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List of epidemics and pandemics

Updated: Wikipedia source

List of epidemics and pandemics

This is a list of the largest known epidemics and pandemics caused by an infectious disease in humans. Widespread non-communicable diseases such as cardiovascular disease and cancer are not included. An epidemic is the rapid spread of disease to a large number of people in a given population within a short period of time; in meningococcal infections, an attack rate in excess of 15 cases per 100,000 people for two consecutive weeks is considered an epidemic. Due to the long time spans, the first plague pandemic (6th century – 8th century) and the second plague pandemic (14th century – early 19th century) are shown by individual outbreaks, such as the Plague of Justinian (first pandemic) and the Black Death (second pandemic). Infectious diseases with high prevalence are listed separately (sometimes in addition to their epidemics), such as malaria, which may have killed 50–60 million people.

Tables

Epidemics and pandemics with at least 1 million deaths · Major epidemics and pandemics › By death toll
1
1
Rank
1
Epidemics/pandemics
1918 "Spanish" influenza pandemic
Disease
Influenza A/H1N1
Death toll
17–100 million
Percentage of population lost
1–5.4% of global population
Years
1918–1920
Location
Worldwide
2
2
Rank
2
Epidemics/pandemics
Plague of Justinian
Disease
Bubonic plague
Death toll
15–100 million
Percentage of population lost
25–60% of European population
Years
541–549
Location
North Africa, Europe, and Western Asia
3
3
Rank
3
Epidemics/pandemics
HIV/AIDS pandemic
Disease
HIV/AIDS
Death toll
44 million (as of 2025[update])
Percentage of population lost
Years
1981–present
Location
Worldwide
4
4
Rank
4
Epidemics/pandemics
Black Death
Disease
Bubonic plague
Death toll
25–50 million
Percentage of population lost
30–60% of European population
Years
1346–1353
Location
Europe, Asia, and North Africa
5
5
Rank
5
Epidemics/pandemics
COVID-19 pandemic
Disease
COVID-19
Death toll
7.1-36.5 million(as of 2025)
Percentage of population lost
Years
2019–present
Location
Worldwide
6
6
Rank
6
Epidemics/pandemics
Third plague pandemic
Disease
Bubonic plague
Death toll
12–15 million
Percentage of population lost
Years
1855–1960
Location
Worldwide
7
7
Rank
7
Epidemics/pandemics
Cocoliztli epidemic of 1545–1548
Disease
Cocoliztli, caused by an unidentified pathogen
Death toll
5–15 million
Percentage of population lost
27–80% of Mexican population
Years
1545–1548
Location
Mexico
8
8
Rank
8
Epidemics/pandemics
Antonine Plague
Disease
Smallpox or measles
Death toll
5–10 million
Percentage of population lost
25–33% of Roman population
Years
165–180 (possibly up to 190)
Location
Roman Empire
9
9
Rank
9
Epidemics/pandemics
1520 Mexico smallpox epidemic
Disease
Smallpox
Death toll
5–8 million
Percentage of population lost
23–37% of Mexican population
Years
1519–1520
Location
Mexico
10
10
Rank
10
Epidemics/pandemics
1957–1958 influenza pandemic
Disease
Influenza A/H2N2
Death toll
1–4 million
Percentage of population lost
Years
1957–1958
Location
Worldwide
11
11
Rank
11
Epidemics/pandemics
Hong Kong flu
Disease
Influenza A/H3N2
Death toll
1–4 million
Percentage of population lost
Years
1968–1969
Location
Worldwide
12
12
Rank
12
Epidemics/pandemics
1918–1922 Russia typhus epidemic
Disease
Typhus
Death toll
2–3 million
Percentage of population lost
1–1.6% of Russian population
Years
1918–1922
Location
Russia
13
13
Rank
13
Epidemics/pandemics
Cocoliztli epidemic of 1576
Disease
Cocoliztli
Death toll
2–2.5 million
Percentage of population lost
50% of Mexican population
Years
1576–1580
Location
Mexico
14
14
Rank
14
Epidemics/pandemics
1772–1773 Persian Plague
Disease
Bubonic plague
Death toll
2 million
Percentage of population lost
Years
1772–1773
Location
Persia
15
15
Rank
15
Epidemics/pandemics
735–737 Japanese smallpox epidemic
Disease
Smallpox
Death toll
2 million
Percentage of population lost
33% of Japanese population
Years
735–737
Location
Japan
16
16
Rank
16
Epidemics/pandemics
Naples Plague
Disease
Bubonic plague
Death toll
1.25 million
Percentage of population lost
Years
1656–1658
Location
Southern Italy
17
17
Rank
17
Epidemics/pandemics
1889–1890 pandemic
Disease
Influenza or human coronavirus OC43
Death toll
1 million
Percentage of population lost
Years
1889–1890
Location
Worldwide
18
18
Rank
18
Epidemics/pandemics
1629–1631 Italian plague
Disease
Bubonic plague
Death toll
1 million
Percentage of population lost
Years
1629–1631
Location
Italy
19
19
Rank
19
Epidemics/pandemics
1846–1860 cholera pandemic
Disease
Cholera
Death toll
1 million
Percentage of population lost
Years
1846–1860
Location
Worldwide
Rank
Epidemics/pandemics
Disease
Death toll
Percentage of population lost
Years
Location
1
1918 "Spanish" influenza pandemic
Influenza A/H1N1
17–100 million
of global population
1918–1920
Worldwide
2
Plague of Justinian
Bubonic plague
15–100 million
25–60% of European population
541–549
North Africa, Europe, and Western Asia
3
HIV/AIDS pandemic
HIV/AIDS
44 million (as of 2025[update])
1981–present
Worldwide
4
Black Death
Bubonic plague
25–50 million
30–60% of European population
1346–1353
Europe, Asia, and North Africa
5
COVID-19 pandemic
COVID-19
million(as of 2025)
2019–present
Worldwide
6
Third plague pandemic
Bubonic plague
12–15 million
1855–1960
Worldwide
7
Cocoliztli epidemic of 1545–1548
Cocoliztli, caused by an unidentified pathogen
5–15 million
27–80% of Mexican population
1545–1548
Mexico
8
Antonine Plague
Smallpox or measles
5–10 million
25–33% of Roman population
165–180 (possibly up to 190)
Roman Empire
9
1520 Mexico smallpox epidemic
Smallpox
5–8 million
23–37% of Mexican population
1519–1520
Mexico
10
1957–1958 influenza pandemic
Influenza A/H2N2
1–4 million
1957–1958
Worldwide
11
Hong Kong flu
Influenza A/H3N2
1–4 million
1968–1969
Worldwide
12
1918–1922 Russia typhus epidemic
Typhus
2–3 million
of Russian population
1918–1922
Russia
13
Cocoliztli epidemic of 1576
Cocoliztli
million
50% of Mexican population
1576–1580
Mexico
14
1772–1773 Persian Plague
Bubonic plague
2 million
1772–1773
Persia
15
735–737 Japanese smallpox epidemic
Smallpox
2 million
33% of Japanese population
735–737
Japan
16
Naples Plague
Bubonic plague
million
1656–1658
Southern Italy
17
1889–1890 pandemic
Influenza or human coronavirus OC43
1 million
1889–1890
Worldwide
18
1629–1631 Italian plague
Bubonic plague
1 million
1629–1631
Italy
19
1846–1860 cholera pandemic
Cholera
1 million
1846–1860
Worldwide
Chronological table of epidemic and pandemic events before the 1500s · Chronology › Pre-1500s
1350 BC plague of Megiddo
1350 BC plague of Megiddo
Event
1350 BC plague of Megiddo
Years
1350 BC (circa)
Location
Megiddo, land of Canaan
Disease
Amarna letters EA 244, Biridiya, the mayor of Megiddo complains to Amenhotep III of his area being "consumed by death, plague and dust"
Death toll (estimate)
Unknown
Hittite Plague/"Hand of Nergal"
Hittite Plague/"Hand of Nergal"
Event
Hittite Plague/"Hand of Nergal"
Years
1330 BC (circa)
Location
Near East, Hittite Empire, Alashiya, possibly Egypt
Disease
Unknown, possibly Tularemia. Mentioned in Amarna letter EA 35 as the "Hand of Nergal", cause of death of Šuppiluliuma I.
Death toll (estimate)
Unknown
Plague of Athens
Plague of Athens
Event
Plague of Athens
Years
430–426 BC
Location
Greece, Libya, Egypt, Ethiopia
Disease
Unknown, possibly typhus, typhoid fever or viral hemorrhagic fever
Death toll (estimate)
75,000–100,000
412 BC epidemic
412 BC epidemic
Event
412 BC epidemic
Years
412 BC
Location
Greece (Northern Greece, Roman Republic)
Disease
Unknown, possibly influenza
Death toll (estimate)
473,000 (10% of the Roman Population)
Antonine Plague
Antonine Plague
Event
Antonine Plague
Years
165–180 (possibly up to 190)
Location
Roman Empire
Disease
Unknown, possibly smallpox
Death toll (estimate)
5–10 million
Plague of Cyprian
Plague of Cyprian
Event
Plague of Cyprian
Years
249–262
Location
Europe
Disease
Unknown, possibly smallpox
Death toll (estimate)
310,000
Plague of Justinian (beginning of first plague pandemic)
Plague of Justinian (beginning of first plague pandemic)
Event
Plague of Justinian (beginning of first plague pandemic)
Years
541–549
Location
Europe and West Asia
Disease
Bubonic plague
Death toll (estimate)
15–100 million
580 Dysentery Epidemic in Gaul
580 Dysentery Epidemic in Gaul
Event
580 Dysentery Epidemic in Gaul
Years
580
Location
Gaul
Disease
Dysentery or possibly smallpox
Death toll (estimate)
450,000 (10% of the Gaul population)
Roman Plague of 590 (part of first plague pandemic)
Roman Plague of 590 (part of first plague pandemic)
Event
Roman Plague of 590 (part of first plague pandemic)
Years
590
Location
Rome, Byzantine Empire
Disease
Bubonic plague
Death toll (estimate)
Unknown
Plague of Sheroe (part of first plague pandemic)
Plague of Sheroe (part of first plague pandemic)
Event
Plague of Sheroe (part of first plague pandemic)
Years
627–628
Location
Bilad al-Sham
Disease
Bubonic plague
Death toll (estimate)
25,000+
Plague of Amwas (part of first plague pandemic)
Plague of Amwas (part of first plague pandemic)
Event
Plague of Amwas (part of first plague pandemic)
Years
638–639
Location
Byzantine Empire, West Asia, Africa
Disease
Bubonic plague
Death toll (estimate)
25,000+
Plague of 664 (part of first plague pandemic)
Plague of 664 (part of first plague pandemic)
Event
Plague of 664 (part of first plague pandemic)
Years
664–689
Location
British Isles
Disease
Bubonic plague
Death toll (estimate)
Unknown
Plague of 698–701 (part of first plague pandemic)
Plague of 698–701 (part of first plague pandemic)
Event
Plague of 698–701 (part of first plague pandemic)
Years
698–701
Location
Byzantine Empire, West Asia, Syria, Mesopotamia
Disease
Bubonic plague
Death toll (estimate)
Unknown
735–737 Japanese smallpox epidemic
735–737 Japanese smallpox epidemic
Event
735–737 Japanese smallpox epidemic
Years
735–737
Location
Japan
Disease
Smallpox
Death toll (estimate)
2 million (approx. .mw- .mw- .mw- .mw- 1⁄3 of Japanese population)
Plague of 746–747 (part of first plague pandemic)
Plague of 746–747 (part of first plague pandemic)
Event
Plague of 746–747 (part of first plague pandemic)
Years
746–747
Location
Byzantine Empire, West Asia, Africa
Disease
Bubonic plague
Death toll (estimate)
Unknown
Black Death (start of the second plague pandemic)
Black Death (start of the second plague pandemic)
Event
Black Death (start of the second plague pandemic)
Years
1346–1353
Location
Eurasia and North Africa
Disease
Bubonic plague
Death toll (estimate)
75–200 million (30–60% of European population and 33% percent of the Middle Eastern population)
Sweating sickness (multiple outbreaks)
Sweating sickness (multiple outbreaks)
Event
Sweating sickness (multiple outbreaks)
Years
1485–1551
Location
Britain (England) and later continental Europe
Disease
Unknown, possibly an unknown species of hantavirus
Death toll (estimate)
10,000+
1489 Spain typhus epidemic
1489 Spain typhus epidemic
Event
1489 Spain typhus epidemic
Years
1489
Location
Spain
Disease
Typhus
Death toll (estimate)
17,000
Event
Years
Location
Disease
Death toll (estimate)
Ref.
