| No. overall | No. in season | Title | Directed by | Written by | Original release date | Prod. code |
| 40 | 1 | "Dead Guy in Room 4" | Bruce McCulloch | Daniel Levy | January 9, 2018 (2018-01-09) | 262452-40 |
| Moira fears she had a hand in a hotel guest's death. Stevie and Johnny work together to distract the other hotel guests from the body's removal. David and Patrick make things official. Alexis helps Ted find her replacement. |
| 41 | 2 | "Pregnancy Test" | Sturla Gunnarsson | David West Read | January 16, 2018 (2018-01-16) | 262452-41 |
| A positive pregnancy test throws the Roses into a tailspin. Alexis finds Elmdale College is not all it's cracked up to be in the brochure. In search of some privacy, David and Patrick run into a surprise guest at Stevie's apartment. |
| 42 | 3 | "Asbestos Fest" | Bruce McCulloch | Monica Heisey | January 23, 2018 (2018-01-23) | 262452-42 |
| Moira may have bitten off more than she can chew headlining Asbestos Fest. Alexis proves a valuable asset at Rose Apothecary. Johnny extends a helping hand and a new job to help Roland cover baby expenses. |
| 43 | 4 | "Girls' Night" | Sturla Gunnarsson | Michael Short | January 30, 2018 (2018-01-30) | 262452-43 |
| Alexis turns to Twyla for comfort and a girls' night out. David tries to learn to compromise at the Apothecary. David and Patrick hit an important milestone. |
| 44 | 5 | "RIP Moira Rose" | Bruce McCulloch | Rupinder Gill | February 6, 2018 (2018-02-06) | 262452-44 |
| Moira enjoys accolades following a false rumour that she has died. Roland asks Johnny an important question. David and Alexis share an awkward lunch with Ted and Heather. Alexis gets vulnerable with David. |
| 45 | 6 | "Open Mic" | Bruce McCulloch | Daniel Levy and Rebecca Kohler | February 27, 2018 (2018-02-27) | 262452-45 |
| Patrick proposes an open mic night at Rose Apothecary, much to David's consternation. Alexis develops a promotional strategy for the motel. Johnny does something meaningful for Stevie. Moira tries to keep the gender of Roland and Jocelyn's baby a secret. |
| 46 | 7 | "The Barbecue" | Sturla Gunnarsson | David West Read | March 6, 2018 (2018-03-06) | 262452-46 |
| Prompted by Patrick and David's four month anniversary, the Roses plan a barbecue. Alexis meets a new friend in the hotel lobby. David and Patrick hit a rough patch. |
| 47 | 8 | "The Jazzaguy" | Sturla Gunnarsson | Kevin White | March 13, 2018 (2018-03-13) | 262452-47 |
| Alexis tries her hand at a local dating app. Stevie persuades David to spend a day at the spa with her, prompting a meaningful conversation. Johnny accidentally joins the Jazzagals, and Moira has a realization. |
| 48 | 9 | "The Olive Branch" | Bruce McCulloch | Rupinder Gill | March 20, 2018 (2018-03-20) | 262452-48 |
| Alexis earns a college degree and quickly forms a business plan. Moira inadvertently steals her first pitch. Patrick pours his heart into his attempts to reconcile with David. Johnny gets Stevie a baffling gift. David extends his own olive branch. |
| 49 | 10 | "Baby Sprinkle" | Bruce McCulloch | David West Read | March 27, 2018 (2018-03-27) | 262452-49 |
| David is roped into throwing a "sprinkle" for Jocelyn on short notice. Moira and Johnny do some participatory research at a dating agency. Alexis runs into some old friends and is offered a ticket out of Schitts Creek. |
| 50 | 11 | "The Rollout" | Sturla Gunnarsson | Michael Short | April 3, 2018 (2018-04-03) | 262452-50 |
| A mystery rash strikes Stevie and David after using Rose Apothecary products. Moira and Jocelyn are called for jury duty. An old beau makes a return, and Alexis makes an important confession to Ted. |
| 51 | 12 | "Singles Week" | Sturla Gunnarsson | Daniel Levy | April 10, 2018 (2018-04-10) | 262452-51 |
| Moira is delayed in kicking off Singles Week by Jocelyn's unexpected labour. Patrick and David grow closer than ever. Alexis proves she has what it takes to stand on her own two feet. Musical chairs ends in a surprise appearance from Ted. Jocelyn and Roland bestow an honour on Moira. |
| 52 | 13 | "Merry Christmas, Johnny Rose" | Andrew Cividino and Daniel Levy | Daniel Levy | December 18, 2018 (2018-12-18) | 262452-52 |
| Johnny tries to drum up excitement for Christmas Eve celebrations with the family, to a less than enthused reception. Alexis feels the pressure of proving herself to Ted's friends. Moira arranges a surprise to give Johnny the Christmas Eve he hoped for. |