List of airlines of the United States
Updated: 5/20/2026, 8:06:00 PM Wikipedia source
This is a list of airlines that have an air operator's certificate issued by the Federal Aviation Administration of the United States. Note: Destinations in bold indicate primary hubs, those in italic indicate secondary hubs, and those with regular font indicate focus cities. For legacy carriers American, Delta, and United, the most strategic/well connected hubs are shown as primary hubs.
Tables
· Passenger airlines › Mainline
Alaska Airlines
Alaska Airlines
Airline
Alaska Airlines
IATA
AS
ICAO
ASA
Callsign
ALASKA
Primary hubs,
secondary hubs
Seattle/Tacoma
Daniel K. Inouye International Airport
Anchorage
Los Angeles
Portland (OR)
San Diego
San Francisco
Founded
1932
Notes
Founded as McGee Airways and commenced operations in 1944 as Alaska Airlines.
Hawaiian Airlines merged into Alaska Air Group in 2024, though the two airlines remain as separately branded.
Allegiant Air
Allegiant Air
Airline
Allegiant Air
IATA
G4
ICAO
AAY
Callsign
ALLEGIANT
Primary hubs,
secondary hubs
Las Vegas
Allentown
Appleton
Asheville
Bellingham
Cincinnati
Destin/Fort Walton Beach
Des Moines
Flint
Fort Lauderdale
Grand Rapids
Indianapolis
Knoxville
Nashville
Orlando/Sanford
Phoenix/Mesa
Pittsburgh
Provo
Punta Gorda
Sarasota
Savannah
St. Petersburg/Clearwater
Founded
1997
Notes
Founded as WestJet Express and began operations in 1998 as Allegiant Air.
American Airlines
American Airlines
Airline
American Airlines
IATA
AA
ICAO
AAL
Callsign
AMERICAN
Primary hubs,
secondary hubs
Charlotte
Chicago–O'Hare
Dallas/Fort Worth
Miami
Philadelphia
Phoenix–Sky Harbor
Los Angeles
New York–JFK
New York–LaGuardia
Washington–National
Founded
1926
Notes
Founded as American Airways and commenced operations in 1936 as American Air Lines
Largest airline in the world based on airline company revenue, and scheduled passenger miles flown (per year) in 2025.
Avelo Airlines
Avelo Airlines
Airline
Avelo Airlines
IATA
XP
ICAO
VXP
Callsign
AVELO
Primary hubs,
secondary hubs
New Haven
Charlotte/Concord
Lakeland
Wilmington (DE)
Founded
1987
Notes
Founded as Casino Express Airlines and commenced operations in 1989. Started scheduled service in Burbank, CA, April 28, 2021.
Breeze Airways
Breeze Airways
Airline
Breeze Airways
IATA
MX
ICAO
MXY
Callsign
MOXY
Primary hubs,
secondary hubs
Charleston (SC)
Akron/Canton
Fort Myers
Hartford
New Orleans
Norfolk
Orlando
Providence
Provo
Raleigh/Durham (begins Q1 2026)
Tampa
Vero Beach
Founded
2018
Notes
Founded as Moxy Airways, but was renamed due to trademark issues.
Delta Air Lines
Delta Air Lines
Airline
Delta Air Lines
IATA
DL
ICAO
DAL
Callsign
DELTA
Primary hubs,
secondary hubs
Atlanta
Detroit
Minneapolis/St. Paul
New York–JFK
Salt Lake City
Boston
Los Angeles
New York–LaGuardia
Seattle/Tacoma
Founded
1924
Notes
Founded as Huff Daland Dusters and commenced operations in 1929 as Delta Air Service.
Frontier Airlines
Frontier Airlines
Airline
Frontier Airlines
IATA
F9
ICAO
FFT
Callsign
FRONTIER FLIGHT
Primary hubs,
secondary hubs
Denver
Atlanta
Chicago–O'Hare
Cincinnati
Cleveland
Las Vegas
Miami
Orlando
Philadelphia
Founded
1994
Hawaiian Airlines
Hawaiian Airlines
Airline
Hawaiian Airlines
IATA
AS
ICAO
ASA
Callsign
ALASKA
Primary hubs,
secondary hubs
Daniel K. Inouye International Airport
Founded
1929
Notes
Hawaiian Airlines merged into Alaska Air Group in 2024, though the two airlines remain as separately branded.
JetBlue
JetBlue
Airline
JetBlue
IATA
B6
ICAO
JBU
Callsign
JETBLUE
Primary hubs,
secondary hubs
New York–JFK
Boston
Los Angeles
Fort Lauderdale
Orlando
Founded
1998
Notes
Founded as New Air and commenced operations in 2000 as JetBlue Airways.
Southwest Airlines
Southwest Airlines
Airline
Southwest Airlines
IATA
WN
ICAO
SWA
Callsign
SOUTHWEST
Primary hubs,
secondary hubs
Dallas–Love
Atlanta
Baltimore
Chicago–Midway
Denver
Houston–Hobby
Las Vegas
Los Angeles
Oakland
Orlando
Phoenix–Sky Harbor
Nashville
Founded
1967
Notes
Founded as Air Southwest and commenced operations in 1971 as Southwest Airlines; largest airline in the world based on number of passengers served per year.
Sun Country Airlines
Sun Country Airlines
Airline
Sun Country Airlines
IATA
SY
ICAO
SCX
Callsign
SUN COUNTRY
Primary hubs,
secondary hubs
Minneapolis/St. Paul
Dallas/Fort Worth
Las Vegas
Founded
1982
Notes
Commenced operations in 1983.
Operates some Amazon Air cargo flights.
United Airlines
United Airlines
Airline
United Airlines
IATA
UA
ICAO
UAL
Callsign
UNITED
Primary hubs,
secondary hubs
Chicago–O'Hare
Denver
Houston–Intercontinental
Newark
San Francisco
Washington–Dulles
Guam
Los Angeles
Founded
1926
Notes
Founded as Varney Air Lines and commenced operations in 1931 as United Air Lines.