1350 BC plague of Megiddo
1350 BC (circa)
Megiddo, land of Canaan
Amarna letters EA 244, Biridiya, the mayor of Megiddo complains to Amenhotep III of his area being "consumed by death, plague and dust"
Unknown
Hittite Plague/"Hand of Nergal"
1330 BC (circa)
Near East, Hittite Empire, Alashiya, possibly Egypt
Unknown, possibly Tularemia. Mentioned in Amarna letter EA 35 as the "Hand of Nergal", cause of death of Šuppiluliuma I.
Unknown
Plague of Athens
430–426 BC
Greece, Libya, Egypt, Ethiopia
Unknown, possibly typhus, typhoid fever or viral hemorrhagic fever
75,000–100,000
412 BC epidemic
412 BC
Greece (Northern Greece, Roman Republic)
Unknown, possibly influenza
473,000 (10% of the Roman Population)
Antonine Plague
165–180 (possibly up to 190)
Roman Empire
Unknown, possibly smallpox
5–10 million
Jian'an Plague
217
Han dynasty
Unknown, possibly typhoid fever or viral hemorrhagic fever
2 million
Plague of Cyprian
249–262
Europe
Unknown, possibly smallpox
310,000
Plague of Justinian (beginning of first plague pandemic)
541–549
Europe and West Asia
Bubonic plague
15–100 million
580 Dysentery Epidemic in Gaul
580
Gaul
Dysentery or possibly smallpox
450,000 (10% of the Gaul population)
Roman Plague of 590 (part of first plague pandemic)
590
Rome, Byzantine Empire
Bubonic plague
Unknown
Plague of Sheroe (part of first plague pandemic)
627–628
Bilad al-Sham
Bubonic plague
25,000+
Plague of Amwas (part of first plague pandemic)
638–639
Byzantine Empire, West Asia, Africa
Bubonic plague
25,000+
Plague of 664 (part of first plague pandemic)
664–689
British Isles
Bubonic plague
Unknown
Plague of 698–701 (part of first plague pandemic)
698–701
Byzantine Empire, West Asia, Syria, Mesopotamia
Bubonic plague
Unknown
735–737 Japanese smallpox epidemic
735–737
Japan
Smallpox
2 million (approx. .mw- .mw- 1⁄3 of Japanese population)
Plague of 746–747 (part of first plague pandemic)
746–747
Byzantine Empire, West Asia, Africa
Bubonic plague
Unknown
Black Death (start of the second plague pandemic)
1346–1353
Eurasia and North Africa
Bubonic plague
75–200 million (30–60% of European population and 33% percent of the Middle Eastern population)
Sweating sickness (multiple outbreaks)
1485–1551
Britain (England) and later continental Europe
Unknown, possibly an unknown species of hantavirus
10,000+
1489 Spain typhus epidemic
1489
Spain
Typhus
17,000
Chronological table of epidemic and pandemic events that started in the 1500s · Chronology › 1500s
1510 influenza pandemic
1510 influenza pandemic
Event
1510 influenza pandemic
Years
1510
Location
Asia, North Africa, Europe
Disease
Influenza
Death toll (estimate)
Unknown, around 1% of those infected
1520 Mexico smallpox epidemic
1520 Mexico smallpox epidemic
Event
1520 Mexico smallpox epidemic
Years
1519–1520
Location
Mexico
Disease
Smallpox
Death toll (estimate)
5–8 million (40% of population)
Cocoliztli epidemic of 1545–1548
Cocoliztli epidemic of 1545–1548
Event
Cocoliztli epidemic of 1545–1548
Years
1545–1548
Location
Mexico
Disease
Possibly Salmonella enterica
Death toll (estimate)
5–15 million (80% of population)
1557 influenza pandemic
1557 influenza pandemic
Event
1557 influenza pandemic
Years
1557–1559
Location
Asia, Africa, Europe, and Americas
Disease
Influenza
Death toll (estimate)
2.5–5 Million (10% of the infected)
1561 Chile smallpox epidemic
1561 Chile smallpox epidemic
Event
1561 Chile smallpox epidemic
Years
1561–1562
Location
Chile
Disease
Smallpox
Death toll (estimate)
120,000–150,000 (20–25% of native population)
1563 London plague (part of the second plague pandemic)
1563 London plague (part of the second plague pandemic)
Event
1563 London plague (part of the second plague pandemic)
Years
1563–1564
Location
London, England
Disease
Bubonic plague
Death toll (estimate)
20,100+
Cocoliztli epidemic of 1576
Cocoliztli epidemic of 1576
Event
Cocoliztli epidemic of 1576
Years
1576–1580
Location
Mexico
Disease
Possibly Salmonella enterica
Death toll (estimate)
2–2.5 million (50% of population)
1582 Tenerife plague epidemic (part of the second plague pandemic)
1582 Tenerife plague epidemic (part of the second plague pandemic)
Event
1582 Tenerife plague epidemic (part of the second plague pandemic)
Years
1582–1583
Location
Tenerife, Spain
Disease
Bubonic plague
Death toll (estimate)
5,000–9,000
1592–1596 Seneca nation measles epidemic
1592–1596 Seneca nation measles epidemic
Event
1592–1596 Seneca nation measles epidemic
Years
1592–1596
Location
Seneca nation, North America
Disease
Measles
Death toll (estimate)
Unknown
1592–1593 Malta plague epidemic (part of the second plague pandemic)
1592–1593 Malta plague epidemic (part of the second plague pandemic)
Event
1592–1593 Malta plague epidemic (part of the second plague pandemic)
Years
1592–1593
Location
Malta
Disease
Bubonic plague
Death toll (estimate)
3,000
1592–1593 London plague (part of the second plague pandemic)
1592–1593 London plague (part of the second plague pandemic)
Event
1592–1593 London plague (part of the second plague pandemic)
Years
1592–1593
Location
London, England
Disease
Bubonic plague
Death toll (estimate)
19,900+
1596–1602 Spain plague epidemic (part of the second plague pandemic)
1596–1602 Spain plague epidemic (part of the second plague pandemic)
Event
1596–1602 Spain plague epidemic (part of the second plague pandemic)
Years
1596–1602
Location
Spain
Disease
Bubonic plague
Death toll (estimate)
600,000–700,000
Event
Years
Location
Disease
Death toll (estimate)
Ref.
1510 influenza pandemic
1510
Asia, North Africa, Europe
Influenza
Unknown, around 1% of those infected
1520 Mexico smallpox epidemic
1519–1520
Mexico
Smallpox
5–8 million (40% of population)
Cocoliztli epidemic of 1545–1548
1545–1548
Mexico
Possibly Salmonella enterica
5–15 million (80% of population)
1557 influenza pandemic
1557–1559
Asia, Africa, Europe, and Americas
Influenza
Million (10% of the infected)
1561 Chile smallpox epidemic
1561–1562
Chile
Smallpox
120,000–150,000 (20–25% of native population)
1563 London plague (part of the second plague pandemic)
1563–1564
London, England
Bubonic plague
20,100+
Cocoliztli epidemic of 1576
1576–1580
Mexico
Possibly Salmonella enterica
million (50% of population)
1582 Tenerife plague epidemic (part of the second plague pandemic)
1582–1583
Tenerife, Spain
Bubonic plague
5,000–9,000
1592–1596 Seneca nation measles epidemic
1592–1596
Seneca nation, North America
Measles
Unknown
1592–1593 Malta plague epidemic (part of the second plague pandemic)
1592–1593
Malta
Bubonic plague
3,000
1592–1593 London plague (part of the second plague pandemic)
1592–1593
London, England
Bubonic plague
19,900+
1596–1602 Spain plague epidemic (part of the second plague pandemic)
1596–1602
Spain
Bubonic plague
600,000–700,000
Chronological table of epidemic and pandemic events that started in the 1600s · Chronology › 1600s
1600–1650 South America malaria epidemic
1600–1650 South America malaria epidemic
Event
1600–1650 South America malaria epidemic
Years
1600–1650
Location
South America
Disease
Malaria
Death toll (estimate)
Unknown
Ref.
[citation needed]
1603 London plague (part of the second plague pandemic)
1603 London plague (part of the second plague pandemic)
Event
1603 London plague (part of the second plague pandemic)
Years
1603
Location
London, England
Disease
Bubonic plague
Death toll (estimate)
40,000
1616 New England infections epidemic
1616 New England infections epidemic
Event
1616 New England infections epidemic
Years
1616–1620
Location
Southern New England, British North America, especially the Wampanoag people
Disease
Unknown, possibly leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D
Death toll (estimate)
1,143,000–3,429,000 (estimated 30–90% of population)
1629–1631 Italian plague (part of the second plague pandemic)
1629–1631 Italian plague (part of the second plague pandemic)
Event
1629–1631 Italian plague (part of the second plague pandemic)
Years
1629–1631
Location
Italy
Disease
Bubonic plague
Death toll (estimate)
1 million
1632–1635 Augsburg plague epidemic (part of the second plague pandemic)
1632–1635 Augsburg plague epidemic (part of the second plague pandemic)
Event
1632–1635 Augsburg plague epidemic (part of the second plague pandemic)
Years
1632–1635
Location
Augsburg, Germany
Disease
Bubonic plague
Death toll (estimate)
13,712
Massachusetts smallpox epidemic
Massachusetts smallpox epidemic
Event
Massachusetts smallpox epidemic
Years
1633–1634
Location
Massachusetts Bay Colony, Thirteen Colonies
Disease
Smallpox
Death toll (estimate)
1,000
1634–1640 Wyandot people epidemic
1634–1640 Wyandot people epidemic
Event
1634–1640 Wyandot people epidemic
Years
1634–1640
Location
Wyandot people, North America
Disease
Smallpox and Influenza
Death toll (estimate)
15,000–25,000
1637 London plague epidemic (part of the second plague pandemic)
1637 London plague epidemic (part of the second plague pandemic)
Event
1637 London plague epidemic (part of the second plague pandemic)
Years
1636–1637
Location
London and Westminster, England
Disease
Bubonic plague
Death toll (estimate)
10,400
Great Plague of Seville (part of the second plague pandemic)
Great Plague of Seville (part of the second plague pandemic)
Event
Great Plague of Seville (part of the second plague pandemic)
Years
1647–1652
Location
Spain
Disease
Bubonic plague
Death toll (estimate)
500,000
1648 Central America yellow fever epidemic
1648 Central America yellow fever epidemic
Event
1648 Central America yellow fever epidemic
Years
1648
Location
Central America
Disease
Yellow fever
Death toll (estimate)
Unknown
Naples Plague (part of the second plague pandemic)
Naples Plague (part of the second plague pandemic)
Event
Naples Plague (part of the second plague pandemic)
Years
1656–1658
Location
Italy
Disease
Bubonic plague
Death toll (estimate)
1,250,000
1663–1664 Amsterdam plague epidemic (part of the second plague pandemic)
1663–1664 Amsterdam plague epidemic (part of the second plague pandemic)
Event
1663–1664 Amsterdam plague epidemic (part of the second plague pandemic)
Years
1663–1664
Location
Amsterdam, Netherlands
Disease
Bubonic plague
Death toll (estimate)
24,148
Great Plague of London (part of the second plague pandemic)
Great Plague of London (part of the second plague pandemic)
Event
Great Plague of London (part of the second plague pandemic)
Years
1665–1666
Location
England
Disease
Bubonic plague
Death toll (estimate)
100,000
1668 France plague (part of the second plague pandemic)
1668 France plague (part of the second plague pandemic)
Event
1668 France plague (part of the second plague pandemic)
Years
1668
Location
France
Disease
Bubonic plague
Death toll (estimate)
40,000
1675–1676 Malta plague epidemic (part of the second plague pandemic)
1675–1676 Malta plague epidemic (part of the second plague pandemic)
Event
1675–1676 Malta plague epidemic (part of the second plague pandemic)
Years
1675–1676
Location
Malta
Disease
Bubonic plague
Death toll (estimate)
11,300
1676–1685 Spain plague (part of the second plague pandemic)
1676–1685 Spain plague (part of the second plague pandemic)
Event
1676–1685 Spain plague (part of the second plague pandemic)
Years
1676–1685
Location
Spain
Disease
Bubonic plague
Death toll (estimate)
Unknown
1677–1678 Boston smallpox epidemic
1677–1678 Boston smallpox epidemic
Event
1677–1678 Boston smallpox epidemic
Years
1677–1678
Location
Massachusetts Bay Colony, British North America
Disease
Smallpox
Death toll (estimate)
750–1,000
Great Plague of Vienna (part of the second plague pandemic)
Great Plague of Vienna (part of the second plague pandemic)
Event
Great Plague of Vienna (part of the second plague pandemic)
Years
1679
Location
Vienna, Austria
Disease
Bubonic plague
Death toll (estimate)
76,000
1681 Prague plague epidemic (part of the second plague pandemic)
1681 Prague plague epidemic (part of the second plague pandemic)
Event
1681 Prague plague epidemic (part of the second plague pandemic)
Years
1681
Location
Prague, Czech Kingdom
Disease
Bubonic plague
Death toll (estimate)
83,000
1687 South Africa influenza outbreak
1687 South Africa influenza outbreak
Event
1687 South Africa influenza outbreak
Years
1687
Location
South Africa
Disease
Unknown, possibly influenza
Death toll (estimate)
Unknown
1693 Boston yellow fever epidemic
1693 Boston yellow fever epidemic
Event
1693 Boston yellow fever epidemic
Years
1693
Location
Boston, Massachusetts Bay Colony, British North America
Disease
Yellow fever
Death toll (estimate)
3,100+
1699 Charleston and Philadelphia yellow fever epidemic
1699 Charleston and Philadelphia yellow fever epidemic
Event
1699 Charleston and Philadelphia yellow fever epidemic
Years
1699
Location
Charleston and Philadelphia, British North America
Disease
Yellow fever
Death toll (estimate)
520 (300 in Charleston, 220 in Philadelphia)
Event
Years
Location
Disease
Death toll (estimate)
Ref.
