| Rank | Institution | State | FY2025 endowment (billions USD) | FY2024 endowment (billions USD) | Change (%) |
| 1 | The University of Texas System | TX | $27 | $24 | +9 % |
| 2 | The Texas A&M University System & Related Foundations | TX | $22 | $20 | +9 % |
| 3 | University of Michigan | MI | $21 | $19 | +10 % |
| 4 | The Regents of the University of California | CA | $20 | $19 | +5 % |
| 5 | University of Virginia | VA | $11 | $10 | +9 % |
| 6 | The Ohio State University | OH | $8 | $7 | +8 % |
| 7 | The University of Texas at Austin | TX | $6 | $6 | +6 % |
| 8 | University of Minnesota & Foundations | MN | $6 | $5 | +8 % |
| 9 | University of North Carolina at Chapel Hill | NC | $6 | $5 | +8 % |
| 10 | University of Pittsburgh | PA | $6 | $5 | +6 % |
| 11 | The Pennsylvania State University | PA | $5 | $4 | +6 % |
| 12 | University of Wisconsin Foundation | WI | $4 | $4 | +14 % |
| 13 | UCLA Foundation | CA | $4 | $4 | +10 % |
| 14 | Michigan State University | MI | $4 | $4 | +4 % |
| 15 | Purdue University | IN | $4 | $4 | +8 % |
| 16 | Indiana University Foundation | IN | $4 | $3 | +6 % |
| 17 | University of Illinois & Foundations | IL | $3 | $3 | +2 % |
| 18 | University of Iowa and Foundations | IA | $3 | $3 | +7 % |
| 19 | Georgia Institute of Technology and Related Foundations | GA | $3 | $3 | +10 % |
| 20 | University of California Berkeley Foundation | CA | $3 | $3 | +9 % |
| 21 | University of California San Francisco | CA | $3 | $2 | +11 % |
| 22 | Virginia Commonwealth University and Affiliated Entities | VA | $3 | $2 | +11 % |
| 23 | Texas Tech University | TX | $3 | $2 | +5 % |
| 24 | University of Nebraska | NE | $2 | $2 | +7 % |
| 25 | University of Florida Foundation Inc. | FL | $2 | $2 | +9 % |
| 26 | The Kansas University Endowment Association | KS | $2 | $2 | +6 % |
| 27 | The Board of Trustees of The University of Alabama | AL | $2 | $2 | +8 % |
| 28 | University of Missouri System | MO | $2 | $2 | +5 % |
| 29 | North Carolina State University | NC | $2 | $2 | +14 % |
| 30 | The University of Texas Southwestern Medical Center | TX | $2 | $2 | +6 % |
| 31 | University of Colorado Foundation | CO | $2 | $2 | +10 % |
| 32 | The University System of Maryland Foundation | MD | $2 | $2 | +7 % |
| 33 | Rutgers The State University of New Jersey | NJ | $2 | $2 | +7 % |
| 34 | The University of Georgia and Related Foundations | GA | $2 | $2 | +6 % |
| 35 | University of Kentucky | KY | $2 | $1 | +9 % |
| 36 | Texas State University System | TX | $2 | $1 | +50 % |
| 37 | Virginia Tech Foundation | VA | $2 | $1 | +7 % |
| 38 | The University of Utah | UT | $2 | $1 | +11 % |
| 39 | University of Delaware | DE | $2 | $1 | +6 % |
| 40 | The University of Texas M . Anderson Cancer Center | TX | $1 | $1 | +6 % |
| 41 | The University of Tennessee System | TN | $1 | $1 | +8 % |
| 42 | Iowa State University | IA | $1 | $1 | +11 % |
| 43 | University of Oregon Foundation | OR | $1 | $1 | +11 % |
| 44 | University of Arkansas at Fayetteville and Foundation | AR | $1 | $1 | +8 % |
| 45 | University of Massachusetts Foundation | MA | $1 | $1 | +16 % |
| 46 | University of California San Diego | CA | $1 | $1 | +12 % |
| 47 | University of Cincinnati | OH | $1 | $1 | +22 % |
| 48 | Arizona State University | AZ | $1 | $1 | +10 % |
| 49 | William & Mary and Foundations | VA | $1 | $1 | +9 % |
