| Event | Years | Location | Disease | Death toll (estimate) | Ref. |
| 1800–1803 Spain yellow fever epidemic | 1800–1803 | Spain | Yellow fever | 60,000+ | |
| 1801 Ottoman Empire and Egypt bubonic plague epidemic | 1801 | Ottoman Empire, Egypt | Bubonic plague | Unknown | |
| 1802–1803 Saint-Domingue yellow fever epidemic | 1802–1803 | Saint-Domingue | Yellow fever | 29,000–55,000 | |
| 1812 Russia typhus epidemic | 1812 | Russia | Typhus | 300,000 | |
| 1812–1819 Ottoman plague epidemic (part of the second plague pandemic) | 1812–1819 | Ottoman Empire | Bubonic plague | 300,000+ | |
| 1813–1814 Malta plague epidemic (part of the second plague pandemic) | 1813–1814 | Malta | Bubonic plague | 4,500 | |
| Caragea's plague (part of the second plague pandemic) | 1813 | Romania | Bubonic plague | 60,000 | |
| 1817–1819 Ireland typhus epidemic | 1817–1819 | Ireland | Typhus | 65,000 | |
| First cholera pandemic | 1817–1824 | Asia, Europe | Cholera | 100,000+ | |
| 1820 Savannah yellow fever epidemic | 1820 | Savannah, Georgia, United States | Yellow fever | 700 | |
| 1821 Barcelona yellow fever epidemic | 1821 | Barcelona, Spain | Yellow fever | 5,000–20,000 | |
| Second cholera pandemic | 1826–1837 | Asia, Europe, North America | Cholera | 100,000+ | |
| 1828–1829 New South Wales smallpox epidemic | 1828–1829 | New South Wales, Australia | Smallpox | 19,000 | |
| Groningen epidemic | 1829 | Netherlands | Malaria | 2,800 | |
| 1829–1833 Pacific Northwest malaria epidemic | 1829–1833 | Pacific Northwest, United States | Malaria, possibly other diseases too | 150,000 | |
| 1829–1835 Iran plague outbreak | 1829–1835 | Iran | Bubonic plague | Unknown | |
| 1834–1836 Egypt plague epidemic | 1834–1836 | Egypt | Bubonic plague | Unknown | |
| 1837 Great Plains smallpox epidemic | 1837–1838 | Great Plains, United States and Canada | Smallpox | 17,000+ | |
| 1841 Southern United States yellow fever epidemic | 1841 | Southern United States (especially Louisiana and Florida) | Yellow fever | 3,498 | |
| 1847 North American typhus epidemic | 1847–1848 | Canada | Typhus | 20,000+ | |
| 1847 Southern United States yellow fever epidemic | 1847 | Southern United States (especially New Orleans) | Yellow fever | 3,400 | |
| 1847–1848 influenza epidemic | 1847–1848 | Worldwide | Influenza | Unknown | |
| 1848–1849 Hawaii epidemic of infections | 1848–1849 | Hawaiian Kingdom | Measles, whooping cough, dysentery and influenza | 10,000 | |
| 1853 New Orleans yellow fever epidemic | 1853 | New Orleans, United States | Yellow fever | 7,970 | |
| Third cholera pandemic | 1846–1860 | Worldwide | Cholera | 1 million+ | |
| 1853 Ottoman Empire plague epidemic | 1853 | Ottoman Empire | Bubonic plague | Unknown | |
| 1853 Copenhagen cholera outbreak | 1853 | Copenhagen, Denmark | Cholera | 4,737 | |
| 1854 Broad Street cholera outbreak | 1854 | London, England | Cholera | 616 | |
| 1855 Norfolk yellow fever epidemic | 1855 | Norfolk and Portsmouth, England | Yellow fever | 3,000 (2,000 in Norfolk, 1,000 in Portsmouth) | |
| Third plague pandemic | 1855–1960 | Worldwide | Bubonic plague | 12–15 million (India and China) | |
| 1855–1857 Montevideo yellow fever epidemic | 1855–1857 | Montevideo, Uruguay | Yellow fever | 3,400 (first wave; 900, second wave; 2,500) | |
| 1857 Lisbon yellow fever epidemic | 1857 | Lisbon, Portugal | Yellow fever | 6,000 | |
| 1857 Victoria smallpox epidemic | 1857 | Victoria, Australia | Smallpox | Unknown | |
| 1857–1859 Europe and the Americas influenza epidemic | 1857–1859 | Europe, North America, South America | Influenza | Unknown | |
| 1862 Pacific Northwest smallpox epidemic | 1862–1863 | Pacific Northwest, Canada and United States | Smallpox | 20,000+ | |
| 1861–1865 United States typhoid fever epidemic | 1861–1865 | United States | Typhoid fever | 80,000 | |
| Fourth cholera pandemic | 1863–1875 | Middle East | Cholera | 600,000 | |
| 1867 Sydney measles epidemic | 1867 | Sydney, Australia | Measles | 748 | |
| 1871 Buenos Aires yellow fever epidemic | 1871 | Buenos Aires, Argentina | Yellow fever | 13,500–26,200 | |
| 1870–1875 Europe smallpox epidemic | 1870–1875 | Europe | Smallpox | 500,000 | |
| 1875 Fiji measles outbreak | 1875 | Fiji | Measles | 40,000 | |
| 1875–1876 Australia scarlet fever epidemic | 1875–1876 | Australia | Scarlet fever | 8,000 | |
| 1876 Ottoman Empire plague epidemic | 1876 | Ottoman Empire | Bubonic plague | 20,000 | |
| 1878 New Orleans yellow fever epidemic | 1878 | New Orleans, United States | Yellow fever | 4,046 | |
| 1878 Mississippi Valley yellow fever epidemic | 1878 | Mississippi Valley, United States | Yellow fever | 13,000 | |
| Fifth cholera pandemic | 1881–1896 | Asia, Africa, Europe, South America | Cholera | 298,600 | |
| 1885 Montreal smallpox epidemic | 1885 | Montreal, Canada | Smallpox | 3,164 | |
| 1889–1890 pandemic | 1889–1890 | Worldwide | Influenza or Human coronavirus OC43 / HCoV-OC43 (disputed) | 1 million | |
| 1894 Hong Kong plague (part of the third plague pandemic) | 1894–1929 | Hong Kong | Bubonic plague | 20,000+ | |