1600–1650 South America malaria epidemic
1600–1650
South America
Malaria
Unknown
[citation needed]
1603 London plague (part of the second plague pandemic)
1603
London, England
Bubonic plague
40,000
1616 New England infections epidemic
1616–1620
Southern New England, British North America, especially the Wampanoag people
Unknown, possibly leptospirosis with Weil syndrome. Classic explanations include yellow fever, bubonic plague, influenza, smallpox, chickenpox, typhus, and syndemic infection of hepatitis B and hepatitis D
1,143,000–3,429,000 (estimated 30–90% of population)
1629–1631 Italian plague (part of the second plague pandemic)
1629–1631
Italy
Bubonic plague
1 million
1632–1635 Augsburg plague epidemic (part of the second plague pandemic)
1632–1635
Augsburg, Germany
Bubonic plague
13,712
Massachusetts smallpox epidemic
1633–1634
Massachusetts Bay Colony, Thirteen Colonies
Smallpox
1,000
1634–1640 Wyandot people epidemic
1634–1640
Wyandot people, North America
Smallpox and Influenza
15,000–25,000
1637 London plague epidemic (part of the second plague pandemic)
1636–1637
London and Westminster, England
Bubonic plague
10,400
Great Plague in the late Ming dynasty (part of the second plague pandemic)
1633–1644
China
Bubonic plague
200,000+
Great Plague of Seville (part of the second plague pandemic)
1647–1652
Spain
Bubonic plague
500,000
1648 Central America yellow fever epidemic
1648
Central America
Yellow fever
Unknown
Naples Plague (part of the second plague pandemic)
1656–1658
Italy
Bubonic plague
1,250,000
1663–1664 Amsterdam plague epidemic (part of the second plague pandemic)
1663–1664
Amsterdam, Netherlands
Bubonic plague
24,148
Great Plague of London (part of the second plague pandemic)
1665–1666
England
Bubonic plague
100,000
1668 France plague (part of the second plague pandemic)
1668
France
Bubonic plague
40,000
1675–1676 Malta plague epidemic (part of the second plague pandemic)
1675–1676
Malta
Bubonic plague
11,300
1676–1685 Spain plague (part of the second plague pandemic)
1676–1685
Spain
Bubonic plague
Unknown
1677–1678 Boston smallpox epidemic
1677–1678
Massachusetts Bay Colony, British North America
Smallpox
750–1,000
Great Plague of Vienna (part of the second plague pandemic)
1679
Vienna, Austria
Bubonic plague
76,000
1681 Prague plague epidemic (part of the second plague pandemic)
1681
Prague, Czech Kingdom
Bubonic plague
83,000
1687 South Africa influenza outbreak
1687
South Africa
Unknown, possibly influenza
Unknown
1693 Boston yellow fever epidemic
1693
Boston, Massachusetts Bay Colony, British North America
Yellow fever
3,100+
1699 Charleston and Philadelphia yellow fever epidemic
1699
Charleston and Philadelphia, British North America
Yellow fever
520 (300 in Charleston, 220 in Philadelphia)
Chronological table of epidemic and pandemic events that started in the 1700s · Chronology › 1700s
1702 New York City yellow fever epidemic
1702 New York City yellow fever epidemic
Event
1702 New York City yellow fever epidemic
Years
1702
Location
New York City, British North America
Disease
Yellow fever
Death toll (estimate)
500
1702–1703 St. Lawrence Valley smallpox epidemic
1702–1703 St. Lawrence Valley smallpox epidemic
Event
1702–1703 St. Lawrence Valley smallpox epidemic
Years
1702–1703
Location
New France, Canada
Disease
Smallpox
Death toll (estimate)
1,300
1707–1708 Iceland smallpox epidemic
1707–1708 Iceland smallpox epidemic
Event
1707–1708 Iceland smallpox epidemic
Years
1707–1709
Location
Iceland
Disease
Smallpox
Death toll (estimate)
18,000+ (36% of population)
Great Northern War plague outbreak (part of the second plague pandemic)
Great Northern War plague outbreak (part of the second plague pandemic)
Event
Great Northern War plague outbreak (part of the second plague pandemic)
Years
1710–1712
Location
Denmark, Sweden, Lithuania
Disease
Bubonic plague
Death toll (estimate)
164,000
1713–1715 North America measles epidemic
1713–1715 North America measles epidemic
Event
1713–1715 North America measles epidemic
Years
1713–1715
Location
Thirteen Colonies and New France, Canada
Disease
Measles
Death toll (estimate)
Unknown
Great Plague of Marseille (part of the second plague pandemic)
Great Plague of Marseille (part of the second plague pandemic)
Event
Great Plague of Marseille (part of the second plague pandemic)
Years
1720–1722
Location
France
Disease
Bubonic plague
Death toll (estimate)
100,000+
1721 Boston smallpox outbreak
1721 Boston smallpox outbreak
Event
1721 Boston smallpox outbreak
Years
1721–1722
Location
Massachusetts Bay Colony
Disease
Smallpox
Death toll (estimate)
844
1730 Cádiz yellow fever epidemic
1730 Cádiz yellow fever epidemic
Event
1730 Cádiz yellow fever epidemic
Years
1730
Location
Cádiz, Spain
Disease
Yellow fever
Death toll (estimate)
2,200
1732–1733 Thirteen Colonies influenza epidemic
1732–1733 Thirteen Colonies influenza epidemic
Event
1732–1733 Thirteen Colonies influenza epidemic
Years
1732–1733
Location
Thirteen Colonies
Disease
Influenza
Death toll (estimate)
Unknown
1733 New France smallpox epidemic
1733 New France smallpox epidemic
Event
1733 New France smallpox epidemic
Years
1733
Location
New France, Canada
Disease
Smallpox
Death toll (estimate)
Unknown
1735–1741 diphtheria epidemic
1735–1741 diphtheria epidemic
Event
1735–1741 diphtheria epidemic
Years
1735–1741
Location
New England, Province of New York, Province of New Jersey, British North America
Disease
Diphtheria
Death toll (estimate)
20,000
Great Plague of 1738 (part of the second plague pandemic)
Great Plague of 1738 (part of the second plague pandemic)
Event
Great Plague of 1738 (part of the second plague pandemic)
Years
1738
Location
Balkans
Disease
Bubonic plague
Death toll (estimate)
50,000
1738–1739 North Carolina smallpox epidemic
1738–1739 North Carolina smallpox epidemic
Event
1738–1739 North Carolina smallpox epidemic
Years
1738–1739
Location
Province of Carolina, Thirteen Colonies
Disease
Smallpox
Death toll (estimate)
7,700–11,700
1741 Cartagena yellow fever epidemic
1741 Cartagena yellow fever epidemic
Event
1741 Cartagena yellow fever epidemic
Years
1741
Location
Cartagena, Colombia
Disease
Yellow fever
Death toll (estimate)
20,000
1743 Sicily plague epidemic (part of the second plague pandemic)
1743 Sicily plague epidemic (part of the second plague pandemic)
Event
1743 Sicily plague epidemic (part of the second plague pandemic)
Years
1743
Location
Messina, Sicily, Italy
Disease
Bubonic plague
Death toll (estimate)
40,000–50,000
1759 North America measles outbreak
1759 North America measles outbreak
Event
1759 North America measles outbreak
Years
1759
Location
North America
Disease
Measles
Death toll (estimate)
Unknown
1760 Charleston smallpox epidemic
1760 Charleston smallpox epidemic
Event
1760 Charleston smallpox epidemic
Years
1760
Location
Charleston, British North America
Disease
Smallpox
Death toll (estimate)
730–940
1762 Havana yellow fever epidemic
1762 Havana yellow fever epidemic
Event
1762 Havana yellow fever epidemic
Years
1762
Location
Havana, Cuba
Disease
Yellow fever
Death toll (estimate)
8,000
1763 Pittsburgh area smallpox outbreak
1763 Pittsburgh area smallpox outbreak
Event
1763 Pittsburgh area smallpox outbreak
Years
1763
Location
North America, present-day Pittsburgh area
Disease
Smallpox
Death toll (estimate)
Unknown
1770–1772 Russian plague (part of the second plague pandemic)
1770–1772 Russian plague (part of the second plague pandemic)
Event
1770–1772 Russian plague (part of the second plague pandemic)
Years
1770–1772
Location
Russia
Disease
Bubonic plague
Death toll (estimate)
50,000
1772 North America measles epidemic
1772 North America measles epidemic
Event
1772 North America measles epidemic
Years
1772
Location
North America
Disease
Measles
Death toll (estimate)
1,080
1772–1773 Persian Plague (part of the second plague pandemic)
1772–1773 Persian Plague (part of the second plague pandemic)
Event
1772–1773 Persian Plague (part of the second plague pandemic)
Years
1772–1773
Location
Persia
Disease
Bubonic plague
Death toll (estimate)
2 million
1775–1776 England influenza outbreak
1775–1776 England influenza outbreak
Event
1775–1776 England influenza outbreak
Years
1775–1776
Location
England
Disease
Influenza
Death toll (estimate)
Unknown
1775–1782 North American smallpox epidemic
1775–1782 North American smallpox epidemic
Event
1775–1782 North American smallpox epidemic
Years
1775–1782
Location
Native populations in what is now the Pacific Northwest of the United States
Disease
Smallpox
Death toll (estimate)
11,000+
1778 Spain dengue fever outbreak
1778 Spain dengue fever outbreak
Event
1778 Spain dengue fever outbreak
Years
1778
Location
Spain
Disease
Dengue fever
Death toll (estimate)
Unknown
1782 Influenza pandemic
1782 Influenza pandemic
Event
1782 Influenza pandemic
Years
1782
Location
Worldwide
Disease
Influenza
Death toll (estimate)
Unknown
1788 Pueblo Indians smallpox epidemic
1788 Pueblo Indians smallpox epidemic
Event
1788 Pueblo Indians smallpox epidemic
Years
1788
Location
Pueblo Indians in northern New Spain (what is now the Southwestern United States)
Disease
Smallpox
Death toll (estimate)
Unknown
1789–1790 New South Wales smallpox epidemic
1789–1790 New South Wales smallpox epidemic
Event
1789–1790 New South Wales smallpox epidemic
Years
1789–1790
Location
New South Wales, Australia
Disease
Smallpox
Death toll (estimate)
125,251–175,351 (50–70% of native population)
1793 Philadelphia yellow fever epidemic
1793 Philadelphia yellow fever epidemic
Event
1793 Philadelphia yellow fever epidemic
Years
1793
Location
Philadelphia, United States
Disease
Yellow fever
Death toll (estimate)
5,000+
Event
Years
Location
Disease
Death toll (estimate)
Ref.