| Airline | Image | IATA | ICAO | Callsign | Primary hubs, secondary hubs | Founded | Notes |
| Alaska Airlines | | AS | ASA | ALASKA | Seattle/Tacoma Daniel K. Inouye International Airport Anchorage Los Angeles Portland (OR) San Diego San Francisco | 1932 | Founded as McGee Airways and commenced operations in 1944 as Alaska Airlines. Hawaiian Airlines merged into Alaska Air Group in 2024, though the two airlines remain as separately branded. |
| Allegiant Air | | G4 | AAY | ALLEGIANT | Las Vegas Allentown Appleton Asheville Bellingham Cincinnati Destin/Fort Walton Beach Des Moines Flint Fort Lauderdale Grand Rapids Indianapolis Knoxville Nashville Orlando/Sanford Phoenix/Mesa Pittsburgh Provo Punta Gorda Sarasota Savannah St. Petersburg/Clearwater | 1997 | Founded as WestJet Express and began operations in 1998 as Allegiant Air. |
| American Airlines | | AA | AAL | AMERICAN | Charlotte Chicago–O'Hare Dallas/Fort Worth Miami Philadelphia Phoenix–Sky Harbor Los Angeles New York–JFK New York–LaGuardia Washington–National | 1926 | Founded as American Airways and commenced operations in 1936 as American Air Lines Largest airline in the world based on airline company revenue, and scheduled passenger miles flown (per year) in 2025. |
| Avelo Airlines | | XP | VXP | AVELO | New Haven Charlotte/Concord Lakeland Wilmington (DE) | 1987 | Founded as Casino Express Airlines and commenced operations in 1989. Started scheduled service in Burbank, CA, April 28, 2021. |
| Breeze Airways | | MX | MXY | MOXY | Charleston (SC) Akron/Canton Fort Myers Hartford New Orleans Norfolk Orlando Providence Provo Raleigh/Durham (begins Q1 2026) Tampa Vero Beach | 2018 | Founded as Moxy Airways, but was renamed due to trademark issues. |
| Delta Air Lines | | DL | DAL | DELTA | Atlanta Detroit Minneapolis/St. Paul New York–JFK Salt Lake City Boston Los Angeles New York–LaGuardia Seattle/Tacoma | 1924 | Founded as Huff Daland Dusters and commenced operations in 1929 as Delta Air Service. |
| Frontier Airlines | | F9 | FFT | FRONTIER FLIGHT | Denver Atlanta Chicago–O'Hare Cincinnati Cleveland Las Vegas Miami Orlando Philadelphia | 1994 | |
| Hawaiian Airlines | | AS | ASA | ALASKA | Daniel K. Inouye International Airport | 1929 | Hawaiian Airlines merged into Alaska Air Group in 2024, though the two airlines remain as separately branded. |
| JetBlue | | B6 | JBU | JETBLUE | New York–JFK Boston Los Angeles Fort Lauderdale Orlando | 1998 | Founded as New Air and commenced operations in 2000 as JetBlue Airways. |
| Southwest Airlines | | WN | SWA | SOUTHWEST | Dallas–Love Atlanta Baltimore Chicago–Midway Denver Houston–Hobby Las Vegas Los Angeles Oakland Orlando Phoenix–Sky Harbor Nashville | 1967 | Founded as Air Southwest and commenced operations in 1971 as Southwest Airlines; largest airline in the world based on number of passengers served per year. |
| Sun Country Airlines | | SY | SCX | SUN COUNTRY | Minneapolis/St. Paul Dallas/Fort Worth Las Vegas | 1982 | Commenced operations in 1983. Operates some Amazon Air cargo flights. |
| United Airlines | | UA | UAL | UNITED | Chicago–O'Hare Denver Houston–Intercontinental Newark San Francisco Washington–Dulles Guam Los Angeles | 1926 | Founded as Varney Air Lines and commenced operations in 1931 as United Air Lines. |
· Passenger airlines › Regional
Air Wisconsin
Air Wisconsin
Airline
Air Wisconsin
IATA
ZW
ICAO
AWI
Callsign
WISCONSIN
Primary hubs,
secondary hubs
Chicago–O'Hare
Washington–Dulles
Founded
1965
Cape Air
Cape Air
Airline
Cape Air
IATA
9K
ICAO
KAP
Callsign
CAIR
Primary hubs,
secondary hubs
Hyannis
Billings
Boston
Nantucket
St. Louis
San Juan
Albany
Martha's Vineyard
Founded
1988
CommuteAir
CommuteAir
Airline
CommuteAir
IATA
C5
ICAO
UCA
Callsign
COMMUTAIR
Primary hubs,
secondary hubs
Denver
Newark
Washington–Dulles
Founded
1989
Notes
Operates as United Express.
Contour Airlines
Contour Airlines
Airline
Contour Airlines
IATA
LF
ICAO
VTE
Callsign
VOLUNTEER
Primary hubs,
secondary hubs
Smyrna (TN)
Founded
1982
Endeavor Air
Endeavor Air
Airline
Endeavor Air
IATA
9E
ICAO
EDV
Callsign
ENDEAVOR
Primary hubs,
secondary hubs
Minneapolis/St. Paul
Atlanta
Cincinnati
Detroit
New York–JFK
New York–LaGuardia
Raleigh/Durham
Founded
1985
Notes
Founded as Express Airlines I. Operates as Delta Connection.
Envoy Air
Envoy Air
Airline
Envoy Air
IATA
MQ
ICAO
ENY
Callsign
ENVOY
Primary hubs,
secondary hubs
Dallas/Fort Worth
Chicago–O'Hare
Miami
Phoenix–Sky Harbor
Founded
1984
Notes
Founded as American Eagle Airlines. Operates as American Eagle.
GoJet Airlines
GoJet Airlines
Airline
GoJet Airlines
IATA
G7
ICAO
GJS
Callsign
LINDBERGH
Primary hubs,
secondary hubs
Chicago–O'Hare
Denver
Founded
2004
Notes
Commenced operations in 2005. Operates as United Express.
Horizon Air
Horizon Air
Airline
Horizon Air
IATA
QX
ICAO
QXE
Callsign
HORIZON
Primary hubs,
secondary hubs
Seattle/Tacoma
Portland (OR)
Founded
1981
Notes
Operates as Alaska Airlines.
Mesa Airlines
Mesa Airlines
Airline
Mesa Airlines
IATA
YV
ICAO
ASH
Callsign
AIR SHUTTLE
Primary hubs,
secondary hubs
Houston-Intercontinental
Washington–Dulles
Founded
1980
Notes
Founded as Mesa Air Shuttle. All but one aircraft operate as United Express.
Piedmont Airlines
Piedmont Airlines
Airline
Piedmont Airlines
IATA
PT
ICAO
PDT
Callsign
PIEDMONT
Primary hubs,
secondary hubs
Charlotte
Philadelphia
Washington–National
Founded
1961
Notes
Founded as Henson Aviation and commenced operations in 1962. Operates as American Eagle.
PSA Airlines
PSA Airlines
Airline
PSA Airlines
IATA
OH
ICAO
JIA
Callsign
BLUE STREAK
Primary hubs,
secondary hubs
Charlotte
Philadelphia
Washington–National
Founded
1979
Notes
Founded as Vee Neal Airlines. Operates as American Eagle.
Republic Airways
Republic Airways
Airline
Republic Airways
IATA
YX
ICAO
RPA
Callsign
BRICKYARD
Primary hubs,
secondary hubs
Indianapolis
Columbus (OH)
New York–LaGuardia
As American Eagle:
Kansas City
Miami
Philadelphia
Pittsburgh
Washington–National
As United Express:
Chicago–O'Hare
Kansas City
Newark
Pittsburgh
Washington–National
As Delta Connection:
Chicago–O'Hare
Founded
1998
Notes
Commenced operations in 2005. Operates as American Eagle, United Express and Delta Connection.
