| Minister (Cabinet members shown in bold) | Office | Date of resignation | Reason |
| | Rt Hon The Lord Agnew of Oulton DL | Minister of State for Efficiency and Transformation | 24 January | Unable to defend the government's track record on tackling fraud in Covid business schemes. |
| | Angela Richardson MP | Parliamentary Private Secretary to the Department for Levelling Up, Housing and Communities | 31 January | Criticised Boris Johnson for his mishandling of the partygate affair. |
| | Rt Hon The Lord Wolfson of Tredegar QC | Parliamentary Under-Secretary of State for Justice | 13 April | Accused Boris Johnson of undermining the rule of law, following his decision not to resign in response to criminal sanctions imposed on him by the Metropolitan Police. |
| | Paul Holmes MP | Parliamentary Private Secretary to the Home Office | 27 May | Concerns around "toxic culture" at the heart of government following the publication of the Sue Gray report. |
| | John Lamont MP | Parliamentary Private Secretary to the Foreign, Commonwealth and Development Office | 6 June | Resigned in order to vote against Boris Johnson in a vote of confidence as leader of the Conservative Party. |
| | Rt Hon Oliver Dowden CBE MP | Chairman of the Conservative Party Minister without Portfolio | 24 June | Resigned over poor results at the Tiverton and Honiton and Wakefield by-elections. |
| | Rt Hon Chris Pincher MP | Government Deputy Chief Whip Treasurer of the Household | 30 June | Reports that he drunkenly groped two men at the Carlton Club on 29 June. |
| | Rt Hon Sajid Javid MP | Secretary of State for Health and Social Care | 5 July | Main article: July 2022 United Kingdom government crisis An historic mass resignation (the largest number of ministerial resignations in a 24-hour period, more than tripling the previous record of 11 resignations, set in 1932 during the 2nd National Government), following a statement by the Prime Minister, in which he confirmed that he had been awa |
| | Rt Hon Rishi Sunak MP | Chancellor of the Exchequer |
| | Saqib Bhatti MBE MP | Parliamentary Private Secretary to the Department for Health and Social Care |
| | Jonathan Gullis MP | Parliamentary Private Secretary to the Northern Ireland Office |
| | Nicola Richards MP | Parliamentary Private Secretary to the Department for Transport |
| | Virginia Crosbie MP | Parliamentary Private Secretary to the Office of the Secretary of State for Wales |
| | Alex Chalk QC MP | Solicitor General for England and Wales |
| | Will Quince MP | Parliamentary Under-Secretary of State for Children and Families | 6 July |
| | Laura Trott MP | Parliamentary Private Secretary to the Department for Transport |
| | Robin Walker MP | Minister of State for School Standards |
| | John Glen MP | Economic Secretary to the Treasury |
| | Felicity Buchan MP | Parliamentary Private Secretary to the Department for Business, Energy and Industrial Strategy |
| | Victoria Atkins MP | Minister of State for Prisons and Probation |
| | Jo Churchill MP | Parliamentary Under-Secretary of State for Agri-Innovation and Climate Adaption |
| | Stuart Andrew MP | Minister of State for Housing |
| | Selaine Saxby MP | Parliamentary Private Secretary to HM Treasury |
| | David Johnston MP | Parliamentary Private Secretary to the Department for Education |
| | Claire Coutinho MP | Parliamentary Private Secretary to HM Treasury |
| | Lee Rowley MP | Parliamentary Under-Secretary of State for Business and Industry |
| | Kemi Badenoch MP | Minister of State for Local Government, Faith and Communities Minister of State for Equalities |
| | Neil O'Brien MP | Parliamentary Under-Secretary of State for Levelling Up, The Union and Constitution |
| | Alex Burghart MP | Parliamentary Under-Secretary of State for Apprenticeships and Skills |
| | Julia Lopez MP | Minister of State for Media, Data, and Digital Infrastructure |
| | Mims Davies MP | Parliamentary Under-Secretary of State for Employment |
| | Duncan Baker MP | Parliamentary Private Secretary to the Department for Levelling Up, Housing and Communities |
| | Craig Williams MP | Parliamentary Private Secretary to HM Treasury |
| | Mark Logan MP | Parliamentary Private Secretary to the Northern Ireland Office |
| | Rachel Maclean MP | Parliamentary Under-Secretary of State for Safeguarding |
| | Mike Freer MP | Parliamentary Under-Secretary of State for Exports |
| | Mark Fletcher MP | Parliamentary Private Secretary to the Department for Business, Energy and Industrial Strategy |
| | Sara Britcliffe MP | Parliamentary Private Secretary to the Department for Education |
| | Ruth Edwards MP | Parliamentary Private Secretary to the Office of the Secretary of State for Scotland |
| | Peter Gibson MP | Parliamentary Private Secretary to the Department for International Trade |
| | James Sunderland MP | Parliamentary Private Secretary to the Department for Environment, Food and Rural Affairs |
| | Jacob Young MP | Parliamentary Private Secretary to the Department for Levelling Up, Housing and Communities |
| | Rt Hon Michael Gove MP | Secretary of State for Levelling Up, Housing and Communities |
| | James Daly MP | Parliamentary Private Secretary to the Department for Work and Pensions |
| | Danny Kruger MBE MP | Parliamentary Private Secretary to the Department for Levelling Up, Housing and Communities |
| | Rt Hon Simon Hart MP | Secretary of State for Wales |
| | Edward Argar MP | Minister of State for Health |
| | Gareth Davies MP | Parliamentary Private Secretary to the Department of Health and Social Care |
| | James Davies MP | Parliamentary Private Secretary to the Department of Health and Social Care |