1702 New York City yellow fever epidemic
1702
New York City, British North America
Yellow fever
500
1702–1703 St. Lawrence Valley smallpox epidemic
1702–1703
New France, Canada
Smallpox
1,300
1707–1708 Iceland smallpox epidemic
1707–1709
Iceland
Smallpox
18,000+ (36% of population)
Great Northern War plague outbreak (part of the second plague pandemic)
1710–1712
Denmark, Sweden, Lithuania
Bubonic plague
164,000
1713–1715 North America measles epidemic
1713–1715
Thirteen Colonies and New France, Canada
Measles
Unknown
Great Plague of Marseille (part of the second plague pandemic)
1720–1722
France
Bubonic plague
100,000+
1721 Boston smallpox outbreak
1721–1722
Massachusetts Bay Colony
Smallpox
844
1730 Cádiz yellow fever epidemic
1730
Cádiz, Spain
Yellow fever
2,200
1732–1733 Thirteen Colonies influenza epidemic
1732–1733
Thirteen Colonies
Influenza
Unknown
1733 New France smallpox epidemic
1733
New France, Canada
Smallpox
Unknown
1735–1741 diphtheria epidemic
1735–1741
New England, Province of New York, Province of New Jersey, British North America
Diphtheria
20,000
Great Plague of 1738 (part of the second plague pandemic)
1738
Balkans
Bubonic plague
50,000
1738–1739 North Carolina smallpox epidemic
1738–1739
Province of Carolina, Thirteen Colonies
Smallpox
7,700–11,700
1741 Cartagena yellow fever epidemic
1741
Cartagena, Colombia
Yellow fever
20,000
1743 Sicily plague epidemic (part of the second plague pandemic)
1743
Messina, Sicily, Italy
Bubonic plague
40,000–50,000
1759 North America measles outbreak
1759
North America
Measles
Unknown
1760 Charleston smallpox epidemic
1760
Charleston, British North America
Smallpox
730–940
1762 Havana yellow fever epidemic
1762
Havana, Cuba
Yellow fever
8,000
1763 Pittsburgh area smallpox outbreak
1763
North America, present-day Pittsburgh area
Smallpox
Unknown
1770–1772 Russian plague (part of the second plague pandemic)
1770–1772
Russia
Bubonic plague
50,000
1772 North America measles epidemic
1772
North America
Measles
1,080
1772–1773 Persian Plague (part of the second plague pandemic)
1772–1773
Persia
Bubonic plague
2 million
1775–1776 England influenza outbreak
1775–1776
England
Influenza
Unknown
1775–1782 North American smallpox epidemic
1775–1782
Native populations in what is now the Pacific Northwest of the United States
Smallpox
11,000+
1778 Spain dengue fever outbreak
1778
Spain
Dengue fever
Unknown
1782 Influenza pandemic
1782
Worldwide
Influenza
Unknown
1788 Pueblo Indians smallpox epidemic
1788
Pueblo Indians in northern New Spain (what is now the Southwestern United States)
Smallpox
Unknown
1789–1790 New South Wales smallpox epidemic
1789–1790
New South Wales, Australia
Smallpox
125,251–175,351 (50–70% of native population)
1793 Philadelphia yellow fever epidemic
1793
Philadelphia, United States
Yellow fever
5,000+
Chronological table of epidemic and pandemic events that started in the 1800s · Chronology › 1800s
1800–1803 Spain yellow fever epidemic
1800–1803 Spain yellow fever epidemic
Event
1800–1803 Spain yellow fever epidemic
Years
1800–1803
Location
Spain
Disease
Yellow fever
Death toll (estimate)
60,000+
1801 Ottoman Empire and Egypt bubonic plague epidemic
1801 Ottoman Empire and Egypt bubonic plague epidemic
Event
1801 Ottoman Empire and Egypt bubonic plague epidemic
Years
1801
Location
Ottoman Empire, Egypt
Disease
Bubonic plague
Death toll (estimate)
Unknown
1802–1803 Saint-Domingue yellow fever epidemic
1802–1803 Saint-Domingue yellow fever epidemic
Event
1802–1803 Saint-Domingue yellow fever epidemic
Years
1802–1803
Location
Saint-Domingue
Disease
Yellow fever
Death toll (estimate)
29,000–55,000
1812 Russia typhus epidemic
1812 Russia typhus epidemic
Event
1812 Russia typhus epidemic
Years
1812
Location
Russia
Disease
Typhus
Death toll (estimate)
300,000
1812–1819 Ottoman plague epidemic (part of the second plague pandemic)
1812–1819 Ottoman plague epidemic (part of the second plague pandemic)
Event
1812–1819 Ottoman plague epidemic (part of the second plague pandemic)
Years
1812–1819
Location
Ottoman Empire
Disease
Bubonic plague
Death toll (estimate)
300,000+
1813–1814 Malta plague epidemic (part of the second plague pandemic)
1813–1814 Malta plague epidemic (part of the second plague pandemic)
Event
1813–1814 Malta plague epidemic (part of the second plague pandemic)
Years
1813–1814
Location
Malta
Disease
Bubonic plague
Death toll (estimate)
4,500
Caragea's plague (part of the second plague pandemic)
Caragea's plague (part of the second plague pandemic)
Event
Caragea's plague (part of the second plague pandemic)
Years
1813
Location
Romania
Disease
Bubonic plague
Death toll (estimate)
60,000
1817–1819 Ireland typhus epidemic
1817–1819 Ireland typhus epidemic
Event
1817–1819 Ireland typhus epidemic
Years
1817–1819
Location
Ireland
Disease
Typhus
Death toll (estimate)
65,000
First cholera pandemic
First cholera pandemic
Event
First cholera pandemic
Years
1817–1824
Location
Asia, Europe
Disease
Cholera
Death toll (estimate)
100,000+
1820 Savannah yellow fever epidemic
1820 Savannah yellow fever epidemic
Event
1820 Savannah yellow fever epidemic
Years
1820
Location
Savannah, Georgia, United States
Disease
Yellow fever
Death toll (estimate)
700
1821 Barcelona yellow fever epidemic
1821 Barcelona yellow fever epidemic
Event
1821 Barcelona yellow fever epidemic
Years
1821
Location
Barcelona, Spain
Disease
Yellow fever
Death toll (estimate)
5,000–20,000
Second cholera pandemic
Second cholera pandemic
Event
Second cholera pandemic
Years
1826–1837
Location
Asia, Europe, North America
Disease
Cholera
Death toll (estimate)
100,000+
1828–1829 New South Wales smallpox epidemic
1828–1829 New South Wales smallpox epidemic
Event
1828–1829 New South Wales smallpox epidemic
Years
1828–1829
Location
New South Wales, Australia
Disease
Smallpox
Death toll (estimate)
19,000
Groningen epidemic
Groningen epidemic
Event
Groningen epidemic
Years
1829
Location
Netherlands
Disease
Malaria
Death toll (estimate)
2,800
1829–1833 Pacific Northwest malaria epidemic
1829–1833 Pacific Northwest malaria epidemic
Event
1829–1833 Pacific Northwest malaria epidemic
Years
1829–1833
Location
Pacific Northwest, United States
Disease
Malaria, possibly other diseases too
Death toll (estimate)
150,000
1829–1835 Iran plague outbreak
1829–1835 Iran plague outbreak
Event
1829–1835 Iran plague outbreak
Years
1829–1835
Location
Iran
Disease
Bubonic plague
Death toll (estimate)
Unknown
1834–1836 Egypt plague epidemic
1834–1836 Egypt plague epidemic
Event
1834–1836 Egypt plague epidemic
Years
1834–1836
Location
Egypt
Disease
Bubonic plague
Death toll (estimate)
Unknown
1837 Great Plains smallpox epidemic
1837 Great Plains smallpox epidemic
Event
1837 Great Plains smallpox epidemic
Years
1837–1838
Location
Great Plains, United States and Canada
Disease
Smallpox
Death toll (estimate)
17,000+
1841 Southern United States yellow fever epidemic
1841 Southern United States yellow fever epidemic
Event
1841 Southern United States yellow fever epidemic
Years
1841
Location
Southern United States (especially Louisiana and Florida)
Disease
Yellow fever
Death toll (estimate)
3,498
1847 North American typhus epidemic
1847 North American typhus epidemic
Event
1847 North American typhus epidemic
Years
1847–1848
Location
Canada
Disease
Typhus
Death toll (estimate)
20,000+
1847 Southern United States yellow fever epidemic
1847 Southern United States yellow fever epidemic
Event
1847 Southern United States yellow fever epidemic
Years
1847
Location
Southern United States (especially New Orleans)
Disease
Yellow fever
Death toll (estimate)
3,400
1847–1848 influenza epidemic
1847–1848 influenza epidemic
Event
1847–1848 influenza epidemic
Years
1847–1848
Location
Worldwide
Disease
Influenza
Death toll (estimate)
Unknown
1848–1849 Hawaii epidemic of infections
1848–1849 Hawaii epidemic of infections
Event
1848–1849 Hawaii epidemic of infections
Years
1848–1849
Location
Hawaiian Kingdom
Disease
Measles, whooping cough, dysentery and influenza
Death toll (estimate)
10,000
1853 New Orleans yellow fever epidemic
1853 New Orleans yellow fever epidemic
Event
1853 New Orleans yellow fever epidemic
Years
1853
Location
New Orleans, United States
Disease
Yellow fever
Death toll (estimate)
7,970
Third cholera pandemic
Third cholera pandemic
Event
Third cholera pandemic
Years
1846–1860
Location
Worldwide
Disease
Cholera
Death toll (estimate)
1 million+
1853 Ottoman Empire plague epidemic
1853 Ottoman Empire plague epidemic
Event
1853 Ottoman Empire plague epidemic
Years
1853
Location
Ottoman Empire
Disease
Bubonic plague
Death toll (estimate)
Unknown
1853 Copenhagen cholera outbreak
1853 Copenhagen cholera outbreak
Event
1853 Copenhagen cholera outbreak
Years
1853
Location
Copenhagen, Denmark
Disease
Cholera
Death toll (estimate)
4,737
1854 Broad Street cholera outbreak
1854 Broad Street cholera outbreak
Event
1854 Broad Street cholera outbreak
Years
1854
Location
London, England
Disease
Cholera
Death toll (estimate)
616
1855 Norfolk yellow fever epidemic
1855 Norfolk yellow fever epidemic
Event
1855 Norfolk yellow fever epidemic
Years
1855
Location
Norfolk and Portsmouth, England
Disease
Yellow fever
Death toll (estimate)
3,000 (2,000 in Norfolk, 1,000 in Portsmouth)
Third plague pandemic
Third plague pandemic
Event
Third plague pandemic
Years
1855–1960
Location
Worldwide
Disease
Bubonic plague
Death toll (estimate)
12–15 million (India and China)
1855–1857 Montevideo yellow fever epidemic
1855–1857 Montevideo yellow fever epidemic
Event
1855–1857 Montevideo yellow fever epidemic
Years
1855–1857
Location
Montevideo, Uruguay
Disease
Yellow fever
Death toll (estimate)
3,400 (first wave; 900, second wave; 2,500)
1857 Lisbon yellow fever epidemic
1857 Lisbon yellow fever epidemic
Event
1857 Lisbon yellow fever epidemic
Years
1857
Location
Lisbon, Portugal
Disease
Yellow fever
Death toll (estimate)
6,000
1857 Victoria smallpox epidemic
1857 Victoria smallpox epidemic
Event
1857 Victoria smallpox epidemic
Years
1857
Location
Victoria, Australia
Disease
Smallpox
Death toll (estimate)
Unknown
1857–1859 Europe and the Americas influenza epidemic
1857–1859 Europe and the Americas influenza epidemic
Event
1857–1859 Europe and the Americas influenza epidemic
Years
1857–1859
Location
Europe, North America, South America
Disease
Influenza
Death toll (estimate)
Unknown
1862 Pacific Northwest smallpox epidemic
1862 Pacific Northwest smallpox epidemic
Event
1862 Pacific Northwest smallpox epidemic
Years
1862–1863
Location
Pacific Northwest, Canada and United States
Disease
Smallpox
Death toll (estimate)
20,000+
1861–1865 United States typhoid fever epidemic
1861–1865 United States typhoid fever epidemic
Event
1861–1865 United States typhoid fever epidemic
Years
1861–1865
Location
United States
Disease
Typhoid fever
Death toll (estimate)
80,000
Fourth cholera pandemic
Fourth cholera pandemic
Event
Fourth cholera pandemic
Years
1863–1875
Location
Middle East
Disease
Cholera
Death toll (estimate)
600,000
1867 Sydney measles epidemic
1867 Sydney measles epidemic
Event
1867 Sydney measles epidemic
Years
1867
Location
Sydney, Australia
Disease
Measles
Death toll (estimate)
748
1871 Buenos Aires yellow fever epidemic
1871 Buenos Aires yellow fever epidemic
Event
1871 Buenos Aires yellow fever epidemic
Years
1871
Location
Buenos Aires, Argentina
Disease
Yellow fever
Death toll (estimate)
13,500–26,200
1870–1875 Europe smallpox epidemic
1870–1875 Europe smallpox epidemic
Event
1870–1875 Europe smallpox epidemic
Years
1870–1875
Location
Europe
Disease
Smallpox
Death toll (estimate)
500,000
1875 Fiji measles outbreak
1875 Fiji measles outbreak
Event
1875 Fiji measles outbreak
Years
1875
Location
Fiji
Disease
Measles
Death toll (estimate)
40,000
1875–1876 Australia scarlet fever epidemic
1875–1876 Australia scarlet fever epidemic
Event
1875–1876 Australia scarlet fever epidemic
Years
1875–1876
Location
Australia
Disease
Scarlet fever
Death toll (estimate)
8,000
1876 Ottoman Empire plague epidemic
1876 Ottoman Empire plague epidemic
Event
1876 Ottoman Empire plague epidemic
Years
1876
Location
Ottoman Empire
Disease
Bubonic plague
Death toll (estimate)
20,000
1878 New Orleans yellow fever epidemic
1878 New Orleans yellow fever epidemic
Event
1878 New Orleans yellow fever epidemic
Years
1878
Location
New Orleans, United States
Disease
Yellow fever
Death toll (estimate)
4,046
1878 Mississippi Valley yellow fever epidemic
1878 Mississippi Valley yellow fever epidemic
Event
1878 Mississippi Valley yellow fever epidemic
Years
1878
Location
Mississippi Valley, United States
Disease
Yellow fever
Death toll (estimate)
13,000
Fifth cholera pandemic
Fifth cholera pandemic
Event
Fifth cholera pandemic
Years
1881–1896
Location
Asia, Africa, Europe, South America
Disease
Cholera
Death toll (estimate)
298,600
1885 Montreal smallpox epidemic
1885 Montreal smallpox epidemic
Event
1885 Montreal smallpox epidemic
Years
1885
Location
Montreal, Canada
Disease
Smallpox
Death toll (estimate)
3,164
1889–1890 pandemic
1889–1890 pandemic
Event
1889–1890 pandemic
Years
1889–1890
Location
Worldwide
Disease
Influenza or Human coronavirus OC43 / HCoV-OC43 (disputed)
Death toll (estimate)
1 million
1894 Hong Kong plague (part of the third plague pandemic)
1894 Hong Kong plague (part of the third plague pandemic)
Event
1894 Hong Kong plague (part of the third plague pandemic)
Years
1894–1929
Location
Hong Kong
Disease
Bubonic plague
Death toll (estimate)
20,000+
Bombay plague epidemic (part of the third plague pandemic)
Bombay plague epidemic (part of the third plague pandemic)
Event
Bombay plague epidemic (part of the third plague pandemic)
Years
1896–1905
Location
Bombay, India
Disease
Bubonic plague
Death toll (estimate)
20,788
1896–1906 Congo Basin African trypanosomiasis epidemic
1896–1906 Congo Basin African trypanosomiasis epidemic
Event
1896–1906 Congo Basin African trypanosomiasis epidemic
Years
1896–1906
Location
Congo Basin
Disease
African trypanosomiasis
Death toll (estimate)
500,000
1899 Porto plague outbreak (part of the third plague pandemic)
1899 Porto plague outbreak (part of the third plague pandemic)
Event
1899 Porto plague outbreak (part of the third plague pandemic)
Years
1899
Location
Porto, Portugal
Disease
Bubonic plague
Death toll (estimate)
132
Sixth cholera pandemic
Sixth cholera pandemic
Event
Sixth cholera pandemic
Years
1899–1923
Location
Europe, Asia, Africa
Disease
Cholera
Death toll (estimate)
800,000+
Event
Years
Location
Disease
Death toll (estimate)
Ref.