SkyWest Airlines
SkyWest Airlines
Airline
SkyWest Airlines
IATA
OO
ICAO
SKW
Callsign
SKYWEST
Primary hubs,
secondary hubs
As Delta Connection:
Atlanta
Detroit
Minneapolis/St. Paul
Salt Lake City
Boise
Colorado Springs
Los Angeles
Seattle/Tacoma
As United Express:
Chicago–O'Hare
Denver
Houston–Intercontinental
San Francisco
Boise
Colorado Springs
Los Angeles
As American Eagle:
Dallas/Ft. Worth
Chicago–O'Hare
Los Angeles
Phoenix–Sky Harbor
As Alaska Airlines:
Seattle/Ta
Founded
1972
Notes
Operates as Delta Connection, United Express, American Eagle and Alaska Airlines.
| Airline | Image | IATA | ICAO | Callsign | Primary hubs, secondary hubs | Founded | Notes |
| Air Wisconsin | | ZW | AWI | WISCONSIN | Chicago–O'Hare Washington–Dulles | 1965 | |
| Cape Air | | 9K | KAP | CAIR | Hyannis Billings Boston Nantucket St. Louis San Juan Albany Martha's Vineyard | 1988 | |
| CommuteAir | | C5 | UCA | COMMUTAIR | Denver Newark Washington–Dulles | 1989 | Operates as United Express. |
| Contour Airlines | | LF | VTE | VOLUNTEER | Smyrna (TN) | 1982 | |
| Endeavor Air | | 9E | EDV | ENDEAVOR | Minneapolis/St. Paul Atlanta Cincinnati Detroit New York–JFK New York–LaGuardia Raleigh/Durham | 1985 | Founded as Express Airlines I. Operates as Delta Connection. |
| Envoy Air | | MQ | ENY | ENVOY | Dallas/Fort Worth Chicago–O'Hare Miami Phoenix–Sky Harbor | 1984 | Founded as American Eagle Airlines. Operates as American Eagle. |
| GoJet Airlines | | G7 | GJS | LINDBERGH | Chicago–O'Hare Denver | 2004 | Commenced operations in 2005. Operates as United Express. |
| Horizon Air | | QX | QXE | HORIZON | Seattle/Tacoma Portland (OR) | 1981 | Operates as Alaska Airlines. |
| Mesa Airlines | | YV | ASH | AIR SHUTTLE | Houston-Intercontinental Washington–Dulles | 1980 | Founded as Mesa Air Shuttle. All but one aircraft operate as United Express. |
| Piedmont Airlines | | PT | PDT | PIEDMONT | Charlotte Philadelphia Washington–National | 1961 | Founded as Henson Aviation and commenced operations in 1962. Operates as American Eagle. |
| PSA Airlines | | OH | JIA | BLUE STREAK | Charlotte Philadelphia Washington–National | 1979 | Founded as Vee Neal Airlines. Operates as American Eagle. |
| Republic Airways | | YX | RPA | BRICKYARD | Indianapolis Columbus (OH) New York–LaGuardia As American Eagle: Kansas City Miami Philadelphia Pittsburgh Washington–National As United Express: Chicago–O'Hare Kansas City Newark Pittsburgh Washington–National As Delta Connection: Chicago–O'Hare | 1998 | Commenced operations in 2005. Operates as American Eagle, United Express and Delta Connection. |
| SkyWest Airlines | | OO | SKW | SKYWEST | As Delta Connection: Atlanta Detroit Minneapolis/St. Paul Salt Lake City Boise Colorado Springs Los Angeles Seattle/Tacoma As United Express: Chicago–O'Hare Denver Houston–Intercontinental San Francisco Boise Colorado Springs Los Angeles As American Eagle: Dallas/Ft. Worth Chicago–O'Hare Los Angeles Phoenix–Sky Harbor As Alaska Airlines: Seattle/Ta | 1972 | Operates as Delta Connection, United Express, American Eagle and Alaska Airlines. |
· Passenger airlines › Commuter
Advanced Air
Advanced Air
Airline
Advanced Air
IATA
AN
ICAO
WSN
Callsign
WINGSPAN
Primary hubs,
secondary hubs
Hawthorne
Founded
2005
Notes
Has EAS contract to serve Silver City.
Aztec Airways
Aztec Airways
Airline
Aztec Airways
Primary hubs,
secondary hubs
Fort Lauderdale International Airport
Founded
1998
Bering Air
Bering Air
Airline
Bering Air
IATA
8E
ICAO
BRG
Callsign
BERING AIR
Primary hubs,
secondary hubs
Nome
Kotzebue
Unalakleet
Founded
1979
Boutique Air
Boutique Air
Airline
Boutique Air
IATA
4B
ICAO
BTQ
Callsign
BOUTIQUE
Primary hubs,
secondary hubs
Dallas/Ft. Worth
Denver
Phoenix–Sky Harbor
Founded
2007
Everts Air
Everts Air
Airline
Everts Air
IATA
5V
ICAO
VTS
Callsign
EVERTS
Primary hubs,
secondary hubs
Fairbanks
Anchorage
Founded
1978
Notes
Founded as Tatonduk Flying Service.
Gem Air
Gem Air
Airline
Gem Air
IATA
S6
ICAO
MBI
Primary hubs,
secondary hubs
Salmon
Founded
2014
Grand Canyon Airlines
Grand Canyon Airlines
Airline
Grand Canyon Airlines
IATA
YR
ICAO
CVU
Callsign
CANYON VIEW
Primary hubs,
secondary hubs
Boulder City
Grand Canyon
Page
Founded
1927
Notes
Founded as Scenic Airways.
Grand Canyon Scenic Airlines
Grand Canyon Scenic Airlines
Airline
Grand Canyon Scenic Airlines
IATA
YR
ICAO
SCE
Callsign
SCENIC
Primary hubs,
secondary hubs
Grand Canyon
Founded
1967
Notes
Founded as Scenic Airlines.
Grant Aviation
Grant Aviation
Airline
Grant Aviation
IATA
GV
ICAO
GUN
Callsign
HOOT
Primary hubs,
secondary hubs
Anchorage
Bethel
Cold Bay
Dillingham
Emmonak
Kenai
King Salmon
Unalaska/Dutch Harbor
Founded
1971
Notes
Founded as Delta Air Services.
Griffing Flying Service
Griffing Flying Service
Airline
Griffing Flying Service
Primary hubs,
secondary hubs
Port Clinton
Founded
1937
Island Airways
Island Airways
Airline
Island Airways
Primary hubs,
secondary hubs
Charlevoix
Founded
1945
Notes
Founded as McPhillips Flying Service.
JSX
JSX
Airline
JSX
IATA
XE
ICAO
JSX
Callsign
BIGSTRIPE
Primary hubs,
secondary hubs
Burbank
Dallas–Love
Las Vegas
Miami–Opa Locka
Scottsdale
Founded
2016
Notes
Operator of Taos Air flights from 2022.
Kenmore Air
Kenmore Air
Airline
Kenmore Air
IATA
M5
ICAO
KEN
Callsign
KENMORE
Primary hubs,
secondary hubs
Kenmore
Seattle–Lake Union
Seattle–Boeing
Founded
1946
Notes
Founded as Mines Collins Munro.
Key Lime Air
Key Lime Air
Airline
Key Lime Air
IATA
KG
ICAO
LYM
Callsign
KEY LIME
Primary hubs,
secondary hubs
Denver–Centennial
Denver
Denver–Rocky Mountain
Grand Junction
Founded
1997
Notes
Operates as Denver Air Connection.
