card | Jacksonville Jaguars | Los Angeles Chargers | TIAA Bank Field, Jacksonville, Florida | Chargers led27–0Jaguars won31–30 | After throwing four interceptions, the Jaguars found themselves in a 27–0 deficit approaching halftime. Starting with a touchdown with 28 seconds left in the second quarter, Jacksonville then outscored the Chargers 31–3 for the rest of the game. The Jaguars successfully converted a two-point conversion after scoring a touchdown, cutting the lead to two points with 5:40 to play in the fourth quarter. After forcing a Chargers punt, the Jaguars drove for Riley Patterson's 36-yard winning field goal. | |
| 6 | 26 points | 1997 | 4 | Buffalo Bills | Indianapolis Colts | Rich Stadium, Orchard Park, New York | Colts led26–0Bills won37–35 | Between 2:12 to play in the 2nd quarter and 1:14 to play in the 4th quarter, Buffalo outscored Indianapolis 37–3. Trailing by eight points, the Colts drove for a late touchdown but failed on a game-tying two-point conversion attempt. | |
| 7 | 25 points | 2016 | Super Bowl | New England Patriots | Atlanta Falcons | NRG Stadium, Houston, Texas | Falcons led 28–3Patriots won 34–28 (OT) | Super Bowl record. Starting with 2:06 to play in the third quarter, New England scored 25 unanswered points from four offensive drives. They tied the game with 57 seconds left in regulation, then won it with a touchdown on the first drive of overtime. | |
| 2014 | 5 | Cleveland Browns | Tennessee Titans | LP Field, Nashville, Tennessee | Titansled 28–3Brownswon 29–28 | Largest comeback by a road team. The Titans ran no further plays in Cleveland territory after taking their 25-point lead in the second quarter. Cleveland scored 26 unanswered points, beginning 12 seconds before halftime and finishing with 1:09 left in the game. | |
| 1987 | 9 | St. Louis Cardinals | Tampa Bay Buccaneers | Busch Stadium, St. Louis, Missouri | Buccaneersled 28–3Cardinalswon 31–28 | The largest fourth-quarter comeback. Starting with 12:42 remaining in the game, St. Louis scored 28 unanswered points to take the lead with 2:01 to play. A 53-yard field goal attempt by Buccaneers kicker Donald Igwebuike struck the crossbar as time expired. | |