1800–1803 Spain yellow fever epidemic
1800–1803
Spain
Yellow fever
60,000+
1801 Ottoman Empire and Egypt bubonic plague epidemic
1801
Ottoman Empire, Egypt
Bubonic plague
Unknown
1802–1803 Saint-Domingue yellow fever epidemic
1802–1803
Saint-Domingue
Yellow fever
29,000–55,000
1812 Russia typhus epidemic
1812
Russia
Typhus
300,000
1812–1819 Ottoman plague epidemic (part of the second plague pandemic)
1812–1819
Ottoman Empire
Bubonic plague
300,000+
1813–1814 Malta plague epidemic (part of the second plague pandemic)
1813–1814
Malta
Bubonic plague
4,500
Caragea's plague (part of the second plague pandemic)
1813
Romania
Bubonic plague
60,000
1817–1819 Ireland typhus epidemic
1817–1819
Ireland
Typhus
65,000
First cholera pandemic
1817–1824
Asia, Europe
Cholera
100,000+
1820 Savannah yellow fever epidemic
1820
Savannah, Georgia, United States
Yellow fever
700
1821 Barcelona yellow fever epidemic
1821
Barcelona, Spain
Yellow fever
5,000–20,000
Second cholera pandemic
1826–1837
Asia, Europe, North America
Cholera
100,000+
1828–1829 New South Wales smallpox epidemic
1828–1829
New South Wales, Australia
Smallpox
19,000
Groningen epidemic
1829
Netherlands
Malaria
2,800
1829–1833 Pacific Northwest malaria epidemic
1829–1833
Pacific Northwest, United States
Malaria, possibly other diseases too
150,000
1829–1835 Iran plague outbreak
1829–1835
Iran
Bubonic plague
Unknown
1834–1836 Egypt plague epidemic
1834–1836
Egypt
Bubonic plague
Unknown
1837 Great Plains smallpox epidemic
1837–1838
Great Plains, United States and Canada
Smallpox
17,000+
1841 Southern United States yellow fever epidemic
1841
Southern United States (especially Louisiana and Florida)
Yellow fever
3,498
1847 North American typhus epidemic
1847–1848
Canada
Typhus
20,000+
1847 Southern United States yellow fever epidemic
1847
Southern United States (especially New Orleans)
Yellow fever
3,400
1847–1848 influenza epidemic
1847–1848
Worldwide
Influenza
Unknown
1848–1849 Hawaii epidemic of infections
1848–1849
Hawaiian Kingdom
Measles, whooping cough, dysentery and influenza
10,000
1853 New Orleans yellow fever epidemic
1853
New Orleans, United States
Yellow fever
7,970
Third cholera pandemic
1846–1860
Worldwide
Cholera
1 million+
1853 Ottoman Empire plague epidemic
1853
Ottoman Empire
Bubonic plague
Unknown
1853 Copenhagen cholera outbreak
1853
Copenhagen, Denmark
Cholera
4,737
1854 Broad Street cholera outbreak
1854
London, England
Cholera
616
1855 Norfolk yellow fever epidemic
1855
Norfolk and Portsmouth, England
Yellow fever
3,000 (2,000 in Norfolk, 1,000 in Portsmouth)
Third plague pandemic
1855–1960
Worldwide
Bubonic plague
12–15 million (India and China)
1855–1857 Montevideo yellow fever epidemic
1855–1857
Montevideo, Uruguay
Yellow fever
3,400 (first wave; 900, second wave; 2,500)
1857 Lisbon yellow fever epidemic
1857
Lisbon, Portugal
Yellow fever
6,000
1857 Victoria smallpox epidemic
1857
Victoria, Australia
Smallpox
Unknown
1857–1859 Europe and the Americas influenza epidemic
1857–1859
Europe, North America, South America
Influenza
Unknown
1862 Pacific Northwest smallpox epidemic
1862–1863
Pacific Northwest, Canada and United States
Smallpox
20,000+
1861–1865 United States typhoid fever epidemic
1861–1865
United States
Typhoid fever
80,000
Fourth cholera pandemic
1863–1875
Middle East
Cholera
600,000
1867 Sydney measles epidemic
1867
Sydney, Australia
Measles
748
1871 Buenos Aires yellow fever epidemic
1871
Buenos Aires, Argentina
Yellow fever
13,500–26,200
1870–1875 Europe smallpox epidemic
1870–1875
Europe
Smallpox
500,000
1875 Fiji measles outbreak
1875
Fiji
Measles
40,000
1875–1876 Australia scarlet fever epidemic
1875–1876
Australia
Scarlet fever
8,000
1876 Ottoman Empire plague epidemic
1876
Ottoman Empire
Bubonic plague
20,000
1878 New Orleans yellow fever epidemic
1878
New Orleans, United States
Yellow fever
4,046
1878 Mississippi Valley yellow fever epidemic
1878
Mississippi Valley, United States
Yellow fever
13,000
Fifth cholera pandemic
1881–1896
Asia, Africa, Europe, South America
Cholera
298,600
1885 Montreal smallpox epidemic
1885
Montreal, Canada
Smallpox
3,164
1889–1890 pandemic
1889–1890
Worldwide
Influenza or Human coronavirus OC43 / HCoV-OC43 (disputed)
1 million
1894 Hong Kong plague (part of the third plague pandemic)
1894–1929
Hong Kong
Bubonic plague
20,000+
Chronological table of epidemic and pandemic events that started in the 1900s · Chronology › 1900s
San Francisco plague of 1900–1904 (part of the third plague pandemic)
San Francisco plague of 1900–1904 (part of the third plague pandemic)
Event
San Francisco plague of 1900–1904 (part of the third plague pandemic)
Years
1900–1904
Location
San Francisco, United States
Disease
Bubonic plague
Death toll (estimate)
119
1900 Sydney bubonic plague epidemic (part of the third plague pandemic)
1900 Sydney bubonic plague epidemic (part of the third plague pandemic)
Event
1900 Sydney bubonic plague epidemic (part of the third plague pandemic)
Years
1900
Location
Australia
Disease
Bubonic plague
Death toll (estimate)
103
1900–1920 Uganda African trypanosomiasis epidemic
1900–1920 Uganda African trypanosomiasis epidemic
Event
1900–1920 Uganda African trypanosomiasis epidemic
Years
1900–1920
Location
Uganda
Disease
African trypanosomiasis
Death toll (estimate)
200,000–300,000
Papua New Guinea kuru epidemic
Papua New Guinea kuru epidemic
Event
Papua New Guinea kuru epidemic
Years
1901–2009
Location
Papua New Guinea
Disease
Kuru
Death toll (estimate)
2,700–3,000+
1903 Fremantle plague epidemic (part of the third plague pandemic)
1903 Fremantle plague epidemic (part of the third plague pandemic)
Event
1903 Fremantle plague epidemic (part of the third plague pandemic)
Years
1903
Location
Fremantle, Western Australia
Disease
Bubonic plague
Death toll (estimate)
4
1906 malaria outbreak in Ceylon
1906 malaria outbreak in Ceylon
Event
1906 malaria outbreak in Ceylon
Years
1906–1936
Location
Ceylon
Disease
Malaria
Death toll (estimate)
80,000
Manchurian plague (part of the third plague pandemic)
Manchurian plague (part of the third plague pandemic)
Event
Manchurian plague (part of the third plague pandemic)
Years
1910–1911
Location
China
Disease
Pneumonic plague
Death toll (estimate)
60,000
1916 United States polio epidemic
1916 United States polio epidemic
Event
1916 United States polio epidemic
Years
1916
Location
United States
Disease
Poliomyelitis
Death toll (estimate)
7,130
1918 influenza pandemic ('Spanish flu')
1918 influenza pandemic ('Spanish flu')
Event
1918 influenza pandemic ('Spanish flu')
Years
1918–1920
Location
Worldwide
Disease
Influenza A virus subtype H1N1
Death toll (estimate)
17–100 million
1918–1922 Russia typhus epidemic
1918–1922 Russia typhus epidemic
Event
1918–1922 Russia typhus epidemic
Years
1918–1922
Location
Russia
Disease
Typhus
Death toll (estimate)
2–3 million
1919–1930 encephalitis lethargica epidemic
1919–1930 encephalitis lethargica epidemic
Event
1919–1930 encephalitis lethargica epidemic
Years
1919–1930
Location
Worldwide
Disease
Encephalitis lethargica
Death toll (estimate)
500,000
1924 Los Angeles pneumonic plague outbreak
1924 Los Angeles pneumonic plague outbreak
Event
1924 Los Angeles pneumonic plague outbreak
Years
1924
Location
Los Angeles, United States
Disease
Pneumonic plague
Death toll (estimate)
30
1924–1925 Minnesota smallpox epidemic
1924–1925 Minnesota smallpox epidemic
Event
1924–1925 Minnesota smallpox epidemic
Years
1924–1925
Location
Minnesota, United States
Disease
Smallpox
Death toll (estimate)
500
1927 Montreal typhoid fever epidemic
1927 Montreal typhoid fever epidemic
Event
1927 Montreal typhoid fever epidemic
Years
1927
Location
Montreal, Canada
Disease
Typhoid fever
Death toll (estimate)
538
1929–1930 psittacosis pandemic
1929–1930 psittacosis pandemic
Event
1929–1930 psittacosis pandemic
Years
1929–1930
Location
Worldwide
Disease
Psittacosis
Death toll (estimate)
100+
1937 Croydon typhoid outbreak
1937 Croydon typhoid outbreak
Event
1937 Croydon typhoid outbreak
Years
1937
Location
Croydon, United Kingdom
Disease
Typhoid fever
Death toll (estimate)
43
1937 Australia polio epidemic
1937 Australia polio epidemic
Event
1937 Australia polio epidemic
Years
1937
Location
Australia
Disease
Poliomyelitis
Death toll (estimate)
Unknown
1940 Sudan yellow fever epidemic
1940 Sudan yellow fever epidemic
Event
1940 Sudan yellow fever epidemic
Years
1940
Location
Sudan
Disease
Yellow fever
Death toll (estimate)
1,627
1942–1944 Egypt malaria epidemic
1942–1944 Egypt malaria epidemic
Event
1942–1944 Egypt malaria epidemic
Years
1942–1944
Location
Egypt
Disease
Malaria
Death toll (estimate)
Unknown
1946 Egypt relapsing fever epidemic
1946 Egypt relapsing fever epidemic
Event
1946 Egypt relapsing fever epidemic
Years
1946
Location
Egypt
Disease
Relapsing fever
Death toll (estimate)
Unknown
1947 Egypt cholera epidemic
1947 Egypt cholera epidemic
Event
1947 Egypt cholera epidemic
Years
1947
Location
Egypt
Disease
Cholera
Death toll (estimate)
10,277
1948–1952 United States polio epidemic
1948–1952 United States polio epidemic
Event
1948–1952 United States polio epidemic
Years
1948–1952
Location
United States
Disease
Poliomyelitis
Death toll (estimate)
9,000
1957–1958 influenza pandemic ('Asian flu')
1957–1958 influenza pandemic ('Asian flu')
Event
1957–1958 influenza pandemic ('Asian flu')
Years
1957–1958
Location
Worldwide
Disease
Influenza A virus subtype H2N2
Death toll (estimate)
1–4 million
1960–1962 Ethiopia yellow fever epidemic
1960–1962 Ethiopia yellow fever epidemic
Event
1960–1962 Ethiopia yellow fever epidemic
Years
1960–1962
Location
Ethiopia
Disease
Yellow fever
Death toll (estimate)
30,000
Hong Kong flu
Hong Kong flu
Event
Hong Kong flu
Years
1968–1970
Location
Worldwide
Disease