Mokulele Airlines
Mokulele Airlines
Airline
Mokulele Airlines
IATA
MW
ICAO
MHO
Callsign
MAHALO
Primary hubs,
secondary hubs
Kailua–Kona
Kahului
Founded
1994
Notes
Founded as Mokulele Flight Service.
New England Airlines
New England Airlines
Airline
New England Airlines
IATA
EJ
ICAO
NEA
Callsign
NEW ENGLAND
Primary hubs,
secondary hubs
Westerly
Founded
1970
Penobscot Island Air
Penobscot Island Air
Airline
Penobscot Island Air
Primary hubs,
secondary hubs
Rockland
Founded
2004
Reliant Air
Reliant Air
Airline
Reliant Air
ICAO
RLI
Callsign
RELIANT
Primary hubs,
secondary hubs
Danbury
Founded
1988
San Juan Airlines
San Juan Airlines
Airline
San Juan Airlines
ICAO
SJN
Callsign
SKYFERRY
Primary hubs,
secondary hubs
Bellingham
Founded
2002
Servant Air
Servant Air
Airline
Servant Air
IATA
8D
Callsign
SERVANT
Primary hubs,
secondary hubs
Kodiak
Founded
2003
Southern Airways Express
Southern Airways Express
Airline
Southern Airways Express
IATA
9X
ICAO
FDY
Callsign
FRIENDLY
Primary hubs,
secondary hubs
Memphis
Destin
Pittsburgh
Washington–Dulles
Founded
2013
Surf Air
Surf Air
Airline
Surf Air
IATA
UF
ICAO
URF
Callsign
SURFAIR
Primary hubs,
secondary hubs
Hawthorne
Oakland
San Carlos
Santa Barbara
Truckee
Founded
2012
Taquan Air
Taquan Air
Airline
Taquan Air
IATA
K3
ICAO
TQN
Callsign
TAQUAN
Primary hubs,
secondary hubs
Ketchikan Harbor
Founded
1977
Tradewind Aviation
Tradewind Aviation
Airline
Tradewind Aviation
IATA
TJ
ICAO
GPD
Callsign
GOODSPEED
Primary hubs,
secondary hubs
Oxford (CT)
San Juan
White Plains
Founded
2001
Ultimate Jet
Ultimate Jet
Airline
Ultimate Jet
IATA
UE
ICAO
UJC
Callsign
ULTIMATE
Primary hubs,
secondary hubs
Cincinnati–Lunken
Founded
2009
Utah Airways
Utah Airways
Airline
Utah Airways
Primary hubs,
secondary hubs
Ogden
Founded
2015
Warbelow's Air Ventures
Warbelow's Air Ventures
Airline
Warbelow's Air Ventures
IATA
4W
ICAO
WAV
Callsign
WARBELOW
Primary hubs,
secondary hubs
Fairbanks
Founded
1958
Wright Air Service
Wright Air Service
Airline
Wright Air Service
IATA
8V
ICAO
WRF
Callsign
WRIGHT FLYER
Primary hubs,
secondary hubs
Fairbanks
Founded
1966
| Airline | Image | IATA | ICAO | Callsign | Primary hubs, secondary hubs | Founded | Notes |
| Advanced Air | AN | WSN | WINGSPAN | Hawthorne | 2005 | Has EAS contract to serve Silver City. | |
| Aztec Airways | Fort Lauderdale International Airport | 1998 | |||||
| Bering Air | | 8E | BRG | BERING AIR | Nome Kotzebue Unalakleet | 1979 | |
| Boutique Air | | 4B | BTQ | BOUTIQUE | Dallas/Ft. Worth Denver Phoenix–Sky Harbor | 2007 | |
| Everts Air | | 5V | VTS | EVERTS | Fairbanks Anchorage | 1978 | Founded as Tatonduk Flying Service. |
| Gem Air | S6 | MBI | Salmon | 2014 | |||
| Grand Canyon Airlines | | YR | CVU | CANYON VIEW | Boulder City Grand Canyon Page | 1927 | Founded as Scenic Airways. |
| Grand Canyon Scenic Airlines | | YR | SCE | SCENIC | Grand Canyon | 1967 | Founded as Scenic Airlines. |
| Grant Aviation | | GV | GUN | HOOT | Anchorage Bethel Cold Bay Dillingham Emmonak Kenai King Salmon Unalaska/Dutch Harbor | 1971 | Founded as Delta Air Services. |
| Griffing Flying Service | Port Clinton | 1937 | |||||
| Island Airways | Charlevoix | 1945 | Founded as McPhillips Flying Service. | ||||
| JSX | | XE | JSX | BIGSTRIPE | Burbank Dallas–Love Las Vegas Miami–Opa Locka Scottsdale | 2016 | Operator of Taos Air flights from 2022. |
| Kenmore Air | | M5 | KEN | KENMORE | Kenmore Seattle–Lake Union Seattle–Boeing | 1946 | Founded as Mines Collins Munro. |
| Key Lime Air | | KG | LYM | KEY LIME | Denver–Centennial Denver Denver–Rocky Mountain Grand Junction | 1997 | Operates as Denver Air Connection. |
| Mokulele Airlines | | MW | MHO | MAHALO | Kailua–Kona Kahului | 1994 | Founded as Mokulele Flight Service. |
| New England Airlines | | EJ | NEA | NEW ENGLAND | Westerly | 1970 | |
| Penobscot Island Air | Rockland | 2004 | |||||
| Reliant Air | | RLI | RELIANT | Danbury | 1988 | ||
| San Juan Airlines | | SJN | SKYFERRY | Bellingham | 2002 | ||
| Servant Air | | 8D | SERVANT | Kodiak | 2003 | ||
| Southern Airways Express | | 9X | FDY | FRIENDLY | Memphis Destin Pittsburgh Washington–Dulles | 2013 | |
| Surf Air | | UF | URF | SURFAIR | Hawthorne Oakland San Carlos Santa Barbara Truckee | 2012 | |
| Taquan Air | | K3 | TQN | TAQUAN | Ketchikan Harbor | 1977 | |
| Tradewind Aviation | | TJ | GPD | GOODSPEED | Oxford (CT) San Juan White Plains | 2001 | |
| Ultimate Jet | | UE | UJC | ULTIMATE | Cincinnati–Lunken | 2009 | |
| Utah Airways | Ogden | 2015 | |||||
| Warbelow's Air Ventures | 4W | WAV | WARBELOW | Fairbanks | 1958 | ||
| Wright Air Service | | 8V | WRF | WRIGHT FLYER | Fairbanks | 1966 |
· Passenger airlines › Charter
Air Charter Bahamas
Air Charter Bahamas
Airline
Air Charter Bahamas
Air Charter Express
Air Charter Express
Airline
Air Charter Express
ICAO
FRG
Callsign
FREIGHT RUNNERS
Primary hubs,
secondary hubs
Milwaukee
Founded
1985
Air Flight Charters
Air Flight Charters
Airline
Air Flight Charters
ICAO
FLL
Primary hubs,
secondary hubs
Ft. Lauderdale
Founded
1987
Airshare
Airshare
Airline
Airshare
ICAO
XSR
Callsign
AIRSHARE
Founded
2000
Notes
Founded as Executive Flight Services.
