| Date | Time‡ | Place | Lat | Long | Deaths | Imax | Mag. | Comments | Sources |
| 17 | n/a | Philadelphia (Alaşehir) | 38 | 28 | n/a | | n/a | see AD 17 Lydia earthquake | |
| 13 December 115 | | Antioch | 36 | 36 | 260,000 | XI | 7 Ms | see 115 Antioch earthquake | |
| 4 January 141 (or 142) | | Lycia, Caria, Dodecanese | 36 | 28 | n/a | VIII | n/a | Triggered a severe tsunami that caused inundation at Rhodes; see 141 Lycia earthquake | |
| 21 December 262 | | South and west coasts of Anatolia | 36 | 27 | n/a | IX | n/a | Damaged many buildings at Ephesus and triggered a tsunami that hit coastal cities; see 262 Southwest Anatolia earthquake | |
| 26 January 447 | Night | Bithynia, Thrace, Byzantine Empire | 41 | 28 | Unknown | IX | | Date uncertain, severely damaged the Theodosian walls in Constantinople see 447 Constantinople earthquake | |
| 20 May 526 | | Antioch | | | 250,000 | VIII | 7 Ms | The city of Antioch was greatly damaged, and some decades later the city's population was just 300,000. see 526 Antioch earthquake | |
| 15 August 554 | | Anatolia | | | | | | The earthquake severely damaged the city of Tralles (modern Aydın) and the island of Kos; See 554 Anatolia earthquake | |
| 14 December 557 | just before midnight | Constantinople | 40 | 28 | n/a | X | 6 Mw | Constantinople was "almost completely razed to the ground" by the earthquake. see 557 Constantinople earthquake | |
| 23 September 1063 | | Constantinople, Sea of Marmara | 40 | 27 | | IX | 7 | see 1063 Marmara earthquake | |
| 14 May 1269 | | Cilicia, Anatolia | 37 | 35 | 60,000 | VIII | ~7 | see 1269 Cilicia earthquake | – |
| 10 September 1509 | | Constantinople | 40 | 28 | 13,000 | IX | 7 Mw | see 1509 Constantinople earthquake | – |
| May 1598 | | Amasya and Çorum | 40 | 35 | 60,000 | IX | 6 Ms | see 1598 Amasya–Çorum earthquake | – |
| 23 February 1653 | | Smyrna | 38 | 28 | 2,500 | IX | 7 | see 1653 East Smyrna earthquake | |
| 17 August 1668 | | Anatolia | 40 | 36 | 8,000 | IX | 8 | see 1668 North Anatolia earthquake | |
| 10 July 1688 | 11:45 | Smyrna | 38 | 26 | 16,000 | X | 7 Ms | see 1688 Smyrna earthquake | |
| 22 May 1766 | 05:10 | Istanbul | 40 | 29 | 4,000 | IX | 7 Ms | see 1766 Istanbul earthquake | |
| 5 August 1766 | | Dardanelles | 40 | 27 | 5,000 | X | 7 Mw | see 1766 Marmara earthquake | |
| 18 July 1784 | | Erzincan | 39 | 40 | 5,000–>10,000 | | 7 Ms | see 1784 Erzincan earthquake | |
| 2 July 1840 | | Ağrı | 39 | 44 | 10,000 | IX | 7 Ms | May have triggered the last eruption of Mount Ararat. Casualties associated with a large landslide on the volcano. see 1840 Ahora earthquake | |
| 28 February 1855 | 01:00 | Bursa | 40 | 29 | 1,900 | X | 6 | see 1855 Bursa earthquake | |
| 2 June 1859 | 10:30 | Erzurum | 39 | 41 | 15,000 | IX | 6 Ms | see 1859 Erzurum earthquake | |
| 12 May 1866 | | Bingöl | 39 | 41 | 680+ | X | 7 Ms | see 1866 Bingöl earthquake | |
| 3 April 1872 | – | Hatay | 36 | 36 | 1,800 | IX | 7 Ms | see 1872 Amik earthquake | |
| | – | Afyonkarahisar | 38 | 29 | 1,300 | IX | 6 Mw | see 1875 Dinar earthquake | |
| 3 April 1881 | 11:30 | Chios, Çeşme, Alaçatı | 38 | 26 | 7,866 | X | 7 Mw | see 1881 Chios earthquake | |
| 10 October 1883 | 13:30 | Çeşme, İzmir, Ayvalık | 38 | 26 | 53–120 | IX | 7 Ms | see 1883 Çeşme earthquake | |
| 10 July 1894 | 12:24 | Gulf of İzmit | 40 | 29 | 1,300 | X | 7 | see 1894 Istanbul earthquake | |
| 20 September 1899 | 04:00 | Büyük Menderes Graben | 37 | 28 | 1,470 | IX | 7 | see 1899 Aydın–Denizli earthquake | |