Influenza A virus subtype H3N2
Death toll (estimate)
1–4 million
1971 Staphorst polio epidemic
1971 Staphorst polio epidemic
Event
1971 Staphorst polio epidemic
Years
1971
Location
Staphorst, Netherlands
Disease
Poliomyelitis
Death toll (estimate)
5
1972 Yugoslav smallpox outbreak
1972 Yugoslav smallpox outbreak
Event
1972 Yugoslav smallpox outbreak
Years
1972
Location
Yugoslavia
Disease
Smallpox
Death toll (estimate)
35
London flu
London flu
Event
London flu
Years
1972–1973
Location
United States
Disease
Influenza A virus subtype H3N2
Death toll (estimate)
1,027
1973 Italy cholera epidemic
1973 Italy cholera epidemic
Event
1973 Italy cholera epidemic
Years
1973
Location
Italy
Disease
Cholera (El Tor strain)
Death toll (estimate)
24
1974 smallpox epidemic in India
1974 smallpox epidemic in India
Event
1974 smallpox epidemic in India
Years
1974
Location
India
Disease
Smallpox
Death toll (estimate)
15,000
1977 Russian flu
1977 Russian flu
Event
1977 Russian flu
Years
1977–1979
Location
Worldwide
Disease
Influenza A virus subtype H1N1
Death toll (estimate)
700,000
Sverdlovsk anthrax leak
Sverdlovsk anthrax leak
Event
Sverdlovsk anthrax leak
Years
1979
Location
Russia
Disease
Anthrax
Death toll (estimate)
105
1984 Western Sahara plague
1984 Western Sahara plague
Event
1984 Western Sahara plague
Years
1984
Location
Western Sahara
Disease
Bubonic plague
Death toll (estimate)
64
Ref.
[citation needed]
1986 Oju yellow fever epidemic
1986 Oju yellow fever epidemic
Event
1986 Oju yellow fever epidemic
Years
1986
Location
Oju, Nigeria
Disease
Yellow fever
Death toll (estimate)
5,600+
1987 Mali yellow fever epidemic
1987 Mali yellow fever epidemic
Event
1987 Mali yellow fever epidemic
Years
1987
Location
Mali
Disease
Yellow fever
Death toll (estimate)
145
1988 Shanghai hepatitis A epidemic
1988 Shanghai hepatitis A epidemic
Event
1988 Shanghai hepatitis A epidemic
Years
1988
Location
Shanghai, China
Disease
Hepatitis A
Death toll (estimate)
31–47
1991 Bangladesh cholera epidemic
1991 Bangladesh cholera epidemic
Event
1991 Bangladesh cholera epidemic
Years
1991
Location
Bangladesh
Disease
Cholera
Death toll (estimate)
8,410–9,432
1991 Latin America cholera epidemic
1991 Latin America cholera epidemic
Event
1991 Latin America cholera epidemic
Years
1991–1993
Location
Peru, Chile, Bolivia, Ecuador, Colombia, Mexico, El Salvador, Guatemala
Disease
Cholera
Death toll (estimate)
8,000
1994 plague in India
1994 plague in India
Event
1994 plague in India
Years
1994
Location
India
Disease
Bubonic plague and Pneumonic plague
Death toll (estimate)
56
United Kingdom BSE outbreak
United Kingdom BSE outbreak
Event
United Kingdom BSE outbreak
Years
1996–2001
Location
United Kingdom
Disease
Variant Creutzfeldt–Jakob disease / vCJD
Death toll (estimate)
178
1996 West Africa meningitis epidemic
1996 West Africa meningitis epidemic
Event
1996 West Africa meningitis epidemic
Years
1996
Location
West Africa
Disease
Meningitis
Death toll (estimate)
10,000
1998–1999 Malaysia Nipah virus outbreak
1998–1999 Malaysia Nipah virus outbreak
Event
1998–1999 Malaysia Nipah virus outbreak
Years
1998–1999
Location
Malaysia
Disease
Nipah virus infection
Death toll (estimate)
105
1998–2000 Democratic Republic of the Congo Marburg virus outbreak
1998–2000 Democratic Republic of the Congo Marburg virus outbreak
Event
1998–2000 Democratic Republic of the Congo Marburg virus outbreak
Years
1998–2000
Location
Democratic Republic of the Congo
Disease
Marburg virus
Death toll (estimate)
128
Event
Years
Location
Disease
Death toll (estimate)
Ref.
San Francisco plague of 1900–1904 (part of the third plague pandemic)
1900–1904
San Francisco, United States
Bubonic plague
119
1900 Sydney bubonic plague epidemic (part of the third plague pandemic)
1900
Australia
Bubonic plague
103
1900–1920 Uganda African trypanosomiasis epidemic
1900–1920
Uganda
African trypanosomiasis
200,000–300,000
Papua New Guinea kuru epidemic
1901–2009
Papua New Guinea
Kuru
2,700–3,000+
1903 Fremantle plague epidemic (part of the third plague pandemic)
1903
Fremantle, Western Australia
Bubonic plague
4
1906 malaria outbreak in Ceylon
1906–1936
Ceylon
Malaria
80,000
Manchurian plague (part of the third plague pandemic)
1910–1911
China
Pneumonic plague
60,000
1916 United States polio epidemic
1916
United States
Poliomyelitis
7,130
1918 influenza pandemic ('Spanish flu')
1918–1920
Worldwide
Influenza A virus subtype H1N1
17–100 million
1918–1922 Russia typhus epidemic
1918–1922
Russia
Typhus
2–3 million
1919–1930 encephalitis lethargica epidemic
1919–1930
Worldwide
Encephalitis lethargica
500,000
1924 Los Angeles pneumonic plague outbreak
1924
Los Angeles, United States
Pneumonic plague
30
1924–1925 Minnesota smallpox epidemic
1924–1925
Minnesota, United States
Smallpox
500
1927 Montreal typhoid fever epidemic
1927
Montreal, Canada
Typhoid fever
538
1929–1930 psittacosis pandemic
1929–1930
Worldwide
Psittacosis
100+
1937 Croydon typhoid outbreak
1937
Croydon, United Kingdom
Typhoid fever
43
1937 Australia polio epidemic
1937
Australia
Poliomyelitis
Unknown
1940 Sudan yellow fever epidemic
1940
Sudan
Yellow fever
1,627
1942–1944 Egypt malaria epidemic
1942–1944
Egypt
Malaria
Unknown
1946 Egypt relapsing fever epidemic
1946
Egypt
Relapsing fever
Unknown
1947 Egypt cholera epidemic
1947
Egypt
Cholera
10,277
1948–1952 United States polio epidemic
1948–1952
United States
Poliomyelitis
9,000
1957–1958 influenza pandemic ('Asian flu')
1957–1958
Worldwide
Influenza A virus subtype H2N2
1–4 million
1960–1962 Ethiopia yellow fever epidemic
1960–1962
Ethiopia
Yellow fever
30,000
Hong Kong flu
1968–1970
Worldwide
Influenza A virus subtype H3N2
1–4 million
1971 Staphorst polio epidemic
1971
Staphorst, Netherlands
Poliomyelitis
5
1972 Yugoslav smallpox outbreak
1972
Yugoslavia
Smallpox
35
London flu
1972–1973
United States
Influenza A virus subtype H3N2
1,027
1973 Italy cholera epidemic
1973
Italy
Cholera (El Tor strain)
24
1974 smallpox epidemic in India
1974
India
Smallpox
15,000
1977 Russian flu
1977–1979
Worldwide
Influenza A virus subtype H1N1
700,000
Sverdlovsk anthrax leak
1979
Russia
Anthrax
105
1984 Western Sahara plague
1984
Western Sahara
Bubonic plague
64
[citation needed]
1986 Oju yellow fever epidemic
1986
Oju, Nigeria
Yellow fever
5,600+
1987 Mali yellow fever epidemic
1987
Mali
Yellow fever
145
1988 Shanghai hepatitis A epidemic
1988
Shanghai, China
Hepatitis A
31–47
1991 Bangladesh cholera epidemic
1991
Bangladesh
Cholera
8,410–9,432
1991 Latin America cholera epidemic
1991–1993
Peru, Chile, Bolivia, Ecuador, Colombia, Mexico, El Salvador, Guatemala
Cholera
8,000
1994 plague in India
1994
India
Bubonic plague and Pneumonic plague
56
United Kingdom BSE outbreak
1996–2001
United Kingdom
Variant Creutzfeldt–Jakob disease / vCJD
178
1996 West Africa meningitis epidemic
1996
West Africa
Meningitis
10,000
1998–1999 Malaysia Nipah virus outbreak
1998–1999
Malaysia
Nipah virus infection
105
1998–2000 Democratic Republic of the Congo Marburg virus outbreak
1998–2000
Democratic Republic of the Congo
Marburg virus
128
Chronological table of epidemic and pandemic events that started in the 2000s · Chronology › 2000s
2000 Central America dengue epidemic
2000 Central America dengue epidemic
Event
2000 Central America dengue epidemic
Years
2000
Location
Central America
Disease
Dengue fever
Death toll (estimate)
40+
2001 Nigeria cholera epidemic
2001 Nigeria cholera epidemic
Event
2001 Nigeria cholera epidemic
Years
2001
Location
Nigeria
Disease
Cholera
Death toll (estimate)
400+
2001 South Africa cholera epidemic
2001 South Africa cholera epidemic
Event
2001 South Africa cholera epidemic
Years
2001
Location
South Africa
Disease
Cholera
Death toll (estimate)
139
2002–2004 SARS outbreak
2002–2004 SARS outbreak
Event
2002–2004 SARS outbreak
Years
2002–2004
Location
Worldwide
Disease
Severe acute respiratory syndrome / SARS
Death toll (estimate)
774
2003–2019 Asia and Egypt avian influenza epidemic
2003–2019 Asia and Egypt avian influenza epidemic
Event
2003–2019 Asia and Egypt avian influenza epidemic
Years
2003–2019
Location
China, Southeast Asia and Egypt
Disease
Influenza A virus subtype H5N1
Death toll (estimate)
455
2004 Indonesia dengue epidemic
2004 Indonesia dengue epidemic
Event
2004 Indonesia dengue epidemic
Years
2004
Location
Indonesia
Disease
Dengue fever
Death toll (estimate)
658
2004 Sudan Ebola outbreak
2004 Sudan Ebola outbreak
Event
2004 Sudan Ebola outbreak
Years
2004
Location
Sudan
Disease
Ebola
Death toll (estimate)
7
2004–2005 Angola Marburg virus outbreak
2004–2005 Angola Marburg virus outbreak
Event
2004–2005 Angola Marburg virus outbreak
Years
2004–2005
Location
Angola
Disease
Marburg virus
Death toll (estimate)
227
2005 dengue outbreak in Singapore
2005 dengue outbreak in Singapore
Event
2005 dengue outbreak in Singapore
Years
2005
Location
Singapore
Disease
Dengue fever
Death toll (estimate)
27
2006 Luanda cholera epidemic
2006 Luanda cholera epidemic
Event
2006 Luanda cholera epidemic
Years
2006
Location
Luanda, Angola
Disease
Cholera
Death toll (estimate)
1,200+
2006 Ituri Province plague epidemic
2006 Ituri Province plague epidemic
Event
2006 Ituri Province plague epidemic
Years
2006
Location
Ituri Province, Democratic Republic of the Congo
Disease
Bubonic plague
Death toll (estimate)
61
2006 India malaria outbreak
2006 India malaria outbreak
Event
2006 India malaria outbreak
Years
2006
Location
India
Disease
Malaria
Death toll (estimate)
17
2006 dengue outbreak in India
2006 dengue outbreak in India
Event
2006 dengue outbreak in India
Years
2006
Location
India
Disease
Dengue fever
Death toll (estimate)
50+
2006 dengue outbreak in Pakistan
2006 dengue outbreak in Pakistan
Event
2006 dengue outbreak in Pakistan
Years
2006
Location