Berry Aviation
Berry Aviation
Airline
Berry Aviation
ICAO
BYA
Callsign
BERRY
Primary hubs,
secondary hubs
San Marcos
Founded
1983
Bighorn Airways
Bighorn Airways
Airline
Bighorn Airways
ICAO
BHR
Callsign
BIGHORN AIR
Primary hubs,
secondary hubs
Sheridan
Founded
1947
Choice Airways
Choice Airways
Airline
Choice Airways
ICAO
CSX
Callsign
CHOICE AIR
Primary hubs,
secondary hubs
Ft. Lauderdale–Executive
Founded
2009
Eastern Air Express
Eastern Air Express
Airline
Eastern Air Express
ICAO
BBQ
Callsign
EASTERN EXPRESS
Primary hubs,
secondary hubs
Kansas City
Miami
Founded
2013
Notes
Founded as ATX Air Services.
Eastern Airlines
Eastern Airlines
Airline
Eastern Airlines
IATA
2D
ICAO
EAL
Callsign
EASTERN
Primary hubs,
secondary hubs
Kansas City
Founded
2010
Notes
Founded as Dynamic Airways.
ExcelAire
ExcelAire
Airline
ExcelAire
ICAO
XLS
Callsign
EXCELAIRE
Primary hubs,
secondary hubs
Long Island/Islip
Founded
1993
Global Crossing Airlines
Global Crossing Airlines
Airline
Global Crossing Airlines
IATA
G6
ICAO
GXA
Callsign
GEMINI
Primary hubs,
secondary hubs
Atlantic City
Las Vegas
Miami
Founded
2018
Gryphon Airlines
Gryphon Airlines
Airline
Gryphon Airlines
IATA
Y3
ICAO
VOS
Primary hubs,
secondary hubs
Kuwait City
Havana Air
Havana Air
Airline
Havana Air
Primary hubs,
secondary hubs
Miami
Founded
2007
Notes
Virtual airline.
IBC Airways
IBC Airways
Airline
IBC Airways
IATA
II
ICAO
CSQ
Callsign
CHASQUI
Primary hubs,
secondary hubs
Ft. Lauderdale
Founded
1991
L-3 Flight International Aviation
L-3 Flight International Aviation
Airline
L-3 Flight International Aviation
ICAO
RTD
Callsign
RIPTIDE
Primary hubs,
secondary hubs
Newport News
Founded
1972
Liberty Jet Management
Liberty Jet Management
Airline
Liberty Jet Management
ICAO
LRT
Callsign
LIBERTY JET
Primary hubs,
secondary hubs
Long Island/Islip
Founded
2006
NetJets
NetJets
Airline
NetJets
IATA
1I
ICAO
EJA
Callsign
EXECJET
Primary hubs,
secondary hubs
Columbus
Founded
1964
Notes
Founded as Executive Jets Aviation.
Omni Air International
Omni Air International
Airline
Omni Air International
IATA
X9
ICAO
OAE
Callsign
OMNI-EXPRESS
Primary hubs,
secondary hubs
Tulsa
Founded
1993
Omni Air Transport
Omni Air Transport
Airline
Omni Air Transport
ICAO
DRL
Callsign
DRILLER
Primary hubs,
secondary hubs
Tulsa
Pacific Coast Jet
Pacific Coast Jet
Airline
Pacific Coast Jet
ICAO
PXT
Callsign
PACK COAST
Founded
2006
Pentastar Aviation
Pentastar Aviation
Airline
Pentastar Aviation
ICAO
DCX
Callsign
TANGO
Primary hubs,
secondary hubs
Waterford
Founded
1964
Notes
Founded as Chrysler Air Transportation.
Phoenix Air
Phoenix Air
Airline
Phoenix Air
IATA
PH
ICAO
PHA
Callsign
GRAY BIRD
Primary hubs,
secondary hubs
Cartersville
Founded
1978
PlaneSense
PlaneSense
Airline
PlaneSense
ICAO
CNS
Callsign
CHRONOS
Primary hubs,
secondary hubs
Portsmouth (NH)
Founded
1992
Presidential Airways
Presidential Airways
Airline
Presidential Airways
ICAO
PRD
Callsign
PRESIDENTIAL
Primary hubs,
secondary hubs
Melbourne/Orlando
Sierra Pacific Airlines
Sierra Pacific Airlines
Airline
Sierra Pacific Airlines
IATA
SI
ICAO
SPA
Callsign
SIERRA PACIFIC
Primary hubs,
secondary hubs
Tucson
Founded
1970
Notes
Commenced operations in 1971.
Skymax
Skymax
Airline
Skymax
ICAO
SMX
Callsign
SKYMAX
Primary hubs,
secondary hubs
Ft. Lauderdale–Executive
Founded
1997
Notes
Commenced operations in 2013.
Stampede Aviation
Stampede Aviation
Airline
Stampede Aviation
Primary hubs,
secondary hubs
Healy/Denali NP
Founded
2011
Superior Air Charter
Superior Air Charter
Airline
Superior Air Charter
ICAO
RSP
Callsign
REDSTRIPE
Founded
2006
Superior Aviation
Superior Aviation
Airline
Superior Aviation
IATA
SO
ICAO
HKA
Callsign
SPEND AIR
Primary hubs,
secondary hubs
Lansing
Founded
1979
Talkeetna Air Taxi
Talkeetna Air Taxi
Airline
Talkeetna Air Taxi
Primary hubs,
secondary hubs
Talkeetna
Founded
1947
Notes
Founded as Talkeetna Flying Service.
Tropic Ocean Airways
Tropic Ocean Airways
Airline
Tropic Ocean Airways
IATA
TI
ICAO
FTO
Callsign
WAGNER
Primary hubs,
secondary hubs
Ft. Lauderdale
Founded
2009
World Atlantic Airlines
World Atlantic Airlines
Airline
World Atlantic Airlines
IATA
WL
ICAO
WAL
Callsign
WORLD ATLANTIC
Primary hubs,
secondary hubs
Miami
Founded
2002
Notes
Founded as Caribbean Sun Airlines.
