| | Date | Fatalities | Injuries | Survivors | Article | Location | Comments |
| 1. | September 11, 2001 | c. 1,700 (including 92 on aircraft; 2,763 total combined with United Airlines Flight 175) | c. 6,000–25,000 (combined with United Airlines Flight 175) | 0 | American Airlines Flight 11 | 1 World Trade Center (North Tower), New York City, New York | One of four flights involved in the September 11 attacks |
| 2. | September 11, 2001 | c. 679 (including 65 on aircraft; 2,763 total combined with American Airlines Flight 11) | c. 6,000–25,000 (combined with American Airlines Flight 11) | 0 | United Airlines Flight 175 | 2 World Trade Center (South Tower), New York City, New York | One of four flights involved in the September 11 attacks |
| 3. | May 25, 1979 † | 273 (including 2 on the ground) | 2 (ground) | 0 | American Airlines Flight 191 | Des Plaines, Illinois | |
| 4. | November 12, 2001 | 265 (including 5 on the ground) | 1 (ground) | 0 | American Airlines Flight 587 | Queens, New York | |
| 5. | July 17, 1996 | 230 | 0 | 0 | TWA Flight 800 | Atlantic Ocean, near Moriches, New York | |
| 6. | August 6, 1997 | 229 | 25 | 25 | Korean Air Flight 801 | Nimitz Hill, Guam | The only incident in a US territory to result over 100 fatalities. |
| 7. | October 31, 1999 | 217 | 0 | 0 | EgyptAir Flight 990 | Atlantic Ocean, near Nantucket, Massachusetts | |
| 8. | September 11, 2001 | 189 (including 125 on the ground) | 106 (ground) | 0 | American Airlines Flight 77 | The Pentagon in Arlington, Virginia | One of four flights involved in the September 11 attacks |
| 9. | August 16, 1987 | 156 (including 2 on the ground) | 6 (including 5 on the ground) | 1 | Northwest Airlines Flight 255 | Romulus, Michigan, (a suburb of Detroit) | |
| 10. | July 9, 1982 | 153 (including 8 on the ground) | 4 (ground) | 0 | Pan Am Flight 759 | Kenner, Louisiana | |
| 11. | September 25, 1978 † | 144 (including 7 on the ground) | 9 (ground) | 0 | PSA Flight 182 | San Diego, California | |
| 12. | August 2, 1985 | 137 (including 1 on the ground) | 28 (including 1 on the ground) | 27 | Delta Air Lines Flight 191 | Dallas/Fort Worth International Airport, Texas | Two passengers who survived the initial crash died months later. |
| 13. | December 16, 1960 † | 134 (including 6 on the ground) | N/A | 0 | 1960 New York mid-air collision | Brooklyn, New York, and Staten Island, New York | One passenger, an 11-year-old boy who was on United Airlines Flight 826, survived the initial crash but died of pneumonia the next day. |
| 14. | September 8, 1994 | 132 | 0 | 0 | USAir Flight 427 | Pittsburgh, Pennsylvania | |
| 15. | June 30, 1956 † | 128 | 0 | 0 | 1956 Grand Canyon mid-air collision | Grand Canyon, Arizona | |
| 16. | June 24, 1975 | 113 | 11 | 11 | Eastern Air Lines Flight 66 | Jamaica, New York | One passenger who survived the initial crash died nine days later due to their injuries. |
| 17. | July 19, 1989 | 112 | 171 | 184 | United Airlines Flight 232 | Sioux City, Iowa | The official number of fatalities was 111. One passenger who survived the initial crash died 31 days later due to their injuries. |
| 18. | September 4, 1971 | 111 | 0 | 0 | Alaska Airlines Flight 1866 | Pacific Ocean, near Juneau, Alaska | |
| 19. | May 11, 1996 | 110 | 0 | 0 | ValuJet Flight 592 | Florida Everglades, Florida | |
| 20. | June 3, 1963 | 101 | 0 | 0 | Northwest Airlines Flight 293 | Pacific Ocean, near Annette Island, Alaska | |
| December 29, 1972 | 101 | 75 | 75 | Eastern Air Lines Flight 401 | Florida Everglades, Florida | |