Pakistan
Disease
Dengue fever
Death toll (estimate)
50+
2006 Philippines dengue epidemic
2006 Philippines dengue epidemic
Event
2006 Philippines dengue epidemic
Years
2006
Location
Philippines
Disease
Dengue fever
Death toll (estimate)
1,000
2006–2007 East Africa Rift Valley fever outbreak
2006–2007 East Africa Rift Valley fever outbreak
Event
2006–2007 East Africa Rift Valley fever outbreak
Years
2006–2007
Location
East Africa
Disease
Rift Valley fever
Death toll (estimate)
394
Mweka Ebola epidemic
Mweka Ebola epidemic
Event
Mweka Ebola epidemic
Years
2007
Location
Democratic Republic of the Congo
Disease
Ebola
Death toll (estimate)
187
2007 Ethiopia cholera epidemic
2007 Ethiopia cholera epidemic
Event
2007 Ethiopia cholera epidemic
Years
2007
Location
Ethiopia
Disease
Cholera
Death toll (estimate)
684
2007 Iraq cholera outbreak
2007 Iraq cholera outbreak
Event
2007 Iraq cholera outbreak
Years
2007
Location
Iraq
Disease
Cholera
Death toll (estimate)
10
2007 Puerto Rico, Dominican Republic, and Mexico dengue fever epidemic
2007 Puerto Rico, Dominican Republic, and Mexico dengue fever epidemic
Event
2007 Puerto Rico, Dominican Republic, and Mexico dengue fever epidemic
Years
2007
Location
Puerto Rico, Dominican Republic, Mexico
Disease
Dengue fever
Death toll (estimate)
183
2007 Uganda Ebola outbreak
2007 Uganda Ebola outbreak
Event
2007 Uganda Ebola outbreak
Years
2007
Location
Uganda
Disease
Ebola
Death toll (estimate)
37
2007 Netherlands Q-fever epidemic
2007 Netherlands Q-fever epidemic
Event
2007 Netherlands Q-fever epidemic
Years
2007–2018
Location
Netherlands
Disease
Q-fever
Death toll (estimate)
95
2008 Brazil dengue epidemic
2008 Brazil dengue epidemic
Event
2008 Brazil dengue epidemic
Years
2008
Location
Brazil
Disease
Dengue fever
Death toll (estimate)
67
2008 Cambodia dengue epidemic
2008 Cambodia dengue epidemic
Event
2008 Cambodia dengue epidemic
Years
2008
Location
Cambodia
Disease
Dengue fever
Death toll (estimate)
407
2008 Chad cholera epidemic
2008 Chad cholera epidemic
Event
2008 Chad cholera epidemic
Years
2008
Location
Chad
Disease
Cholera
Death toll (estimate)
123
2008–2017 China hand, foot, and mouth disease epidemic
2008–2017 China hand, foot, and mouth disease epidemic
Event
2008–2017 China hand, foot, and mouth disease epidemic
Years
2008–2017
Location
China
Disease
Hand, foot, and mouth disease
Death toll (estimate)
3,322+
2008 India cholera epidemic
2008 India cholera epidemic
Event
2008 India cholera epidemic
Years
2008
Location
India
Disease
Cholera
Death toll (estimate)
115
2008 Madagascar plague outbreak
2008 Madagascar plague outbreak
Event
2008 Madagascar plague outbreak
Years
2008
Location
Madagascar
Disease
Bubonic plague
Death toll (estimate)
18+
2008 Philippines dengue epidemic
2008 Philippines dengue epidemic
Event
2008 Philippines dengue epidemic
Years
2008
Location
Philippines
Disease
Dengue fever
Death toll (estimate)
172
2008 Zimbabwean cholera outbreak
2008 Zimbabwean cholera outbreak
Event
2008 Zimbabwean cholera outbreak
Years
2008–2009
Location
Zimbabwe
Disease
Cholera
Death toll (estimate)
4,293
2009 Bolivian dengue fever epidemic
2009 Bolivian dengue fever epidemic
Event
2009 Bolivian dengue fever epidemic
Years
2009
Location
Bolivia
Disease
Dengue fever
Death toll (estimate)
18
2009 Gujarat hepatitis outbreak
2009 Gujarat hepatitis outbreak
Event
2009 Gujarat hepatitis outbreak
Years
2009
Location
India
Disease
Hepatitis B
Death toll (estimate)
49
Queensland 2009 dengue outbreak
Queensland 2009 dengue outbreak
Event
Queensland 2009 dengue outbreak
Years
2009
Location
Queensland, Australia
Disease
Dengue fever
Death toll (estimate)
1+ (503 cases)
2009–2010 West African meningitis outbreak
2009–2010 West African meningitis outbreak
Event
2009–2010 West African meningitis outbreak
Years
2009–2010
Location
West Africa
Disease
Meningitis
Death toll (estimate)
1,100
2009 swine flu pandemic
2009 swine flu pandemic
Event
2009 swine flu pandemic
Years
2009–2010
Location
Worldwide
Disease
Influenza A virus subtype H1N1
Death toll (estimate)
Lab confirmed deaths: 18,449 (reported to the WHO)
Estimated death toll: 284,000 (possible range 151,700–575,400)
Estimated death toll: 284,000 (possible range 151,700–575,400)
Event
Estimated death toll: 284,000 (possible range 151,700–575,400)
2010s Haiti cholera outbreak
2010s Haiti cholera outbreak
Event
2010s Haiti cholera outbreak
Years
2010–2019
Location
Haiti
Disease
Cholera (strain serogroup O1, serotype Ogawa)
Death toll (estimate)
10,075
2010–2014 Democratic Republic of the Congo measles outbreak
2010–2014 Democratic Republic of the Congo measles outbreak
Event
2010–2014 Democratic Republic of the Congo measles outbreak
Years
2010–2014
Location
Democratic Republic of the Congo
Disease
Measles
Death toll (estimate)
4,500+
2011 Vietnam hand, foot, and mouth disease epidemic
2011 Vietnam hand, foot, and mouth disease epidemic
Event
2011 Vietnam hand, foot, and mouth disease epidemic
Years
2011
Location
Vietnam
Disease
Hand, foot, and mouth disease
Death toll (estimate)
170
2011 dengue outbreak in Pakistan
2011 dengue outbreak in Pakistan
Event
2011 dengue outbreak in Pakistan
Years
2011
Location
Pakistan
Disease
Dengue fever
Death toll (estimate)
350+
2012 yellow fever outbreak in Darfur, Sudan
2012 yellow fever outbreak in Darfur, Sudan
Event
2012 yellow fever outbreak in Darfur, Sudan
Years
2012
Location
Darfur, Sudan
Disease
Yellow fever
Death toll (estimate)
171
2013 dengue outbreak in Singapore
2013 dengue outbreak in Singapore
Event
2013 dengue outbreak in Singapore
Years
2013
Location
Singapore
Disease
Dengue fever
Death toll (estimate)
8
2013 Vietnam measles outbreak
2013 Vietnam measles outbreak
Event
2013 Vietnam measles outbreak
Years
2013–2014
Location
Vietnam
Disease
Measles
Death toll (estimate)
142
Western African Ebola virus epidemic
Western African Ebola virus epidemic
Event
Western African Ebola virus epidemic
Years
2013–2016
Location
Worldwide, primarily concentrated in Guinea, Liberia, Sierra Leone
Disease
Ebola
Death toll (estimate)
11,323+
2013–2014 chikungunya outbreak
2013–2014 chikungunya outbreak
Event
2013–2014 chikungunya outbreak
Years
2013–2015
Location
Americas
Disease
Chikungunya
Death toll (estimate)
183
2013–19 avian influenza epidemic
2013–19 avian influenza epidemic
Event
2013–19 avian influenza epidemic
Years
2013–2019
Location
China
Disease
Influenza A virus subtype H7N9
Death toll (estimate)
616
21st century Madagascar plague outbreaks
21st century Madagascar plague outbreaks
Event
21st century Madagascar plague outbreaks
Years
2014–2017
Location
Madagascar
Disease
Bubonic plague
Death toll (estimate)
292
Flint water crisis
Flint water crisis
Event
Flint water crisis
Years
2014–2015
Location
Flint, Michigan, United States
Disease
Legionnaires' disease
Death toll (estimate)
12
2014 Odisha hepatitis outbreak
2014 Odisha hepatitis outbreak
Event
2014 Odisha hepatitis outbreak
Years
2014–2015
Location
India
Disease
Primarily Hepatitis E, but also Hepatitis A
Death toll (estimate)
36
2015 Indian swine flu outbreak
2015 Indian swine flu outbreak
Event
2015 Indian swine flu outbreak
Years
2015
Location
India
Disease
Influenza A virus subtype H1N1
Death toll (estimate)
2,035
2015–16 Zika virus epidemic
2015–16 Zika virus epidemic
Event
2015–16 Zika virus epidemic
Years
2015–2016
Location
Worldwide
Disease
Zika virus
Death toll (estimate)
53
2016 Angola and Democratic Republic of the Congo yellow fever outbreak
2016 Angola and Democratic Republic of the Congo yellow fever outbreak
Event
2016 Angola and Democratic Republic of the Congo yellow fever outbreak
Years
2016
Location
Angola and Democratic Republic of the Congo
Disease
Yellow fever
Death toll (estimate)
498 (377 in Angola, 121 in Congo)
2016–2022 Yemen cholera outbreak
2016–2022 Yemen cholera outbreak
Event
2016–2022 Yemen cholera outbreak
Years
2016–2023
Location
Yemen
Disease
Cholera
Death toll (estimate)
4,004 (as of June 11, 2023[update])
2017 Nigeria Lassa fever epidemic
2017 Nigeria Lassa fever epidemic
Event
2017 Nigeria Lassa fever epidemic
Years
2017–2023
Location
Nigeria
Disease
Lassa fever
Death toll (estimate)
1103 (as of April 2023)
2017 dengue outbreak in Peshawar
2017 dengue outbreak in Peshawar
Event
2017 dengue outbreak in Peshawar
Years
2017
Location
Peshawar, Pakistan
Disease
Dengue fever
Death toll (estimate)
69
2017 Gorakhpur hospital deaths
2017 Gorakhpur hospital deaths
Event
2017 Gorakhpur hospital deaths
Years
2017
Location
India
Disease
Japanese encephalitis
Death toll (estimate)
1,317
2017 dengue outbreak in Sri Lanka
2017 dengue outbreak in Sri Lanka
Event
2017 dengue outbreak in Sri Lanka
Years
2017
Location
Sri Lanka
Disease
Dengue fever
Death toll (estimate)
440
2018 Nipah virus outbreak in Kerala
2018 Nipah virus outbreak in Kerala
Event
2018 Nipah virus outbreak in Kerala
Years
2018
Location
India
Disease
Nipah virus infection
Death toll (estimate)
17
Kivu Ebola epidemic
Kivu Ebola epidemic
Event
Kivu Ebola epidemic
Years
2018–2020
Location
Democratic Republic of the Congo and Uganda
Disease
Ebola
Death toll (estimate)
2,280
2018 NDM-CRE outbreak in Italy
2018 NDM-CRE outbreak in Italy
Event
2018 NDM-CRE outbreak in Italy
Years
2018–2019
Location
Italy
Disease
New Delhi metallo-beta-lactamase-producing Carbapenem-resistant enterobacteriaceae
Death toll (estimate)
31 (as of September 2019)
2019–2020 measles outbreak in the Democratic Republic of the Congo
2019–2020 measles outbreak in the Democratic Republic of the Congo
Event
2019–2020 measles outbreak in the Democratic Republic of the Congo
Years
2019–2020
Location
Democratic Republic of the Congo
Disease
Measles
Death toll (estimate)
7,018+
2019–2020 New Zealand measles outbreak
