| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes |
| H-201 | 4.10 | 6.60 | H-1 in Halawa, HI | H-1 in Honolulu, HI | 02004-01-012004 | current | Signed as Route 78 until 2004 |
| I-105 | 17.32 | 27.87 | SR 1 in El Segundo, CA | I-605 in Norwalk, CA | 01963-01-011963 | current | Replaced segments of SR 42 |
| I-205 | 12.97 | 20.87 | I-580 near Tracy, CA | I-5 near Tracy, CA | 01970-01-011970 | current | |
| I-305 | 6.00 | 9.66 | I-80 in West Sacramento, CA | I-80 Bus/US 50/SR 99 in Sacramento, CA | 01981-01-011981 | current | Unsigned |
| I-405 | 72.15 | 116.11 | I-5 in Irvine, CA | I-5 in Mission Hills, CA | 01964-01-011964 | current | |
| I-505 | 32.98 | 53.08 | I-80 in Vacaville, CA | I-5 in Dunnigan, CA | 01977-01-011977 | current | Originally part of I-5W |
| I-605 | 27.40 | 44.10 | I-405 in Seal Beach, CA | I-210 in Irwindale, CA | 01964-01-011964 | current | |
| I-805 | 28.02 | 45.09 | I-5 in San Ysidro, CA | I-5 in Sorrento Valley, CA | 01959-01-011959 | current | |
| I-905 | 8.96 | 14.42 | I-5 in San Ysidro, CA | Fed. 2 at the United States-Mexico border in Otay Mesa, CA | proposed | — | Currently SR 905, proposed to be signed as an Interstate |
| I-105 | 3.49 | 5.62 | OR 99 in Eugene, OR | I-5 in Springfield, OR | 01958-01-011958 | current | Concurrent with Oregon Route 126 |
| I-305 | — | — | Pine Street in Salem, OR | I-5 in Keizer, OR | 01957-01-011957 | 01976-01-011976 | Canceled |
| I-405 | 3.53 | 5.68 | I-5 in Portland, OR | I-5 in Portland, OR | 01958-01-011958 | current | |
| I-505 | 3.17 | 5.10 | US 30 in Portland, OR | I-405 in Portland, OR | 01969-01-011969 | 01979-01-011979 | Canceled |
| I-205 | 36.64 | 58.97 | I-5 in Tualatin, OR | I-5 in Salmon Creek, WA | 01958-01-011958 | current | |
| I-405 | 30.30 | 48.76 | I-5/SR 518 in Tukwila, WA | I-5/SR 525 in Lynnwood, WA | 01957-01-011957 | current | |
| I-605 | — | — | WA 99 in Federal Way, WA | I-5 in Everett, WA | — | — | Never built, was planned to bypass Seattle, WA |
| I-705 | 1.50 | 2.41 | I-5/SR 7 in Tacoma, WA | Schuster Parkway in Tacoma | 01978-01-011978 | current |
| I-210 | 4.9 | 7.9 | I-10 in Mobile, AL | I-65 in Prichard, AL | — | — | Currently I-165, the route number was decommissioned because it had no connection to I-10 |
| I-410 | — | — | I-10/I-17 in Phoenix, AZ | I-10 in Phoenix, AZ | — | — | Now part of I-10 in Phoenix, AZ |
| I-510 | — | — | I-10/SR 51 in Phoenix, AZ | SR 101 in Phoenix, AZ | — | — | Currently designated as SR 51 (Piestewa Freeway) |
| I-710 | — | — | I-10 in Tucson, AZ | North Campbell Avenue/East 6th Street in Tucson, AZ | — | — | Mostly never built freeway that was to connect to University of Arizona campus from I-10 |
| I-110 | 20.43 | 32.88 | SR 47 in San Pedro, CA | I-10/SR 110 in Los Angeles, CA | 01978-01-011978 | current | Originally part of US 6, then signed as SR 11 |
| I-210 | 48.72 | 78.41 | I-5 in Sylmar, CA | SR 57/SR 210 in Glendora, CA | 01964-01-011964 | current | Does not connect physically with I-10 as segment from SR 57 east to I-10 is still signed as SR 210, formerly SR 30 prior to 2007. |
| I-710 | 19.66 | 31.64 | Terminal Island in Long Beach, CA | Valley Boulevard in Alhambra, CA | 01983-01-011983 | current | Originally signed as SR 7 |
| I-110 | 6.94 | 11.17 | US 98 Bus. near Pensacola, FL | I-10 near Pensacola, FL | 01969-01-011969 | current | |
