| Minister (Cabinet members shown in bold) | Office | Date of resignation | Reason |
| | Rt Hon The Lord Agnew of Oulton DL | Minister of State for Efficiency and Transformation | 24 January | Unable to defend the government's track record on tackling fraud in Covid business schemes. |
| | Angela Richardson MP | Parliamentary Private Secretary to the Department for Levelling Up, Housing and Communities | 31 January | Criticised Boris Johnson for his mishandling of the partygate affair. |
| | Rt Hon The Lord Wolfson of Tredegar QC | Parliamentary Under-Secretary of State for Justice | 13 April | Accused Boris Johnson of undermining the rule of law, following his decision not to resign in response to criminal sanctions imposed on him by the Metropolitan Police. |
| | Paul Holmes MP | Parliamentary Private Secretary to the Home Office | 27 May | Concerns around "toxic culture" at the heart of government following the publication of the Sue Gray report. |
| | John Lamont MP | Parliamentary Private Secretary to the Foreign, Commonwealth and Development Office | 6 June | Resigned in order to vote against Boris Johnson in a vote of confidence as leader of the Conservative Party. |
| | Rt Hon Oliver Dowden CBE MP | Chairman of the Conservative PartyMinister without Portfolio | 24 June | Resigned over poor results at the Tiverton and Honiton and Wakefield by-elections. |
| | Rt Hon Chris Pincher MP | Government Deputy Chief WhipTreasurer of the Household | 30 June | Reports that he drunkenly groped two men at the Carlton Club on 29 June. |
| | Rt Hon Sajid Javid MP | Secretary of State for Health and Social Care | 5 July | Main article: July 2022 United Kingdom government crisis An historic mass resignation (the largest number of ministerial resignations in a 24-hour period, more than tripling the previous record of 11 resignations, set in 1932 during the 2nd National Government), following a statement by the Prime Minister, in which he confirmed that he had been aware of sexual misconduct allegations against Chris Pincher before appointing him to the government. This contributed to the resignation of Johnson as leader of the Conservative Party and later Prime Minister, with him replaced by Liz Truss as party leader on 5 September and as Prime Minister the following day. |
| | Rt Hon Rishi Sunak MP | Chancellor of the Exchequer |
| | Saqib Bhatti MBE MP | Parliamentary Private Secretary to the Department for Health and Social Care |
| | Jonathan Gullis MP | Parliamentary Private Secretary to the Northern Ireland Office |
| | Nicola Richards MP | Parliamentary Private Secretary to the Department for Transport |
| | Virginia Crosbie MP | Parliamentary Private Secretary to the Office of the Secretary of State for Wales |
| | Alex Chalk QC MP | Solicitor General for England and Wales |
| | Will Quince MP | Parliamentary Under-Secretary of State for Children and Families | 6 July |
| | Laura Trott MP | Parliamentary Private Secretary to the Department for Transport |
| | Robin Walker MP | Minister of State for School Standards |
| | John Glen MP | Economic Secretary to the Treasury |
| | Felicity Buchan MP | Parliamentary Private Secretary to the Department for Business, Energy and Industrial Strategy |
| | Victoria Atkins MP | Minister of State for Prisons and Probation |
| | Jo Churchill MP | Parliamentary Under-Secretary of State for Agri-Innovation and Climate Adaption |
| | Stuart Andrew MP | Minister of State for Housing |
| | Selaine Saxby MP | Parliamentary Private Secretary to HM Treasury |
| | David Johnston MP | Parliamentary Private Secretary to the Department for Education |
| | Claire Coutinho MP | Parliamentary Private Secretary to HM Treasury |
| | Lee Rowley MP | Parliamentary Under-Secretary of State for Business and Industry |
| | Kemi Badenoch MP | Minister of State for Local Government, Faith and CommunitiesMinister of State for Equalities |
| | Neil O'Brien MP | Parliamentary Under-Secretary of State for Levelling Up, The Union and Constitution |
| | Alex Burghart MP | Parliamentary Under-Secretary of State for Apprenticeships and Skills |
| | Julia Lopez MP | Minister of State for Media, Data, and Digital Infrastructure |
| | Mims Davies MP | Parliamentary Under-Secretary of State for Employment |
| | Duncan Baker MP | Parliamentary Private Secretary to the Department for Levelling Up, Housing and Communities |
| | Craig Williams MP | Parliamentary Private Secretary to HM Treasury |
| | Mark Logan MP | Parliamentary Private Secretary to the Northern Ireland Office |
| | Rachel Maclean MP | Parliamentary Under-Secretary of State for Safeguarding |
| | Mike Freer MP | Parliamentary Under-Secretary of State for Exports |
| | Mark Fletcher MP | Parliamentary Private Secretary to the Department for Business, Energy and Industrial Strategy |
| | Sara Britcliffe MP | Parliamentary Private Secretary to the Department for Education |
| | Ruth Edwards MP | Parliamentary Private Secretary to the Office of the Secretary of State for Scotland |
| | Peter Gibson MP | Parliamentary Private Secretary to the Department for International Trade |
| | James Sunderland MP | Parliamentary Private Secretary to the Department for Environment, Food and Rural Affairs |
| | Jacob Young MP | Parliamentary Private Secretary to the Department for Levelling Up, Housing and Communities |
| | Rt Hon Michael Gove MP | Secretary of State for Levelling Up, Housing and Communities |
| | James Daly MP | Parliamentary Private Secretary to the Department for Work and Pensions |
| | Danny Kruger MBE MP | Parliamentary Private Secretary to the Department for Levelling Up, Housing and Communities |
| | Rt Hon Simon Hart MP | Secretary of State for Wales |
| | Edward Argar MP | Minister of State for Health |
| | Gareth Davies MP | Parliamentary Private Secretary to the Department of Health and Social Care |
| | James Davies MP | Parliamentary Private Secretary to the Department of Health and Social Care |