2019–2020 New Zealand measles outbreak
Event
2019–2020 New Zealand measles outbreak
Years
2019–2020
Location
New Zealand
Disease
Measles
Death toll (estimate)
2
2019 measles outbreak in the Philippines
2019 measles outbreak in the Philippines
Event
2019 measles outbreak in the Philippines
Years
2019
Location
Philippines
Disease
Measles
Death toll (estimate)
415
2019 Kuala Koh measles outbreak
2019 Kuala Koh measles outbreak
Event
2019 Kuala Koh measles outbreak
Years
2019
Location
Kuala Koh, Malaysia
Disease
Measles
Death toll (estimate)
15
2019 Samoa measles outbreak
2019 Samoa measles outbreak
Event
2019 Samoa measles outbreak
Years
2019
Location
Samoa
Disease
Measles
Death toll (estimate)
83
2019–2020 dengue fever epidemic
2019–2020 dengue fever epidemic
Event
2019–2020 dengue fever epidemic
Years
2019–2020
Location
Asia-Pacific, Latin America
Disease
Dengue fever
Death toll (estimate)
3,931
2020 Democratic Republic of the Congo Ebola outbreak
2020 Democratic Republic of the Congo Ebola outbreak
Event
2020 Democratic Republic of the Congo Ebola outbreak
Years
2020
Location
Democratic Republic of the Congo
Disease
Ebola
Death toll (estimate)
55
2020 dengue outbreak in Singapore
2020 dengue outbreak in Singapore
Event
2020 dengue outbreak in Singapore
Years
2020
Location
Singapore
Disease
Dengue fever
Death toll (estimate)
32
2020 Nigeria yellow fever epidemic
2020 Nigeria yellow fever epidemic
Event
2020 Nigeria yellow fever epidemic
Years
2020
Location
Nigeria
Disease
Yellow fever
Death toll (estimate)
296 (as of 31 December 2020)
2021 South Sudan disease outbreak
2021 South Sudan disease outbreak
Event
2021 South Sudan disease outbreak
Years
2021
Location
South Sudan
Disease
Unknown
Death toll (estimate)
97 (as of December 2021)
2021 India black fungus epidemic
2021 India black fungus epidemic
Event
2021 India black fungus epidemic
Years
2021–2022
Location
India
Disease
Black fungus (COVID-19 condition)
Death toll (estimate)
4,332
2022 hepatitis of unknown origin in children
2022 hepatitis of unknown origin in children
Event
2022 hepatitis of unknown origin in children
Years
2021–2022
Location
Worldwide
Disease
Hepatitis by Adenovirus variant AF41 (Unconfirmed)
Death toll (estimate)
18
2022–2024 Southern Africa cholera outbreak
2022–2024 Southern Africa cholera outbreak
Event
2022–2024 Southern Africa cholera outbreak
Years
2022–2024
Location
Southern Africa
Disease
Cholera
Death toll (estimate)
11,400+
2022–2023 mpox outbreak
2022–2023 mpox outbreak
Event
2022–2023 mpox outbreak
Years
2022–2023
Location
Worldwide
Disease
Mpox
Death toll (estimate)
280
2022 Uganda Ebola outbreak
2022 Uganda Ebola outbreak
Event
2022 Uganda Ebola outbreak
Years
2022–2023
Location
Uganda
Disease
Sudan ebolavirus
Death toll (estimate)
77
2023–2024 Zambian cholera outbreak (part of the 2022–2024 Southern Africa cholera outbreak)
2023–2024 Zambian cholera outbreak (part of the 2022–2024 Southern Africa cholera outbreak)
Event
2023–2024 Zambian cholera outbreak (part of the 2022–2024 Southern Africa cholera outbreak)
Years
2023–2024
Location
Zambia
Disease
Cholera
Death toll (estimate)
685
2023 South Poland Legionellosis outbreak
2023 South Poland Legionellosis outbreak
Event
2023 South Poland Legionellosis outbreak
Years
2023
Location
Poland
Disease
Legionnaires' disease
Death toll (estimate)
41
2023–2024 Bangsamoro measles outbreak
2023–2024 Bangsamoro measles outbreak
Event
2023–2024 Bangsamoro measles outbreak
Years
2023–2024
Location
Bangsamoro, Philippines
Disease
Measles
Death toll (estimate)
14
2023–2024 Oropouche virus disease outbreak
2023–2024 Oropouche virus disease outbreak
Event
2023–2024 Oropouche virus disease outbreak
Years
2023–2024
Location
Brazil
Disease
Oropouche fever
Death toll (estimate)
2
2024 American dengue epidemic
2024 American dengue epidemic
Event
2024 American dengue epidemic
Years
2024
Location
Latin America and the Caribbean
Disease
Dengue fever
Death toll (estimate)
9,875
2024 Kwango province malaria outbreak
2024 Kwango province malaria outbreak
Event
2024 Kwango province malaria outbreak
Years
2024
Location
Democratic Republic of the Congo
Disease
Malaria
Death toll (estimate)
143
Event
Years
Location
Disease
Death toll (estimate)
Ref.
2000 Central America dengue epidemic
2000
Central America
Dengue fever
40+
2001 Nigeria cholera epidemic
2001
Nigeria
Cholera
400+
2001 South Africa cholera epidemic
2001
South Africa
Cholera
139
2002–2004 SARS outbreak
2002–2004
Worldwide
Severe acute respiratory syndrome / SARS
774
2003–2019 Asia and Egypt avian influenza epidemic
2003–2019
China, Southeast Asia and Egypt
Influenza A virus subtype H5N1
455
2004 Indonesia dengue epidemic
2004
Indonesia
Dengue fever
658
2004 Sudan Ebola outbreak
2004
Sudan
Ebola
7
2004–2005 Angola Marburg virus outbreak
2004–2005
Angola
Marburg virus
227
2005 dengue outbreak in Singapore
2005
Singapore
Dengue fever
27
2006 Luanda cholera epidemic
2006
Luanda, Angola
Cholera
1,200+
2006 Ituri Province plague epidemic
2006
Ituri Province, Democratic Republic of the Congo
Bubonic plague
61
2006 India malaria outbreak
2006
India
Malaria
17
2006 dengue outbreak in India
2006
India
Dengue fever
50+
2006 dengue outbreak in Pakistan
2006
Pakistan
Dengue fever
50+
2006 Philippines dengue epidemic
2006
Philippines
Dengue fever
1,000
2006–2007 East Africa Rift Valley fever outbreak
2006–2007
East Africa
Rift Valley fever
394
Mweka Ebola epidemic
2007
Democratic Republic of the Congo
Ebola
187
2007 Ethiopia cholera epidemic
2007
Ethiopia
Cholera
684
2007 Iraq cholera outbreak
2007
Iraq
Cholera
10
2007 Puerto Rico, Dominican Republic, and Mexico dengue fever epidemic
2007
Puerto Rico, Dominican Republic, Mexico
Dengue fever
183
2007 Uganda Ebola outbreak
2007
Uganda
Ebola
37
2007 Netherlands Q-fever epidemic
2007–2018
Netherlands
Q-fever
95
2008 Brazil dengue epidemic
2008
Brazil
Dengue fever
67
2008 Cambodia dengue epidemic
2008
Cambodia
Dengue fever
407
2008 Chad cholera epidemic
2008
Chad
Cholera
123
2008–2017 China hand, foot, and mouth disease epidemic
2008–2017
China
Hand, foot, and mouth disease
3,322+
2008 India cholera epidemic
2008
India
Cholera
115
2008 Madagascar plague outbreak
2008
Madagascar
Bubonic plague
18+
2008 Philippines dengue epidemic
2008
Philippines
Dengue fever
172
2008 Zimbabwean cholera outbreak
2008–2009
Zimbabwe
Cholera
4,293
2009 Bolivian dengue fever epidemic
2009
Bolivia
Dengue fever
18
2009 Gujarat hepatitis outbreak
2009
India
Hepatitis B
49
Queensland 2009 dengue outbreak
2009
Queensland, Australia
Dengue fever
1+ (503 cases)
2009–2010 West African meningitis outbreak
2009–2010
West Africa
Meningitis
1,100
2009 swine flu pandemic
2009–2010
Worldwide
Influenza A virus subtype H1N1
Lab confirmed deaths: 18,449 (reported to the WHO)
Estimated death toll: 284,000 (possible range 151,700–575,400)
2010s Haiti cholera outbreak
2010–2019
Haiti
Cholera (strain serogroup O1, serotype Ogawa)
10,075
2010–2014 Democratic Republic of the Congo measles outbreak
2010–2014
Democratic Republic of the Congo
Measles
4,500+
2011 Vietnam hand, foot, and mouth disease epidemic
2011
Vietnam
Hand, foot, and mouth disease
170
2011 dengue outbreak in Pakistan
2011
Pakistan
Dengue fever
350+
2012 yellow fever outbreak in Darfur, Sudan
2012
Darfur, Sudan
Yellow fever
171
2013 dengue outbreak in Singapore
2013
Singapore
Dengue fever
8
2013 Vietnam measles outbreak
2013–2014
Vietnam
Measles
142
Western African Ebola virus epidemic
2013–2016
Worldwide, primarily concentrated in Guinea, Liberia, Sierra Leone
Ebola
11,323+
2013–2014 chikungunya outbreak
2013–2015
Americas
Chikungunya
183
2013–19 avian influenza epidemic
2013–2019
China
Influenza A virus subtype H7N9
616
21st century Madagascar plague outbreaks
2014–2017
Madagascar
Bubonic plague
292
Flint water crisis
2014–2015
Flint, Michigan, United States
Legionnaires' disease
12
2014 Odisha hepatitis outbreak
2014–2015
India
Primarily Hepatitis E, but also Hepatitis A
36
Chronological table of ongoing epidemic and pandemic events · Chronology › Ongoing
Seventh cholera pandemic
Seventh cholera pandemic
Event
Seventh cholera pandemic
Years
1961–present
Location
Worldwide
Disease
Cholera (El Tor strain)
Death toll (estimate)
36,000[citation needed]
HIV/AIDS pandemic
HIV/AIDS pandemic
Event
HIV/AIDS pandemic
Years
1981–present
Location
Worldwide
Disease
HIV/AIDS
Death toll (estimate)
44 million (as of 2025[update])
MERS outbreak
MERS outbreak
Event
MERS outbreak
Years
2012–present
Location
Worldwide
Disease
Middle East respiratory syndrome / MERS-CoV
Death toll (estimate)
941 (as of 8 May 2021[update])
COVID-19 pandemic
COVID-19 pandemic
Event
COVID-19 pandemic
Years
2019–present
Location
Worldwide
Disease
COVID-19
Death toll (estimate)
7.1–36.5 million
2023–2025 mpox epidemic
2023–2025 mpox epidemic
Event
2023–2025 mpox epidemic
Years
2023–present
Location
Worldwide, primarily Africa
Disease
Mpox
Death toll (estimate)
812
2024–2025 Sudanese cholera epidemic
2024–2025 Sudanese cholera epidemic
Event
2024–2025 Sudanese cholera epidemic
Years
2024–present
Location
Sudan, South Sudan, and Chad
Disease
Cholera
Death toll (estimate)
5,869
Event
Years
Location
Disease
Death toll (estimate)
Ref.
Seventh cholera pandemic
1961–present
Worldwide
Cholera (El Tor strain)
36,000[citation needed]
HIV/AIDS pandemic
1981–present
Worldwide
HIV/AIDS
44 million (as of 2025[update])
MERS outbreak
2012–present
Worldwide
Middle East respiratory syndrome / MERS-CoV
941 (as of 8 May 2021[update])
COVID-19 pandemic
2019–present
Worldwide
COVID-19
million
2023–2025 mpox epidemic
2023–present
Worldwide, primarily Africa
Mpox
812
2024–2025 Sudanese cholera epidemic
2024–present
Sudan, South Sudan, and Chad
Cholera
5,869

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