| Year | Nominee / work | Award | Result |
| 1984 | "International Lover" | Best Male R&B Vocal Performance | Nominated |
| 1999 | Best Male Pop Vocal Performance | Nominated |
| 1985 | Purple Rain | Album of the Year | Nominated |
| Best Rock Performance by a Duo or Group with Vocal | Won |
| Best Score Soundtrack for Visual Media | Won |
| "I Feel for You" | Best R&B Song | Won |
| Prince & The Revolution | Producer of the Year, Non-Classical | Nominated |
| 1986 | Prince and the Revolution: Live | Best Music Film | Nominated |
| 1987 | "Kiss" | Best R&B Performance by a Duo or Group with Vocals | Won |
| Best R&B Song | Nominated |
| 1988 | Sign o' the Times | Album of the Year | Nominated |
| "U Got the Look" | Best R&B Performance by a Duo or Group with Vocals | Nominated |
| Best R&B Song | Nominated |
| 1990 | Batman | Best Male Pop Vocal Performance | Nominated |
| "Batdance" | Best Male R&B Vocal Performance | Nominated |
| "Partyman" | Best Song Written for Visual Media | Nominated |
| Prince | Producer of the Year, Non-Classical | Nominated |
| 1991 | "Nothing Compares 2 U" | Song of the Year | Nominated |
| 1992 | "Gett Off" | Best R&B Performance by a Duo or Group with Vocals | Nominated |
| 1993 | "Diamonds and Pearls" | Best Pop Performance by a Duo or Group with Vocals | Nominated |
| 1995 | "The Most Beautiful Girl in the World" | Best Male Pop Vocal Performance | Nominated |
| 1996 | "I Hate U" | Best Male R&B Vocal Performance | Nominated |
| The Gold Experience | Best R&B Album | Nominated |
| 2004 | N·E·W·S | Best Pop Instrumental Album | Nominated |
| 2005 | "Cinnamon Girl" | Best Male Pop Vocal Performance | Nominated |
| "Call My Name" | Best Male R&B Vocal Performance | Won |
| Best R&B Song | Nominated |
| "Musicology" | Best Traditional R&B Performance | Won |
| Musicology | Best R&B Album | Nominated |
| 2007 | "Black Sweat" | Best Male R&B Vocal Performance | Nominated |
| Best R&B Song | Nominated |
| "Beautiful, Loved and Blessed" | Best R&B Performance by a Duo or Group with Vocals | Nominated |
| "3121" | Best Urban/Alternative Performance | Nominated |
| 3121 | Best R&B Album | Nominated |
| 2008 | "Future Baby Mama" | Best Male R&B Vocal Performance | Won |
| "The Song of the Heart" (from Happy Feet) | Best Song Written for Visual Media | Nominated |
| 1999 | Hall of Fame | Inducted |
| 2010 | "Dreamer" | Best Solo Rock Vocal Performance | Nominated |
| 2011 | Purple Rain | Hall of Fame | Inducted |
| 2017 | Hit n Run Phase Two | Best Engineered Album, Non-Classical | Nominated |
| Sign o' the Times | Hall of Fame | Inducted |
| 2025 | Himself | Lifetime Achievement Award | Honored |