XOJET Aviation LLC
XOJET Aviation LLC
Airline
XOJET Aviation LLC
ICAO
XOJ
Callsign
XOJET
Primary hubs,
secondary hubs
Sacramento–McClellan
Founded
2006
| Airline | Image | IATA | ICAO | Callsign | Primary hubs, secondary hubs | Founded | Notes |
| Air Charter Bahamas | |||||||
| Air Charter Express | | FRG | FREIGHT RUNNERS | Milwaukee | 1985 | ||
| Air Flight Charters | FLL | Ft. Lauderdale | 1987 | ||||
| Airshare | | XSR | AIRSHARE | 2000 | Founded as Executive Flight Services. | ||
| Berry Aviation | | BYA | BERRY | San Marcos | 1983 | ||
| Bighorn Airways | | BHR | BIGHORN AIR | Sheridan | 1947 | ||
| Choice Airways | CSX | CHOICE AIR | Ft. Lauderdale–Executive | 2009 | |||
| Eastern Air Express | | BBQ | EASTERN EXPRESS | Kansas City Miami | 2013 | Founded as ATX Air Services. | |
| Eastern Airlines | | 2D | EAL | EASTERN | Kansas City | 2010 | Founded as Dynamic Airways. |
| ExcelAire | | XLS | EXCELAIRE | Long Island/Islip | 1993 | ||
| Global Crossing Airlines | | G6 | GXA | GEMINI | Atlantic City Las Vegas Miami | 2018 | |
| Gryphon Airlines | Y3 | VOS | Kuwait City | ||||
| Havana Air | Miami | 2007 | Virtual airline. | ||||
| IBC Airways | | II | CSQ | CHASQUI | Ft. Lauderdale | 1991 | |
| L-3 Flight International Aviation | RTD | RIPTIDE | Newport News | 1972 | |||
| Liberty Jet Management | LRT | LIBERTY JET | Long Island/Islip | 2006 | |||
| NetJets | | 1I | EJA | EXECJET | Columbus | 1964 | Founded as Executive Jets Aviation. |
| Omni Air International | | X9 | OAE | OMNI-EXPRESS | Tulsa | 1993 | |
| Omni Air Transport | | DRL | DRILLER | Tulsa | |||
| Pacific Coast Jet | PXT | PACK COAST | 2006 | ||||
| Pentastar Aviation | | DCX | TANGO | Waterford | 1964 | Founded as Chrysler Air Transportation. | |
| Phoenix Air | | PH | PHA | GRAY BIRD | Cartersville | 1978 | |
| PlaneSense | | CNS | CHRONOS | Portsmouth (NH) | 1992 | ||
| Presidential Airways | | PRD | PRESIDENTIAL | Melbourne/Orlando | |||
| Sierra Pacific Airlines | | SI | SPA | SIERRA PACIFIC | Tucson | 1970 | Commenced operations in 1971. |
| Skymax | | SMX | SKYMAX | Ft. Lauderdale–Executive | 1997 | Commenced operations in 2013. | |
| Stampede Aviation | Healy/Denali NP | 2011 | |||||
| Superior Air Charter | | RSP | REDSTRIPE | 2006 | |||
| Superior Aviation | SO | HKA | SPEND AIR | Lansing | 1979 | ||
| Talkeetna Air Taxi | Talkeetna | 1947 | Founded as Talkeetna Flying Service. | ||||
| Tropic Ocean Airways | | TI | FTO | WAGNER | Ft. Lauderdale | 2009 | |
| World Atlantic Airlines | | WL | WAL | WORLD ATLANTIC | Miami | 2002 | Founded as Caribbean Sun Airlines. |
| XOJET Aviation LLC | | XOJ | XOJET | Sacramento–McClellan | 2006 |
· Cargo airlines
7Air Cargo
7Air Cargo
Airline
7Air Cargo
IATA
R7
ICAO
TXG
Callsign
CARGO BOX
Primary hubs,
secondary hubs
Miami
Founded
2020
21 Air
21 Air
Airline
21 Air
IATA
2I
ICAO
CSB
Callsign
CARGO SOUTH
Primary hubs,
secondary hubs
Greensboro
Founded
2014
ABX Air
ABX Air
Airline
ABX Air
IATA
GB
ICAO
ABX
Callsign
ABEX
Primary hubs,
secondary hubs
Wilmington (OH)
Cincinnati
Miami
Founded
1980
Notes
Founded as Midwest Air Charter.
Operates some Amazon Air flights.
Air Cargo Carriers
Air Cargo Carriers
Airline
Air Cargo Carriers
IATA
2Q
ICAO
SNC
Callsign
NIGHT CARGO
Primary hubs,
secondary hubs
Milwaukee
Cincinnati
Founded
1986
Notes
Commenced operations in 1980.
AirNet Express
AirNet Express
Airline
AirNet Express
ICAO
USC
Callsign
STAR CHECK
Primary hubs,
secondary hubs
Columbus–Rickenbacker
Founded
1974
Notes
Founded as Financial Air Express.
Air Transport International
Air Transport International
Airline
Air Transport International
IATA
8C
ICAO
ATN
Callsign
AIR TRANSPORT
Primary hubs,
secondary hubs
Wilmington (OH)
Cincinnati
Founded
1978
Notes
Founded as US Airways and commenced operations in 1980.
Operates some Amazon Air flights.
Alaska Central Express
Alaska Central Express
Airline
Alaska Central Express
IATA
KO
ICAO
AER
Callsign
ACE AIR
Primary hubs,
secondary hubs
Anchorage
Founded
1996
Aloha Air Cargo
Aloha Air Cargo
Airline
Aloha Air Cargo
IATA
KH
ICAO
AAH
Callsign
ALOHA
Primary hubs,
secondary hubs
Honolulu
Founded
1946
Notes
Founded as Trans-Pacific Airlines.
Separated from now-defunct Aloha Airlines in 2008.
Alpine Air Express
Alpine Air Express
Airline
Alpine Air Express
IATA
5A
ICAO
AIP
Callsign
ALPINE AIR
Primary hubs,
secondary hubs
Provo
Billings
Sioux Falls
Founded
1971
Amazon Air
Amazon Air
Airline
Amazon Air
IATA
AFW
ICAO
KAFW
Callsign
AMAZON AIR
Primary hubs,
secondary hubs
Ft. Worth–Alliance
Cincinnati
Leipzig/Halle
San Bernardino
Ontario
Wilmington
Founded
2015
Notes
Formerly Amazon Prime Air.
Ameriflight
Ameriflight
Airline
Ameriflight
IATA
A8
ICAO
AMF
Callsign
AMFLIGHT
Primary hubs,
secondary hubs
Dallas/Ft. Worth
Burbank
Founded
1968
Notes
Founded as California Air Charter.
Amerijet International
Amerijet International
Airline
Amerijet International
IATA
M6
ICAO
AJT
Callsign
AMERIJET
Primary hubs,
secondary hubs
Miami
Port of Spain
Founded
1974
Ameristar Jet Charter
Ameristar Jet Charter
Airline
Ameristar Jet Charter
IATA
7Z
ICAO
AJI
Callsign
AMERISTAR
Primary hubs,
secondary hubs
Dallas–Addison
El Paso
Willow Run
Founded
2000
Asia Pacific Airlines
Asia Pacific Airlines
Airline
Asia Pacific Airlines
IATA
P9
ICAO
MGE
Callsign
MAGELLAN
Primary hubs,
secondary hubs
Guam
Honolulu
Founded
1998
Atlas Air
Atlas Air
Airline
Atlas Air
IATA
5Y
ICAO
GTI
Callsign
GIANT
Primary hubs,
secondary hubs
New York–JFK
Anchorage
Cincinnati
Houston–Intercontinental
Huntsville
Los Angeles
Miami
Founded
1992
Notes
Commenced operations in 1993. Operates some Amazon Air flights.