| I-110 | 8.89 | 14.31 | I-10 in Baton Rouge, LA | US 61 in Baton Rouge, LA | 01964-01-011964 | current | |
| I-210 | 12.40 | 19.96 | I-10 west of Lake Charles, LA | I-10 east of Lake Charles, LA | 01964-01-011964 | current | |
| I-310 | 11.25 | 18.11 | US 90/LA 3127 in Boutte, LA | I-10 west of Kenner, LA | 01983-01-011983 | current | |
| I-310 | 2.70 | 4.35 | US 90 Bus. in New Orleans, LA | I-10 in New Orleans, LA | 01964-01-011964 | 01969-01-011969 | Canceled Vieux Carré Riverfront Expressway |
| I-410 | 1.90 | 3.06 | LA 67 in Baton Rouge, LA | I-10 in Baton Rouge, LA | 01961-01-011961 | 01964-01-011964 | Renumbered as I-110 |
| I-410 | 48.5 | 78.1 | I-10 west of New Orleans, LA | I-10 in New Orleans, LA | 01969-01-011969 | 01977-01-011977 | Canceled southern bypass of New Orleans; completed portions became I-310 and I-510 |
| I-510 | 3.04 | 4.89 | LA 47 in New Orleans, LA | I-10/LA 47 in New Orleans, LA | 01992-01-011992 | current | |
| I-610 | 4.52 | 7.27 | I-10 at Metairie–New Orleans, LA line | I-10 in New Orleans, LA | 01965-01-011965 | current | |
| I-910 | 9.70 | 15.61 | US 90 Bus. in Marrero, LA | I-10/US 90 Bus. in New Orleans, LA | 01999-01-011999 | current | Unsigned; completely concurrent with US 90 Bus.; both designation are temporary placeholders for Future I-49 |
| I-110 | 4.10 | 6.60 | US 90 in Biloxi, MS | I-10 in D'Iberville, MS | 01988-01-011988 | current | |
| I-310 | — | — | US 90 near the Port of Gulfport, MS | I-10 in Gulfport, MS | proposed | — | Future spur into Gulfport, MS |
| I-110 | 0.92 | 1.48 | Av Abraham Lincoln at the United States-Mexico border in El Paso, TX | I-10 in El Paso, TX | 01967-01-011967 | current | |
| I-410 | 49.49 | 79.65 | Beltway around San Antonio, TX | 01959-01-011959 | current | |
| I-610 | 37.97 | 61.11 | Beltway around Houston, TX | 01975-01-011975 | current | |
| I-215 | 54.50 | 87.71 | I-15 in Murrieta, CA | I-15 in Devore, CA | 01982-01-011982 | current | Originally signed as I-15E, then SR 215 |
| I-115 | 1.19 | 1.92 | I-15/I-90 in Butte, MT | Iron Street in Butte, MT | 01971-01-011971 | current | |
| I-315 | 0.83 | 1.34 | I-15 in Great Falls, MT | I-15 Bus/US 89 in Great Falls, MT | 01960-11-041960 | current | Unsigned |
| I-215 | 11.10 | 17.86 | I-15/Clark County Route 215 in Enterprise, NV | I-11/US 93/SR 564 in Henderson, NV | 01996-01-011996 | current | |
| I-515 | 20.54 | 33.06 | US 93/US 95 in Henderson, NV | I-15/US 93/US 95 in Las Vegas, NV | 01976-01-011976 | 02024-01-012024 | Not signed until 1994, this route is entirely concurrent with US 93/US 95; replaced by northward extensions of I-11 in 2017 and 2024 |
| I-215 | 29.02 | 46.70 | I-80 in Salt Lake City, UT | I-15 in North Salt Lake, UT | 01963-01-011963 | current | |
| I-415 | 2.39 | 3.85 | I-80 in Salt Lake City, UT | 4430 S in Holladay, UT | 01965-01-011965 | 01969-01-011969 | Designation was scrapped to provide a single route number 215 for the entire route. |
| I-516 | 6.49 | 10.44 | SR 21/SR 204 in Savannah, GA | SR 21 in Garden City, GA | 01985-01-011985 | current | |
| I-420 | 5.40 | 8.69 | I-285 in College Park, GA | I-20 in Atlanta, GA | 01983-01-011983 | 01986-01-011986 | Never built, was planned to bypass Atlanta, GA |
| I-520 | 23.34 | 37.56 | I-20 in Augusta, GA | I-20 in North Augusta, SC | 01980-01-011980 | current | |