| Year | Horse | Fence No. | Fate | Going | Ran | Details | Source |
| 2025 | Celebre D'Allen | While running | Pulled up | Good-soft | 34 | Pulled up on the run-in, died two days later. Jockey Micheal Nolan was given a ten-day ban prior to the horse's death for continuing to race despite the horse showing signs of tiring. | |
| 2023 | Hill Sixteen | 1 | Fell | Good | 39 | Fell at first and sustained "unrecoverable injury". The fence was skipped on the second lap. | |
| 2022 | Eclair Surf | 3 (& 19) | Fell | Good-soft | 40 | Fell at 3rd fence, was stabilised and taken back to the stables, only to be euthanised the day after due to head trauma. | |
| 2022 | Discorama | While running | Pulled up | Good-soft | 40 | Pulled up before the 13th fence, was found to have incurred a pelvic injury and was euthanised. | |
| 2021 | The Long Mile | While running | Pulled up | Good-soft | 40 | Was euthanised after the race. | |
| 2019 | Up For Review | 1 | Brought down | Good-soft | 40 | Jumped successfully but was brought down by another fallen horse. The fence was skipped in the subsequent lap. | |
| 2012 | Synchronised | 11 (& 26) | Fell | Good | 40 | Fell at Becher's Brook but continued running riderless until the 11th fence where he fractured his right-hind tibia and fibula and was euthanised. | |
| 2012 | According to Pete | (6 &) 21 | Brought down | Good | 40 | Fractured his left-fore humerus and was euthanised as a result of the fall on the second lap at Becher's Brook. Was the 21st fence because the fifth fence was skipped on the second lap as a jockey was being treated after falling during the first lap. | |
| 2011 | Ornais | 4 | Fell | Good | 40 | Incurred a cervical fracture upon falling and died. Under a new rule implemented, the horses skipped this fence on the next lap. | |
| 2011 | Dooneys Gate | 6 | Fell | Good | 40 | Fractured his thoracolumbar upon falling and was euthanised. Horses skipped this fence on the second lap. | |
| 2009 | Hear The Echo | While running | Collapsed | Good-soft | 40 | Collapsed on the run-in and died. | |
| 2008 | McKelvey | While running riderless | Collided with barrier | Good | 40 | Unseated rider at 20th fence and continued running riderless until he collided with railings, was unable to regain his feet due to injuries, and was euthanised. | |
| 2007 | Graphic Approach | While running riderless | Collapsed | Good | 40 | Fell at Becher's Brook but continued running riderless before collapsing with concussion; he was euthanised several days later. | |
| 2006 | Tyneandthyneagain | 1 (& 17) | Fell | Good-soft | 40 | Continued running riderless until falling later, was diagnosed with a spinal injury and was euthanised. | |
| 2003 | Goguenard | (3 &) 19 | Brought down | Good | 40 | Injured in a mêlée by another falling horse and was euthanised. | |
| 2002 | The Last Fling | (8 &) 24 | Fell | Good | 40 | Broke his back upon falling and died. | |
| 2002 | Manx Magic | (4 &) 20 | Fell | Good | 40 | Incurred a cervical fracture upon falling and died. | |
| 1999 | Eudipe | (6 &) 22 | Fell | Good | 32 | Broke his back upon falling and was euthanised. | |
| 1998 | Pashto | 1 (& 17) | Fell | Heavy | 37 | Collapsed after falling and was euthanised. | |
| 1998 | Do Rightly | 4 (& 20) | Fell | Heavy | 37 | Suffered a heart attack whilst jumping the fence. | |
| 1998 | Griffins Bar | While running | Fell | Heavy | 37 | Incurred a shoulder fracture after jumping the fifth fence and fell; later was euthanised. | |
| 1997 | Straight Talk | 14 (& 30) | Fell | Good | 36 | Incurred a leg fracture upon falling and was euthanised. | |
| 1997 | Smith's Band | (4 &) 20 | Fell | Good | 36 | Incurred a cervical fracture upon falling and died. | |
| 1996 | Rust Never Sleeps | While running | Pulled up | Good | 27 | Pulled up lame before the 13th fence, diagnosed with a broken shoulder and euthanised. | |
| 1991 | Ballyhane | After finishing | Collapsed | Good-soft | 40 | Suffered a haemorrhage after completing the race and died. | |
| 1990 | Roll-A-Joint | 8 (& 24) | Fell | Firm | 38 | Incurred a cervical fracture upon falling and died. | |
| 1990 | Hungary Hur | While running | Pulled up | Firm | 38 | Incurred a leg fracture while running towards the 19th fence, pulled up and euthanised. | |
| 1989 | Brown Trix | 6 (& 22) | Fell | Heavy | 40 | Incurred a shoulder fracture upon falling. | |
| 1989 | Seeandem | 6 (& 22) | Fell | Heavy | 40 | Broke his back upon falling and died. | |
| 1987 | Dark Ivy | 6 (& 22) | Fell | Good | 40 | Incurred a cervical fracture upon falling and died. | |
| 1984 | Earthstopper | After finishing | Collapsed | Good | 40 | Collapsed and died after finishing the race. | |
| 1983 | Duncreggan | 8 (& 24) | Fell | Soft | 41 | Injured in fall and later euthanised. | |
| 1982 | Again The Same | 8 (& 24) | Pulled up | | 39 | Upon his return home the horse was found to have broken a bone in his knee and was euthanised. | |
| 1979 | Kintai | 15 | Brought down | Good | 34 | Injured in fall and later euthanised. | |
| 1979 | Alverton | (6 &) 22 | Fell | Good | 34 | Incurred a cervical fracture upon falling and died. | |
| 1978 | Rag Trade | While running | Pulled up | Firm | 37 | Pulled up lame before the 21st fence and later euthanised. | |
| 1977 | Winter Rain | 6 (& 22) | Fell | Good | 42 | Injured in fall and later euthanised. | |
| 1977 | Zeta's Son | (9 &) 25 | Fell | Good | 42 | Injured in fall and later euthanised. | |
| 1975 | Land Lark | 15 | Fell | Good | 31 | Suffered a heart attack while jumping the fence. | |
| 1975 | Beau Bob | (6 &) 22 | Fell | Good | 31 | Incurred a cervical fracture upon falling and died. | |
| 1973 | Grey Sombrero | 15 | Fell | Firm | 38 | Incurred a shoulder fracture upon falling and was euthanised. | |
| 1970 | Racoon | 3 (& 19) | Fell | Good | 28 | Incurred a cervical fracture upon falling and was euthanised. | |
| 1967 | Vulcano | 3 (& 19) | Fell | Good | 44 | Injured in fall and euthanised. | |
| 1960 | Belsize II | (4 &) 20 | Fell | Good | 26 | Injured in fall and euthanised with a suspected cervical fracture. | |
| 1959 | Slippery Serpent | 13 (& 29) | Fell | Good | 34 | Broke a leg bone, which was initially treated, however was euthanised three days later. | |
| 1959 | Henry Purcell | 6 (& 22) | Fell | Good | 34 | Broke his back upon falling and was euthanised. | |
| 1954 | Dominick's Bar | 2 (& 18) | Fell | Soft | 29 | Suffered a heart attack while jumping the fence. | |
| 1954 | Paris New York | 4 (& 20) | Fell | Soft | 29 | Incurred a cervical fracture upon falling and died. | |
| 1954 | Legal Joy | 13 (& 29) | Fell | Soft | 29 | Broke a leg in a fall and was euthanised. | |