Bemidji Airlines
Bemidji Airlines
Airline
Bemidji Airlines
IATA
CH
ICAO
BMJ
Callsign
BEMIDJI
Primary hubs,
secondary hubs
Bemidji
Minneapolis/St. Paul
Founded
1946
Notes
Commenced operations in 1947.
Castle Aviation
Castle Aviation
Airline
Castle Aviation
ICAO
CSJ
Callsign
CASTLE
Primary hubs,
secondary hubs
Akron/Canton
Founded
1986
Corporate Air
Corporate Air
Airline
Corporate Air
ICAO
CPT
Callsign
AIRSPUR
Primary hubs,
secondary hubs
Billings
Founded
1981
CSA Air
CSA Air
Airline
CSA Air
ICAO
IRO
Callsign
IRON AIR
Primary hubs,
secondary hubs
Iron Mountain
Founded
1998
Empire Airlines
Empire Airlines
Airline
Empire Airlines
IATA
EM
ICAO
CFS
Callsign
EMPIRE
Primary hubs,
secondary hubs
Coeur d'Alene
Spokane
Founded
1977
Everts Air Cargo
Everts Air Cargo
Airline
Everts Air Cargo
IATA
5V
ICAO
VTS
Callsign
EVERTS
Primary hubs,
secondary hubs
Fairbanks
Anchorage
Founded
1995
FedEx Express
FedEx Express
Airline
FedEx Express
IATA
FX
ICAO
FDX
Callsign
FEDEX
Primary hubs,
secondary hubs
Memphis
Anchorage
Cologne/Bonn
Dubai
Ft. Worth–Alliance
Greensboro
Guangzhou
Indianapolis
Miami
Milan–Malpensa
Newark
Oakland
Osaka–Kansai
Paris–CDG
Seoul–Incheon
Toronto–Pearson
Founded
1971
Notes
Founded as Federal Express and commenced operations in 1973.
Freight Runners Express
Freight Runners Express
Airline
Freight Runners Express
ICAO
FRG
Callsign
FREIGHT RUNNERS
Primary hubs,
secondary hubs
Milwaukee
Founded
1985
IFL Group
IFL Group
Airline
IFL Group
IATA
IF
ICAO
IFL
Callsign
EIFFEL
Primary hubs,
secondary hubs
Waterford
Miami
Founded
1983
Notes
Founded as Air Contract Cargo.
Kalitta Air
Kalitta Air
Airline
Kalitta Air
IATA
K4
ICAO
CKS
Callsign
CONNIE
Primary hubs,
secondary hubs
Ypsilanti
Anchorage
Bahrain
Cincinnati
Hong Kong
New York–JFK
Founded
1967
Notes
Founded as American International Airways.
Kalitta Charters
Kalitta Charters
Airline
Kalitta Charters
IATA
CB
ICAO
KFS
Callsign
KALITTA
Primary hubs,
secondary hubs
Ypsilanti
Kamaka Air
Kamaka Air
Airline
Kamaka Air
Primary hubs,
secondary hubs
Honolulu
Founded
1993
Lynden Air Cargo
Lynden Air Cargo
Airline
Lynden Air Cargo
IATA
L2
ICAO
LYC
Callsign
LYNDEN
Primary hubs,
secondary hubs
Anchorage
Founded
1995
Martinaire
Martinaire
Airline
Martinaire
ICAO
MRA
Callsign
MARTEX
Primary hubs,
secondary hubs
Addison
Founded
1978
Merlin Airways
Merlin Airways
Airline
Merlin Airways
ICAO
MEI
Callsign
AVALON
Primary hubs,
secondary hubs
Billings
Miami
San Juan
Founded
1983
Mountain Air Cargo
Mountain Air Cargo
Airline
Mountain Air Cargo
IATA
C2
ICAO
MTN
Callsign
MOUNTAIN
Primary hubs,
secondary hubs
Kinston
Founded
1974
National Airlines
National Airlines
Airline
National Airlines
IATA
N8
ICAO
NCR
Callsign
NATIONAL CARGO
Primary hubs,
secondary hubs
Orlando/Sanford
Founded
1985
Notes
Commenced operations in 1986.
Northern Air Cargo
Northern Air Cargo
Airline
Northern Air Cargo
IATA
NC
ICAO
NAC
Callsign
YUKON
Primary hubs,
secondary hubs
Anchorage
Miami
Founded
1956
Polar Air Cargo
Polar Air Cargo
Airline
Polar Air Cargo
IATA
PO
ICAO
PAC
Callsign
POLAR
Primary hubs,
secondary hubs
Anchorage
Cincinnati
Hong Kong
Honolulu
Los Angeles
Leipzig/Halle
Seoul–Incheon
Shanghai–Pudong
Sharjah
Sydney
Founded
1993
Royal Air Freight
Royal Air Freight
Airline
Royal Air Freight
ICAO
RAX
Callsign
AIR ROYAL
Primary hubs,
secondary hubs
Waterford
Founded
1961
Ryan Air Services
Ryan Air Services
Airline
Ryan Air Services
IATA
7S
ICAO
RYA
Callsign
RYAN AIR
Primary hubs,
secondary hubs
Anchorage
Aniak
Bethel
Emmonak
Kotzebue
Nome
St. Mary's
Unalakleet
Founded
1953
Notes
Founded as Unalakleet Air Taxi.
Sky Lease Cargo
Sky Lease Cargo
Airline
Sky Lease Cargo
IATA
GG
ICAO
KYE
Callsign
SKY CUBE
Primary hubs,
secondary hubs
Miami
Founded
1969
Notes
Founded as Wrangler Aviation and commenced operations in 1973.
Skyway Enterprises
Skyway Enterprises
Airline
Skyway Enterprises
IATA
KI
ICAO
SKZ
Callsign
SKYWAY-INC
Founded
1981
Notes
Commenced operations in 1983.
StratAir
StratAir
Airline
StratAir
Primary hubs,
secondary hubs
Miami
Founded
2018
Notes
Virtual airline on behalf of Northern Air Cargo.
Trans Executive Airlines
Trans Executive Airlines
Airline
Trans Executive Airlines
IATA
KH
ICAO
MUI
Callsign
RHOADES EXPRESS
Primary hubs,
secondary hubs
Honolulu
Founded
1982
UPS Airlines
UPS Airlines
Airline
UPS Airlines
IATA
5X
ICAO
UPS
Callsign
UPS
Primary hubs,
secondary hubs
Louisville
Chicago/Rockford
Cologne/Bonn
Columbia (SC)
Dallas/Ft. Worth
Hamilton
Hong Kong
Kuala Lumpur
Miami
Ontario
Philadelphia
Shanghai–Pudong
Shenzhen
Founded
1988
USA Jet Airlines
USA Jet Airlines
Airline
USA Jet Airlines
IATA
UJ
ICAO
JUS
Callsign
JET USA
Primary hubs,
secondary hubs
Ypsilanti
Laredo
Founded
1994
West Air
West Air
Airline
West Air
ICAO
PCM
Callsign
PAC VALLEY
Primary hubs,
secondary hubs
Las Vegas
Oakland
Ontario
Sacramento
San Diego
Founded
1988
Western Global Airlines
Western Global Airlines
Airline
Western Global Airlines
IATA
KD
ICAO
WGN
Callsign
WESTERN GLOBAL
Primary hubs,
secondary hubs
Fort Myers
Anchorage
Hong Kong
Liege
Los Angeles
Miami
Seoul–Incheon
Founded
2013
Wiggins Airways
Wiggins Airways
Airline
Wiggins Airways
IATA
WG
ICAO
WIG
Callsign
WIGGINS AIRWAYS
Primary hubs,
secondary hubs
Manchester
Founded
1929
| Airline | Image | IATA | ICAO | Callsign | Primary hubs, secondary hubs | Founded | Notes |
| 7Air Cargo | | R7 | TXG | CARGO BOX | Miami | 2020 | |
| 21 Air | | 2I | CSB | CARGO SOUTH | Greensboro | 2014 | |
| ABX Air | | GB | ABX | ABEX | Wilmington (OH) Cincinnati Miami | 1980 | Founded as Midwest Air Charter. Operates some Amazon Air flights. |
| Air Cargo Carriers | | 2Q | SNC | NIGHT CARGO | Milwaukee Cincinnati | 1986 | Commenced operations in 1980. |
| AirNet Express | | USC | STAR CHECK | Columbus–Rickenbacker | 1974 | Founded as Financial Air Express. | |
| Air Transport International | | 8C | ATN | AIR TRANSPORT | Wilmington (OH) Cincinnati | 1978 | Founded as US Airways and commenced operations in 1980. Operates some Amazon Air flights. |
| Alaska Central Express | | KO | AER | ACE AIR | Anchorage | 1996 | |
| Aloha Air Cargo | | KH | AAH | ALOHA | Honolulu | 1946 | Founded as Trans-Pacific Airlines. Separated from now-defunct Aloha Airlines in 2008. |
| Alpine Air Express | | 5A | AIP | ALPINE AIR | Provo Billings Sioux Falls | 1971 | |
| Amazon Air | | AFW | KAFW | AMAZON AIR | Ft. Worth–Alliance Cincinnati Leipzig/Halle San Bernardino Ontario Wilmington | 2015 | Formerly Amazon Prime Air. |
| Ameriflight | | A8 | AMF | AMFLIGHT | Dallas/Ft. Worth Burbank | 1968 | Founded as California Air Charter. |
| Amerijet International | | M6 | AJT | AMERIJET | Miami Port of Spain | 1974 | |
| Ameristar Jet Charter | | 7Z | AJI | AMERISTAR | Dallas–Addison El Paso Willow Run | 2000 | |
| Asia Pacific Airlines | | P9 | MGE | MAGELLAN | Guam Honolulu | 1998 | |
| Atlas Air | | 5Y | GTI | GIANT | New York–JFK Anchorage Cincinnati Houston–Intercontinental Huntsville Los Angeles Miami | 1992 | Commenced operations in 1993. Operates some Amazon Air flights. |
| Bemidji Airlines | | CH | BMJ | BEMIDJI | Bemidji Minneapolis/St. Paul | 1946 | Commenced operations in 1947. |
| Castle Aviation | CSJ | CASTLE | Akron/Canton | 1986 | |||
| Corporate Air | | CPT | AIRSPUR | Billings | 1981 | ||
| CSA Air | CSA Air photo added. | IRO | IRON AIR | Iron Mountain | 1998 | ||
| Empire Airlines | | EM | CFS | EMPIRE | Coeur d'Alene Spokane | 1977 | |
| Everts Air Cargo | | 5V | VTS | EVERTS | Fairbanks Anchorage | 1995 | |
| FedEx Express | | FX | FDX | FEDEX | Memphis Anchorage Cologne/Bonn Dubai Ft. Worth–Alliance Greensboro Guangzhou Indianapolis Miami Milan–Malpensa Newark Oakland Osaka–Kansai Paris–CDG Seoul–Incheon Toronto–Pearson | 1971 | Founded as Federal Express and commenced operations in 1973. |
| Freight Runners Express | | FRG | FREIGHT RUNNERS | Milwaukee | 1985 | ||
| IFL Group | | IF | IFL | EIFFEL | Waterford Miami | 1983 | Founded as Air Contract Cargo. |
| Kalitta Air | | K4 | CKS | CONNIE | Ypsilanti Anchorage Bahrain Cincinnati Hong Kong New York–JFK | 1967 | Founded as American International Airways. |
| Kalitta Charters | | CB | KFS | KALITTA | Ypsilanti | ||
| Kamaka Air | | Honolulu | 1993 | ||||
| Lynden Air Cargo | | L2 | LYC | LYNDEN | Anchorage | 1995 | |
| Martinaire | | MRA | MARTEX | Addison | 1978 | ||
| Merlin Airways | MEI | AVALON | Billings Miami San Juan | 1983 | |||
| Mountain Air Cargo | | C2 | MTN | MOUNTAIN | Kinston | 1974 | |
| National Airlines | | N8 | NCR | NATIONAL CARGO | Orlando/Sanford | 1985 | Commenced operations in 1986. |
| Northern Air Cargo | | NC | NAC | YUKON | Anchorage Miami | 1956 | |
| Polar Air Cargo | | PO | PAC | POLAR | Anchorage Cincinnati Hong Kong Honolulu Los Angeles Leipzig/Halle Seoul–Incheon Shanghai–Pudong Sharjah Sydney | 1993 | |
| Royal Air Freight | RAX | AIR ROYAL | Waterford | 1961 | |||
| Ryan Air Services | | 7S | RYA | RYAN AIR | Anchorage Aniak Bethel Emmonak Kotzebue Nome St. Mary's Unalakleet | 1953 | Founded as Unalakleet Air Taxi. |
| Sky Lease Cargo | | GG | KYE | SKY CUBE | Miami | 1969 | Founded as Wrangler Aviation and commenced operations in 1973. |
| Skyway Enterprises | | KI | SKZ | SKYWAY-INC | 1981 | Commenced operations in 1983. | |
| StratAir | | Miami | 2018 | Virtual airline on behalf of Northern Air Cargo. | |||
| Trans Executive Airlines | | KH | MUI | RHOADES EXPRESS | Honolulu | 1982 | |
| UPS Airlines | | 5X | UPS | UPS | Louisville Chicago/Rockford Cologne/Bonn Columbia (SC) Dallas/Ft. Worth Hamilton Hong Kong Kuala Lumpur Miami Ontario Philadelphia Shanghai–Pudong Shenzhen | 1988 | |
| USA Jet Airlines | | UJ | JUS | JET USA | Ypsilanti Laredo | 1994 | |
| West Air | | PCM | PAC VALLEY | Las Vegas Oakland Ontario Sacramento San Diego | 1988 | ||
| Western Global Airlines | | KD | WGN | WESTERN GLOBAL | Fort Myers Anchorage Hong Kong Liege Los Angeles Miami Seoul–Incheon | 2013 | |
| Wiggins Airways | | WG | WIG | WIGGINS AIRWAYS | Manchester | 1929 |